TY - JOUR AU - Brück, C.C. AU - Mwangi, L.W. AU - van, Wifferen F. AU - Hsu, L. AU - Thomas, M. AU - Peters, U. TI - Risk-based screening for early detection of colorectal cancer: an overview JF - BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY J2 - BEST PRACT RES CL GA PY - 2025 SN - 1521-6918 DO - 10.1016/j.bpg.2025.102014 UR - https://m2.mtmt.hu/api/publication/36235238 ID - 36235238 N1 - Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands Decision Modeling Center, Department of Epidemiology and Data Science, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Public Health, Amsterdam, Netherlands Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States Department of Biostatistics, University of Washington, Seattle, WA, United States Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States Export Date: 08 July 2025; Cited By: 0; Correspondence Address: C.C. Brück; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; email: c.bruck@erasmusmc.nl; CODEN: BPRCB AB - Screening programs for colorectal cancer (CRC) reduce CRC incidence and mortality, while balancing benefits and harms of the population. However, benefits vary widely among individuals. Low-risk individuals may face unnecessary burdens, while high-risk individuals could benefit from more intensive screening. Risk-based screening addresses these issues by tailoring screening strategies using risk factors such as age, sex, race, ethnicity, lifestyle factors, genetic predisposition, and previous screening results. Potential benefits of risk-based screening include improved cost-effectiveness, efficient resource use and reduced unnecessary procedures. Challenges include a lack of validated risk stratification tools, data availability, healthcare capacity, and ethical considerations. Several countries started to evaluate risk-based screening programs with optimistic results. While promising, further research is necessary to address the remaining challenges. Nevertheless, risk-based screening has the potential to enhance patient experiences, optimize the balance of individual-level benefits and harms, and positively impact the overall burden and costs associated with CRC screening. © 2025 LA - English DB - MTMT ER - TY - JOUR AU - Crecca, E. AU - Di, Giuseppe G. AU - Camplone, C. AU - Vigiano, Benedetti V. AU - Melaiu, O. AU - Mezza, T. AU - Cencioni, C. AU - Spallotta, F. TI - The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy JF - PHARMACOLOGY & THERAPEUTICS J2 - PHARMACOL THERAPEUT VL - 270 PY - 2025 SN - 0163-7258 DO - 10.1016/j.pharmthera.2025.108847 UR - https://m2.mtmt.hu/api/publication/36235242 ID - 36235242 N1 - Institute of System Analysis and Informatics “Antonio Ruberti”, National Research Council (IASI-CNR), Rome, 00185, Italy Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, 00168, Italy Department of Biology and Biotechnologies “Charles Darwin”, Sapienza University, Rome, 00185, Italy Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, Rome, 00185, Italy Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Rome, Italy Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy Export Date: 08 July 2025; Cited By: 0; Correspondence Address: F. Spallotta; Department of Biology and Biotechnology Charles Darwin, Sapienza University and Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Via dei Sardi, 70, 00185, Italy; email: francesco.spallotta@uniroma1.it; C. Cencioni; Institute for Systems Analysis and Computer Science “A. Ruberti”, National Research Council (IASI-CNR), Rome, Via dei Taurini, 19, 00185, Italy; email: chiara.cencioni@cnr.it; CODEN: PHTHD AB - Metabolic syndrome (MetS) is defined by the presence of at least three of five clinical parameters including abdominal obesity, insulin resistance, elevated triglycerides, reduced high-density lipoprotein (HDL) and hypertension. Major features describing MetS have been recognized risk factors for cancer onset, with an alarming impact on gastrointestinal (GI) tumors. Intriguingly, therapeutic administration of drugs to improve glycemic control and dyslipidemia (including metformin, statins) has been shown to have a preventive role in the development and in prognosis improvement of several cancer types. Overall, these observations highlight the key role of altered metabolism prevalently in cancer risk development and unveil anti-MetS agent repurposing potential beyond their conventional pharmacological action. The objective of this review is to summarize the current knowledge about the antitumor activity of anti-diabetic and anti-lipemic agents in GI cancer onset and progression. Here, pre-clinical evidence of their therapeutic potential and of their integration in novel compelling therapeutic strategies will be discussed. Possible clinical outcomes of these novel therapeutic combined protocols specifically dedicated to GI cancer patients will be put under the spotlight. In the future, these novel therapeutic options should be considered to improve conventional chemotherapy response and prognosis of this group of patients. © 2025 LA - English DB - MTMT ER - TY - CHAP AU - Fazekas-Pongor, Vince AU - Lehoczki, Andrea Marianna AU - Pázmándi, Eszter Melinda AU - Fekete, Mónika ED - Kilicaslan, Emine TI - Primacy of exercise-based interventions in the management of sarcopenic obesity. A narrative review in older adults TS - A narrative review in older adults T2 - 4th International Scientific Research and Innovation Congress PB - Liberty Publishing House CY - New York, New York SN - 9798896953036 PY - 2025 SP - 776 EP - 783 PG - 8 UR - https://m2.mtmt.hu/api/publication/36796162 ID - 36796162 LA - English DB - MTMT ER - TY - CHAP AU - Fazekas-Pongor, Vince AU - Lehoczki, Andrea Marianna AU - Pázmándi, Eszter AU - Fekete, Mónika ED - Akcya, Ekrem Yasar ED - Savascihabes, Asuman ED - Cengiz, Emre ED - Kirkyol, Mine ED - Zouaoui, Satla TI - Sarcopenia And Cognitive Impairment. Mechanisms Of The “Muscle- Brain Axis” And Therapeutic Perspectives TS - Mechanisms Of The “Muscle- Brain Axis” And Therapeutic Perspectives T2 - 5. Uluslararasi Gaziantep Bilimsel Arastirmalar Kongresi 2 PB - ISARC (International Science and Art Research Center) CY - [s.l.] SN - 9786253785550 PY - 2025 SP - 960 EP - 967 PG - 8 UR - https://m2.mtmt.hu/api/publication/36851760 ID - 36851760 LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Mónika AU - Lehoczki, Andrea Marianna AU - Szappanos, Ágnes AU - Zábó, Virág AU - Kaposvári, Csilla AU - Horváth, A. AU - Farkas, Árpád AU - Fazekas-Pongor, Vince AU - Major, Dávid AU - Lipécz, Ágnes AU - Csípő, Tamás AU - Varga, János Tamás TI - Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 8 PG - 31 SN - 2072-6643 DO - 10.3390/nu17081351 UR - https://m2.mtmt.hu/api/publication/36132799 ID - 36132799 N1 - Fekete Mónika, Lehoczki Andrea és Szappanos Ágnes megosztott első szerzők. AB - Vitamin D plays a crucial role in the regulation of the immune system, with immunomodulatory effects that are key in the prevention of colorectal cancer (CRC). Over the past decades, research has shown that this steroid hormone impacts much more than bone health, significantly influencing immune responses. Vitamin D enhances immune organ functions such as the spleen and lymph nodes, and boosts T-cell activity, which is essential in defending the body against tumors. Additionally, vitamin D mitigates inflammatory responses closely linked to cancer development, reducing the inflammation that contributes to CRC. It acts via vitamin D receptors (VDRs) expressed on immune cells, modulating immune responses. Adequate vitamin D levels influence gene expression related to inflammation and cell proliferation, inhibiting tumor development. Vitamin D also activates mechanisms that suppress cancer cell survival, proliferation, migration, and metastasis. Low levels of vitamin D have been associated with an increased risk of CRC, with deficiency correlating with higher disease incidence. Lifestyle factors, such as a diet high in red meat and calories but low in fiber, fruits, and vegetables, as well as physical inactivity, contribute significantly to CRC risk. Insufficient calcium and vitamin D intake are also linked to disease occurrence and poorer clinical outcomes. Maintaining optimal vitamin D levels and adequate dietary intake is crucial in preventing CRC and improving patient prognosis. This review explores the role of vitamin D in immune regulation and summarizes findings from randomized clinical trials assessing the effects of vitamin D supplementation on CRC outcomes. LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Mónika AU - Lehoczki, Andrea Marianna AU - Kryczyk-Poprawa, Agata AU - Zábó, Virág AU - Varga, János Tamás AU - Madarász, Bálint AU - Fazekas-Pongor, Vince AU - Csípő, Tamás AU - Rząsa-Duran, Elżbieta AU - Varga, Péter TI - Functional Foods in Modern Nutrition Science: Mechanisms, Evidence, and Public Health Implications JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 13 PG - 35 SN - 2072-6643 DO - 10.3390/nu17132153 UR - https://m2.mtmt.hu/api/publication/36216529 ID - 36216529 N1 - Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, Budapest, 1085, Hungary Health Sciences Division, Doctoral College, Semmelweis University, Budapest, 1085, Hungary Fodor Center for Prevention and Healthy Aging, Semmelweis University, Budapest, 1085, Hungary Department of Inorganic Chemistry and Pharmaceutical Analytics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, 31-008, Poland Department of Pulmonology, Semmelweis University, Budapest, 1085, Hungary Branch in Krakow-Hospital Pharmacy, Maria Sklodowska-Curie National Research Institute of Oncology, Garncarska 11 Str., Krakow, 31-115, Poland Export Date: 25 August 2025; Cited By: 0; Correspondence Address: M. Fekete; Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, Budapest, 1085, Hungary; email: fekete.monika@semmelweis.hu AB - In recent years, functional foods have garnered increasing scientific and public health interest due to their potential to confer physiological benefits beyond basic nutritional value. International bodies such as EFSA, FDA, and WHO define functional foods as those containing bioactive components that may contribute to the prevention and management of chronic non-communicable diseases, including cardiovascular disease, type 2 diabetes, and certain cancers. The evolving paradigm of “food as medicine” reflects a broader shift in nutritional science towards proactive, health-oriented dietary strategies. This article provides a comprehensive, interdisciplinary overview of functional foods by examining their biological mechanisms, clinical evidence, public health significance, regulatory frameworks, and future prospects—particularly in the context of advances in personalized nutrition and nutrigenomics. A thorough literature review was conducted, drawing from recent peer-reviewed studies and guidelines from key health authorities. The review highlights the roles of specific compounds such as probiotics and prebiotics in modulating the gut microbiome, flavonoids and polyphenols in anti-inflammatory processes, omega-3 fatty acids in cardiometabolic regulation, and vitamins and minerals in supporting immune function. While an expanding body of clinical trials and meta-analyses supports the health benefits of these compounds—including reductions in LDL cholesterol, improved insulin sensitivity, and mitigation of oxidative stress—the integration of functional foods into everyday diets remains challenging. Socioeconomic disparities and limited health literacy often impede their accessibility and widespread adoption in public health practice. Functional foods represent a promising component of prevention-focused modern healthcare. To maximize their impact, a coordinated, evidence-based approach is essential, involving collaboration among healthcare professionals, nutrition scientists, policymakers, and the food industry. Looking forward, innovations in artificial intelligence, microbiome research, and genomic technologies may unlock novel opportunities for the targeted and effective application of functional foods in population health. LA - English DB - MTMT ER - TY - CHAP AU - Fekete, Mónika AU - Jarecsny, Tamás ED - Ciftci, Hasan ED - Amanzholova, Alina TI - Nutritional approaches in migraine prevention. evidence for the role of mediterranean, ketogenic, and omega-3–based diets TS - evidence for the role of mediterranean, ketogenic, and omega-3–based diets T2 - Meetcon - X International Congress on Scientific Research PB - Liberty Academic Publishers CY - New York, New York SN - 9798896952176 PY - 2025 SP - 253 EP - 259 PG - 7 UR - https://m2.mtmt.hu/api/publication/36427715 ID - 36427715 LA - English DB - MTMT ER - TY - JOUR AU - García-Fernández, Andrés AU - del Pozo-Elso, Pilar AU - Villadóniga-Sánchez, Arantxa AU - Martínez, Raquel AU - Suárez, Miguel TI - Watch and wait in locally advanced rectal cancer: Evolution, current evidence, and future directions JF - WORLD JOURNAL OF GASTROINTESTINAL SURGERY J2 - WORLD J GASTROINTEST SURG VL - 17 PY - 2025 IS - 9 SN - 1948-9366 DO - 10.4240/wjgs.v17.i9.107831 UR - https://m2.mtmt.hu/api/publication/36386803 ID - 36386803 AB - The treatment of locally advanced rectal cancer (LARC) has evolved significantly over the past century, driven by a deeper understanding of tumor biology, technological advancements, and multidisciplinary approaches. This article reviews the historical progression of LARC management, emphasizing the latest breakthroughs that are reshaping treatment paradigms. Key developments include the watch and wait strategy for patients achieving a complete clinical response after neoadjuvant therapy, the emergence of total neoadjuvant therapy as a standard approach, and the adoption of minimally invasive surgical techniques, such as transanal endoscopic microsurgery. Watch and wait may reduce treatment-related morbidity and help preserve anorectal function, but it requires rigorous patient selection and close long-term surveillance to ensure oncologic safety. Additionally, the role of targeted therapies and immunotherapy is gaining prominence, offering new opportunities for personalized treatment. These innovations aim to improve oncological outcomes while minimizing morbidity and preserving organ function, ultimately enhancing patients’ quality of life. Despite these advancements, challenges remain in optimizing patient selection, refining treatment strategies, and ensuring long-term safety and efficacy. A multidisciplinary approach involving surgeons, oncologists, and radiation specialists is crucial to tailoring therapies to individual patient profiles. As research continues, integrating novel therapeutic strategies will be key to further improving survival rates and reducing treatment-related morbidity in LARC patients. LA - English DB - MTMT ER - TY - JOUR AU - Kim, Dong Hyun TI - Epidemiology of colonic adenoma and cancer JF - CLINICAL ENDOSCOPY J2 - CLIN ENDOSC PY - 2025 SN - 2234-2400 DO - 10.5946/ce.2025.189 UR - https://m2.mtmt.hu/api/publication/36386801 ID - 36386801 LA - English DB - MTMT ER - TY - CHAP AU - Lehoczki, Andrea Marianna AU - Jarecsny, Tamás AU - Zábó, Virág AU - Fekete, Mónika ED - Akkoyun, Mahire Bayramoglu ED - Ak, Endam Cetinkaya TI - Osteosarcopenic obesity. complex disruption of the bone– muscle axis and therapeutic approaches TS - complex disruption of the bone– muscle axis and therapeutic approaches T2 - 10th International Conference on Medical & Health Sciences PB - İSPEC Enstitüsü CY - Ankara SN - 9798896951766 PY - 2025 SP - 990 EP - 997 PG - 1 UR - https://m2.mtmt.hu/api/publication/36358316 ID - 36358316 LA - English DB - MTMT ER - TY - JOUR AU - Lehoczki, Andrea Marianna AU - Csípő, Tamás AU - Lipécz, Ágnes AU - Major, Dávid AU - Fazekas-Pongor, Vince AU - Csík, Boglárka AU - Mózes, Noémi AU - Fehér, Ágnes AU - Dósa, Norbert Sándor AU - Árva, Dorottya AU - Pártos, Katalin AU - Kaposvári, Csilla AU - Horváth, Krisztián AU - Varga, Péter AU - Fekete, Mónika TI - Western Diet and Cognitive Decline: A Hungarian Perspective—Implications for the Design of the Semmelweis Study JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 15 PG - 42 SN - 2072-6643 DO - 10.3390/nu17152446 UR - https://m2.mtmt.hu/api/publication/36270709 ID - 36270709 N1 - Lehoczki Andrea és Csípő Tamás megosztott első szerző AB - Background: Accelerated demographic aging in Hungary and across Europe presents significant public health and socioeconomic challenges, particularly in preserving cognitive function and preventing neurodegenerative diseases. Modifiable lifestyle factors—especially dietary habits—play a critical role in brain aging and cognitive decline. Objective: This narrative review explores the mechanisms by which Western dietary patterns contribute to cognitive impairment and neurovascular aging, with specific attention to their relevance in the Hungarian context. It also outlines the rationale and design of the Semmelweis Study and its workplace-based health promotion program targeting lifestyle-related risk factors. Methods: A review of peer-reviewed literature was conducted focusing on Western diet, cognitive decline, cerebrovascular health, and dietary interventions. Emphasis was placed on mechanistic pathways involving systemic inflammation, oxidative stress, endothelial dysfunction, and decreased neurotrophic support. Key findings: Western dietary patterns—characterized by high intakes of saturated fats, refined sugars, ultra-processed foods, and linoleic acid—are associated with elevated levels of 4-hydroxynonenal (4-HNE), a lipid peroxidation product linked to neuronal injury and accelerated cognitive aging. In contrast, adherence to Mediterranean dietary patterns—particularly those rich in polyphenols from extra virgin olive oil and moderate red wine consumption—supports neurovascular integrity and promotes brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) activity. The concept of “cognitive frailty” is introduced as a modifiable, intermediate state between healthy aging and dementia. Application: The Semmelweis Study is a prospective cohort study involving employees of Semmelweis University aged ≥25 years, collecting longitudinal data on dietary, psychosocial, and metabolic determinants of aging. The Semmelweis–EUniWell Workplace Health Promotion Model translates these findings into practical interventions targeting diet, physical activity, and cardiovascular risk factors in the workplace setting. Conclusions: Improving our understanding of the diet–brain health relationship through population-specific longitudinal research is crucial for developing culturally tailored preventive strategies. The Semmelweis Study offers a scalable, evidence-based model for reducing cognitive decline and supporting healthy aging across diverse populations. LA - English DB - MTMT ER - TY - CONF AU - Mae Ann Yuen, Michele TI - Obesity and Its Complications T2 - Obesity - Exploring Integrative Strategies and Novel Perspectives - Integrative Strategies and Non-Pharmacological Perspectives in Obesity Care [Working Title] PB - IntechOpen PY - 2025 SP - online DO - 10.5772/intechopen.1010254 UR - https://m2.mtmt.hu/api/publication/36128202 ID - 36128202 AB - Obesity is associated with many health complications, which are attributable to several mechanistic changes that take place as excess adipose tissue builds up in the body. These changes include chronic inflammation, oxidative stress, insulin resistance, endothelial dysfunction, elevated levels of growth-promoting adipokines, mechanical effects of excess adiposity due to ectopic deposition and direct loading, and heightened activities of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system (SNS). These mechanistic processes may occur in isolation or in combination to contribute to the development of obesity-associated comorbidities. Understanding the full spectrum of obesity-associated comorbidities will help to guide the clinical assessment as well as treatment and monitoring of individuals with obesity. This chapter will include a review of the current evidence in relation to the scope of obesity-associated comorbidities and discussions on how excess adiposity can contribute to their pathogenesis. LA - English DB - MTMT ER - TY - JOUR AU - Martinez, P. AU - Grant, W.B. TI - Vitamin D: What role in obesity-related cancer? JF - SEMINARS IN CANCER BIOLOGY J2 - SEMIN CANCER BIOL VL - 112 PY - 2025 SP - 135 EP - 149 PG - 15 SN - 1044-579X DO - 10.1016/j.semcancer.2025.03.007 UR - https://m2.mtmt.hu/api/publication/36089318 ID - 36089318 N1 - Export Date: 13 April 2025; Cited By: 0; Correspondence Address: P. Martinez; Association Cancer et Métabolisme, Nîmes, 30000, France; email: pierrick.martinez@ifoga.fr; CODEN: SECBE AB - Obesity is an important risk factor for incidence and death for many types of cancer. Vitamin D reduces risk of incidence and death for many types of cancer. This review outlines the mechanisms by which obesity increases risk of cancer, how vitamin D reduces risk of cancer, and the extent to which vitamin D counters the effects of obesity in cancer. Vitamin D is a partial ally against some of obesity's pro-carcinogenic effects, notably by reducing inflammation and regulating sex hormone receptors, leptin resistance, cellular energy metabolism, the microbiome, and hypoxia. However, it can act stronger in against the renin-angiotensin system, insulin resistance, and oxidative stress in cancer. Additionally, excess fat tissue sequesters vitamin D and, along with its dilution in increased body volume, further reduces its bioavailability and serum concentration, limiting its protective effects against cancer. In conclusion, while vitamin D cannot reverse obesity, it plays a significant role in mitigating its pro-carcinogenic effects by targeting several mechanisms. © 2025 LA - English DB - MTMT ER - TY - JOUR AU - Masci, Domiziana AU - Puxeddu, Michela AU - Colla, Claudia AU - Coluccia, Antonio AU - Santelli, Martina AU - Sciò, Pietro AU - Mariotto, Elena AU - Viola, Giampietro AU - Hamel, Ernest AU - Lerose, Rosa AU - Mazzoccoli, Carmela AU - Silvestri, Romano AU - La Regina, Giuseppe TI - Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach JF - RSC MEDICINAL CHEMISTRY J2 - RSC MED CHEM PY - 2025 SN - 2632-8682 DO - 10.1039/D5MD00406C UR - https://m2.mtmt.hu/api/publication/36283237 ID - 36283237 N1 - Funding Agency and Grant Number: Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute [HHSN261200800001E]; AIRC-IG 2020 [24703, 23109]; Sapienza University of Rome [RG11816428A9B4D5, RM120172A7EAD07C, RG123188B4D193AE, RG120172AD61BE52]; MUR PRIN; Progetti di Avvio alla Ricerca; Catholic University of the Sacred Heart "Premi alle pubblicazioni di alta quality" [R4124501568]; Italian Ministry of Health; UNIPD@STARS-StG; IRP-StG [24/12 IRP]; Umberto Veronesi Foundation (FUV) [5318] Funding text: The authors declare no competing financial interest. This research was supported in part by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute, which includes federal funds under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, products, or organizations imply endorsement by the U.S. Government. The authors thank the financial support of AIRC-IG 2020 n. 24703, to RS and AIRC-IG 2019 n. 23109, to GV, Sapienza University of Rome RG11816428A9B4D5 and RM120172A7EAD07C to RS, RG123188B4D193AE to GLR, RG120172AD61BE52 to AC, MUR PRIN 2022 2022TPPNTK (European Union-Next Generation EU) to GLR, Progetti di Avvio alla Ricerca to MP and Catholic University of the Sacred Heart "Premi alle pubblicazioni di alta quality-2024" (R4124501568) to DM. The authors also thank UNIPD@STARS-StG (#STUMBLE) and IRP-StG 2023 (#24/12 IRP) and Umberto Veronesi Foundation (FUV #5318) to EM. This work was supported by the Italian Ministry of Health (Ricerca Corrente 2022 to Fondazione Policlinico A. Gemelli IRCCS). AB - Microwave-assisted synthesis of new pyrrole and indole derivatives as tubulin assembly inhibitors was performed with remarkably improved yields and short reaction times. LA - English DB - MTMT ER - TY - JOUR AU - Nicholas, A. Kerna AU - Taylor, M. Nicely AU - Uwakmfonabasi, A. Umoudoh AU - Adina, Boulos AU - Ogonna, P. Arisi AU - Chibuike, Eze AU - Breanna, Jomsky AU - Dabeluchi, C. Ngwu AU - Hilary, M. Holets TI - Obesity and Cancer: Excess Body Fat as a Risk Factor in Carcinogenesis; Consequences Across Human Body Systems and Significance for Associated Medical Specialties JF - European Journal of Medical and Health Research J2 - ejmhr VL - 3 PY - 2025 IS - 2 SP - 122 EP - 135 PG - 14 SN - 2786-8524 DO - 10.59324/ejmhr.2025.3(2).12 UR - https://m2.mtmt.hu/api/publication/36055237 ID - 36055237 LA - English DB - MTMT ER - TY - JOUR AU - Nor, El Houda Khelif AU - Zakaria, Seoudi AU - Anis, Khelif AU - Djamila, Si Ahmed AU - Fayçal, Bouali AU - Samir, Rouabhia TI - The Link Between Adiposity and Colorectal Cancer: Troubling Statistics JF - Batna Journal of Medical Sciences (BJMS) VL - 12 PY - 2025 IS - 1 SP - 128 EP - 131 PG - 4 SN - 2437-0665 DO - 10.48087/BJMSra.2025.12125 UR - https://m2.mtmt.hu/api/publication/35860305 ID - 35860305 LA - English DB - MTMT ER - TY - JOUR AU - Obomanu, E. AU - Anebo, T. AU - Byfield, K. AU - Akinrinmade, A. AU - Varadi, G. TI - Impact of Obesity on Cancer-Specific Survival and Overall Survival in Colorectal Cancer JF - NUTRITION AND CANCER : AN INTERNATIONAL JOURNAL J2 - NUTR CANCER VL - 77 PY - 2025 IS - 7-8 SP - 729 EP - 736 PG - 8 SN - 0163-5581 DO - 10.1080/01635581.2025.2514782 UR - https://m2.mtmt.hu/api/publication/36235240 ID - 36235240 AB - Obesity is a well-established risk factor for colorectal cancer (CRC) development, yet its influence on cancer-specific survival (CSS) and overall survival (OS) remains paradoxical. While obesity correlates with adverse outcomes such as increased recurrence, metastasis, and treatment-related complications, emerging evidence highlights a counterintuitive “obesity paradox,” where overweight and moderately obese patients with Body Mass Index(BMI 25–30) exhibit improved CSS and OS compared to underweight (BMI <18.5) or morbidly obese (BMI >35) individuals. Proposed mechanisms for this paradox include altered molecular signaling (adipokine imbalances), enhanced energy metabolism, and greater treatment tolerance due to metabolic reserves. However, these findings are contentious, as BMI, a crude measure, fails to distinguish lean mass from visceral adiposity, key determinants of prognosis. Studies suggest that moderate obesity may buffer treatment toxicity, while extremes of BMI reflect frailty or metabolic dysfunction, worsening survival. This review critically examines the biological underpinnings of the obesity paradox and challenges BMI’s reliability as a prognostic tool. Research must prioritize advanced body composition metrics (visceral fat quantification via imaging) to disentangle obesity’s dual role in CRC outcomes. Such precision could guide tailored interventions, transforming the paradox from a scientific curiosity into a therapeutic strategy, optimizing survival for CRC patients across the weight spectrum. © 2025 Taylor & Francis Group, LLC. LA - English DB - MTMT ER - TY - CHAP AU - Pázmándi, Eszter Melinda AU - Jarecsny, Tamás AU - Lehoczki, Andrea Marianna AU - Fekete, Mónika ED - Simsir, Mehmet ED - Inan, Salih Cem ED - Yildiz, Sayiter ED - Yabas, Ebru TI - Synergistic Effects of Polyphenol-Rich Foods and Resistance Training in the Prevention and Management of Sarcopenia T2 - III.International Congress on Advanced Research and Applications PB - Liberty Academic Publishers CY - New York, New York SN - 9798896952619 PY - 2025 SP - 358 EP - 364 PG - 7 UR - https://m2.mtmt.hu/api/publication/36546932 ID - 36546932 LA - English DB - MTMT ER - TY - JOUR AU - Sun, Yu AU - Keat, Ooi Boon AU - Rajabi, Sogand TI - The role of physical activity and epigenetic changes in colorectal cancer prevention JF - CANCER CELL INTERNATIONAL J2 - CANCER CELL INT VL - 25 PY - 2025 IS - 1 SN - 1475-2867 DO - 10.1186/s12935-025-03872-1 UR - https://m2.mtmt.hu/api/publication/36204483 ID - 36204483 LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Fekete, Mónika AU - Varga, Péter AU - Lehoczki, Andrea Marianna AU - Munkácsy, Gyöngyi AU - Fekete, János Tibor AU - Bianchini, Giampaolo AU - Ocana, Alberto AU - Buda, Annamaria AU - Ungvári, Anna Sára AU - Győrffy, Balázs TI - Association between red and processed meat consumption and colorectal cancer risk : a comprehensive meta-analysis of prospective studies JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 47 PY - 2025 IS - 3 SP - 5123 EP - 5140 PG - 18 SN - 2509-2715 DO - 10.1007/s11357-025-01646-1 UR - https://m2.mtmt.hu/api/publication/36088936 ID - 36088936 N1 - * Megosztott szerzőség AB - Increasing evidence suggests that red and processed meat consumption may elevate the risk of colorectal cancer (CRC), yet the magnitude and consistency of this association remain debated. This meta-analysis aims to quantify the relationship between red and processed meat intake and the risk of CRC, colon cancer, and rectal cancer using the most comprehensive set of prospective studies to date. We conducted a comprehensive search in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar databases from 1990 to November 2024, to identify relevant prospective studies examining red, processed, and total meat consumption in relation to colorectal, colon, and rectal cancer risk. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted for each study and pooled using a random-effects model to account for variability among studies. Statistical evaluation was executed using the online platform MetaAnalysisOnline.com. A total of 60 prospective studies were included. Red meat consumption was associated with a significantly increased risk of colon cancer (HR = 1.22, 95% CI 1.15-1.30), colorectal cancer (HR = 1.15, 95% CI 1.10-1.21), and rectal cancer (HR = 1.22, 95% CI 1.07-1.39). Processed meat consumption showed similar associations with increased risk for colon cancer (HR = 1.13, 95% CI 1.07-1.20), colorectal cancer (HR = 1.21, 95% CI 1.14-1.28), and rectal cancer (HR = 1.17, 95% CI 1.05-1.30). Total meat consumption also correlated with an elevated risk of colon cancer (HR = 1.22, 95% CI 1.11-1.35), colorectal cancer (HR = 1.17, 95% CI 1.12-1.22), and rectal cancer (HR = 1.28, 95% CI 1.10-1.48). This meta-analysis provides robust evidence that high consumption of red and processed meats is significantly associated with an increased risk of colorectal, colon, and rectal cancers. These findings reinforce current dietary recommendations advocating for the limitation of red and processed meat intake as part of cancer prevention strategies. LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Fekete, Mónika AU - Lehoczki, Andrea Marianna AU - Munkácsy, Gyöngyi AU - Fekete, János Tibor AU - Zábó, Virág AU - Purebl, György AU - Varga, Péter AU - Ungvári, Anna Sára AU - Győrffy, Balázs TI - Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 47 PY - 2025 IS - 3 SP - 4679 EP - 4695 PG - 17 SN - 2509-2715 DO - 10.1007/s11357-025-01593-x UR - https://m2.mtmt.hu/api/publication/35925785 ID - 35925785 N1 - * Megosztott szerzőség AB - The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short and long sleep durations impact stroke incidence and mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar up to November 1, 2024, to identify cohort studies evaluating sleep duration and stroke outcomes. Meta-analysis was performed using MetaAnalysisOnline.com and a random-effects model to estimate pooled hazard ratios (HRs). Results were visualized through Forest and Funnel plots. Analysis of 43 studies (35 on stroke incidence, 8 on mortality) revealed significant associations between sleep duration and stroke outcomes. Short sleep duration (≤ 5–6 h) was associated with increased stroke incidence (HR 1.29, 95% CI 1.19–1.40, p < 0.01) and modestly elevated mortality (HR 1.12, 95% CI 1.01–1.25, p = 0.03). Long sleep duration (> 8–9 h) demonstrated stronger associations with both increased stroke incidence (HR 1.46, 95% CI 1.33–1.60, p < 0.01) and mortality (HR 1.45, 95% CI 1.31–1.60, p < 0.01). Significant heterogeneity was observed in incidence studies ( I 2 = 74–75%), while mortality analyses showed moderate to low heterogeneity ( I 2 = 35–40%). This meta-analysis highlights a U-shaped association between sleep duration and stroke risk, with both short and long sleep durations linked to higher stroke incidence and mortality. These findings underscore the importance of balanced sleep duration as a modifiable risk factor in stroke prevention strategies and provide a foundation for the Semmelweis Study, a prospective workplace cohort investigating the role of modifiable lifestyle factors in unhealthy cerebrovascular and brain aging. LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Fekete, Mónika AU - Fekete, János Tibor AU - Lehoczki, Andrea Marianna AU - Buda, Annamaria AU - Munkácsy, Gyöngyi AU - Varga, Péter AU - Ungvári, Anna Sára AU - Győrffy, Balázs TI - Treatment delay significantly increases mortality in colorectal cancer : a meta-analysis JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 47 PY - 2025 IS - 3 SP - 5337 EP - 5353 PG - 17 SN - 2509-2715 DO - 10.1007/s11357-025-01648-z UR - https://m2.mtmt.hu/api/publication/36084206 ID - 36084206 N1 - * Megosztott szerzőség AB - Delaying the initiation of cancer treatment increases the risk of mortality, particularly in colorectal cancer (CRC), which is among the most common and deadliest malignancies. This study aims to explore the impact of treatment delays on mortality in CRC. A systematic literature search was conducted in PubMed, Web of Science, and Scopus for studies published between 2000 and 2025. Meta-analyses were performed using random-effects models with inverse variance method to calculate hazard ratios (HRs) for both overall and cancer-specific survival at 4-, 8-, and 12-week treatment delay intervals, with heterogeneity assessed through I2-statistics and publication bias evaluated using funnel plots and Egger's test. A total of 20 relevant studies were included in the meta-analysis. The analyses of all patients demonstrated a progressively increasing risk of 12-39% with longer treatment delays (4 weeks, HR = 1.12; 95% CI, 1.08-1.16; 8 weeks, HR = 1.24; 95% CI, 1.16-1.34; 12 weeks, HR = 1.39; 95% CI, 1.25-1.55). In particular, incrementally higher hazard ratios were observed for all-cause mortality at 4 weeks (HR = 1.14; 95% CI, 1.09-1.18), 8 weeks (HR = 1.29; 95% CI, 1.20-1.39), and 12 weeks (HR = 1.47; 95% CI, 1.31-1.64). In contrast, cancer-specific survival analysis showed a similar trend but did not reach statistical significance (4 weeks, HR = 1.07; 95% CI, 0.98-1.18; 8 weeks, HR = 1.15; 95% CI, 0.95-1.39; 12 weeks, HR = 1.23; 95% CI, 0.93-1.63). Treatment delays in colorectal cancer patients were associated with progressively worsening overall survival, with each 4-week delay increment leading to a substantially higher mortality risk. This study suggests that timely treatment initiation should be prioritized in clinical practice, as these efforts can lead to substantial improvements in survival rates. LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Fekete, Mónika AU - Varga, Péter AU - Fekete, János Tibor AU - Lehoczki, Andrea Marianna AU - Buda, Annamária AU - Szappanos, Ágnes AU - Purebl, György AU - Ungvári, Anna Sára AU - Győrffy, Balázs TI - Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 47 PY - 2025 IS - 3 SP - 4545 EP - 4566 PG - 22 SN - 2509-2715 DO - 10.1007/s11357-025-01592-y UR - https://m2.mtmt.hu/api/publication/35912335 ID - 35912335 N1 - * Megosztott szerzőség AB - Sleep duration is a crucial factor influencing health outcomes, yet its relationship with mortality remains debated. In this meta-analysis, we aimed to investigate the association between short and long sleep duration and all-cause mortality in adults, including sex-specific differences. A systematic search was performed in multiple databases, including PubMed, Cochrane Central, and Web of Science, up to October 2024. Retrospective and prospective cohort studies involving adults with at least 1 year of follow-up and data on sleep duration and all-cause mortality were included. Hazard ratios were pooled using a random-effects model, with subgroup analyses performed based on sex and sleep duration categories. A total of 79 cohort studies were included, with data stratified by sex and categorized into short and long sleep durations. Short sleep duration (< 7 h per night) was associated with a 14% increase in mortality risk compared to the reference of 7–8 h, with a pooled hazard ratio of 1.14 (95% CI 1.10 to 1.18). Conversely, long sleep duration (≥ 9 h per night) was associated with a 34% higher risk of mortality, with a hazard ratio of 1.34 (95% CI 1.26 to 1.42). Sex-specific analyses indicated that both short and long sleep durations significantly elevated mortality risk in men and women, although the effect was more pronounced for long sleep duration in women. Both short and long sleep durations are associated with increased all-cause mortality, though the degree of risk varies by sex. These findings underscore the importance of considering optimal sleep duration in public health strategies aimed at enhancing longevity and highlight the need for sex-specific approaches in sleep health research. LA - English DB - MTMT ER - TY - JOUR AU - Vahed, Iman Elahi AU - Moshgelgosha, Mahsa AU - Kor, Abdolmajid AU - Minadi, Mona AU - Ebrahimi, Faezeh AU - Azhdarian, Aylar AU - Arjmandi, Mobina AU - Alamdar, Aida AU - Zare, Maede AU - Shabani, Niloufar AU - Soltaninejad, Hossein AU - Rahmanian, Mohammad TI - The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis JF - BMC CANCER J2 - BMC CANCER VL - 25 PY - 2025 IS - 1 SN - 1471-2407 DO - 10.1186/s12885-025-14362-y UR - https://m2.mtmt.hu/api/publication/36171800 ID - 36171800 N1 - Export Date: 08 July 2025; Cited By: 1; Correspondence Address: H. Soltaninejad; Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran; email: hossein.soltani@modares.ac.ir; M. Rahmanian; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; email: mmdrahmanian@gmail.com; CODEN: BCMAC LA - English DB - MTMT ER - TY - JOUR AU - Xie, D. AU - Zhang, L. AU - He, N. AU - Yang, C. AU - Zhang, M. AU - Zhang, R. AU - Hao, L. AU - Xu, W. TI - Changing patterns and potential overdiagnosis of major screened cancers in Pudong New Area of Shanghai JF - CHINESE JOURNAL OF CANCER PREVENTION AND TREATMENT J2 - CHIN J CANCER PREV TREATM VL - 32 PY - 2025 IS - 10 SP - 599 EP - 607 PG - 9 SN - 1673-5269 DO - 10.16073/j.cnki.cjcpt.2025.10.02 UR - https://m2.mtmt.hu/api/publication/36235239 ID - 36235239 N1 - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China Department of Cancer and Injury Prevention, Center for Disease Control and Prevention of Pudong New Area, Shanghai, 200136, China Export Date: 08 July 2025; Cited By: 0; Correspondence Address: L. Hao; Department of Cancer and Injury Prevention, Center for Disease Control and Prevention of Pudong New Area, Shanghai, 200136, China; email: hlpmail@126.com; W. Xu; Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China; email: wanghong.xu@fudan.edu.cn AB - Objective To investigate the potential overdiagnosis of major screened cancers at the population level by comparing secular trends of incidence and mortality based on cancer surveillance data. Methods Data on the incidence and mortality of cancers of lung, thyroid cancer, female breast cancer, colorectal cancer, gastric cancer, liver cancer, esophageal cancer, prostate cancer, and cervical cancer were extracted from the Shanghai Pudong New Area cancer registry and cause-of-death registration system during January 1, 2002 and December 31, 2019. The age-standardized incidence rates, mortality rates, and stage-specific (Stage I to IV) incidence rates were calculated separately for males and females according to the year of diagnosis or death. Joinpoint regression was used to calculate the segmented annual percentage change(APC), the average annual percent change(AAPC), and their 95%CI for the standardized rates. Results Three changing patterns in age-standardized incidence and mortality were observed for the nine cancers. The first pattern was characterized with significant increases in both incidence and mortality. The pattern was mainly observed for prostate cancer, cervical cancer, and male colorectal cancer, with an AAPC ranging from 1.78% to 6.39% for incidence and from 1.61% to 5.78% for mortality. The second pattern with significantly decreased incidence and mortality was found for gastric cancer, liver cancer and esophageal cancer, with an AAPC of -6.63% to -3.13% for incidence and -7.01% to - 3.56% for mortality. The third pattern manifested as significant increased incidence accompanying by decreased or stable mortality, which was observed for thyroid cancer, lung cancer, and female breast cancer. The APC(95%CI) of thyroid cancer incidence during 2002 and 2019 was 19.72% (17.75% to 21.72%) in men and 17.19% (15.27% to 19.14%) in women, whereas the AAPC(95%CI) of thyroid cancer mortality was 3.83%(-1.73% to 9.71%) in men and 2.76% (-1.51% to 8.01%) in women. For female breast cancer, the AAPC(95%CI) was 1.74%(1.17% to 2.45%) for incidence and 0.66% (-0.15% to 1.50%) for mortality. Regarding lung cancer, the incidence in men decreased from 56.21 per 100000 in 2002 to 48.77 per 100000 in 2009, and thereafter increased with an APC of 2.03% (95% CI: 0.85% to 5.59%); the incidence in women increased 13.44%(95%CI: 11.72% to 15.20%) per year since 2012. In comparison, the lung cancer mortality significantly declined during 2002 and 2019, with an AAPC(95%CI) of -1.75%(-2.29% to -1.15%) in men and -1.59%(-2.29% to -0.88%) in women. The incidences of stage-I thyroid cancer, female lung cancer and female breast cancer increased significantly during the period, while those of late-stage cancers remained stable. Conclusions Overdiagnosis may exist in thyroid cancer, female lung cancer and female breast cancers in Pudong New Area of Shanghai. Further studies are needed to confirm our results and quantify the overdiagnosis in the populations. © 2025 Chinese Journal of Cancer Prevention and Treatment, Editorial board. All rights reserved. LA - Chinese DB - MTMT ER - TY - JOUR AU - Zábó, Virág AU - Lehoczki, Andrea Marianna AU - Varga, János Tamás AU - Szappanos, Ágnes AU - Lipécz, Ágnes AU - Csípő, Tamás AU - Fazekas-Pongor, Vince AU - Major, Dávid AU - Fekete, Mónika TI - Digital Microinterventions in Nutrition: Virtual Culinary Medicine Programs and Their Effectiveness in Promoting Plant-Based Diets—A Narrative Review JF - NUTRIENTS J2 - NUTRIENTS VL - 17 PY - 2025 IS - 20 PG - 27 SN - 2072-6643 DO - 10.3390/nu17203310 UR - https://m2.mtmt.hu/api/publication/36393199 ID - 36393199 AB - Background: Plant-based diets are associated with reduced risk of chronic diseases and improved health outcomes. However, sustaining dietary changes remains challenging. Digital interventions—including virtual culinary medicine programs, web-based nutrition coaching, SMS and email reminders, mobile application–based self-management, and hybrid community programs—offer promising strategies to support behavior change, enhance cooking skills, and improve dietary adherence. These approaches are relevant for both healthy individuals and those living with chronic conditions. Methods: We conducted a narrative review of studies published between 2000 and 2025 in PubMed/MEDLINE, Scopus, and Web of Science, supplemented with manual searches. Included studies comprised randomized controlled trials, quasi-experimental designs, feasibility studies, and qualitative research. Interventions were categorized by modality (SMS, email, web platforms, mobile apps, virtual culinary programs, and hybrid formats) and population (healthy adults, patients with chronic diseases). Outcomes examined included dietary quality, self-efficacy, psychosocial well-being, and program engagement. Results: Most studies reported improvements in dietary quality, cooking skills, nutrition knowledge, and psychosocial outcomes. Virtual cooking programs enhanced dietary adherence and engagement, particularly among individuals at cardiovascular risk. Digital nutrition education supported behavior change in chronic disease populations, including patients with multiple sclerosis. SMS and email reminders improved self-monitoring and participation rates, while mobile applications facilitated real-time feedback and goal tracking. Hybrid programs combining online and in-person components increased motivation, social support, and long-term adherence. Reported barriers included limited technological access or skills, lack of personalization, and privacy concerns. Conclusions: Virtual culinary medicine programs and other digital microinterventions—including SMS, email, web, mobile, and hybrid formats—are effective tools to promote plant-based diets. Future interventions should focus on personalized, accessible, and hybrid strategies, with attention to underserved populations, to maximize engagement and sustain long-term dietary change. LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Jinhai AU - Yang, Jingge TI - Worldwide burden and cross-regional health inequalities of high BMI-attributable colorectal cancer by gender from 1990 to 2021, with predictions through 2041 JF - BMC GASTROENTEROLOGY J2 - BMC GASTROENTEROL VL - 25 PY - 2025 IS - 1 SN - 1471-230X DO - 10.1186/s12876-025-03938-4 UR - https://m2.mtmt.hu/api/publication/36158283 ID - 36158283 N1 - Funding Agency and Grant Number: Science and Technology Projects in Guangzhou [2024A03J12592, 2024A03J1117]; Guangdong Basic and Applied Basic Research Foundation [2024A151522098] Funding text: Funding by Science and Technology Projects in Guangzhou (No.2024A03J12592); Science and Technology Projects in Guangzhou (No.2024A03J1117); Guangdong Basic and Applied Basic Research Foundation (No.2024A151522098). LA - English DB - MTMT ER - TY - CHAP AU - Mózes, Noémi AU - Lehoczki, Andrea Marianna AU - Varga, János Tamás AU - Fekete, Mónika AU - Csípő, Tamás ED - Günay, Nazan TI - Spermidine-rich foods and chronic disease prevention. Insights from nutritional studies TS - Insights from nutritional studies T2 - 3rd International EGE Congress on Scientific Research PB - IKSAD Publications CY - Ankara SN - 9786253781217 PY - 2024 SP - 424 EP - 429 PG - 6 UR - https://m2.mtmt.hu/api/publication/35657047 ID - 35657047 LA - English DB - MTMT ER - TY - JOUR AU - Roslan, Nur Hazirah AU - Zarkasi, Khairul Anwar AU - Mohd Yusof, Yasmin Anum AU - Makpol, Suzana TI - Chemopreventive Effects of Piper betle (Sirih) on High-Fat Diet-Induced and Azoxymethane-Induced Colon Cancer in Male Sprague-Dawley Rats JF - CUREUS J2 - CUREUS VL - 16 PY - 2024 IS - 12 SN - 2168-8184 DO - 10.7759/cureus.76260 UR - https://m2.mtmt.hu/api/publication/35650736 ID - 35650736 LA - English DB - MTMT ER -