TY - JOUR AU - Wang, X. AU - Shi, X. AU - Liao, S. AU - Su, T. AU - Gu, Y. AU - Zhang, H. AU - Li, Z. TI - Multidimensional effects of genetic mechanisms in cancer occurrence, development and treatment JF - CANCER GENETICS J2 - CANCER GENET VL - 304-305 PY - 2026 SP - 58 EP - 75 PG - 18 SN - 2210-7762 DO - 10.1016/j.cancergen.2026.03.006 UR - https://m2.mtmt.hu/api/publication/37077507 ID - 37077507 N1 - Export Date: 15 April 2026; Cited By: 0; Correspondence Address: Z. Li; School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, 210023, China; email: ziyunli@njucm.edu.cn; LA - English DB - MTMT ER - TY - JOUR AU - Bianchetto, Wolf N. AU - Mainta, I.C. AU - Fitsiori, A. AU - Colarusso, G. AU - Tsantoulis, P. AU - Egervari, K.L. AU - Garibotto, V. TI - Case Report: Pituitary metastasis from prostate adenocarcinoma: an integrated diagnosis via 68Ga-PSMA PET/CT and methylome analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 12 PY - 2025 SN - 2296-858X DO - 10.3389/fmed.2025.1618256 UR - https://m2.mtmt.hu/api/publication/36249108 ID - 36249108 N1 - Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland Division of Neuroradiology, Geneva University Hospitals, Geneva, Switzerland Division of Oncology, Geneva University Hospitals, Geneva, Switzerland Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland Export Date: 15 July 2025; Cited By: 0; Correspondence Address: V. Garibotto; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland; email: valentina.garibotto@hug.ch LA - English DB - MTMT ER - TY - JOUR AU - Borbiev, Talaibek AU - Babcock, Kevin AU - Sinopole, Kayleigh AU - Chesnut, Gregory T. AU - Petrovics, Gyorgy TI - Ancestry-Specific DNA Damage Repair Gene Mutations and Prostate Cancer JF - CANCERS J2 - CANCERS VL - 17 PY - 2025 IS - 4 PG - 21 SN - 2072-6694 DO - 10.3390/cancers17040682 UR - https://m2.mtmt.hu/api/publication/35881728 ID - 35881728 N1 - Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, 20814, MD, United States Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, 20817, MD, United States Internal Medicine, Alexander T. Augusta Military Medicine Center, Fort Belvoir, 22060, VA, United States School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, 20814, MD, United States Export Date: 24 March 2025; Cited By: 0; Correspondence Address: G. Petrovics; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, 20814, United States; email: gpetrovics@cpdr.org LA - English DB - MTMT ER - TY - JOUR AU - Constancio, Vera AU - Lobo, Joao AU - Sequeira, Jose Pedro AU - Henrique, Rui AU - Jeronimo, Carmen TI - Prostate cancer epigenetics - from pathophysiology to clinical application JF - NATURE REVIEWS UROLOGY J2 - NAT REV UROL VL - 22 PY - 2025 SP - 447 EP - 469 PG - 23 SN - 1759-4812 DO - 10.1038/s41585-024-00991-8 UR - https://m2.mtmt.hu/api/publication/35724858 ID - 35724858 N1 - Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal Doctoral Program in Biomedical Sciences, ICBAS — School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Porto, Portugal Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), Porto, Portugal Department of Pathology and Molecular Immunology, ICBAS — School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal Export Date: 23 March 2025; Cited By: 1; Correspondence Address: C. Jerónimo; Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; email: carmenjeronimo@ipoporto.min-saude.pt AB - Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, which is the study of changes in gene expression without altering the DNA sequence, has been recognized as a major driver of this disease. In the past 50 years, advancements in technological tools to characterize the epigenome have highlighted crucial roles of epigenetic mechanisms throughout the entire spectrum of prostate cancer, from initiation to progression, including localized disease, metastatic dissemination, castration resistance and neuroendocrine transdifferentiation. Substantial advances in the understanding of epigenetic mechanisms in the pathophysiology of prostate cancer have been carried out, but translating preclinical achievements into clinical practice remains challenging. Ongoing research and biomarker-oriented clinical trials are expected to increase the likelihood of successfully integrating epigenetics into prostate cancer clinical management. LA - English DB - MTMT ER - TY - JOUR AU - Gao, S. AU - Patten, N.D. AU - Cai, C. TI - Alterations in AR-FOXA1 signaling in prostate cancer progression and therapeutic resistance JF - JOURNAL OF THE NATIONAL CANCER CENTER J2 - J. Natl. Cancer Cent. VL - 6 PY - 2025 IS - 1 SP - 58 EP - 72 PG - 15 SN - 2096-8663 DO - 10.1016/j.jncc.2025.05.003 UR - https://m2.mtmt.hu/api/publication/36249109 ID - 36249109 N1 - Funding Agency and Grant Number: NIH [R01CA282906, R01CA299202, U54CA156734]; DOD [W81XWH-21-1-0267, W81XWH-19-1-0777]; Proposal Development Award from University of Massachusetts Boston Funding text: This work is supported by grants from NIH (grant numbers: R01CA282906, R01CA299202, and U54CA156734 to C.C.) and DOD (grant numbers: W81XWH-21-1-0267 to C.C., W81XWH-19-1-0777 to S.G.) . C.C. was supported by Proposal Development Award from University of Massachusetts Boston. LA - English DB - MTMT ER -