(K_18 128881) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal
(K_22 142604) Támogató: Hungarian National Research, Development and Innovation Office
(UNKP-20-3-II-SE-36) Támogató: Innovációs és Technológiai Minisztérium
(ÚNKP-21-4-I-SE-32)
Szakterületek:
Onkológia
The prognostic value of histological phenomena tumor budding (TB) and poorly differentiated
clusters (PDCs) have been less studied in gastric cancer (GAC) and the data provided
so far are controversial. In our study, 290 surgically resected GAC cases were evaluated
for TB according to the criteria of International Tumor Budding Consensus Conference
(ITBCC) and PDC, and both parameters were scored on a three-grade scale as described
for colorectal cancer previously (0: Grade0, 1-4: Grade1, 5-9: Grade2 and ≥10: Grade3)
and classified as low (Grade0-2) and high (Grade3) TB/PDC. High TB/PDC was associated
with diffuse-type morphology, higher pT status, incomplete surgical resection, poor
tumor differentiation and perineural and lymphovascular invasion. Multivariable survival
analyses have shown an independent prognostic role of high TB with poorer overall
survival in the total cohort (p = 0.014) and in intestinal-type adenocarcinomas (p
= 0.005). Multivariable model revealed high TB as an independent predictor for lymph
node metastasis in both the total cohort (p = 0.019) and in the intestinal type adenocarcinomas
(p = 0.038). In contrast to tumor budding, no significant association was found between
PDC and the occurrence of lymph node metastasis and tumor stage and even survival.
In conclusion, tumor budding is an independent prognostic factor of survival in gastric
cancer, especially in intestinal-type adenocarcinomas.
