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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10022837"> <a href="/gui2/?type=authors&mode=browse&sel=10022837" target="_blank">Mándity, István</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, Edit</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, Tamás ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10033721"> <a href="/gui2/?type=authors&mode=browse&sel=10033721" target="_blank">Olajos, Gábor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000556"> <a href="/gui2/?type=authors&mode=browse&sel=10000556" target="_blank">Tóth, Gábor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10025639"> <a href="/gui2/?type=authors&mode=browse&sel=10025639" target="_blank">Vass, Elemér</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1381350"> <a href="/gui2/?type=authors&mode=browse&sel=1381350" target="_blank">Fülöp, Ferenc ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1232853" mtid="1232853" target="_blank">Design of Peptidic Foldamer Helices: A Stereochemical Patterning Approach</a></div> <div class="pub-info"> <span class="journal-title">ANGEWANDTE CHEMIE-INTERNATIONAL EDITION</span> <span class="journal-volume">48</span> : <span class="journal-issue">12</span> <span class="page"> pp. 2171-2175. , 5 p. </span> <span class="year">(2009)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1002/anie.200805095" target="_blank" href="https://doi.org/10.1002/anie.200805095"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="36266" target="_blank" href="http://real.mtak.hu/36266"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000264411800025" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000264411800025"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="61949370890" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-61949370890"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="19212995" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19212995&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="7813" target="_blank" href="http://publicatio.bibl.u-szeged.hu/7813"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1232853 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 110</span> | Független: 80 | Függő: 30 | Nem jelölt: 0 | WoS jelölt: 98 | Scopus jelölt: 101 | WoS/Scopus jelölt: 102 | DOI jelölt: 105 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10022837"><a href="/gui2/?type=authors&mode=browse&sel=10022837" target="_blank">Mándity István (<span class="authorship-author-name">Mándity István</span> <span class="authorAux-mtmt"> Gyógyszerkémia, gyógyszerkutatás</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span> ; 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Universität Regensburg, Institut für Organische Chemie, Universitätsstrasse 31, 93053 Regensburg, Germany
Department of Bioorganic Chemistry, Wrocław University of Technology, 50-370 Wrocław, Poland
Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Hungary
Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44801 Bochum, Germany
Paris Lodron University Salzburg, Department of Molecular Biology, Billrothstrasse 11, 5020 Salzburg, Austria
Cited By :69
Export Date: 1 October 2021
CODEN: ACIEF
Correspondence Address: Martinek, T.A.; Institute of Pharmaceutical Chemistry, , 6720 Szeged, Hungary; email: martinek@pharm.u-szeged.hu
Chemicals/CAS: cycloleucine, 52-52-8; Cycloleucine, 52-52-8; Peptides
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Waterproof: cis-β-Aminocylopentanecarboxylic acid is a highly suitable building block for the synthesis of α,β- and α,α,β, β-peptides that have unique helical structures with high stability in methanol and aqueous media. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Berlicki, Ł </span> <span class="author-type"> </span> ; <span class="author-name" > Pilsl, L </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Wéber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10022837"> <a href="/gui2/?type=authors&mode=browse&sel=10022837" target="_blank">Mándity, I M</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Cabrele, C </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, T A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1381350"> <a href="/gui2/?type=authors&mode=browse&sel=1381350" target="_blank">Fülöp, F</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Reiser, O ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1926671" mtid="1926671" target="_blank">Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid</a></div> <div class="pub-info"> <span class="journal-title">ANGEWANDTE CHEMIE-INTERNATIONAL EDITION</span> <span class="journal-volume">51</span> : <span class="journal-issue">9</span> <span class="page"> pp. 2208-2212. , 5 p. </span> <span class="year">(2012)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1002/anie.201107702" target="_blank" href="https://doi.org/10.1002/anie.201107702"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000300691900039" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000300691900039"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84857609735" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84857609735"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22282376" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22282376&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="http://onlinelibrary.wiley.com/doi/10.1002/anie.201107702/pdf" target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201107702/pdf"> Egyéb URL </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="10388" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10388"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1926671 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző Duplum </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 83</span> | Független: 51 | Függő: 32 | Nem jelölt: 0 | WoS jelölt: 78 | Scopus jelölt: 76 | WoS/Scopus jelölt: 81 | DOI jelölt: 78 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1926671" target="_blank">Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid</a></div> <div> <span class="journal-title">ANGEWANDTE CHEMIE-INTERNATIONAL EDITION</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1433-7851">1433-7851</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-3773">1521-3773</a>)</span>:
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<div class="duplumMark">Duplumjelölés:
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(Lövei Anett (ELTE TTK 5-ös admin))
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<div class="lastModified">Utolsó módosítás: 2022.07.17. 01:55 Áts József (admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Universität Regensburg, Institut für Organische Chemie, Universitätsstrasse 31, 93053 Regensburg, Germany
Department of Bioorganic Chemistry, Wrocław University of Technology, 50-370 Wrocław, Poland
Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Hungary
Faculty of Chemistry and Biochemistry, Ruhr ...</pre>
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Department of Pharmacognosy, Comenius University, Odbojárov 10, SK-83232 Bratislava, Slovakia
Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary
Institute of Ecology and Botany, the Hungarian Academy of Sciences, Alkotmány 2, H-2163 Vácrátót, Hungary
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10001254"> <a href="/gui2/?type=authors&mode=browse&sel=10001254" target="_blank">Háznagy-Radnai, E ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Réthy, B </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10062730"> <a href="/gui2/?type=authors&mode=browse&sel=10062730" target="_blank">Czigle, SZ</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001074"> <a href="/gui2/?type=authors&mode=browse&sel=10001074" target="_blank">Zupko, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Wéber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, T</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003944"> <a href="/gui2/?type=authors&mode=browse&sel=10003944" target="_blank">Falkay, GY</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10009338"> <a href="/gui2/?type=authors&mode=browse&sel=10009338" target="_blank">Máthé, I</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;124766" mtid="124766" target="_blank">Cytotoxic activities of Stachys species.</a></div> <div class="pub-info"> <span class="journal-title">FITOTERAPIA</span> <span class="journal-volume">79</span> : <span class="journal-issue">7-8</span> <span class="page"> pp. 595-597. , 3 p. </span> <span class="year">(2008)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.fitote.2008.06.009" target="_blank" href="https://doi.org/10.1016/j.fitote.2008.06.009"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000261602400023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000261602400023"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="55049089066" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-55049089066"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18672034" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18672034&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="10395" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10395"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:124766 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Rövid közlemény ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span> | Független: 58 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 48 | Scopus jelölt: 46 | WoS/Scopus jelölt: 51 | DOI jelölt: 47 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;124766" target="_blank">Cytotoxic activities of Stachys species.</a></div> <div> <span class="journal-title">FITOTERAPIA</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0367-326X">0367-326X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-6971">1873-6971</a>)</span>:
<span class="journal-volume">79</span> <span class="journal-issue">7-8</span>
<span class="page">
pp 595-597
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span>
| Független: 58
| Függő: 1
| Nem jelölt: 0
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Pharmacognosy, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary
Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary
Department of Pharmacognosy, Comenius University, Odbojárov 10, SK-83232 Bratislava, Slovakia
Institute of Pharmaceutical Chemistry, Univers...</pre>
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Chemicals/CAS: Amyloid; Amyloid beta-Protein; Buffers; Formic Acid Esters; Peptide Fragments; Propanols; Serine, 56-45-1; amyloid beta-protein (1-42); hexafluoroisopropanol, 920-66-1; t-butyloxycarbonyl group
Funding Agency and Grant Number: Hungarian National Sciences Foundation [OTKA NK 73672]; NKTH; Janos Bolyai Postdoctoral Fellowship; [FP-7 201159]; [FP-7 211696]\n Funding text: This work was supported by the following grants: OTKA NK 73672 from the Hungarian National Sciences Foundation; Memoload FP-7 201159 and Lipididiet FP-7 211696 and the Teller Ede (Napbio) grant of NKTH. L.F. and A.H. acknowledges support from a Janos Bolyai Postdoctoral Fellowship.\n
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Controlled in situ preparation of Aβ(1-42) oligomers from the isopeptide "iso-Aβ(1-42)", physicochemical and biological characterization
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beta-Amyloid (A beta) peptides play a crucial role in the pathology of the neurodegeneration in Alzheimer's disease (AD). Biological experiments (both in vitro and animal model studies of AD) require synthetic A beta peptides of standard quality, aggregation grade, neurotoxicity and water solubility. The synthesis of A beta peptides has been difficult, owing to their hydrophobic character, poor solubility and high tendency for aggregation. Recently an isopeptide precursor (iso-A beta(1-42)) was synthesized by Fmoc-chemistry and transformed at neutral pH to A beta(1-42) by O -> N acyl migration in a short period of time. We prepared the same precursor peptide using Boc-chemistry and studied the transformation to A beta(1-42) by acyl migration. The peptide conformation and aggregation processes were studied by several methods (circular dichroism, atomic force and transmission electron microscopy, dynamic light scattering). The biological activity of the synthetic A beta(1-42) was measured by ex vivo (long-term potentiation studies in rat hippocampal slices) and in vivo experiments (spatial learning of rats). It was proven that O -> N acyl migration of the precursor isopeptide results in a water soluble oligomeric mixture of neurotoxic A beta(1-42). These oligomers; are formed in situ just before the biological experiments and their aggregation grade could be standardized. (C) 2009 Elsevier Inc. All rights reserved.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10011919"> <a href="/gui2/?type=authors&mode=browse&sel=10011919" target="_blank">Bozso, Z ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000481"> <a href="/gui2/?type=authors&mode=browse&sel=10000481" target="_blank">Penke, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10026778"> <a href="/gui2/?type=authors&mode=browse&sel=10026778" target="_blank">Simon, D</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10006301"> <a href="/gui2/?type=authors&mode=browse&sel=10006301" target="_blank">Laczko, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10063613"> <a href="/gui2/?type=authors&mode=browse&sel=10063613" target="_blank">Juhasz, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027696"> <a href="/gui2/?type=authors&mode=browse&sel=10027696" target="_blank">Szegedi, V</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10030034"> <a href="/gui2/?type=authors&mode=browse&sel=10030034" target="_blank">Kasza, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017320"> <a href="/gui2/?type=authors&mode=browse&sel=10017320" target="_blank">Soos, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001147"> <a href="/gui2/?type=authors&mode=browse&sel=10001147" target="_blank">Hetenyi, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1329681" mtid="1329681" target="_blank">Controlled in situ preparation of Aβ(1-42) oligomers from the isopeptide "iso-Aβ(1-42)", physicochemical and biological characterization</a></div> <div class="pub-info"> <span class="journal-title">PEPTIDES</span> <span class="journal-volume">31</span> : <span class="journal-issue">2</span> <span class="page"> pp. 248-256. , 9 p. </span> <span class="year">(2010)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/j.peptides.2009.12.001" target="_blank" href="https://doi.org/10.1016/j.peptides.2009.12.001"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000274877200009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000274877200009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="73949154685" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-73949154685"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="19995586" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19995586&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="10392" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10392"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:1329681 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span> | Független: 35 | Függő: 24 | Nem jelölt: 0 | WoS jelölt: 41 | Scopus jelölt: 41 | WoS/Scopus jelölt: 42 | DOI jelölt: 50 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" mtid="10011919"><a
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
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<span class="author-name" mtid="10000481"><a
href="/gui2/?type=authors&mode=browse&sel=10000481" target="_blank">Penke B
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Orvosi Vegytani Intézet">OVI</span>/MTA-SZTE Szupramolekuláris és Nanoszerkezetű Anyagok Kutatócsoport; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
;
<span class="author-name" mtid="10026778"><a
href="/gui2/?type=authors&mode=browse&sel=10026778" target="_blank">Simon D
(<span class="authorship-author-name">Simon Dóra</span>
<span class="authorAux-mtmt"> Neurobiológia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
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<span class="author-name" mtid="10006301"><a
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<span class="authorAux-mtmt"> Biofizika</span>)
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<span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Biofizikai Intézet</span>
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<span class="authorAux-mtmt"> elektofiziológia</span>)
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<span class="author-name" mtid="10027696"><a
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<span class="author-affil">Bay Zoltán Alkalmazott Kutatási Közalapítvány</span>
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<span class="author-name" mtid="10030034"><a
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<span class="author-name" mtid="10017320"><a
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<span class="author-name" mtid="10027663"><a
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<span class="author-name" mtid="10018425"><a
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<span class="author-name" mtid="10001165"><a
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Fizikus Tanszékcsoport">FTCS</span>/Optikai és Kvantumelektronikai Tanszék</span>
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<span class="author-name" mtid="10008625"><a
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
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<span class="author-name" mtid="10000567"><a
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1329681" target="_blank">Controlled in situ preparation of Aβ(1-42) oligomers from the isopeptide "iso-Aβ(1-42)", physicochemical and biological characterization</a></div> <div> <span class="journal-title">PEPTIDES</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0196-9781">0196-9781</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-5169">1873-5169</a>)</span>:
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<div class="lockedBy">Ideiglenesen zárolva 2024.03.11. 18:47 Pécsi Éva (MTMT Közp 3, admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-21792922
Chemicals/CAS: Amyloid; Amyloid beta-Protein; Buffers; Formic Acid Esters; Peptide Fragments; Propanols; Serine, 56-45-1; amyloid beta-protein (1-42); hexafluoroisopropanol, 920-66-1; t-butyloxycarbonyl group
Funding Agency and Grant Number: Hungarian National Sciences Foundation [OTKA NK 73672]; NKTH; Janos Bolyai Postdoctoral Fellowship; [FP-7 201159]; [FP-7 211696]\n Fund...</pre>
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The tea from the white mulberry (Morus alba L.) leaf is a worldwide known traditional medicine of type II diabetes. Here, we report the investigation of the dichloromethane-soluble fraction obtained in a 0.24% m/m yield from the hot water extract of mulberry leaves. A significant, dose-dependent activity was found by means of the 24-h glucose consumption of fully differentiated adipocytes both in the absence and presence of insulin. The fraction was characterized by HPLC-DAD, GC-MS and GC-FID. The main constituent (40.3% by means of GC-FID) was isolated and identified as loliolide by EIMS, HRESIMS and NMR spectroscopy. In the active fraction benzyl alcohol, ethyl benzoate, t-cinnamic acid, p-hydroxyacetophenone, t-coniferyl alcohol and synapil alcohol were also identified by GC-MS and quantified by GC-FID (0.7, 1.3, 1.5, 2.9, 7.5 and 2.6%, respectively). Copyright (c) 2012 John Wiley & Sons, Ltd.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10020644"> <a href="/gui2/?type=authors&mode=browse&sel=10020644" target="_blank">Hunyadi, A ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027383"> <a href="/gui2/?type=authors&mode=browse&sel=10027383" target="_blank">Veres, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028610"> <a href="/gui2/?type=authors&mode=browse&sel=10028610" target="_blank">Danko, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10021901"> <a href="/gui2/?type=authors&mode=browse&sel=10021901" target="_blank">Kele, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001147"> <a href="/gui2/?type=authors&mode=browse&sel=10001147" target="_blank">Hetenyi, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001074"> <a href="/gui2/?type=authors&mode=browse&sel=10001074" target="_blank">Zupko, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Hsieh, TJ ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2102858" mtid="2102858" target="_blank">In vitro Anti‐diabetic Activity and Chemical Characterization of an Apolar Fraction of Morus alba Leaf Water Extract</a></div> <div class="pub-info"> <span class="journal-title">PHYTOTHERAPY RESEARCH</span> <span class="journal-volume">27</span> : <span class="journal-issue">6</span> <span class="page"> pp. 847-851. , 5 p. </span> <span class="year">(2013)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/ptr.4803" target="_blank" href="https://doi.org/10.1002/ptr.4803"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000320114500008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000320114500008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84878875426" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84878875426"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22899346" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22899346&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="4292" target="_blank" href="http://publicatio.bibl.u-szeged.hu/4292"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2102858 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 40</span> | Független: 37 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt: 27 | WoS/Scopus jelölt: 28 | DOI jelölt: 32 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2102858" target="_blank">In vitro Anti‐diabetic Activity and Chemical Characterization of an Apolar Fraction of Morus alba Leaf Water Extract</a></div> <div> <span class="journal-title">PHYTOTHERAPY RESEARCH</span>
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research Fund [OTKA PD75383]; New Hungary Development Plan [TAMOP-4.2.1/B-09/1/KONV-2010-0005]; Baross Gabor Program [MFB-00339/2010]; National Science Council of Taiwan [NSC 982314B037011MY3]\n Funding text: This work was carried out within the framework of COST Action CM0804, Chemical Biology with Natural Products. The project was supported ...</pre>
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Funding Agency and Grant Number: EU FP7 [HEALTH-F2-2007-201159, HEALTH-F2-2007-211696]; COST [CM0803]; Hungarian Research Foundation [NK81371, PD83581, PD83600, K68152]; Hungarian Academy of Sciences, Lendulet programme\n Funding text: This work was supported by the EU FP7 (HEALTH-F2-2007-201159, HEALTH-F2-2007-211696 and COST CM0803) (http://cordis.europa.eu/fp7/home_en.html); the Hungarian Research Foundation (NK81371, PD83581, PD83600 and K68152) (http://www.otka.hu/); and the Hungarian Academy of Sciences, Lendulet programme (http://mta.hu/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.\n
Department of Medical Chemistry, University of Szeged, Szeged, Hungary
Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary
Bay Zoltán Foundation for Applied Research - BAYGEN, Szeged, Hungary
Department of Physical Chemistry and Materials Science, University of Szeged, Szeged, Hungary
Cited By :31
Export Date: 24 April 2020
Correspondence Address: Martinek, T. A.; Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary; email: martinek@pharm.u-szeged.hu
Chemicals/CAS: amyloid beta protein, 109770-29-8; Amyloid beta-Peptides; Dendrimers
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<sec><title>Background and Aims</title><p>Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity through their helical foldamer tentacles. Oligomeric Aβ species play pivotal role in Alzheimer's disease, therefore recognition and direct inhibition of this undruggable target is a great current challenge.</p></sec><sec><title>Methods and Results</title><p>Short helical β-peptide foldamers with designed secondary structures and side chain chemistry patterns were applied as potential recognition segments and their binding to the target was tested with NMR methods (saturation transfer difference and transferred-nuclear Overhauser effect). Helices exhibiting binding in the µM region were coupled to a tetravalent G0-PAMAM dendrimer. <italic>In vitro</italic> biophysical (isothermal titration calorimetry, dynamic light scattering, transmission electron microscopy and size-exclusion chromatography) and biochemical tests (ELISA and dot blot) indicated the tight binding between the foldamer conjugates and the Aβ oligomers. Moreover, a selective low nM interaction with the low molecular weight fraction of the Aβ oligomers was found. <italic>Ex vivo</italic> electrophysiological experiments revealed that the new material rescues the long-term potentiation from the toxic Aβ oligomers in mouse hippocampal slices at submicromolar concentration.</p></sec><sec><title>Conclusions</title><p>The combination of the foldamer methodology, the fragment-based approach and the multivalent design offers a pathway to unnatural protein mimetics that are capable of specific molecular recognition, and has already resulted in an inhibitor for an extremely difficult target.</p></sec>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10000567"> <a href="/gui2/?type=authors&mode=browse&sel=10000567" target="_blank">Fülöp, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10022837"> <a href="/gui2/?type=authors&mode=browse&sel=10022837" target="_blank">Mándity, IM</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10063613"> <a href="/gui2/?type=authors&mode=browse&sel=10063613" target="_blank">Juhász, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027696"> <a href="/gui2/?type=authors&mode=browse&sel=10027696" target="_blank">Szegedi, V</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001147"> <a href="/gui2/?type=authors&mode=browse&sel=10001147" target="_blank">Hetényi, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Wéber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011919"> <a href="/gui2/?type=authors&mode=browse&sel=10011919" target="_blank">Bozsó, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10026778"> <a href="/gui2/?type=authors&mode=browse&sel=10026778" target="_blank">Simon, D</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10031637"> <a href="/gui2/?type=authors&mode=browse&sel=10031637" target="_blank">Benkő, M</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="2034559"> <a href="/gui2/?type=authors&mode=browse&sel=2034559" target="_blank">Király, Z</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2034805" mtid="2034805" target="_blank">A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic Beta-Amyloid Oligomers</a></div> <div class="pub-info"> <span class="journal-title">PLOS ONE</span> <span class="journal-volume">7</span> : <span class="journal-issue">7</span> <span class="page"> Paper: e39485 , 17 p. </span> <span class="year">(2012)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0039485" target="_blank" href="https://doi.org/10.1371/journal.pone.0039485"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="46068" target="_blank" href="http://real.mtak.hu/46068"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000306950900007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000306950900007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84864443157" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84864443157"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22859942" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22859942&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="11876" target="_blank" href="http://publicatio.bibl.u-szeged.hu/11876"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:2034805 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 47</span> | Független: 33 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 36 | Scopus jelölt: 38 | WoS/Scopus jelölt: 38 | DOI jelölt: 41 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="authorAux-mtmt"> Neurodegeneratív betegségekkel kapcsolatos gyóg...</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span>
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span>
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2034805" target="_blank">A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic Beta-Amyloid Oligomers</a></div> <div> <span class="journal-title">PLOS ONE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>:
<span class="journal-volume">7</span> <span class="journal-issue">7</span>
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Paper e39485.
17 p.
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 47</span>
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: EU FP7 [HEALTH-F2-2007-201159, HEALTH-F2-2007-211696]; COST [CM0803]; Hungarian Research Foundation [NK81371, PD83581, PD83600, K68152]; Hungarian Academy of Sciences, Lendulet programme\n Funding text: This work was supported by the EU FP7 (HEALTH-F2-2007-201159, HEALTH-F2-2007-211696 and COST CM0803) (http://cordis.europa.eu/fp7/home_en.html); the Hungarian Re...</pre>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Benedek, G </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013052"> <a href="/gui2/?type=authors&mode=browse&sel=10013052" target="_blank">Palko, M</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, TA</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002835"> <a href="/gui2/?type=authors&mode=browse&sel=10002835" target="_blank">Forro, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1381350"> <a href="/gui2/?type=authors&mode=browse&sel=1381350" target="_blank">Fulop, F ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1128281" mtid="1128281" target="_blank">Efficient synthesis of hydroxy-substituted cispentacin derivatives</a></div> <div class="pub-info"> <span class="journal-title">EUROPEAN JOURNAL OF ORGANIC CHEMISTRY</span> <span class="journal-volume">2008</span> : <span class="journal-issue">21</span> <span class="page"> pp. 3724-3730. , 7 p. </span> <span class="year">(2008)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/ejoc.200800345" target="_blank" href="https://doi.org/10.1002/ejoc.200800345"> DOI </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <span class="isbnOrIssn"> ISSN: </span> <a style="color:blue" title="1099-0690" target="_blank" href="https://portal.issn.org/resource/ISSN/1099-0690"> 1099-0690 </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000258087600016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000258087600016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="53749089399" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-53749089399"> Scopus </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="10394" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10394"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1128281 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző Duplum </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 41</span> | Független: 26 | Függő: 15 | Nem jelölt: 0 | WoS jelölt: 37 | Scopus jelölt: 37 | WoS/Scopus jelölt: 37 | DOI jelölt: 39 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Benedek G
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<span class="authorAux-mtmt"> Gyógyszerkémia, szintetikus szerves kémia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span>
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="MTA-SZTE Sztereokémiai Kutatócsoport">MTASZTESZK</span>/MTA-SZTE Sztereokémiai Kutatócsoport-GYTK</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1128281" target="_blank">Efficient synthesis of hydroxy-substituted cispentacin derivatives</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF ORGANIC CHEMISTRY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1434-193X">1434-193X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1099-0690">1099-0690</a>)</span>:
<span class="journal-volume">2008</span> <span class="journal-issue">21</span>
<span class="page">
pp 3724-3730
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<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
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<a style="color:blue" title="000258087600016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000258087600016">
WoS
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 41</span>
| Független: 26
| Függő: 15
| Nem jelölt: 0
| WoS jelölt: 37
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<a target="_blank" href="/api/publication?cond=citations.related;eq;1128281&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 11
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1128281</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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<span class="oldId">Régi azonosító: 1128281</span> |
Forrás Idéző
Duplum
| <span class="type-subtype">Folyóiratcikk
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)
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| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">WOS</span>
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<div class="duplumMark">Duplumjelölés:
2023.09.05. 20:01
(Hetényi Anasztázia (SZTE ÁOK admin5 Orvosi Vegytani Intézet))
</div>
<div class="lastModified">Utolsó módosítás: 2023.09.06. 12:46 Hetényi Anasztázia (SZTE ÁOK admin5 Orvosi Vegytani Intézet)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: CAplus AN 2008:935386 (Journal);</pre>
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Two histidine-rich branched peptides with one lysine as a branching unit have been designed and synthesized by solid-phase peptide synthesis. Their complex formation with Cu(ii) and Zn(ii) as well as their ability to attenuate the metal-ion induced amyloid aggregation has been characterized. Both peptides can keep Cu(ii) and Zn(ii) in complexed forms at pH 7.4 and can bind two equivalents of metal ions in solutions with excess metal. The stoichiometry, stability and structure of the complexes formed have been determined by pH potentiometry, UV-Vis spectrophotometry, circular dichroism, EPR and NMR spectroscopy and ESI-MS. Both mono- and bimetallic species have been detected over the whole pH range studied. The basic binding mode is either a tridentate {Namino, Namide, Nim} or a histamine-type of coordination which is complemented by the binding of far imidazole or amino groups leading to macrochelate formation. The peptides were able to prevent Cu(ii)-induced A[small beta](1-40) aggregation but could not effectively compete for Zn(ii) in vitro. Our results suggest that branched peptides containing potential metal-binding sites may be suitable metal chelators for reducing the risk of amyloid plaque formation in Alzheimer's disease.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Lakatos, Andrea ✉ </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002832"> <a href="/gui2/?type=authors&mode=browse&sel=10002832" target="_blank">Gyurcsik, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002991"> <a href="/gui2/?type=authors&mode=browse&sel=10002991" target="_blank">Nagy, NV</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10030083"> <a href="/gui2/?type=authors&mode=browse&sel=10030083" target="_blank">Csendes, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000567"> <a href="/gui2/?type=authors&mode=browse&sel=10000567" target="_blank">Fulop, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000634"> <a href="/gui2/?type=authors&mode=browse&sel=10000634" target="_blank">Kiss, Tamas ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1847217" mtid="1847217" target="_blank">Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS</span> <span class="journal-volume">41</span> : <span class="journal-issue">6</span> <span class="page"> pp. 1713-1726. , 14 p. </span> <span class="year">(2012)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1039/c1dt10989h" target="_blank" href="https://doi.org/10.1039/c1dt10989h"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000299292400009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000299292400009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84856741247" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84856741247"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22159144" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22159144&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="10389" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10389"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:1847217 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 37</span> | Független: 34 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 37 | Scopus jelölt: 36 | WoS/Scopus jelölt: 37 | DOI jelölt: 36 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lakatos Andrea ✉ </span> ; <span class="author-name" mtid="10002832"><a href="/gui2/?type=authors&mode=browse&sel=10002832" target="_blank">Gyurcsik B (<span class="authorship-author-name">Gyurcsik Béla</span> <span class="authorAux-mtmt"> Biokoordinációs kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Tanszékcsoport">KTCS</span>/Szervetlen és Analitikai Kémiai Tanszék</span> ; <span class="author-name" mtid="10002991"><a href="/gui2/?type=authors&mode=browse&sel=10002991" target="_blank">Nagy NV (<span class="authorship-author-name">May Nóra Veronika</span> <span class="authorAux-mtmt"> Egykristály Röntgendiffrakció és ESR-spektroszk...</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Molekuláris Farmakológiai Intézet</span> ; <span class="author-name" mtid="10030083"><a href="/gui2/?type=authors&mode=browse&sel=10030083" target="_blank">Csendes Z (<span class="authorship-author-name">Csendes Zita</span> <span class="authorAux-mtmt"> Kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Tanszékcsoport">KTCS</span>/Szervetlen és Analitikai Kémiai Tanszék</span> ; <span class="author-name" mtid="10027663"><a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber E (<span class="authorship-author-name">Wéber Edit</span> <span class="authorAux-mtmt"> gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span> ; <span class="author-name" mtid="10000567"><a href="/gui2/?type=authors&mode=browse&sel=10000567" target="_blank">Fulop L (<span class="authorship-author-name">Fülöp Lívia</span> <span class="authorAux-mtmt"> Neurodegeneratív betegségekkel kapcsolatos gyóg...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10000634"><a href="/gui2/?type=authors&mode=browse&sel=10000634" target="_blank">Kiss Tamas ✉ (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> Szervetlen kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Tanszékcsoport">KTCS</span>/Szervetlen és Analitikai Kémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1847217" target="_blank">Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease</a></div> <div> <span class="journal-title">JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1472-7773">1472-7773</a> )</span>: <span class="journal-volume">41</span> <span class="journal-issue">6</span> <span class="page"> pp 1713-1726 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1039/c1dt10989h" target="_blank" href="https://doi.org/10.1039/c1dt10989h"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000299292400009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000299292400009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84856741247" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84856741247"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22159144" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22159144&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="10389" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10389"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 37</span> | Független: 34 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 37 | Scopus jelölt: 36 | WoS/Scopus jelölt: 37 | DOI jelölt: 36 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1847217&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1847217</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1847217</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.03.11. 15:54 Pécsi Éva (MTMT Közp 3, admin) </div> <div class="lockedBy">Ideiglenesen zárolva 2024.03.11. 18:47 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>
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The principles of beta-sheet folding and design for alpha-peptidic sequences are well established, while those for sheet mimetics containing homologated amino acid building blocks are still under investigation. To reveal the structure-function relations of beta-amino-acid-containing foldamers, we followed a top-down approach to study a series of alpha/beta-peptidic analogs of anginex, a beta-sheet-forming antiangiogenic peptide. Eight anginex analogs were developed by systematic alpha --> beta(3) substitutions and analyzed by using NMR and CD spectroscopy. The foldamers retained the beta-sheet tendency, though with a decreased folding propensity. beta-Sheet formation could be induced by a micellar environment, similarly to that of the parent peptide. The destructuring effect was higher when the alpha --> beta(3) exchange was located in the beta-sheet core. Analysis of the beta-sheet stability versus substitution pattern and the local conformational bias of the bulky beta(3)V and beta(3)I residues revealed that a mismatch between the H-bonding preferences of the alpha- and beta-residues played a minor role in the structure-breaking effect. Temperature-dependent CD and NMR measurements showed that the hydrophobic stabilization was scaled-down for the alpha/beta-peptides. Analysis of the biological activity of the foldamer peptides showed that four anginex derivatives dose-dependently inhibited the proliferation of a mouse endothelial cell line. The alpha --> beta(3) substitution strategy applied in this work can be a useful approach to the construction of bioactive beta-sheet mimetics with a reduced aggregation tendency and improved pharmacokinetic properties.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10043382"> <a href="/gui2/?type=authors&mode=browse&sel=10043382" target="_blank">Hegedus, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E<sup>*</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10030596"> <a href="/gui2/?type=authors&mode=browse&sel=10030596" target="_blank">Kriston-Pal, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10051196"> <a href="/gui2/?type=authors&mode=browse&sel=10051196" target="_blank">Makra, Ildikó</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10018848"> <a href="/gui2/?type=authors&mode=browse&sel=10018848" target="_blank">Czibula, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008944"> <a href="/gui2/?type=authors&mode=browse&sel=10008944" target="_blank">Monostori, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001168"> <a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek, TA ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2459240" mtid="2459240" target="_blank">Foldameric α/β-Peptide Analogs of the β-Sheet-Forming Antiangiogenic Anginex: Structure and Bioactivity</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF THE AMERICAN CHEMICAL SOCIETY</span> <span class="journal-volume">135</span> : <span class="journal-issue">44</span> <span class="page"> pp. 16578-16584. , 7 p. </span> <span class="year">(2013)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1021/ja408054f" target="_blank" href="https://doi.org/10.1021/ja408054f"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:black" title="60950" target="_blank" href="http://real.mtak.hu/60950"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000326774300057" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000326774300057"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84887699703" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84887699703"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24088182" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24088182&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="http://pubs.acs.org/doi/ipdf/10.1021/ja408054f" target="_blank" href="http://pubs.acs.org/doi/ipdf/10.1021/ja408054f"> Teljes dokumentum </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="4156" target="_blank" href="http://publicatio.bibl.u-szeged.hu/4156"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2459240 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 34</span> | Független: 28 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt: 33 | WoS/Scopus jelölt: 33 | DOI jelölt: 32 (Nem nyilvános: 1) </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043382"><a href="/gui2/?type=authors&mode=browse&sel=10043382" target="_blank">Hegedus Z (<span class="authorship-author-name">Hegedüs Zsófia</span> <span class="authorAux-mtmt"> gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerkémiai Intézet">GYKI</span>/MTA-SZTE Lendület Peptidfoldamer Kutatócsoport</span> ; <span class="author-name" mtid="10027663"><a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber E<sup>*</sup> (<span class="authorship-author-name">Wéber Edit</span> <span class="authorAux-mtmt"> gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerkémiai Intézet">GYKI</span>/MTA-SZTE Lendület Peptidfoldamer Kutatócsoport</span> ; <span class="author-name" mtid="10030596"><a href="/gui2/?type=authors&mode=browse&sel=10030596" target="_blank">Kriston-Pal E (<span class="authorship-author-name">Kriston-Pál Éva</span> <span class="authorAux-mtmt"> tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ; <span class="author-name" mtid="10051196"><a href="/gui2/?type=authors&mode=browse&sel=10051196" target="_blank">Makra Ildikó (<span class="authorship-author-name">Makra Ildikó</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> ; <span class="author-name" mtid="10018848"><a href="/gui2/?type=authors&mode=browse&sel=10018848" target="_blank">Czibula A (<span class="authorship-author-name">Czibula Ágnes</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ; <span class="author-name" mtid="10008944"><a href="/gui2/?type=authors&mode=browse&sel=10008944" target="_blank">Monostori E (<span class="authorship-author-name">Monostori Éva</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ; <span class="author-name" mtid="10001168"><a href="/gui2/?type=authors&mode=browse&sel=10001168" target="_blank">Martinek TA ✉ (<span class="authorship-author-name">Martinek Tamás</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerkémiai Intézet">GYKI</span>/MTA-SZTE Lendület Peptidfoldamer Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;2459240" target="_blank">Foldameric α/β-Peptide Analogs of the β-Sheet-Forming Antiangiogenic Anginex: Structure and Bioactivity</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN CHEMICAL SOCIETY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0002-7863">0002-7863</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1520-5126">1520-5126</a>)</span>: <span class="journal-volume">135</span> <span class="journal-issue">44</span> <span class="page"> pp 16578-16584 </span> <span class="year">(2013)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1021/ja408054f" target="_blank" href="https://doi.org/10.1021/ja408054f"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:black" title="60950" target="_blank" href="http://real.mtak.hu/60950"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000326774300057" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000326774300057"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84887699703" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84887699703"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24088182" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24088182&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="http://pubs.acs.org/doi/ipdf/10.1021/ja408054f" target="_blank" href="http://pubs.acs.org/doi/ipdf/10.1021/ja408054f"> Teljes dokumentum </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="4156" target="_blank" href="http://publicatio.bibl.u-szeged.hu/4156"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 34</span> | Független: 28 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt: 33 | WoS/Scopus jelölt: 33 | DOI jelölt: 32 (Nem nyilvános: 1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2459240&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2459240</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 2459240</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2024.02.27. 14:48 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>
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Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2H-Azirines via Joullie-Ugi Three-Component Reaction
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A ZnCl2-catalyzed diastereoselective Joullie Ugi three-component reaction from 2H-azirines, isocyanides, and carboxylic acids was established. The protocol allows the preparation of highly and diversely functionalized N-acylaziridine-2-carboxamide derivatives in up to 82% isolated yields. Moreover, the applicability of N-acylaziridines is demonstrated through a variety of transformations.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10048220"> <a href="/gui2/?type=authors&mode=browse&sel=10048220" target="_blank">Angyal, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10063710"> <a href="/gui2/?type=authors&mode=browse&sel=10063710" target="_blank">Demjen, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027663"> <a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10061492"> <a href="/gui2/?type=authors&mode=browse&sel=10061492" target="_blank">Kovacs, AK</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000356"> <a href="/gui2/?type=authors&mode=browse&sel=10000356" target="_blank">Wolfling, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010041"> <a href="/gui2/?type=authors&mode=browse&sel=10010041" target="_blank">Puskas, LG</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10064926"> <a href="/gui2/?type=authors&mode=browse&sel=10064926" target="_blank">Kanizsai, I ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3389411" mtid="3389411" target="_blank">Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2H-Azirines via Joullie-Ugi Three-Component Reaction</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF ORGANIC CHEMISTRY</span> <span class="journal-volume">83</span> : <span class="journal-issue">7</span> <span class="page"> pp. 3570-3581. , 12 p. </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1021/acs.joc.7b03189" target="_blank" href="https://doi.org/10.1021/acs.joc.7b03189"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000429886100014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000429886100014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85045127856" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85045127856"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29498845" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29498845&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="13637" target="_blank" href="http://publicatio.bibl.u-szeged.hu/13637"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3389411 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 27</span> | Független: 25 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt: 25 | WoS/Scopus jelölt: 27 | DOI jelölt: 26 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10048220"><a href="/gui2/?type=authors&mode=browse&sel=10048220" target="_blank">Angyal A (<span class="authorship-author-name">Angyal Anikó</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Szerves Kémiai Tanszék</span> ; <span class="author-name" mtid="10063710"><a href="/gui2/?type=authors&mode=browse&sel=10063710" target="_blank">Demjen A (<span class="authorship-author-name">Demjén András</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> ; <span class="author-name" mtid="10027663"><a href="/gui2/?type=authors&mode=browse&sel=10027663" target="_blank">Weber E (<span class="authorship-author-name">Wéber Edit</span> <span class="authorAux-mtmt"> gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszeranalitikai Intézet</span> ; <span class="author-name" mtid="10061492"><a href="/gui2/?type=authors&mode=browse&sel=10061492" target="_blank">Kovacs AK (<span class="authorship-author-name">Kovács Anita Kármen</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10000356"><a href="/gui2/?type=authors&mode=browse&sel=10000356" target="_blank">Wolfling J (<span class="authorship-author-name">Wölfling János</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Szerves Kémiai Tanszék</span> ; <span class="author-name" mtid="10010041"><a href="/gui2/?type=authors&mode=browse&sel=10010041" target="_blank">Puskas LG (<span class="authorship-author-name">Puskás László</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ; <span class="author-name" mtid="10064926"><a href="/gui2/?type=authors&mode=browse&sel=10064926" target="_blank">Kanizsai I ✉ (<span class="authorship-author-name">Kanizsai Iván</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;3389411" target="_blank">Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2H-Azirines via Joullie-Ugi Three-Component Reaction</a></div> <div> <span class="journal-title">JOURNAL OF ORGANIC CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-3263">0022-3263</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1520-6904">1520-6904</a>)</span>: <span class="journal-volume">83</span> <span class="journal-issue">7</span> <span class="page"> pp 3570-3581 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1021/acs.joc.7b03189" target="_blank" href="https://doi.org/10.1021/acs.joc.7b03189"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000429886100014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000429886100014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85045127856" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85045127856"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29498845" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29498845&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="13637" target="_blank" href="http://publicatio.bibl.u-szeged.hu/13637"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 27</span> | Független: 25 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt: 25 | WoS/Scopus jelölt: 27 | DOI jelölt: 26 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3389411</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3389411</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2020.04.23. 14:10 Nemesvári Zoltánné (SZTE admin5) </div> </div></div>