TY  - JOUR
AU  - Diwadkar, VA
AU  - Flaugher, B
AU  - Jones, T
AU  - Zalányi, László András
AU  - Ujfalussy, Balázs Benedek
AU  - Keshavan, MS
AU  - Érdi, Péter
TI  - Impaired associative learning in schizophrenia: Behavioral and computational studies.
JF  - COGNITIVE NEURODYNAMICS
J2  - COGN NEURODYN
VL  - 2
PY  - 2008
IS  - 3
SP  - 207
EP  - 218
PG  - 12
SN  - 1871-4080
DO  - 10.1007/s11571-008-9054-0
UR  - https://m2.mtmt.hu/api/publication/1228374
ID  - 1228374
AB  - Associative learning is a central building block of human cognition and in large part depends on mechanisms of synaptic plasticity, memory capacity and fronto-hippocampal interactions. A disorder like schizophrenia is thought to be characterized by altered plasticity, and impaired frontal and hippocampal function. Understanding the expression of this dysfunction through appropriate experimental studies, and understanding the processes that may give rise to impaired behavior through biologically plausible computational models will help clarify the nature of these deficits. We present a preliminary computational model designed to capture learning dynamics in healthy control and schizophrenia subjects. Experimental data was collected on a spatial-object paired-associate learning task. The task evinces classic patterns of negatively accelerated learning in both healthy control subjects and patients, with patients demonstrating lower rates of learning than controls. Our rudimentary computational model of the task was based on biologically plausible assumptions, including the separation of dorsal/spatial and ventral/object visual streams, implementation of rules of learning, the explicit parameterization of learning rates (a plausible surrogate for synaptic plasticity), and learning capacity (a plausible surrogate for memory capacity). Reductions in learning dynamics in schizophrenia were well-modeled by reductions in learning rate and learning capacity. The synergy between experimental research and a detailed computational model of performance provides a framework within which to infer plausible biological bases of impaired learning dynamics in schizophrenia.
LA  - English
DB  - MTMT
ER  - 

TY  - BOOK
AU  - Arbib, MA
AU  - Érdi, Péter
AU  - Szentágothai, János
TI  - Neural Organization Structure, Function, and Dynamics
PB  - MIT Press
CY  - London
CY  - Cambridge, Massachusetts
PY  - 1998
SP  - 408
SN  - 9780262011594
UR  - https://m2.mtmt.hu/api/publication/1228876
ID  - 1228876
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Érdi, Péter
TI  - The brain as a hermeneutic device
JF  - BIOSYSTEMS
J2  - BIOSYSTEMS
VL  - 38
PY  - 1996
IS  - 2-3
SP  - 179
EP  - 189
PG  - 11
SN  - 0303-2647
DO  - 10.1016/0303-2647(95)01589-2
UR  - https://m2.mtmt.hu/api/publication/1290362
ID  - 1290362
AB  - An attempt has been made to reconcile the 'device approach' and the 'philosophical approach' to the brain. Systems exhibiting high structural and dynamic complexity may be candidates of being hermeneutic devices. The human brain, which is a structurally and dynamically complex device, not only perceives but also creates new reality: it is a hermeneutic device
LA  - English
DB  - MTMT
ER  -