TY  - JOUR
AU  - Bascuñán, Karla A.
AU  - Araya, Magdalena
AU  - Rodríguez, Juan Manuel
AU  - Roncoroni, Leda
AU  - Elli, Luca
AU  - Alvarez, Josefina Del Pilar López
AU  - Valenzuela, Rodrigo
TI  - Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis
JF  - NUTRIENTS
J2  - NUTRIENTS
VL  - 17
PY  - 2025
IS  - 4
SN  - 2072-6643
DO  - 10.3390/nu17040621
UR  - https://m2.mtmt.hu/api/publication/35761180
ID  - 35761180
N1  - Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile            
            Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, 7830490, Chile            
            Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy            
            Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, 20122, Italy            
            Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, 20122, Italy            
            Export Date: 6 March 2025            
            Correspondence Address: Valenzuela, R.; Department of Nutrition, Chile; email: rvalenzuelab@uchile.cl
AB  - Celiac disease (CD) is a chronic autoimmune disorder driven by both genetic and environmental factors, with the HLA DQ2/DQ8 genotypes playing a central role in its development. Despite the genetic predisposition, only a small percentage of individuals carrying these genotypes develop the disease. Gluten, a protein found in wheat, rye, and barley, is the primary environmental trigger, but other factors, such as the intestinal microbiota, may also contribute to disease progression. While the gluten-free diet (GFD) remains the cornerstone of treatment, many CD patients experience persistent inflammation and gut dysbiosis, leading to ongoing symptoms and complications. This chronic inflammation, which impairs nutrient absorption, increases the risk of malnutrition, anemia, and other autoimmune disorders. Recent studies have identified an altered gut microbiota in CD patients, both on and off the GFD, highlighting the potential role of the microbiota in disease pathogenesis. An emerging area of interest is the supplementation of n-3 polyunsaturated fatty acids (PUFAs), known for their anti-inflammatory properties, as a potential therapeutic strategy. n-3 PUFAs, found in fish oil and certain plant oils, modulate the immune cell function and cytokine production, making them a promising intervention for controlling chronic inflammation in CD. This review explores the current understanding of n-3 PUFAs’ effects on the gut microbiota’s composition and inflammation in CD, with the goal of identifying new avenues for complementary treatments to improve disease management.
LA  - English
DB  - MTMT
ER  -