(Open access funding provided by Semmelweis University)
Subjects:
Biological sciences
The UNIfied database of TransMembrane Proteins (UniTmp) is a comprehensive and freely
accessible resource of transmembrane protein structural information at different levels,
from localization of protein segments, through the topology of the protein to the
membrane-embedded 3D structure. We not only annotated tens of thousands of new structures
and experiments, but we also developed a new system that can serve these resources
in parallel. UniTmp is a unified platform that merges TOPDB (Topology Data Bank of
Transmembrane Proteins), TOPDOM (database of conservatively located domains and motifs
in proteins), PDBTM (Protein Data Bank of Transmembrane Proteins) and HTP (Human Transmembrane
Proteome) databases and provides interoperability between the incorporated resources
and an easy way to keep them regularly updated. The current update contains 9235 membrane-embedded
structures, 9088 sequences with 536 035 topology-annotated segments and 8692 conservatively
localized protein domains or motifs as well as 5466 annotated human transmembrane
proteins. The UniTmp database can be accessed at https://www.unitmp.org.Graphical
Abstract
