@article{MTMT:33548398, title = {Analysis of malaria infection byproducts with Mueller matrix transmission ellipsometry}, url = {https://m2.mtmt.hu/api/publication/33548398}, author = {Basa, Péter and Fodor, B. and Nagy, Zs. and Oyunbolor, B. and Hajtman, A. and Bordács, Sándor and Kézsmárki, István and Halbritter, András Ernő and Orbánová, Agnesa}, doi = {10.1016/j.tsf.2022.139637}, journal-iso = {THIN SOLID FILMS}, journal = {THIN SOLID FILMS}, volume = {766}, unique-id = {33548398}, issn = {0040-6090}, abstract = {In this work, hemozoin, a microcrystalline byproduct of the malaria parasites was studied by transmission Mueller matrix ellipsometry. Measurement data was collected for different magnetic field orientations and as a function of the density of the hemozoin suspension. Our ellipsometric study demonstrates the magnetic alignment of the hemozoin crystals via the corresponding large linear birefringence and dichroism signals. These results reveal optical anisotropies of this material, which could be utilized for future optimization of detection schemes or optical instruments for diagnostic use.}, keywords = {IRON; Environment; Materials Science, Multidisciplinary; Physics, Applied; Materials Science, Coatings & Films}, year = {2023}, eissn = {1879-2731}, orcid-numbers = {Basa, Péter/0000-0003-1317-1709; Bordács, Sándor/0000-0003-0420-5997; Halbritter, András Ernő/0000-0003-4837-9745} } @article{MTMT:33780709, title = {An automated neural network-based stage-specific malaria detection software using dimension reduction: The malaria microscopy classifier}, url = {https://m2.mtmt.hu/api/publication/33780709}, author = {Preißinger, Katharina and Kézsmárki, István and Török, János}, doi = {10.1016/j.mex.2023.102189}, journal-iso = {METHODSX}, journal = {METHODSX}, volume = {10}, unique-id = {33780709}, year = {2023}, eissn = {2215-0161} } @misc{MTMT:33112501, title = {Refining magnetic interactions from the magnetic field dependence of spin-wave excitations in magnetoelectric LiFePO4}, url = {https://m2.mtmt.hu/api/publication/33112501}, author = {Peedu, L. and Kocsis, V. and Szaller, Dávid and Forrai, B. and Bordács, Sándor and Kézsmárki, István and Viirok, J. and Nagel, U. and Bernáth, Bence and Kamenskyi, D. L. and Miyata, A. and Portugall, O. and Tokunaga, Y. and Tokura, Y. and Taguchi, Y. and Rõõm, T.}, unique-id = {33112501}, year = {2022}, orcid-numbers = {Szaller, Dávid/0000-0003-4451-118X; Bordács, Sándor/0000-0003-0420-5997} } @article{MTMT:33189817, title = {Terahertz spectroscopy of spin excitations in magnetoelectric LiFePO4 in high magnetic fields}, url = {https://m2.mtmt.hu/api/publication/33189817}, author = {Peedu, L. and Kocsis, V. and Szaller, Dávid and Forrai, B. and Bordács, Sándor and Kézsmárki, István and Viirok, J. and Nagel, U. and Bernáth, Bence and Kamenskyi, D.L. and Miyata, A. and Portugall, O. and Tokunaga, Y. and Tokura, Y. and Taguchi, Y. and Rõõm, T.}, doi = {10.1103/PhysRevB.106.134413}, journal-iso = {PHYS REV B}, journal = {PHYSICAL REVIEW B}, volume = {106}, unique-id = {33189817}, issn = {2469-9950}, year = {2022}, eissn = {2469-9969}, orcid-numbers = {Szaller, Dávid/0000-0003-4451-118X; Bordács, Sándor/0000-0003-0420-5997} } @article{MTMT:32716803, title = {How Correlations and Spin-Orbit Coupling Work within Extended Orbitals of Transition-Metal Tetrahedra of 4d/5d Lacunar Spinels}, url = {https://m2.mtmt.hu/api/publication/32716803}, author = {Petersen, T. and Prodan, L. and Tsurkan, V. and Krug, Von Nidda H.-A. and Kézsmárki, István and Rößler, U.K. and Hozoi, L.}, doi = {10.1021/acs.jpclett.1c04100}, journal-iso = {J PHYS CHEM LETT}, journal = {JOURNAL OF PHYSICAL CHEMISTRY LETTERS}, volume = {13}, unique-id = {32716803}, issn = {1948-7185}, year = {2022}, pages = {1681-1686} } @article{MTMT:33133343, title = {Reducing data dimension boosts neural network-based stage-specific malaria detection}, url = {https://m2.mtmt.hu/api/publication/33133343}, author = {Preißinger, Katharina and Kellermayer, Miklós and Vértessy, Beáta (Grolmuszné) and Kézsmárki, István and Török, János}, doi = {10.1038/s41598-022-19601-x}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {33133343}, abstract = {Although malaria has been known for more than 4 thousand years 1 , it still imposes a global burden with approx. 240 million annual cases 2 . Improvement in diagnostic techniques is a prerequisite for its global elimination. Despite its main limitations, being time-consuming and subjective, light microscopy on Giemsa-stained blood smears is still the gold-standard diagnostic method used worldwide. Autonomous computer assisted recognition of malaria infected red blood cells (RBCs) using neural networks (NNs) has the potential to overcome these deficiencies, if a fast, high-accuracy detection can be achieved using low computational power and limited sets of microscopy images for training the NN. Here, we report on a novel NN-based scheme that is capable of the high-speed classification of RBCs into four categories—healthy ones and three classes of infected ones according to the parasite age—with an accuracy as high as 98%. Importantly, we observe that a smart reduction of data dimension, using characteristic one-dimensional cross-sections of the RBC images, not only speeds up the classification but also significantly improves its performance with respect to the usual two-dimensional NN schemes. Via comparative studies on RBC images recorded by two additional techniques, fluorescence and atomic force microscopy, we demonstrate that our method is universally applicable for different types of microscopy images. This robustness against imaging platform-specific features is crucial for diagnostic applications. Our approach for the reduction of data dimension could be straightforwardly generalised for the classification of different parasites, cells and other types of objects.}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:32780100, title = {Magnetic Order and Sign of the Dzyaloshinskii-Moriya Interaction in 2-D Antiferromagnet Ba2CoGe2O7 Under Applied Magnetic Field}, url = {https://m2.mtmt.hu/api/publication/32780100}, author = {Thoma, Henrik and Hutanu, Vladimir and Dutta, Rajesh and Gukasov, Arsen and Kocsis, Vilmos and Tokunaga, Yusuke and Taguchi, Yasujiro and Tokura, Yoshinori and Kézsmárki, István and Roth, Georg and Angst, Manuel}, doi = {10.1109/TMAG.2021.3082983}, journal-iso = {IEEE T MAGN}, journal = {IEEE TRANSACTIONS ON MAGNETICS}, volume = {58}, unique-id = {32780100}, issn = {0018-9464}, abstract = {The Dzyaloshinskii-Moriya interaction (DMI), i.e., the antisymmetric part of the exchange coupling tensor, favors the perpendicular arrangement of magnetic moment, thus inducing canting in otherwise collinear structures. The DMI is the prerequisite for the emergence of weak ferromagnetism in antiferromagnets, but can stabilize twisted magnetic textures, such as spin spirals, soliton lattices, and magnetic skyrmions. While the magnitude of the DMI determines the canting angle of adjacent spins, its sign dictates the sense of the spin rotation. Based on focused polarized neutron diffraction (PND) study, combined with symmetry analysis, we determine the sign of the DMI in the unconventional multiferroic Ba2CoGe2O7 and reveal its detailed magnetic structure in magnetic fields applied in the tetragonal plane. As PND gives unique access to the scattering contribution from the phase-sensitive nuclear-magnetic interference, it is a valuable tool for a straightforward DMI sign determination in bulk materials and allows to disclose even very weak magnetic moments. Remarkably, the sign of the DMI could be determined from the PND measurement of a single reflection, which is demonstrated to be reliable for a large range of applied magnetic field directions and values.}, keywords = {CRYSTALS; GERMANIUM; barium; Neutrons; magnetic moments; frequency modulation; Perpendicular magnetic anisotropy; MULTIFERROICS; Engineering, Electrical & Electronic; Dzyaloshinskii-Moriya interaction (DMI); polarized neutron diffraction (PND)}, year = {2022}, eissn = {1941-0069}, orcid-numbers = {Thoma, Henrik/0000-0003-0396-8159; Hutanu, Vladimir/0000-0001-6772-8985; Tokura, Yoshinori/0000-0002-2732-4983} } @article{MTMT:31902046, title = {Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea}, url = {https://m2.mtmt.hu/api/publication/31902046}, author = {Arndt, L. and Koleala, T. and Orbánová, Agnesa and Ibam, C. and Lufele, E. and Timinao, L. and Lorry, L. and Butykai, Ádám and Kaman, P. and Molnár, Petra and Krohns, S. and Nate, E. and Kucsera, I. and Orosz, E. and Moore, B. and Robinson, L.J. and Laman, M. and Kézsmárki, István and Karl, S.}, doi = {10.1038/s41467-021-21110-w}, journal-iso = {NAT COMMUN}, journal = {NATURE COMMUNICATIONS}, volume = {12}, unique-id = {31902046}, abstract = {Improved methods for malaria diagnosis are urgently needed. Here, we evaluate a novel method named rotating-crystal magneto-optical detection (RMOD) in 956 suspected malaria patients in Papua New Guinea. RMOD tests can be conducted within minutes and at low cost. We systematically evaluate the capability of RMOD to detect infections by directly comparing it with expert light microscopy, rapid diagnostic tests and polymerase chain reaction on capillary blood samples. We show that compared to light microscopy, RMOD exhibits 82% sensitivity and 84% specificity to detect any malaria infection and 87% sensitivity and 88% specificity to detect Plasmodium vivax. This indicates that RMOD could be useful in P. vivax dominated elimination settings. Parasite density correlates well with the quantitative magneto-optical signal. Importantly, residual hemozoin present in malaria-negative patients is also detectable by RMOD, indicating its ability to detect previous infections. This could be exploited to reveal transmission hotspots in low-transmission settings. © 2021, The Author(s).}, year = {2021}, eissn = {2041-1723}, orcid-numbers = {Molnár, Petra/0000-0002-3027-3777} } @article{MTMT:32526224, title = {Selection rules and dynamic magnetoelectric effect of the spin waves in multiferroic BiFe O3}, url = {https://m2.mtmt.hu/api/publication/32526224}, author = {Farkas, Dániel Gergely and Szaller, Dávid and Kézsmárki, István and Nagel, U. and Rõõm, T. and Peedu, L. and Viirok, J. and White, J.S. and Cubitt, R. and Ito, T. and Fishman, R.S. and Bordács, Sándor}, doi = {10.1103/PhysRevB.104.174429}, journal-iso = {PHYS REV B}, journal = {PHYSICAL REVIEW B}, volume = {104}, unique-id = {32526224}, issn = {2469-9950}, abstract = {We report the magnetic-field dependence of the THz absorption and nonreciprocal directional dichroism spectra of BiFeO3 measured on the three principal crystal cuts for fields applied along the three principal directions of each cut. From the systematic study of the light polarization dependence, we deduced the optical selection rules of the spin-wave excitations. Our THz data, combined with small-angle neutron scattering results showed that (i) an in-plane magnetic field rotates the q vectors of the cycloids perpendicular to the magnetic field and (ii) the selection rules are mostly determined by the orientation of the q vector with respect to the electromagnetic fields. We observed a magnetic field history-dependent change in the strength and the frequency of the spin-wave modes, which we attributed to the change of the orientation and the length of the cycloidal q vector, respectively. Finally, we compared our experimental data with the results of linear spin-wave theory that reproduces the magnetic-field dependence of the spin-wave frequencies and most of the selection rules, from which we identified the spin-polarization coupling terms relevant for the optical magnetoelectric effect. © 2021 American Physical Society.}, keywords = {Binary alloys; magnetic fields; MAGNETIC-FIELD; Electromagnetic Fields; neutron scattering; Terahertz waves; Systematic study; Selection rules; SPIN POLARIZATION; Spin waves; MULTIFERROICS; Magnetic field dependences; nonreciprocal; polarization dependence; Principal directions; Dichroism spectrum; Q-vector}, year = {2021}, eissn = {2469-9969}, orcid-numbers = {Szaller, Dávid/0000-0003-4451-118X; Bordács, Sándor/0000-0003-0420-5997} } @article{MTMT:32277585, title = {Sensitive detection of Plasmodium vivax malaria by the rotating-crystal magneto-optical method in Thailand}, url = {https://m2.mtmt.hu/api/publication/32277585}, author = {Orban, Agnes and Longley, Rhea J. and Sripoorote, Piyarat and Maneechai, Nongnuj and Nguitragool, Wang and Butykai, Ádám and Mueller, Ivo and Sattabongkot, Jetsumon and Karl, Stephan and Kézsmárki, István}, doi = {10.1038/s41598-021-97532-9}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {11}, unique-id = {32277585}, abstract = {The rotating-crystal magneto-optical detection (RMOD) method has been developed for the rapid and quantitative diagnosis of malaria and tested systematically on various malaria infection models. Very recently, an extended field trial in a high-transmission region of Papua New Guinea demonstrated its great potential for detecting malaria infections, in particular Plasmodium vivax. In the present small-scale field test, carried out in a low-transmission area of Thailand, RMOD confirmed malaria in all samples found to be infected with Plasmodium vivax by microscopy, our reference method. Moreover, the magneto-optical signal for this sample set was typically 1-3 orders of magnitude higher than the cut-off value of RMOD determined on uninfected samples. Based on the serial dilution of the original patient samples, we expect that the method can detect Plasmodium vivax malaria in blood samples with parasite densities as low as similar to 5-10 parasites per microliter, a limit around the pyrogenic threshold of the infection. In addition, by investigating the correlation between the magnitude of the magneto-optical signal, the parasite density and the erythrocytic stage distribution, we estimate the relative hemozoin production rates of the ring and the trophozoite stages of in vivo Plasmodium vivax infections.}, year = {2021}, eissn = {2045-2322} }