@article{MTMT:36235238,
	title = {Risk-based screening for early detection of colorectal cancer: an overview},
	url = {https://m2.mtmt.hu/api/publication/36235238},
	author = {Brück, C.C. and Mwangi, L.W. and van, Wifferen F. and Hsu, L. and Thomas, M. and Peters, U.},
	doi = {10.1016/j.bpg.2025.102014},
	journal-iso = {BEST PRACT RES CL GA},
	journal = {BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY},
	unique-id = {36235238},
	issn = {1521-6918},
	abstract = {Screening programs for colorectal cancer (CRC) reduce CRC incidence and mortality, while balancing benefits and harms of the population. However, benefits vary widely among individuals. Low-risk individuals may face unnecessary burdens, while high-risk individuals could benefit from more intensive screening. Risk-based screening addresses these issues by tailoring screening strategies using risk factors such as age, sex, race, ethnicity, lifestyle factors, genetic predisposition, and previous screening results. Potential benefits of risk-based screening include improved cost-effectiveness, efficient resource use and reduced unnecessary procedures. Challenges include a lack of validated risk stratification tools, data availability, healthcare capacity, and ethical considerations. Several countries started to evaluate risk-based screening programs with optimistic results. While promising, further research is necessary to address the remaining challenges. Nevertheless, risk-based screening has the potential to enhance patient experiences, optimize the balance of individual-level benefits and harms, and positively impact the overall burden and costs associated with CRC screening. © 2025},
	keywords = {MORTALITY; review; human; Incidence; Race; risk factor; diagnosis; colorectal cancer; genetic predisposition; cost effectiveness analysis; ETHNICITY; lifestyle; unnecessary procedure},
	year = {2025},
	eissn = {1532-1916}
}

@article{MTMT:36235242,
	title = {The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy},
	url = {https://m2.mtmt.hu/api/publication/36235242},
	author = {Crecca, E. and Di, Giuseppe G. and Camplone, C. and Vigiano, Benedetti V. and Melaiu, O. and Mezza, T. and Cencioni, C. and Spallotta, F.},
	doi = {10.1016/j.pharmthera.2025.108847},
	journal-iso = {PHARMACOL THERAPEUT},
	journal = {PHARMACOLOGY & THERAPEUTICS},
	volume = {270},
	unique-id = {36235242},
	issn = {0163-7258},
	abstract = {Metabolic syndrome (MetS) is defined by the presence of at least three of five clinical parameters including abdominal obesity, insulin resistance, elevated triglycerides, reduced high-density lipoprotein (HDL) and hypertension. Major features describing MetS have been recognized risk factors for cancer onset, with an alarming impact on gastrointestinal (GI) tumors. Intriguingly, therapeutic administration of drugs to improve glycemic control and dyslipidemia (including metformin, statins) has been shown to have a preventive role in the development and in prognosis improvement of several cancer types. Overall, these observations highlight the key role of altered metabolism prevalently in cancer risk development and unveil anti-MetS agent repurposing potential beyond their conventional pharmacological action. The objective of this review is to summarize the current knowledge about the antitumor activity of anti-diabetic and anti-lipemic agents in GI cancer onset and progression. Here, pre-clinical evidence of their therapeutic potential and of their integration in novel compelling therapeutic strategies will be discussed. Possible clinical outcomes of these novel therapeutic combined protocols specifically dedicated to GI cancer patients will be put under the spotlight. In the future, these novel therapeutic options should be considered to improve conventional chemotherapy response and prognosis of this group of patients. © 2025},
	keywords = {Animals; Humans; review; human; animal; risk factor; Therapy; GLYCEMIC CONTROL; HYPERTENSION; Insulin Resistance; Metabolic Syndrome X; dyslipidemia; abdominal obesity; high density lipoprotein; metabolic syndrome; metabolic syndrome; Hypoglycemic Agents; antidiabetic agent; antidiabetic agent; drug mechanism; antineoplastic agent; side effect; HYPERTRIGLYCERIDEMIA; cancer therapy; Antineoplastic Agents; cancer patient; cancer risk; ANTINEOPLASTIC ACTIVITY; Complication; antilipemic agent; antilipemic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; Drug therapy; adverse drug reaction; Statins; metformin; metformin; Gastrointestinal Neoplasms; cancer inhibition; gastrointestinal tumor; gastrointestinal tumor; Clinical outcome; glucagon like peptide 1 receptor agonist; GLP-1 receptor agonists; Hypolipidemic Agents; anti-cancer therapy; gastrointestinal cancer; Gastrointestinal cancers},
	year = {2025},
	eissn = {1879-016X}
}

@inproceedings{MTMT:36796162,
	title = {Primacy of exercise-based interventions in the management of sarcopenic obesity. A narrative review in older adults},
	url = {https://m2.mtmt.hu/api/publication/36796162},
	author = {Fazekas-Pongor, Vince and Lehoczki, Andrea Marianna and Pázmándi, Eszter Melinda and Fekete, Mónika},
	booktitle = {4th International Scientific Research and Innovation Congress},
	unique-id = {36796162},
	year = {2025},
	pages = {776-783},
	orcid-numbers = {Fazekas-Pongor, Vince/0000-0002-6405-4003; Pázmándi, Eszter Melinda/0000-0002-0634-4002; Fekete, Mónika/0000-0001-8632-2120}
}

@inproceedings{MTMT:36851760,
	title = {Sarcopenia And Cognitive Impairment. Mechanisms Of The “Muscle- Brain Axis” And Therapeutic Perspectives},
	url = {https://m2.mtmt.hu/api/publication/36851760},
	author = {Fazekas-Pongor, Vince and Lehoczki, Andrea Marianna and Pázmándi, Eszter and Fekete, Mónika},
	booktitle = {5. Uluslararasi Gaziantep Bilimsel Arastirmalar Kongresi 2},
	unique-id = {36851760},
	year = {2025},
	pages = {960-967},
	orcid-numbers = {Fazekas-Pongor, Vince/0000-0002-6405-4003; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:36132799,
	title = {Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications},
	url = {https://m2.mtmt.hu/api/publication/36132799},
	author = {Fekete, Mónika and Lehoczki, Andrea Marianna and Szappanos, Ágnes and Zábó, Virág and Kaposvári, Csilla and Horváth, A. and Farkas, Árpád and Fazekas-Pongor, Vince and Major, Dávid and Lipécz, Ágnes and Csípő, Tamás and Varga, János Tamás},
	doi = {10.3390/nu17081351},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {17},
	unique-id = {36132799},
	abstract = {Vitamin D plays a crucial role in the regulation of the immune system, with immunomodulatory effects that are key in the prevention of colorectal cancer (CRC). Over the past decades, research has shown that this steroid hormone impacts much more than bone health, significantly influencing immune responses. Vitamin D enhances immune organ functions such as the spleen and lymph nodes, and boosts T-cell activity, which is essential in defending the body against tumors. Additionally, vitamin D mitigates inflammatory responses closely linked to cancer development, reducing the inflammation that contributes to CRC. It acts via vitamin D receptors (VDRs) expressed on immune cells, modulating immune responses. Adequate vitamin D levels influence gene expression related to inflammation and cell proliferation, inhibiting tumor development. Vitamin D also activates mechanisms that suppress cancer cell survival, proliferation, migration, and metastasis. Low levels of vitamin D have been associated with an increased risk of CRC, with deficiency correlating with higher disease incidence. Lifestyle factors, such as a diet high in red meat and calories but low in fiber, fruits, and vegetables, as well as physical inactivity, contribute significantly to CRC risk. Insufficient calcium and vitamin D intake are also linked to disease occurrence and poorer clinical outcomes. Maintaining optimal vitamin D levels and adequate dietary intake is crucial in preventing CRC and improving patient prognosis. This review explores the role of vitamin D in immune regulation and summarizes findings from randomized clinical trials assessing the effects of vitamin D supplementation on CRC outcomes.},
	year = {2025},
	eissn = {2072-6643},
	orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Zábó, Virág/0000-0001-8948-8636; Fazekas-Pongor, Vince/0000-0002-6405-4003; Major, Dávid/0000-0002-6108-9745; Varga, János Tamás/0000-0002-8552-1336}
}

@article{MTMT:36216529,
	title = {Functional Foods in Modern Nutrition Science: Mechanisms, Evidence, and Public Health Implications},
	url = {https://m2.mtmt.hu/api/publication/36216529},
	author = {Fekete, Mónika and Lehoczki, Andrea Marianna and Kryczyk-Poprawa, Agata and Zábó, Virág and Varga, János Tamás and Madarász, Bálint and Fazekas-Pongor, Vince and Csípő, Tamás and Rząsa-Duran, Elżbieta and Varga, Péter},
	doi = {10.3390/nu17132153},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {17},
	unique-id = {36216529},
	abstract = {In recent years, functional foods have garnered increasing scientific and public health interest due to their potential to confer physiological benefits beyond basic nutritional value. International bodies such as EFSA, FDA, and WHO define functional foods as those containing bioactive components that may contribute to the prevention and management of chronic non-communicable diseases, including cardiovascular disease, type 2 diabetes, and certain cancers. The evolving paradigm of “food as medicine” reflects a broader shift in nutritional science towards proactive, health-oriented dietary strategies. This article provides a comprehensive, interdisciplinary overview of functional foods by examining their biological mechanisms, clinical evidence, public health significance, regulatory frameworks, and future prospects—particularly in the context of advances in personalized nutrition and nutrigenomics. A thorough literature review was conducted, drawing from recent peer-reviewed studies and guidelines from key health authorities. The review highlights the roles of specific compounds such as probiotics and prebiotics in modulating the gut microbiome, flavonoids and polyphenols in anti-inflammatory processes, omega-3 fatty acids in cardiometabolic regulation, and vitamins and minerals in supporting immune function. While an expanding body of clinical trials and meta-analyses supports the health benefits of these compounds—including reductions in LDL cholesterol, improved insulin sensitivity, and mitigation of oxidative stress—the integration of functional foods into everyday diets remains challenging. Socioeconomic disparities and limited health literacy often impede their accessibility and widespread adoption in public health practice. Functional foods represent a promising component of prevention-focused modern healthcare. To maximize their impact, a coordinated, evidence-based approach is essential, involving collaboration among healthcare professionals, nutrition scientists, policymakers, and the food industry. Looking forward, innovations in artificial intelligence, microbiome research, and genomic technologies may unlock novel opportunities for the targeted and effective application of functional foods in population health.},
	keywords = {PREVENTION; public health; polyphenols; Probiotics; functional foods; health claims; Nutrigenomics; nutritional science; nutrition and health; prevention of chronic diseases},
	year = {2025},
	eissn = {2072-6643},
	orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Zábó, Virág/0000-0001-8948-8636; Varga, János Tamás/0000-0002-8552-1336; Madarász, Bálint/0000-0002-7110-6692; Fazekas-Pongor, Vince/0000-0002-6405-4003}
}

@inproceedings{MTMT:36427715,
	title = {Nutritional approaches in migraine prevention. evidence for the role of mediterranean, ketogenic, and omega-3–based diets},
	url = {https://m2.mtmt.hu/api/publication/36427715},
	author = {Fekete, Mónika and Jarecsny, Tamás},
	booktitle = {Meetcon - X International Congress on Scientific Research},
	unique-id = {36427715},
	year = {2025},
	pages = {253-259},
	orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:36386803,
	title = {Watch and wait in locally advanced rectal cancer: Evolution, current evidence, and future directions},
	url = {https://m2.mtmt.hu/api/publication/36386803},
	author = {García-Fernández, Andrés and del Pozo-Elso, Pilar and Villadóniga-Sánchez, Arantxa and Martínez, Raquel and Suárez, Miguel},
	doi = {10.4240/wjgs.v17.i9.107831},
	journal-iso = {WORLD J GASTROINTEST SURG},
	journal = {WORLD JOURNAL OF GASTROINTESTINAL SURGERY},
	volume = {17},
	unique-id = {36386803},
	issn = {1948-9366},
	abstract = {The treatment of locally advanced rectal cancer (LARC) has evolved significantly over the past century, driven by a deeper understanding of tumor biology, technological advancements, and multidisciplinary approaches. This article reviews the historical progression of LARC management, emphasizing the latest breakthroughs that are reshaping treatment paradigms. Key developments include the watch and wait strategy for patients achieving a complete clinical response after neoadjuvant therapy, the emergence of total neoadjuvant therapy as a standard approach, and the adoption of minimally invasive surgical techniques, such as transanal endoscopic microsurgery. Watch and wait may reduce treatment-related morbidity and help preserve anorectal function, but it requires rigorous patient selection and close long-term surveillance to ensure oncologic safety. Additionally, the role of targeted therapies and immunotherapy is gaining prominence, offering new opportunities for personalized treatment. These innovations aim to improve oncological outcomes while minimizing morbidity and preserving organ function, ultimately enhancing patients’ quality of life. Despite these advancements, challenges remain in optimizing patient selection, refining treatment strategies, and ensuring long-term safety and efficacy. A multidisciplinary approach involving surgeons, oncologists, and radiation specialists is crucial to tailoring therapies to individual patient profiles. As research continues, integrating novel therapeutic strategies will be key to further improving survival rates and reducing treatment-related morbidity in LARC patients.},
	year = {2025},
	eissn = {1948-9366}
}

@article{MTMT:36386801,
	title = {Epidemiology of colonic adenoma and cancer},
	url = {https://m2.mtmt.hu/api/publication/36386801},
	author = {Kim, Dong Hyun},
	doi = {10.5946/ce.2025.189},
	journal-iso = {CLIN ENDOSC},
	journal = {CLINICAL ENDOSCOPY},
	unique-id = {36386801},
	issn = {2234-2400},
	year = {2025},
	eissn = {2234-2443}
}

@inproceedings{MTMT:36358316,
	title = {Osteosarcopenic obesity. complex disruption of the bone– muscle axis and therapeutic approaches},
	url = {https://m2.mtmt.hu/api/publication/36358316},
	author = {Lehoczki, Andrea Marianna and Jarecsny, Tamás and Zábó, Virág and Fekete, Mónika},
	booktitle = {10th International Conference on Medical & Health Sciences},
	unique-id = {36358316},
	year = {2025},
	pages = {990-997},
	orcid-numbers = {Zábó, Virág/0000-0001-8948-8636; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:36270709,
	title = {Western Diet and Cognitive Decline: A Hungarian Perspective—Implications for the Design of the Semmelweis Study},
	url = {https://m2.mtmt.hu/api/publication/36270709},
	author = {Lehoczki, Andrea Marianna and Csípő, Tamás and Lipécz, Ágnes and Major, Dávid and Fazekas-Pongor, Vince and Csík, Boglárka and Mózes, Noémi and Fehér, Ágnes and Dósa, Norbert Sándor and Árva, Dorottya and Pártos, Katalin and Kaposvári, Csilla and Horváth, Krisztián and Varga, Péter and Fekete, Mónika},
	doi = {10.3390/nu17152446},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {17},
	unique-id = {36270709},
	abstract = {Background: Accelerated demographic aging in Hungary and across Europe presents significant public health and socioeconomic challenges, particularly in preserving cognitive function and preventing neurodegenerative diseases. Modifiable lifestyle factors—especially dietary habits—play a critical role in brain aging and cognitive decline. Objective: This narrative review explores the mechanisms by which Western dietary patterns contribute to cognitive impairment and neurovascular aging, with specific attention to their relevance in the Hungarian context. It also outlines the rationale and design of the Semmelweis Study and its workplace-based health promotion program targeting lifestyle-related risk factors. Methods: A review of peer-reviewed literature was conducted focusing on Western diet, cognitive decline, cerebrovascular health, and dietary interventions. Emphasis was placed on mechanistic pathways involving systemic inflammation, oxidative stress, endothelial dysfunction, and decreased neurotrophic support. Key findings: Western dietary patterns—characterized by high intakes of saturated fats, refined sugars, ultra-processed foods, and linoleic acid—are associated with elevated levels of 4-hydroxynonenal (4-HNE), a lipid peroxidation product linked to neuronal injury and accelerated cognitive aging. In contrast, adherence to Mediterranean dietary patterns—particularly those rich in polyphenols from extra virgin olive oil and moderate red wine consumption—supports neurovascular integrity and promotes brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) activity. The concept of “cognitive frailty” is introduced as a modifiable, intermediate state between healthy aging and dementia. Application: The Semmelweis Study is a prospective cohort study involving employees of Semmelweis University aged ≥25 years, collecting longitudinal data on dietary, psychosocial, and metabolic determinants of aging. The Semmelweis–EUniWell Workplace Health Promotion Model translates these findings into practical interventions targeting diet, physical activity, and cardiovascular risk factors in the workplace setting. Conclusions: Improving our understanding of the diet–brain health relationship through population-specific longitudinal research is crucial for developing culturally tailored preventive strategies. The Semmelweis Study offers a scalable, evidence-based model for reducing cognitive decline and supporting healthy aging across diverse populations.},
	year = {2025},
	eissn = {2072-6643},
	orcid-numbers = {Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Árva, Dorottya/0000-0003-3964-2708; Fekete, Mónika/0000-0001-8632-2120}
}

@CONFERENCE{MTMT:36128202,
	title = {Obesity and Its Complications},
	url = {https://m2.mtmt.hu/api/publication/36128202},
	author = {Mae Ann Yuen, Michele},
	booktitle = {Obesity - Exploring Integrative Strategies and Novel Perspectives - Integrative Strategies and Non-Pharmacological Perspectives in Obesity Care [Working Title]},
	doi = {10.5772/intechopen.1010254},
	unique-id = {36128202},
	abstract = {Obesity is associated with many health complications, which are attributable to several mechanistic changes that take place as excess adipose tissue builds up in the body. These changes include chronic inflammation, oxidative stress, insulin resistance, endothelial dysfunction, elevated levels of growth-promoting adipokines, mechanical effects of excess adiposity due to ectopic deposition and direct loading, and heightened activities of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system (SNS). These mechanistic processes may occur in isolation or in combination to contribute to the development of obesity-associated comorbidities. Understanding the full spectrum of obesity-associated comorbidities will help to guide the clinical assessment as well as treatment and monitoring of individuals with obesity. This chapter will include a review of the current evidence in relation to the scope of obesity-associated comorbidities and discussions on how excess adiposity can contribute to their pathogenesis.},
	year = {2025},
	pages = {online}
}

@article{MTMT:36089318,
	title = {Vitamin D: What role in obesity-related cancer?},
	url = {https://m2.mtmt.hu/api/publication/36089318},
	author = {Martinez, P. and Grant, W.B.},
	doi = {10.1016/j.semcancer.2025.03.007},
	journal-iso = {SEMIN CANCER BIOL},
	journal = {SEMINARS IN CANCER BIOLOGY},
	volume = {112},
	unique-id = {36089318},
	issn = {1044-579X},
	abstract = {Obesity is an important risk factor for incidence and death for many types of cancer. Vitamin D reduces risk of incidence and death for many types of cancer. This review outlines the mechanisms by which obesity increases risk of cancer, how vitamin D reduces risk of cancer, and the extent to which vitamin D counters the effects of obesity in cancer. Vitamin D is a partial ally against some of obesity's pro-carcinogenic effects, notably by reducing inflammation and regulating sex hormone receptors, leptin resistance, cellular energy metabolism, the microbiome, and hypoxia. However, it can act stronger in against the renin-angiotensin system, insulin resistance, and oxidative stress in cancer. Additionally, excess fat tissue sequesters vitamin D and, along with its dilution in increased body volume, further reduces its bioavailability and serum concentration, limiting its protective effects against cancer. In conclusion, while vitamin D cannot reverse obesity, it plays a significant role in mitigating its pro-carcinogenic effects by targeting several mechanisms. © 2025},
	keywords = {Adult; Female; Inflammation; Inflammation; MECHANISMS; CANCER; BREAST; review; human; risk factor; Therapy; OBESITY; OBESITY; Insulin Resistance; Insulin Resistance; leptin; renin angiotensin aldosterone system; BIOAVAILABILITY; energy metabolism; cancer risk; vitamin D; vitamin D; HYPOXIA; prostate; prostate; sex hormone; Drug therapy; Adipose Tissue; cell energy; malignant neoplasm; Colorectal; carcinogen testing; body volume; Oxidative stress; Oxidative stress; neoplastic cell transformation},
	year = {2025},
	eissn = {1096-3650},
	pages = {135-149}
}

@article{MTMT:36283237,
	title = {Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach},
	url = {https://m2.mtmt.hu/api/publication/36283237},
	author = {Masci, Domiziana and Puxeddu, Michela and Colla, Claudia and Coluccia, Antonio and Santelli, Martina and Sciò, Pietro and Mariotto, Elena and Viola, Giampietro and Hamel, Ernest and Lerose, Rosa and Mazzoccoli, Carmela and Silvestri, Romano and La Regina, Giuseppe},
	doi = {10.1039/D5MD00406C},
	journal-iso = {RSC MED CHEM},
	journal = {RSC MEDICINAL CHEMISTRY},
	unique-id = {36283237},
	abstract = {Microwave-assisted synthesis of new pyrrole and indole derivatives as tubulin assembly inhibitors was performed with remarkably improved yields and short reaction times.},
	year = {2025},
	eissn = {2632-8682},
	orcid-numbers = {Masci, Domiziana/0000-0002-5615-5111; Viola, Giampietro/0000-0001-9329-165X; Hamel, Ernest/0000-0003-3648-103X; Silvestri, Romano/0000-0003-2489-0178; La Regina, Giuseppe/0000-0003-3252-1161}
}

@article{MTMT:36055237,
	title = {Obesity and Cancer: Excess Body Fat as a Risk Factor in Carcinogenesis; Consequences Across Human Body Systems and Significance for Associated Medical Specialties},
	url = {https://m2.mtmt.hu/api/publication/36055237},
	author = {Nicholas, A. Kerna and Taylor, M. Nicely and Uwakmfonabasi, A. Umoudoh and Adina, Boulos and Ogonna, P. Arisi and Chibuike, Eze and Breanna, Jomsky and Dabeluchi, C. Ngwu and Hilary, M. Holets},
	doi = {10.59324/ejmhr.2025.3(2).12},
	journal-iso = {ejmhr},
	journal = {European Journal of Medical and Health Research},
	volume = {3},
	unique-id = {36055237},
	year = {2025},
	eissn = {2786-8524},
	pages = {122-135}
}

@article{MTMT:35860305,
	title = {The Link Between Adiposity and Colorectal Cancer: Troubling Statistics},
	url = {https://m2.mtmt.hu/api/publication/35860305},
	author = {Nor, El Houda Khelif and Zakaria, Seoudi and Anis, Khelif and Djamila, Si Ahmed and Fayçal, Bouali and Samir, Rouabhia},
	doi = {10.48087/BJMSra.2025.12125},
	journal = {Batna Journal of Medical Sciences (BJMS)},
	volume = {12},
	unique-id = {35860305},
	year = {2025},
	eissn = {2437-0665},
	pages = {128-131}
}

@article{MTMT:36235240,
	title = {Impact of Obesity on Cancer-Specific Survival and Overall Survival in Colorectal Cancer},
	url = {https://m2.mtmt.hu/api/publication/36235240},
	author = {Obomanu, E. and Anebo, T. and Byfield, K. and Akinrinmade, A. and Varadi, G.},
	doi = {10.1080/01635581.2025.2514782},
	journal-iso = {NUTR CANCER},
	journal = {NUTRITION AND CANCER : AN INTERNATIONAL JOURNAL},
	volume = {77},
	unique-id = {36235240},
	issn = {0163-5581},
	abstract = {Obesity is a well-established risk factor for colorectal cancer (CRC) development, yet its influence on cancer-specific survival (CSS) and overall survival (OS) remains paradoxical. While obesity correlates with adverse outcomes such as increased recurrence, metastasis, and treatment-related complications, emerging evidence highlights a counterintuitive “obesity paradox,” where overweight and moderately obese patients with Body Mass Index(BMI 25–30) exhibit improved CSS and OS compared to underweight (BMI <18.5) or morbidly obese (BMI >35) individuals. Proposed mechanisms for this paradox include altered molecular signaling (adipokine imbalances), enhanced energy metabolism, and greater treatment tolerance due to metabolic reserves. However, these findings are contentious, as BMI, a crude measure, fails to distinguish lean mass from visceral adiposity, key determinants of prognosis. Studies suggest that moderate obesity may buffer treatment toxicity, while extremes of BMI reflect frailty or metabolic dysfunction, worsening survival. This review critically examines the biological underpinnings of the obesity paradox and challenges BMI’s reliability as a prognostic tool. Research must prioritize advanced body composition metrics (visceral fat quantification via imaging) to disentangle obesity’s dual role in CRC outcomes. Such precision could guide tailored interventions, transforming the paradox from a scientific curiosity into a therapeutic strategy, optimizing survival for CRC patients across the weight spectrum. © 2025 Taylor & Francis Group, LLC.},
	keywords = {Female; Male; signal transduction; METASTASIS; review; human; risk factor; major clinical study; OBESITY; biological marker; Reliability; body composition; body mass; energy metabolism; colorectal cancer; overall survival; metabolic disorder; adipocytokine; Intra-Abdominal Fat; underweight; Benchmarking; Obesity paradox; Frailty; cancer specific survival},
	year = {2025},
	eissn = {1532-7914},
	pages = {729-736}
}

@inproceedings{MTMT:36546932,
	title = {Synergistic Effects of Polyphenol-Rich Foods and Resistance Training in the Prevention and Management of Sarcopenia},
	url = {https://m2.mtmt.hu/api/publication/36546932},
	author = {Pázmándi, Eszter Melinda and Jarecsny, Tamás and Lehoczki, Andrea Marianna and Fekete, Mónika},
	booktitle = {III.International Congress on Advanced Research and Applications},
	unique-id = {36546932},
	year = {2025},
	pages = {358-364},
	orcid-numbers = {Pázmándi, Eszter Melinda/0000-0002-0634-4002; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:36204483,
	title = {The role of physical activity and epigenetic changes in colorectal cancer prevention},
	url = {https://m2.mtmt.hu/api/publication/36204483},
	author = {Sun, Yu and Keat, Ooi Boon and Rajabi, Sogand},
	doi = {10.1186/s12935-025-03872-1},
	journal-iso = {CANCER CELL INT},
	journal = {CANCER CELL INTERNATIONAL},
	volume = {25},
	unique-id = {36204483},
	issn = {1475-2867},
	year = {2025},
	eissn = {1475-2867}
}

@article{MTMT:36088936,
	title = {Association between red and processed meat consumption and colorectal cancer risk : a comprehensive meta-analysis of prospective studies},
	url = {https://m2.mtmt.hu/api/publication/36088936},
	author = {Ungvári, Zoltán István and Fekete, Mónika and Varga, Péter and Lehoczki, Andrea Marianna and Munkácsy, Gyöngyi and Fekete, János Tibor and Bianchini, Giampaolo and Ocana, Alberto and Buda, Annamaria and Ungvári, Anna Sára and Győrffy, Balázs},
	doi = {10.1007/s11357-025-01646-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {47},
	unique-id = {36088936},
	issn = {2509-2715},
	abstract = {Increasing evidence suggests that red and processed meat consumption may elevate the risk of colorectal cancer (CRC), yet the magnitude and consistency of this association remain debated. This meta-analysis aims to quantify the relationship between red and processed meat intake and the risk of CRC, colon cancer, and rectal cancer using the most comprehensive set of prospective studies to date. We conducted a comprehensive search in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar databases from 1990 to November 2024, to identify relevant prospective studies examining red, processed, and total meat consumption in relation to colorectal, colon, and rectal cancer risk. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted for each study and pooled using a random-effects model to account for variability among studies. Statistical evaluation was executed using the online platform MetaAnalysisOnline.com. A total of 60 prospective studies were included. Red meat consumption was associated with a significantly increased risk of colon cancer (HR = 1.22, 95% CI 1.15-1.30), colorectal cancer (HR = 1.15, 95% CI 1.10-1.21), and rectal cancer (HR = 1.22, 95% CI 1.07-1.39). Processed meat consumption showed similar associations with increased risk for colon cancer (HR = 1.13, 95% CI 1.07-1.20), colorectal cancer (HR = 1.21, 95% CI 1.14-1.28), and rectal cancer (HR = 1.17, 95% CI 1.05-1.30). Total meat consumption also correlated with an elevated risk of colon cancer (HR = 1.22, 95% CI 1.11-1.35), colorectal cancer (HR = 1.17, 95% CI 1.12-1.22), and rectal cancer (HR = 1.28, 95% CI 1.10-1.48). This meta-analysis provides robust evidence that high consumption of red and processed meats is significantly associated with an increased risk of colorectal, colon, and rectal cancers. These findings reinforce current dietary recommendations advocating for the limitation of red and processed meat intake as part of cancer prevention strategies.},
	keywords = {[Meta-analysis]},
	year = {2025},
	eissn = {2509-2723},
	pages = {5123-5140},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Fekete, Mónika/0000-0001-8632-2120; Munkácsy, Gyöngyi/0000-0001-9124-4788; Fekete, János Tibor/0000-0002-6672-6563; Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:35925785,
	title = {Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality},
	url = {https://m2.mtmt.hu/api/publication/35925785},
	author = {Ungvári, Zoltán István and Fekete, Mónika and Lehoczki, Andrea Marianna and Munkácsy, Gyöngyi and Fekete, János Tibor and Zábó, Virág and Purebl, György and Varga, Péter and Ungvári, Anna Sára and Győrffy, Balázs},
	doi = {10.1007/s11357-025-01593-x},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {47},
	unique-id = {35925785},
	issn = {2509-2715},
	abstract = {The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short and long sleep durations impact stroke incidence and mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar up to November 1, 2024, to identify cohort studies evaluating sleep duration and stroke outcomes. Meta-analysis was performed using MetaAnalysisOnline.com and a random-effects model to estimate pooled hazard ratios (HRs). Results were visualized through Forest and Funnel plots. Analysis of 43 studies (35 on stroke incidence, 8 on mortality) revealed significant associations between sleep duration and stroke outcomes. Short sleep duration (≤ 5–6 h) was associated with increased stroke incidence (HR 1.29, 95% CI 1.19–1.40, p  < 0.01) and modestly elevated mortality (HR 1.12, 95% CI 1.01–1.25, p  = 0.03). Long sleep duration (> 8–9 h) demonstrated stronger associations with both increased stroke incidence (HR 1.46, 95% CI 1.33–1.60, p  < 0.01) and mortality (HR 1.45, 95% CI 1.31–1.60, p  < 0.01). Significant heterogeneity was observed in incidence studies ( I 2 = 74–75%), while mortality analyses showed moderate to low heterogeneity ( I 2 = 35–40%). This meta-analysis highlights a U-shaped association between sleep duration and stroke risk, with both short and long sleep durations linked to higher stroke incidence and mortality. These findings underscore the importance of balanced sleep duration as a modifiable risk factor in stroke prevention strategies and provide a foundation for the Semmelweis Study, a prospective workplace cohort investigating the role of modifiable lifestyle factors in unhealthy cerebrovascular and brain aging.},
	year = {2025},
	eissn = {2509-2723},
	pages = {4679-4695},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Fekete, Mónika/0000-0001-8632-2120; Munkácsy, Gyöngyi/0000-0001-9124-4788; Fekete, János Tibor/0000-0002-6672-6563; Zábó, Virág/0000-0001-8948-8636; Purebl, György/0000-0002-9750-2001; Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:36084206,
	title = {Treatment delay significantly increases mortality in colorectal cancer : a meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/36084206},
	author = {Ungvári, Zoltán István and Fekete, Mónika and Fekete, János Tibor and Lehoczki, Andrea Marianna and Buda, Annamaria and Munkácsy, Gyöngyi and Varga, Péter and Ungvári, Anna Sára and Győrffy, Balázs},
	doi = {10.1007/s11357-025-01648-z},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {47},
	unique-id = {36084206},
	issn = {2509-2715},
	abstract = {Delaying the initiation of cancer treatment increases the risk of mortality, particularly in colorectal cancer (CRC), which is among the most common and deadliest malignancies. This study aims to explore the impact of treatment delays on mortality in CRC. A systematic literature search was conducted in PubMed, Web of Science, and Scopus for studies published between 2000 and 2025. Meta-analyses were performed using random-effects models with inverse variance method to calculate hazard ratios (HRs) for both overall and cancer-specific survival at 4-, 8-, and 12-week treatment delay intervals, with heterogeneity assessed through I2-statistics and publication bias evaluated using funnel plots and Egger's test. A total of 20 relevant studies were included in the meta-analysis. The analyses of all patients demonstrated a progressively increasing risk of 12-39% with longer treatment delays (4 weeks, HR = 1.12; 95% CI, 1.08-1.16; 8 weeks, HR = 1.24; 95% CI, 1.16-1.34; 12 weeks, HR = 1.39; 95% CI, 1.25-1.55). In particular, incrementally higher hazard ratios were observed for all-cause mortality at 4 weeks (HR = 1.14; 95% CI, 1.09-1.18), 8 weeks (HR = 1.29; 95% CI, 1.20-1.39), and 12 weeks (HR = 1.47; 95% CI, 1.31-1.64). In contrast, cancer-specific survival analysis showed a similar trend but did not reach statistical significance (4 weeks, HR = 1.07; 95% CI, 0.98-1.18; 8 weeks, HR = 1.15; 95% CI, 0.95-1.39; 12 weeks, HR = 1.23; 95% CI, 0.93-1.63). Treatment delays in colorectal cancer patients were associated with progressively worsening overall survival, with each 4-week delay increment leading to a substantially higher mortality risk. This study suggests that timely treatment initiation should be prioritized in clinical practice, as these efforts can lead to substantial improvements in survival rates.},
	keywords = {[Meta-analysis]},
	year = {2025},
	eissn = {2509-2723},
	pages = {5337-5353},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Fekete, Mónika/0000-0001-8632-2120; Fekete, János Tibor/0000-0002-6672-6563; Munkácsy, Gyöngyi/0000-0001-9124-4788; Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:35912335,
	title = {Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/35912335},
	author = {Ungvári, Zoltán István and Fekete, Mónika and Varga, Péter and Fekete, János Tibor and Lehoczki, Andrea Marianna and Buda, Annamária and Szappanos, Ágnes and Purebl, György and Ungvári, Anna Sára and Győrffy, Balázs},
	doi = {10.1007/s11357-025-01592-y},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {47},
	unique-id = {35912335},
	issn = {2509-2715},
	abstract = {Sleep duration is a crucial factor influencing health outcomes, yet its relationship with mortality remains debated. In this meta-analysis, we aimed to investigate the association between short and long sleep duration and all-cause mortality in adults, including sex-specific differences. A systematic search was performed in multiple databases, including PubMed, Cochrane Central, and Web of Science, up to October 2024. Retrospective and prospective cohort studies involving adults with at least 1 year of follow-up and data on sleep duration and all-cause mortality were included. Hazard ratios were pooled using a random-effects model, with subgroup analyses performed based on sex and sleep duration categories. A total of 79 cohort studies were included, with data stratified by sex and categorized into short and long sleep durations. Short sleep duration (< 7 h per night) was associated with a 14% increase in mortality risk compared to the reference of 7–8 h, with a pooled hazard ratio of 1.14 (95% CI 1.10 to 1.18). Conversely, long sleep duration (≥ 9 h per night) was associated with a 34% higher risk of mortality, with a hazard ratio of 1.34 (95% CI 1.26 to 1.42). Sex-specific analyses indicated that both short and long sleep durations significantly elevated mortality risk in men and women, although the effect was more pronounced for long sleep duration in women. Both short and long sleep durations are associated with increased all-cause mortality, though the degree of risk varies by sex. These findings underscore the importance of considering optimal sleep duration in public health strategies aimed at enhancing longevity and highlight the need for sex-specific approaches in sleep health research.},
	keywords = {[Meta-analysis]},
	year = {2025},
	eissn = {2509-2723},
	pages = {4545-4566},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Fekete, Mónika/0000-0001-8632-2120; Fekete, János Tibor/0000-0002-6672-6563; Purebl, György/0000-0002-9750-2001; Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:36171800,
	title = {The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/36171800},
	author = {Vahed, Iman Elahi and Moshgelgosha, Mahsa and Kor, Abdolmajid and Minadi, Mona and Ebrahimi, Faezeh and Azhdarian, Aylar and Arjmandi, Mobina and Alamdar, Aida and Zare, Maede and Shabani, Niloufar and Soltaninejad, Hossein and Rahmanian, Mohammad},
	doi = {10.1186/s12885-025-14362-y},
	journal-iso = {BMC CANCER},
	journal = {BMC CANCER},
	volume = {25},
	unique-id = {36171800},
	issn = {1471-2407},
	year = {2025},
	eissn = {1471-2407}
}

@article{MTMT:36235239,
	title = {Changing patterns and potential overdiagnosis of major screened cancers in Pudong New Area of Shanghai},
	url = {https://m2.mtmt.hu/api/publication/36235239},
	author = {Xie, D. and Zhang, L. and He, N. and Yang, C. and Zhang, M. and Zhang, R. and Hao, L. and Xu, W.},
	doi = {10.16073/j.cnki.cjcpt.2025.10.02},
	journal-iso = {CHIN J CANCER PREV TREATM},
	journal = {CHINESE JOURNAL OF CANCER PREVENTION AND TREATMENT},
	volume = {32},
	unique-id = {36235239},
	issn = {1673-5269},
	abstract = {Objective To investigate the potential overdiagnosis of major screened cancers at the population level by comparing secular trends of incidence and mortality based on cancer surveillance data. Methods Data on the incidence and mortality of cancers of lung, thyroid cancer, female breast cancer, colorectal cancer, gastric cancer, liver cancer, esophageal cancer, prostate cancer, and cervical cancer were extracted from the Shanghai Pudong New Area cancer registry and cause-of-death registration system during January 1, 2002 and December 31, 2019. The age-standardized incidence rates, mortality rates, and stage-specific (Stage I to IV) incidence rates were calculated separately for males and females according to the year of diagnosis or death. Joinpoint regression was used to calculate the segmented annual percentage change(APC), the average annual percent change(AAPC), and their 95%CI for the standardized rates. Results Three changing patterns in age-standardized incidence and mortality were observed for the nine cancers. The first pattern was characterized with significant increases in both incidence and mortality. The pattern was mainly observed for prostate cancer, cervical cancer, and male colorectal cancer, with an AAPC ranging from 1.78% to 6.39% for incidence and from 1.61% to 5.78% for mortality. The second pattern with significantly decreased incidence and mortality was found for gastric cancer, liver cancer and esophageal cancer, with an AAPC of -6.63% to -3.13% for incidence and -7.01% to - 3.56% for mortality. The third pattern manifested as significant increased incidence accompanying by decreased or stable mortality, which was observed for thyroid cancer, lung cancer, and female breast cancer. The APC(95%CI) of thyroid cancer incidence during 2002 and 2019 was 19.72% (17.75% to 21.72%) in men and 17.19% (15.27% to 19.14%) in women, whereas the AAPC(95%CI) of thyroid cancer mortality was 3.83%(-1.73% to 9.71%) in men and 2.76% (-1.51% to 8.01%) in women. For female breast cancer, the AAPC(95%CI) was 1.74%(1.17% to 2.45%) for incidence and 0.66% (-0.15% to 1.50%) for mortality. Regarding lung cancer, the incidence in men decreased from 56.21 per 100000 in 2002 to 48.77 per 100000 in 2009, and thereafter increased with an APC of 2.03% (95% CI: 0.85% to 5.59%); the incidence in women increased 13.44%(95%CI: 11.72% to 15.20%) per year since 2012. In comparison, the lung cancer mortality significantly declined during 2002 and 2019, with an AAPC(95%CI) of -1.75%(-2.29% to -1.15%) in men and -1.59%(-2.29% to -0.88%) in women. The incidences of stage-I thyroid cancer, female lung cancer and female breast cancer increased significantly during the period, while those of late-stage cancers remained stable. Conclusions Overdiagnosis may exist in thyroid cancer, female lung cancer and female breast cancers in Pudong New Area of Shanghai. Further studies are needed to confirm our results and quantify the overdiagnosis in the populations. © 2025 Chinese Journal of Cancer Prevention and Treatment, Editorial board. All rights reserved.},
	keywords = {CANCER; Screening; overdiagnosis; cancer surveillance},
	year = {2025},
	pages = {599-607}
}

@article{MTMT:36393199,
	title = {Digital Microinterventions in Nutrition: Virtual Culinary Medicine Programs and Their Effectiveness in Promoting Plant-Based Diets—A Narrative Review},
	url = {https://m2.mtmt.hu/api/publication/36393199},
	author = {Zábó, Virág and Lehoczki, Andrea Marianna and Varga, János Tamás and Szappanos, Ágnes and Lipécz, Ágnes and Csípő, Tamás and Fazekas-Pongor, Vince and Major, Dávid and Fekete, Mónika},
	doi = {10.3390/nu17203310},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {17},
	unique-id = {36393199},
	abstract = {Background: Plant-based diets are associated with reduced risk of chronic diseases and improved health outcomes. However, sustaining dietary changes remains challenging. Digital interventions—including virtual culinary medicine programs, web-based nutrition coaching, SMS and email reminders, mobile application–based self-management, and hybrid community programs—offer promising strategies to support behavior change, enhance cooking skills, and improve dietary adherence. These approaches are relevant for both healthy individuals and those living with chronic conditions. Methods: We conducted a narrative review of studies published between 2000 and 2025 in PubMed/MEDLINE, Scopus, and Web of Science, supplemented with manual searches. Included studies comprised randomized controlled trials, quasi-experimental designs, feasibility studies, and qualitative research. Interventions were categorized by modality (SMS, email, web platforms, mobile apps, virtual culinary programs, and hybrid formats) and population (healthy adults, patients with chronic diseases). Outcomes examined included dietary quality, self-efficacy, psychosocial well-being, and program engagement. Results: Most studies reported improvements in dietary quality, cooking skills, nutrition knowledge, and psychosocial outcomes. Virtual cooking programs enhanced dietary adherence and engagement, particularly among individuals at cardiovascular risk. Digital nutrition education supported behavior change in chronic disease populations, including patients with multiple sclerosis. SMS and email reminders improved self-monitoring and participation rates, while mobile applications facilitated real-time feedback and goal tracking. Hybrid programs combining online and in-person components increased motivation, social support, and long-term adherence. Reported barriers included limited technological access or skills, lack of personalization, and privacy concerns. Conclusions: Virtual culinary medicine programs and other digital microinterventions—including SMS, email, web, mobile, and hybrid formats—are effective tools to promote plant-based diets. Future interventions should focus on personalized, accessible, and hybrid strategies, with attention to underserved populations, to maximize engagement and sustain long-term dietary change.},
	year = {2025},
	eissn = {2072-6643},
	orcid-numbers = {Zábó, Virág/0000-0001-8948-8636; Varga, János Tamás/0000-0002-8552-1336; Fazekas-Pongor, Vince/0000-0002-6405-4003; Major, Dávid/0000-0002-6108-9745; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:36158283,
	title = {Worldwide burden and cross-regional health inequalities of high BMI-attributable colorectal cancer by gender from 1990 to 2021, with predictions through 2041},
	url = {https://m2.mtmt.hu/api/publication/36158283},
	author = {Zhang, Jinhai and Yang, Jingge},
	doi = {10.1186/s12876-025-03938-4},
	journal-iso = {BMC GASTROENTEROL},
	journal = {BMC GASTROENTEROLOGY},
	volume = {25},
	unique-id = {36158283},
	issn = {1471-230X},
	year = {2025},
	eissn = {1471-230X}
}

@inproceedings{MTMT:35657047,
	title = {Spermidine-rich foods and chronic disease prevention. Insights from nutritional studies},
	url = {https://m2.mtmt.hu/api/publication/35657047},
	author = {Mózes, Noémi and Lehoczki, Andrea Marianna and Varga, János Tamás and Fekete, Mónika and Csípő, Tamás},
	booktitle = {3rd International EGE Congress on Scientific Research},
	unique-id = {35657047},
	year = {2024},
	pages = {424-429},
	orcid-numbers = {Varga, János Tamás/0000-0002-8552-1336; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:35650736,
	title = {Chemopreventive Effects of Piper betle (Sirih) on High-Fat Diet-Induced and Azoxymethane-Induced Colon Cancer in Male Sprague-Dawley Rats},
	url = {https://m2.mtmt.hu/api/publication/35650736},
	author = {Roslan, Nur Hazirah and Zarkasi, Khairul Anwar and Mohd Yusof, Yasmin Anum and Makpol, Suzana},
	doi = {10.7759/cureus.76260},
	journal-iso = {CUREUS},
	journal = {CUREUS},
	volume = {16},
	unique-id = {35650736},
	year = {2024},
	eissn = {2168-8184}
}