(TKP2021-EGA-23) Funder: Ministry for Innovation and Technology
(STIA-KFI-2021)
(K131996)
(K147265)
(K138816) Funder: NRDIO
(FK138929)
(FK131864)
University of Pécs Medical School Research Fund(300909)
Subjects:
Gastroenterology and hepatology
MEDICAL AND HEALTH SCIENCES
Pancreatic cancer (PC) is a leading cause of cancer mortality, often diagnosed at
advanced stages. Acute pancreatitis (AP), particularly idiopathic cases, may serve
as an early indicator of PC.This multicenter cohort study investigated the incidence
of PC before and after an AP episode, focusing on idiopathic AP and the role of pseudocysts
as potential early markers for PC development.We analyzed data from 2356 AP patients
across 25 centers, with a median follow-up of 4.1 years (IQR: 1.6-6.8 years). Patients
were categorized into 'PC before AP' and 'PC after AP' groups, and relative risk (RR)
and adjusted odds ratios (OR) were calculated for idiopathic AP cases to quantify
PC risk.Among all cases, 69 patients (2.9 %) developed PC: 1.4 % (n = 34) before and
1.5 % (n = 35) after AP. Idiopathic AP cases had a fourfold higher risk of PC (OR
= 4.46, [2.25-8.85]). Notably, pseudocysts were five times more prevalent in the PC
group (14 %) compared to controls (3 %) (RR = 5.66; p < 0.01), often located at the
tumor site. PC developed in 3 % of idiopathic AP cases versus 1.0 % in non-idiopathic
cases. The median time to PC diagnosis post-AP was 373 days.Idiopathic AP and pseudocyst
formation significantly elevate the risk of PC, particularly within two years. These
findings underscore the need for structured follow-up and early screening in idiopathic
AP cases to improve PC detection and survival outcomes.
