Background Oxidative stress is an important factor in the pathomechanism of atherosclerosis.
Advanced oxidation protein products (AOPPs) are considered markers of oxidative stress.
Thickening of the carotid intima-media layers indicates subclinical atherosclerosis
and can be detected by carotid ultrasound. Objective Our aim was to examine the association
between carotid intima-media thickness (CIMT) and the level of AOPPs. Methods Carotid
duplex scans and measurements of AOPPs were performed on 476 participants of a cardiovascular
population study. The presence of conventional cardiovascular risk factors was investigated
with a questionnaire, physical examination, and laboratory tests. Results There was
a positive correlation between maximum CIMT and the level of AOPPs only in the male
population (r = 0.219, p = 0.033). Multivariate analysis has revealed that the association
between AOPPs and mean or maximum CIMT was independent of cardiovascular risk factors
(OR = 1.458, p = 0.004, and OR = 2.038, p < 0.001). Conclusions Among males, the elevated
level of AOPPs as a marker of oxidative stress may signal the existence of early atherosclerotic
alterations.
