@article{MTMT:36188415,
	title = {Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype},
	url = {https://m2.mtmt.hu/api/publication/36188415},
	author = {Horváth, Dorottya and Pénzes, Zsófia and Molnár, Petra and Rebenku, István and Vereb, György and Szántó, Magdolna and Muzsai, Szabolcs and Szegedi, Andrea and Dajnoki, Zsolt and Pázmándi, Kitti Linda and Fekete, Tünde and Bácsi, Attila and Szöllősi, Attila},
	doi = {10.3389/fimmu.2025.1593141},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {16},
	unique-id = {36188415},
	issn = {1664-3224},
	year = {2025},
	eissn = {1664-3224},
	pages = {1-14},
	orcid-numbers = {Muzsai, Szabolcs/0000-0002-0073-2194}
}

@article{MTMT:34720432,
	title = {Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells},
	url = {https://m2.mtmt.hu/api/publication/34720432},
	author = {Pázmándi, Kitti Linda and Ágics, Beatrix and Szöllősi, Attila and Bácsi, Attila and Fekete, Tünde},
	doi = {10.1016/j.ejphar.2024.176399},
	journal-iso = {EUR J PHARMACOL},
	journal = {EUROPEAN JOURNAL OF PHARMACOLOGY},
	volume = {967},
	unique-id = {34720432},
	issn = {0014-2999},
	year = {2024},
	eissn = {1879-0712}
}

@article{MTMT:35079207,
	title = {The “root” causes behind the anti-inflammatory actions of ginger compounds in immune cells},
	url = {https://m2.mtmt.hu/api/publication/35079207},
	author = {Pázmándi, Kitti Linda and Szöllősi, Attila and Fekete, Tünde},
	doi = {10.3389/fimmu.2024.1400956},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {35079207},
	issn = {1664-3224},
	abstract = {Ginger ( Zingiber officinale ) is one of the most well-known spices and medicinal plants worldwide that has been used since ancient times to treat a plethora of diseases including cold, gastrointestinal complaints, nausea, and migraine. Beyond that, a growing body of literature demonstrates that ginger exhibits anti-inflammatory, antioxidant, anti-cancer and neuroprotective actions as well. The beneficial effects of ginger can be attributed to the biologically active compounds of its rhizome such as gingerols, shogaols, zingerone and paradols. Among these compounds, gingerols are the most abundant in fresh roots, and shogaols are the major phenolic compounds of dried ginger. Over the last two decades numerous in vitro and in vivo studies demonstrated that the major ginger phenolics are able to influence the function of various immune cells including macrophages, neutrophils, dendritic cells and T cells. Although the mechanism of action of these compounds is not fully elucidated yet, some studies provide a mechanistic insight into their anti-inflammatory effects by showing that ginger constituents are able to target multiple signaling pathways. In the first part of this review, we summarized the current literature about the immunomodulatory actions of the major ginger compounds, and in the second part, we focused on the possible molecular mechanisms that may underlie their anti-inflammatory effects.},
	year = {2024},
	eissn = {1664-3224}
}

@article{MTMT:35149243,
	title = {Anandamide modulation of monocyte-derived Langerhans cells: implications for immune homeostasis and skin inflammation},
	url = {https://m2.mtmt.hu/api/publication/35149243},
	author = {Pénzes, Zsófia and Horváth, Dorottya and Molnár, Petra and Fekete, Tünde and Pázmándi, Kitti Linda and Bácsi, Attila and Szöllősi, Attila},
	doi = {10.3389/fimmu.2024.1423776},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {35149243},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	pages = {1-16}
}

@article{MTMT:33104558,
	title = {Correlation between Type I Interferon Associated Factors and COVID-19 Severity},
	url = {https://m2.mtmt.hu/api/publication/33104558},
	author = {Bencze, Dóra and Fekete, Tünde and Pázmándi, Kitti Linda},
	doi = {10.3390/ijms231810968},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33104558},
	issn = {1661-6596},
	abstract = {Antiviral type I interferons (IFN) produced in the early phase of viral infections effectively inhibit viral replication, prevent virus-mediated tissue damages and promote innate and adaptive immune responses that are all essential to the successful elimination of viruses. As professional type I IFN producing cells, plasmacytoid dendritic cells (pDC) have the ability to rapidly produce waste amounts of type I IFNs. Therefore, their low frequency, dysfunction or decreased capacity to produce type I IFNs might increase the risk of severe viral infections. In accordance with that, declined pDC numbers and delayed or inadequate type I IFN responses could be observed in patients with severe coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as compared to individuals with mild or no symptoms. Thus, besides chronic diseases, all those conditions, which negatively affect the antiviral IFN responses lengthen the list of risk factors for severe COVID-19. In the current review, we would like to briefly discuss the role and dysregulation of pDC/type I IFN axis in COVID-19, and introduce those type I IFN-dependent factors, which account for an increased risk of COVID-19 severity and thus are responsible for the different magnitude of individual immune responses to SARS-CoV-2.},
	year = {2022},
	eissn = {1422-0067}
}

@article{MTMT:33225737,
	title = {Interactions between the NLRP3-Dependent IL-1β and the Type I Interferon Pathways in Human Plasmacytoid Dendritic Cells},
	url = {https://m2.mtmt.hu/api/publication/33225737},
	author = {Bencze, Dóra and Fekete, Tünde and Pfliegler, Valter Péter and Szöőr, Árpád and Csoma, Eszter and Szántó, Antónia and Tarr, Tünde and Bácsi, Attila and Kemény, Lajos and Veréb, Zoltán and Pázmándi, Kitti Linda},
	doi = {10.3390/ijms232012154},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33225737},
	issn = {1661-6596},
	abstract = {Generally, a reciprocal antagonistic interaction exists between the antiviral type I interferon (IFN) and the antibacterial nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3)-dependent IL-1β pathways that can significantly shape immune responses. Plasmacytoid dendritic cells (pDCs), as professional type I IFN-producing cells, are the major coordinators of antiviral immunity; however, their NLRP3-dependent IL-1β secretory pathway is poorly studied. Our aim was to determine the functional activity of the IL-1β pathway and its possible interaction with the type I IFN pathway in pDCs. We found that potent nuclear factor-kappa B (NF-κB) inducers promote higher levels of pro-IL-1β during priming compared to those activation signals, which mainly trigger interferon regulatory factor (IRF)-mediated type I IFN production. The generation of cleaved IL-1β requires certain secondary signals in pDCs and IFN-α or type I IFN-inducing viruses inhibit IL-1β production of pDCs, presumably by promoting the expression of various NLRP3 pathway inhibitors. In line with that, we detected significantly lower IL-1β production in pDCs of psoriasis patients with elevated IFN-α levels. Collectively, our results show that the NLRP3-dependent IL-1β secretory pathway is inducible in pDCs; however, it may only prevail under inflammatory conditions, in which the type I IFN pathway is not dominant.},
	keywords = {Humans; NUCLEOTIDES; INHIBITION; metabolism; INTERFERON-ALPHA; DENDRITIC CELLS; signal transduction; signal transduction; INTERFERON; NUCLEOTIDE; human; Interferon Type I; alpha interferon; Antiviral Agents; antivirus agent; antiinfective agent; anti-bacterial agents; NF-kappa B; immunoglobulin enhancer binding protein; Interleukin-1beta; interleukin 1beta; IL-1β; Dendritic cell; psoriasis; Interaction; inflammasome; inflammasome; cryopyrin; plasmacytoid dendritic cell; Inflammasomes; NLRP3; type I interferon; interferon regulatory factor; Interferon Regulatory Factors; NLR family; pyrin domain-containing 3 protein},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Pfliegler, Valter Péter/0000-0001-6723-4416; Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155}
}

@article{MTMT:32008413,
	title = {Type I Interferon Production of Plasmacytoid Dendritic Cells under Control},
	url = {https://m2.mtmt.hu/api/publication/32008413},
	author = {Bencze, Dóra and Fekete, Tünde and Pázmándi, Kitti Linda},
	doi = {10.3390/ijms22084190},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32008413},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067}
}

@article{MTMT:32075885,
	title = {Az I-es típusú interferonok jelentősége COVID-19-ben},
	url = {https://m2.mtmt.hu/api/publication/32075885},
	author = {Bencze, Dóra and Fekete, Tünde and Pázmándi, Kitti Linda},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {13},
	unique-id = {32075885},
	issn = {2061-0203},
	keywords = {terápia; rizikófaktor; COVID-19; SARS-CoV-2; I-es típusú IFN; IFN-szignatúra; antivirális immunitás},
	year = {2021},
	pages = {26-49}
}

@article{MTMT:33104946,
	title = {Az NLRP3 inflammaszóma aktivitásának és szabályozásának vizsgálata humán plazmacitoid dendritikus sejtekben},
	url = {https://m2.mtmt.hu/api/publication/33104946},
	author = {Bencze, Dóra and Fekete, Tünde and Berki-Pál, Angéla and Pázmándi, Kitti Linda},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {13},
	unique-id = {33104946},
	issn = {2061-0203},
	year = {2021},
	pages = {27}
}

@article{MTMT:31927666,
	title = {Focusing on the Cell Type Specific Regulatory Actions of NLRX1},
	url = {https://m2.mtmt.hu/api/publication/31927666},
	author = {Fekete, Tünde and Bencze, Dóra and Bíró, Eduárd and Benkő, Szilvia and Pázmándi, Kitti Linda},
	doi = {10.3390/ijms22031316},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {31927666},
	issn = {1661-6596},
	abstract = {Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect exogenous or endogenous danger signals and even the changes of their microenvironment. However, some cytosolic NOD-like receptors (NLR), including NLRX1, serve more functions than just being general pattern recognition receptors. The dynamic translocation between the cytosol and the mito-chondria allows NLRX1 to interact with many molecules and thereby to control multiple cellular functions. As a regulatory NLR, NLRX1 fine-tunes inflammatory signaling cascades, regulates mi-tochondria-associated functions, and controls metabolism, autophagy and cell death. Nevertheless, literature data are inconsistent and often contradictory regarding its effects on individual cellular functions. One plausible explanation might be that the regulatory effects of NLRX1 are highly cell type specific and the features of NLRX1 mediated regulation might be determined by the unique functional activity or metabolic profile of the given cell type. Here we review the cell type specific actions of NLRX1 with a special focus on cells of the immune system. NLRX1 has already emerged as a potential therapeutic target in numerous immune-related diseases, thus we aim to highlight which regulatory properties of NLRX1 are manifested in disease-associated dominant immune cells that presumably offer promising therapeutic solutions to treat these disorders. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.},
	keywords = {metabolism; Mitochondria; Regulation; immune cells; Autophagy; MYELOID CELLS; NF-κB pathway; lymphoid cells; NLRX1; Antiviral immunity},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Benkő, Szilvia/0000-0001-7356-6345; Pázmándi, Kitti Linda/0000-0001-7709-6707}
}