In this review we summarize the cellular and molecular events of inflammation induced
epithelial-to-mesenchymal (EMT) and mesothelial-to-macrophage transition (MET) during
regeneration. Since the receptor transmits the environmental stimulus, downregulating
or upregulating the process on an epigenetic level, the intracellular localization
of receptors (signaling organelles: early endosomes or lysosomal degradation: late
endosomes) plays a crucial role in the signaling events regulating inflammation and
regeneration. Therefore, we focused on the internalization of the receptors as well
as the intracellular compartmentalization of signaling molecules during EMT and MET.
The review draws the reader's attention to the plasticity of mesothelial cells and
supports the idea that during inflammation an ambient macrophage population might
derive from mesothelial cells.
