@article{MTMT:35998973, title = {Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa}, url = {https://m2.mtmt.hu/api/publication/35998973}, author = {Alexander, Kelsey L. and Naman, C. Benjamin and Iwasaki, Arihiro and Mangoni, Alfonso and Leao, Tiago and Reher, Raphael and Petras, Daniel and Kim, Hyunwoo and Ternon, Eva and Caro-Diaz, Eduardo J. E. and Glukhov, Evgenia and Mitrevska, Jana A. and Avalon, Nicole E. and Duggan, Brendan M. and Gerwick, Lena and Gerwick, William H.}, doi = {10.1021/acs.jnatprod.4c01051}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {88}, unique-id = {35998973}, issn = {0163-3864}, year = {2025}, eissn = {1520-6025}, pages = {322-335}, orcid-numbers = {Kim, Hyunwoo/0000-0003-2473-8360} } @article{MTMT:36011963, title = {Diversity of Cyanobacterial Genera Present in Cabo Verde Marine Environments and the Description of Gibliniella gelatinosa sp. nov}, url = {https://m2.mtmt.hu/api/publication/36011963}, author = {Morais, Joao and Cruz, Pedro and Hentschke, Guilherme Scotta and Silva, Bruna and Oliveira, Flavio and Neves, Jorge and Silva, Raquel and Ramos, Vitor and Leao, Pedro N. and Vasconcelos, Vitor M.}, doi = {10.3390/plants14030299}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {14}, unique-id = {36011963}, issn = {2223-7747}, keywords = {PHYLOGENY; Biodiversity; taxonomy; new species; Cabo Verde}, year = {2025}, eissn = {2223-7747} } @article{MTMT:35884373, title = {Advances in the Study of Halogenated Natural Products}, url = {https://m2.mtmt.hu/api/publication/35884373}, author = {Zhang, Lijing and Liu, Bing and Zhu, Ting and Tian, Xue and Chen, Ning and Wang, Yuxin}, doi = {10.2174/0115680266344796241211214414}, journal-iso = {CURR TOP MED CHEM}, journal = {CURRENT TOPICS IN MEDICINAL CHEMISTRY}, volume = {25}, unique-id = {35884373}, issn = {1568-0266}, keywords = {biosynthesis; Chlorides; BROMIDES; bioactivities; Halogenated natural products}, year = {2025}, eissn = {1873-4294}, pages = {1217-1250} } @article{MTMT:35437887, title = {Screening of Lipid-Reducing Activity and Cytotoxicity of the Exometabolome from Cyanobacteria}, url = {https://m2.mtmt.hu/api/publication/35437887}, author = {Luz, R. and Cordeiro, R. and Gonçalves, V. and Vasconcelos, V. and Urbatzka, R.}, doi = {10.3390/md22090412}, journal-iso = {MAR DRUGS}, journal = {MARINE DRUGS}, volume = {22}, unique-id = {35437887}, issn = {1660-3397}, abstract = {Cyanobacteria are rich producers of secondary metabolites, excreting some of these to the culture media. However, the exometabolome of cyanobacteria has been poorly studied, and few studies have dwelled on its characterization and bioactivity assessment. In this work, exometabolomes of 56 cyanobacterial strains were characterized by HR-ESI-LC-MS/MS. Cytotoxicity was assessed on two carcinoma cell lines, HepG2 and HCT116, while the reduction in lipids was tested in zebrafish larvae and in a steatosis model with fatty acid-overloaded human liver cells. The exometabolome analysis using GNPS revealed many complex clusters of unique compounds in several strains, with no identifications in public databases. Three strains reduced viability in HCT116 cells, namely Tolypotrichaceae BACA0428 (30.45%), Aphanizomenonaceae BACA0025 (40.84%), and Microchaetaceae BACA0110 (46.61%). Lipid reduction in zebrafish larvae was only observed by exposure to Dulcicalothrix sp. BACA0344 (60%). The feature-based molecular network shows that this bioactivity was highly correlated with two flavanones, a compound class described in the literature to have lipid reduction activity. The exometabolome characterization of cyanobacteria strains revealed a high chemodiversity, which supports it as a source for novel bioactive compounds, despite most of the time being overlooked. © 2024 by the authors.}, keywords = {Animals; Humans; ZEBRAFISH; ZEBRAFISH; LIPIDS; human; animal; Chemistry; liquid chromatography; larva; larva; drug effect; CYANOBACTERIA; Chromatography, Liquid; lipid metabolism; lipid metabolism; lipid; Flavonoids; Hep G2 Cells; exudate; tandem mass spectrometry; tandem mass spectrometry; zebra fish; cyanobacterium; Metabolome; Metabolome; HCT116 Cells; Hep-G2 cell line; HCT 116 cell line; Lipid reduction; Chemodiversity; Extracellular compounds; anti-steatosis}, year = {2024}, eissn = {1660-3397} }