https://m2.mtmt.hu/ eng 2026-06-14 12:23 true true 1 1 1 20 100 1 1 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 35761180 VALIDATED true Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, 7830490, Chile Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, 20122, Italy Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, 20122, Italy Export Date: 6 March 2025 Correspondence Address: Valenzuela, R.; Department of Nutrition, Chile; email: rvalenzuelab@uchile.cl 0 false 2026-01-29T13:05:39.336+0000 2025-10-31T10:40:05.940+0000 2025-02-14T13:04:07.264+0000 true 10073702 Heronyányi Zsolt /api/admin/10073702 Admin true 2026-01-29T13:03:04.875+0000 2026-01-29T13:03:04.875+0000 2025-03-06T13:55:54.056+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2025-03-08T03:17:01.609+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Bascuñán, Karla A. Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 17 4 621 621 2025 Celiac disease (CD) is a chronic autoimmune disorder driven by both genetic and environmental factors, with the HLA DQ2/DQ8 genotypes playing a central role in its development. Despite the genetic predisposition, only a small percentage of individuals carrying these genotypes develop the disease. Gluten, a protein found in wheat, rye, and barley, is the primary environmental trigger, but other factors, such as the intestinal microbiota, may also contribute to disease progression. While the gluten-free diet (GFD) remains the cornerstone of treatment, many CD patients experience persistent inflammation and gut dysbiosis, leading to ongoing symptoms and complications. This chronic inflammation, which impairs nutrient absorption, increases the risk of malnutrition, anemia, and other autoimmune disorders. Recent studies have identified an altered gut microbiota in CD patients, both on and off the GFD, highlighting the potential role of the microbiota in disease pathogenesis. An emerging area of interest is the supplementation of n-3 polyunsaturated fatty acids (PUFAs), known for their anti-inflammatory properties, as a potential therapeutic strategy. n-3 PUFAs, found in fish oil and certain plant oils, modulate the immune cell function and cytokine production, making them a promising intervention for controlling chronic inflammation in CD. This review explores the current understanding of n-3 PUFAs’ effects on the gut microbiota’s composition and inflammation in CD, with the goal of identifying new avenues for complementary treatments to improve disease management. true 2025 true true true false false GOLD 2026-01-29 false http://www.mdpi.com/journal/nutrients/ 0 0 0 0 0 0 0 0 0 0 0 0 3 3 D1 false false false false 2025-03-05T13:55:53.581+0000 22 58 0 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123335823 /api/authorship/123335823 1 0.14285715 true false false Bascuñán Karla A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335824 /api/authorship/123335824 2 0.14285715 false false false Araya Magdalena true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335825 /api/authorship/123335825 3 0.14285715 false false false Rodríguez Juan Manuel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335826 /api/authorship/123335826 4 0.14285715 false false false Roncoroni Leda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335827 /api/authorship/123335827 5 0.14285715 false false false Elli Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335828 /api/authorship/123335828 6 0.14285715 false false false Alvarez Josefina Del Pilar López true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123335829 /api/authorship/123335829 7 0.14285715 false true false Valenzuela Rodrigo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28403923 /api/publicationidentifier/28403923 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/nu17040621 https://doi.org/10.3390/nu17040621 false true PublicationIdentifier 28596346 /api/publicationidentifier/28596346 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001429774300001 https://www.webofscience.com/wos/woscc/full-record/001429774300001 true true PublicationIdentifier 28596334 /api/publicationidentifier/28596334 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85218456369 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218456369 true true SjrRating 11583199 /api/sjrrating/11583199 23 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true D1 FROM_LAST_YEAR true true /api/publication/35761180 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bascuñán Karla A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Araya Magdalena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rodríguez Juan Manuel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roncoroni Leda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Elli Luca </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alvarez Josefina Del Pilar López </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valenzuela Rodrigo </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35761180" target="_blank">Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">4</span> <span class="page"> Paper 621. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/nu17040621" target="_blank" href="https://doi.org/10.3390/nu17040621"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001429774300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001429774300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218456369" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218456369"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35761180&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35761180</span> | <span class="status-data status-VALIDATED"> Validated </span> Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.10.31. 11:40 Andrea Hegedűs (SE_ETK_Admin5_HA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, 7830490, Chile Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20...</pre> </div></div>