Myopia-26, a Mendelian form of early-onset high-myopia (eoHM) caused by mutations
in the X-chromosomal ARR3 gene and predominantly affecting females, curiously, may
provide an alternative route of investigation to unveil retinal mechanisms underlying
pathological eye growth. We conducted a case-control cross-sectional prospective electrophysiological
study in genetically characterized Myopia-26 patients (ARR3 heterozygous symptomatic
females) compared with high myopes harboring intact ARR3 alleles and one carrier hemizygous
male.
