Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule,
(ii) a peptide and (iii) a linker. The drug molecule is mandatory for the biological
action, however, its efficacy can be enhanced by targeted delivery, which often also
reduces unwanted side effects. For site-specificity the peptide part is mainly responsible.
The linker attaches chemically the drug to the peptide, but it could also be biodegradable
which ensures controlled liberation of the small drug. Despite the importance of the
field, there is no public comprehensive database on these species. Herein we describe
ConjuPepBD, a freely available, fully annotated and manually curated database of peptide
drug conjugates. ConjuPepDB contains basic information about the entries, e.g. CAS
number. Furthermore, it also implies their biomedical application and the type of
chemical conjugation employed. It covers more than 1600 conjugates from ∼230 publications.
The web-interface is user-friendly, intuitive, and useable on several devices, e.g.
phones, tablets, PCs. The webpage allows the user to search for content using numerous
criteria, chemical structure and a help page is also provided. Besides giving quick
insight for newcomers, ConjuPepDB is hoped to be also helpful for researchers from
various related fields. The database is accessible at: https://conjupepdb.ttk.hu/.
