https://m2.mtmt.hu/ hun 2026-05-15 05:55 true true 1 5 5 10 100 1 5 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 36340313 APPROVED true Funding Agency and Grant Number: European Union [956126, 101058422]; Horizon Europe - Pillar II [101058422] Funding Source: Horizon Europe - Pillar II Funding text: This work was supported by the European Union's Horizon 2020 research and innovation program "E-MUSE" under the Marie Sklo-dowska-Curie grant agreement no.956126, and by the European Union's Horizon Europe research and innovation programme "SUPREME" under grant agreement no. 101058422. 0 false 2025-09-19T12:49:00.961+0000 2025-09-19T12:48:01.843+0000 2025-09-19T12:47:31.003+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true 2025-09-19T12:48:02.100+0000 2025-09-19T12:48:02.100+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Wang, Jian Signaling dynamics in microbial communities: A reduced-complexity mathematical analysis true true /api/journal/972 REVIEWED true false 972 false 972 true 0009-2509 1873-4405 Journal FOREIGN 319 121962 121962 10 2026 Quorum sensing (QS) enables bacterial communities to coordinate behaviors essential for survival and competitiveness. However, QS systems are vulnerable to exploitation, where an exploitative strain manipulates QS signals without incurring metabolic costs. Here, we introduce a reduced-complexity mathematical framework to examine how metabolic investments in signaling by the focal QS strain can influence its population fitness under exploitation. Our results demonstrate that intermediate metabolic investment in QS signaling optimizes population fitness, preventing premature activation of costly traits while maintaining competitive resilience. Moreover, the numerical analysis identifies robust "no-loss" regions where focal QS strain sustains its fitness despite exploitation. Finally, the game-theoretic analysis reveals that an evolutionarily stable state (ESS) emerges when both the QS and exploitative strain adopt intermediate investment levels. This work provides a quantitative framework for understanding microbial signaling dynamics, offering insights into designing synthetic QS-based microbial systems for antimicrobial and biotechnological applications. 2025 true true true false false NONE 2025-09-19 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q1 false false false false 2025-12-18T13:48:01.730+0000 4 23 0 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127852080 /api/authorship/127852080 1 0.25 true false false Wang Jian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852081 /api/authorship/127852081 2 0.25 false false false Hashem Ihab true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852082 /api/authorship/127852082 3 0.25 false false false Bhonsale Satyajeet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852083 /api/authorship/127852083 4 0.25 false true false Van Impe Jan F. M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29872543 /api/publicationidentifier/29872543 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1016/j.ces.2025.121962 https://doi.org/10.1016/j.ces.2025.121962 false true PublicationIdentifier 29872544 /api/publicationidentifier/29872544 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true 001540548600001 https://www.webofscience.com/wos/woscc/full-record/001540548600001 false true PublicationIdentifier 29872548 /api/publicationidentifier/29872548 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 105011080784 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011080784 false true Keyword 1652 /api/keyword/1652 true 1652 true Keyword 2603 /api/keyword/2603 true 2603 true Keyword 9628 /api/keyword/9628 true 9628 true Keyword 1066206 /api/keyword/1066206 true 1066206 true Keyword 1069290 /api/keyword/1069290 true 1069290 true Keyword 1466810 /api/keyword/1466810 true 1466810 true Keyword 1504986 /api/keyword/1504986 true true Keyword 1891876 /api/keyword/1891876 true true Keyword 3909709 /api/keyword/3909709 true true SjrRating 11699173 /api/sjrrating/11699173 156 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2604 /api/classificationexternal/2604 true 2604 true Q1 FROM_PREVIOUS_TO_LAST_YEAR true true /api/publication/36340313 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Wang Jian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hashem Ihab </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhonsale Satyajeet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van Impe Jan F. M. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36340313" target="_blank">Signaling dynamics in microbial communities: A reduced-complexity mathematical analysis</a></div> <div> <span class="journal-title">CHEMICAL ENGINEERING SCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0009-2509">0009-2509</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-4405">1873-4405</a>)</span>: <span class="journal-volume">319</span> <span class="page"> Paper 121962. 10 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/j.ces.2025.121962" target="_blank" href="https://doi.org/10.1016/j.ces.2025.121962"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001540548600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001540548600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105011080784" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011080784"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36340313&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36340313</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.09.19. 14:48 Szabó Regina (ELTE TTK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: European Union [956126, 101058422]; Horizon Europe - Pillar II [101058422] Funding Source: Horizon Europe - Pillar II Funding text: This work was supported by the European Union's Horizon 2020 research and innovation program "E-MUSE" under the Marie Sklo-dowska-Curie grant agreement no.956126, and by the European Union's Horizon Europe research and i...</pre> </div></div> JournalArticle 36126813 APPROVED true Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, 200005, Nigeria Department of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu, 410001, Nigeria Department of Public Health, Faculty of Basic Medical and Health Sciences, Lead City University, Ibadan, 200255, Nigeria Medical Institute, Sumy State University, Sumy, 40007, Ukraine Western Kentucky University, Bowling Green, United States Department of Microbiology, College of Natural Sciences, Federal University of Agriculture, Abeokuta, 111101, Nigeria Department of Physiology, Faculty of Basic Medical Sciences, Osun State University, Osogbo, Nigeria Department of Agriculture, Faculty of Agriculture, University of Ilorin, Ilorin, Nigeria Export Date: 08 May 2025; Cited By: 0; Correspondence Address: I.E. Mba; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, 200005, Nigeria; email: mbaifeanyie@gmail.com; CODEN: FOMIA 0 false 2026-04-28T12:43:52.357+0000 2026-04-28T12:08:40.686+0000 2025-05-08T15:09:16.665+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true 2026-04-28T12:08:41.030+0000 2026-04-28T12:08:41.030+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Mba, I.E. New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae true true /api/journal/1606 REVIEWED true false 1606 false 1606 true 0015-5632 1874-9356 Journal FOREIGN 70 517 533 517 17 2025 true 2025 true true true false false false NONE 2026-04-28 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2025-08-06T15:10:32.911+0000 4 23 0 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126407180 /api/authorship/126407180 1 0.16666667 true false false Mba I.E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126407181 /api/authorship/126407181 2 0.16666667 false false false Mba T.O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126407182 /api/authorship/126407182 3 0.16666667 false false false Uwazie C.K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126407183 /api/authorship/126407183 4 0.16666667 false false false Aina F.A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126407184 /api/authorship/126407184 5 0.16666667 false false false Kemisola A.O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126407185 /api/authorship/126407185 6 0.16666667 false true false Uwazie I.J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29326393 /api/publicationidentifier/29326393 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1007/s12223-025-01261-9 https://doi.org/10.1007/s12223-025-01261-9 false true PublicationIdentifier 29326394 /api/publicationidentifier/29326394 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS 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autype0"> <span class="author-name" >Mba I.E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mba T.O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Uwazie C.K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aina F.A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kemisola A.O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Uwazie I.J. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36126813" target="_blank">New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae</a></div> <div> <span class="journal-title">FOLIA MICROBIOLOGICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0015-5632">0015-5632</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1874-9356">1874-9356</a>)</span>: <span class="journal-volume">70</span> <span class="page"> pp 517-533 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1007/s12223-025-01261-9" target="_blank" href="https://doi.org/10.1007/s12223-025-01261-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001461659500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001461659500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105002459398" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002459398"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36126813&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36126813</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.28. 14:08 Szatmári Erika (BME admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, 200005, Nigeria Department of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu, 410001, Nigeria Department of Public Health, Faculty of Basic Medical and Health Sciences, Lead City University, Ibadan, 200255, Nigeria ...</pre> </div></div> JournalArticle 36802678 VALIDATED true 0 false 2026-01-01T13:47:33.779+0000 2026-01-01T13:46:26.224+0000 2026-01-01T13:46:25.107+0000 true 521 Szuper Admin /api/admin/521 Admin true 2026-01-01T13:46:24.995+0000 2026-01-01T13:46:24.995+0000 2026-01-01T13:46:25.312+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mendez-Veras, Rebeca "The Holobiont as a Biosemiotic System: Health and Dysbiosis Signals in the Human Gut Microbiome" true true /api/journal/10022910 REVIEWED true false 10022910 false 10022910 true 1875-1342 1875-1350 Journal FOREIGN 18 3 403 430 403 28 2025 2026 true true true false false NONE 2026-01-01 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q1 false false false false 4 23 0 1 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 132285307 /api/authorship/132285307 1 1.0 true false true Mendez-Veras Rebeca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31020516 /api/publicationidentifier/31020516 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1007/s12304-025-09627-9 https://doi.org/10.1007/s12304-025-09627-9 false true PublicationIdentifier 31020515 /api/publicationidentifier/31020515 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001591957400001 https://www.webofscience.com/wos/woscc/full-record/001591957400001 false true Classification 13055 /api/classification/13055 true true Classification 12969 /api/classification/12969 true true Keyword 1386520 /api/keyword/1386520 true 1386520 true Keyword 1504304 /api/keyword/1504304 true true Keyword 1836412 /api/keyword/1836412 true true Keyword 2172359 /api/keyword/2172359 true true Keyword 4143044 /api/keyword/4143044 true true Keyword 4143045 /api/keyword/4143045 true true SjrRating 11595893 /api/sjrrating/11595893 206 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3310 /api/classificationexternal/3310 true 3310 true Q1 FROM_LAST_YEAR true true /api/publication/36802678 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Mendez-Veras Rebeca ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36802678" target="_blank">"The Holobiont as a Biosemiotic System: Health and Dysbiosis Signals in the Human Gut Microbiome"</a></div> <div> <span class="journal-title">BIOSEMIOTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1875-1342">1875-1342</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1875-1350">1875-1350</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">3</span> <span class="page"> pp 403-430 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1007/s12304-025-09627-9" target="_blank" href="https://doi.org/10.1007/s12304-025-09627-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001591957400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001591957400001"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36802678&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36802678</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.01. 14:46 Szuper Admin (admin) </div> </div></div> JournalArticle 36340314 VALIDATED true Funding Agency and Grant Number: European Union's Horizon 2020 research and innovation program [956126, 101058422] Funding text: This work was supported by the European Union's Horizon 2020 research and innovation program (under the Marie Sklodowska-Curie grant agreement no. 956126 "E-MUSE" to J.W. and J.F.M.V.I.) and by the European Union's Horizon Europe research and innovation program (under the grant agreement no. 101058422 SUPREME to I.H. and J.F.M.V.I.). 0 false 2026-01-21T07:43:40.759+0000 2026-01-02T16:30:36.881+0000 2025-09-19T12:47:33.425+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true 2026-01-02T16:30:35.348+0000 2026-01-02T16:30:35.505+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Wang, Jian Individual-based modeling unravels spatial and social interactions in bacterial communities true true /api/journal/10007051 REVIEWED true false 10007051 false 10007051 true 1751-7362 1751-7370 Journal FOREIGN 19 1 wraf116 wraf116 18 2025 Bacterial interactions are fundamental in shaping community structure and function, driving processes that range from plastic degradation in marine ecosystems to dynamics within the human gut microbiome. Yet, studying these interactions is challenging due to difficulties in resolving spatiotemporal scales, quantifying interaction strengths, and integrating intrinsic cellular behaviors with extrinsic environmental conditions. Individual-based modeling addresses these challenges through single-cell-level simulations that explicitly model growth, division, motility, and environmental responses. By capturing both the spatial organization and social interactions, individual-based modeling reveals how microbial interactions and environmental gradients collectively shape community architecture, species coexistence, and adaptive responses. In particular, individual-based modeling provides mechanistic insights into how social behaviors-such as competition, metabolic cooperation, and quorum sensing-are regulated by spatial structure, uncovering the interplay between localized interactions and emergent community properties. In this review, we synthesize recent applications of individual-based modeling in studying bacterial spatial and social interactions, highlighting how their interplay governs community stability, diversity, and resilience. By linking individual-scale interactions with the ecosystem-level organization, individual-based modeling offers a predictive framework for understanding microbial ecology and informing strategies for controlling and engineering bacterial consortia in both natural and applied settings. 2025 true true true false false NONE 2026-01-21 false 0 0 0 0 0 0 0 0 0 0 0 0 2 2 D1 false false false false 2025-12-18T13:48:00.486+0000 6 35 0 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127852084 /api/authorship/127852084 1 0.25 true false false Wang Jian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852085 /api/authorship/127852085 2 0.25 false false false Hashem Ihab true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852086 /api/authorship/127852086 3 0.25 false false false Bhonsale Satyajeet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127852087 /api/authorship/127852087 4 0.25 false true false Van Impe Jan F. 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M. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36340314" target="_blank">Individual-based modeling unravels spatial and social interactions in bacterial communities</a></div> <div> <span class="journal-title">ISME JOURNAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1751-7362">1751-7362</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1751-7370">1751-7370</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">1</span> <span class="page"> Paper wraf116. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/ismejo/wraf116" target="_blank" href="https://doi.org/10.1093/ismejo/wraf116"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001564489800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001564489800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105015542148" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105015542148"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40838740" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40838740&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36340314&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36340314</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.02. 17:30 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: European Union's Horizon 2020 research and innovation program [956126, 101058422] Funding text: This work was supported by the European Union's Horizon 2020 research and innovation program (under the Marie Sklodowska-Curie grant agreement no. 956126 "E-MUSE" to J.W. and J.F.M.V.I.) and by the European Union's Horizon Europe research and innovation pr...</pre> </div></div> JournalArticle 34843185 VALIDATED true Correspondence Address: Zachar, I.; Department of Plant Systematics Ecology and Theoretical Biology, Hungary; email: zachar.istvan@ecolres.hu 0 false 2026-05-11T11:35:08.357+0000 2025-09-26T09:41:48.788+0000 2024-05-08T09:51:32.132+0000 true 10077554 Vass Johanna /api/admin/10077554 Admin true 2026-05-11T11:28:47.688+0000 2025-05-22T08:05:36.391+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-05-21T15:23:26.111+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Oszoli, István Group-selection via aggregative propagule-formation enables cooperative multicellularity in an individual based, spatial model true true /api/journal/10003477 REVIEWED true false 10003477 false 10003477 true 1553-734X 1553-7358 Journal FOREIGN 20 5 e1012107 e1012107 26 2024 The emergence of multicellularity is one of the major transitions in evolution that happened multiple times independently. During aggregative multicellularity, genetically potentially unrelated lineages cooperate to form transient multicellular groups. Unlike clonal multicellularity, aggregative multicellular organisms do not rely on kin selection instead other mechanisms maintain cooperation against cheater phenotypes that benefit from cooperators but do not contribute to groups. Spatiality with limited diffusion can facilitate group selection, as interactions among individuals are restricted to local neighbourhoods only. Selection for larger size (e.g. avoiding predation) may facilitate the emergence of aggregation, though it is unknown, whether and how much role such selection played during the evolution of aggregative multicellularity. We have investigated the effect of spatiality and the necessity of predation on the stability of aggregative multicellularity via individual-based modelling on the ecological timescale. We have examined whether aggregation facilitates the survival of cooperators in a temporally heterogeneous environment against cheaters, where only a subset of the population is allowed to periodically colonize a new, resource-rich habitat. Cooperators constitutively produce adhesive molecules to promote aggregation and propagule-formation while cheaters spare this expense to grow faster but cannot aggregate on their own, hence depending on cooperators for long-term survival. We have compared different population-level reproduction modes with and without individual selection (predation) to evaluate the different hypotheses. In a temporally homogeneous environment without propagule-based colonization, cheaters always win. Predation can benefit cooperators, but it is not enough to maintain the necessary cooperator amount in successive dispersals, either randomly or by fragmentation. Aggregation-based propagation however can ensure the adequate ratio of cooperators-to-cheaters in the propagule and is sufficient to do so even without predation. Spatiality combined with temporal heterogeneity helps cooperators via group selection, thus facilitating aggregative multicellularity. External stress selecting for larger size (e.g. predation) may facilitate aggregation, however, according to our results, it is neither necessary nor sufficient for aggregative multicellularity to be maintained when there is effective group-selection. Funding 2057702 /api/funding/2057702 false true true 2024 true true true false true false GOLD 2026-05-11 true https://doi.org/10.1371/journal.pcbi.1012107 1 0 1 1 0 1 1 1 0 1 1 1 1 1 0 0 1 1 1 1 0 11 11 D1 false false false false 2024-08-06T09:52:14.828+0000 Evolúciótudományi Intézet (HUN-REN ÖK); Növényrendszertani, Ökológiai és Elméleti Bioló... 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<span class="author-name" mtid="10018723"><a href="/gui2/?type=authors&mode=browse&sel=10018723" target="_blank">Zachar István ✉ (<span class="authorship-author-name">Zachar István</span> <span class="authorAux-mtmt"> Evolúcióbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Ökológiai Kutatóközpont">HUN-REN ÖK</span>/Evolúciótudományi Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Növényrendszertani, Ökológiai és Elméleti Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34843185" target="_blank">Group-selection via aggregative propagule-formation enables cooperative multicellularity in an individual based, spatial model</a></div> <div> <span class="journal-title">PLOS COMPUTATIONAL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1553-734X">1553-734X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1553-7358">1553-7358</a>)</span>: <span class="journal-volume">20</span> <span class="journal-issue">5</span> <span class="page"> Paper e1012107. 26 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pcbi.1012107" target="_blank" href="https://doi.org/10.1371/journal.pcbi.1012107"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001218610000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001218610000001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="225283" target="_blank" href="http://real.mtak.hu/225283"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85192986630" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85192986630"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38713735" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38713735&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://dx.plos.org/10.1371/journal.pcbi.1012107" target="_blank" href="https://dx.plos.org/10.1371/journal.pcbi.1012107"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computational Theory and Mathematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Modeling and Simulation&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34843185&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34843185</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> MTA Bolyai János Research Scholarship(BO/00570/22/8) </div> <div class="lastModified">Utolsó módosítás: 2025.09.26. 11:41 Ribai Richárdné (ÖK ÖBI admin 5) </div> <div class="lockedBy">Központi kezelésű 2025.05.21. 17:23 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Correspondence Address: Zachar, I.; Department of Plant Systematics Ecology and Theoretical Biology, Hungary; email: zachar.istvan@ecolres.hu</pre> </div></div>