@article{MTMT:36979352,
	title = {New 3-(6-Bromo-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic Acid Derivatives: Synthesis and Biological Activity Against Bacterial Pathogens},
	url = {https://m2.mtmt.hu/api/publication/36979352},
	author = {Bertašiūtė, Monika and Šiugždaitė, Jūratė and Grybaitė, Birutė and Sapijanskaitė-Banevič, Birutė and Tubytė, Livija and Lelešius, Raimundas and Belyakov, Sergey and Marksa, Mindaugas and Ževžikovas, Andrejus and Mickevičius, Vytautas},
	doi = {10.3390/app16042096},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {16},
	unique-id = {36979352},
	abstract = {Continuing our work in the field of synthesis and research of amino acids, their derivatives, and cyclization products, in this work, we synthesized various 3-(6-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid derivatives and investigated their antimicrobial activity. A total of eighteen synthesized chemical compounds (No. 1–18), including several structural analogues (e.g., 3a, 3b, 4a–4e, 8a–8m, 9a–9d), were evaluated for their antibacterial properties. The antibacterial activity was assessed using the Kirby–Bauer disk diffusion method, and inhibition zone diameters (mm) were measured against five representative bacterial strains: S. aureus, MRSA, B. subtilis, E. coli, and P. aeruginosa. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of the most active synthesized compounds were determined against representative Gram-positive and Gram-negative bacterial strains, including S. aureus, MRSA, B. subtilis, and E. coli. Overall, these results indicate that the tested compounds display selective antibacterial activity, mainly against Gram-positive bacteria, with compound 12 emerging as the most promising derivative in the series. The antibacterial activities of several synthesized compounds were systematically evaluated against S. aureus and MRSA over a 24 h incubation period, with optical density measured at ten time points. Bacterial growth was monitored spectrophotometrically at 600 nm (OD600) at 1, 2, 3, 4, 5, 6, 7, 8, 20, and 24 h, enabling a detailed assessment of growth kinetics and the temporal dynamics of inhibition. The effect of compound 11 on the growth kinetics of S. aureus was evaluated by quantifying viable bacterial counts (log10 CFU/mL) over a 6 h incubation period, and the results are presented in the time–kill curve. Compound 11 was selected for this experiment because it exhibited the most pronounced antibacterial activity against S. aureus in the disk diffusion assay. The cytotoxicity of compounds 9a, 11, 12, and 13 was evaluated at concentrations ranging from 125 to 1.95 µg/mL. The results showed a clear, concentration-dependent decrease in cytotoxicity for all tested compounds. The molecular structure of compound 3a was confirmed by a single-crystal X-ray diffraction.},
	year = {2026},
	eissn = {2076-3417},
	pages = {2096},
	orcid-numbers = {Šiugždaitė, Jūratė/0009-0004-7523-2698; Grybaitė, Birutė/0000-0003-0982-1342; Tubytė, Livija/0009-0009-2830-6072; Lelešius, Raimundas/0000-0001-5007-6853; Belyakov, Sergey/0000-0002-9078-3920; Mickevičius, Vytautas/0000-0002-9961-2941}
}

@article{MTMT:37397039,
	title = {Experimental and theoretical investigations of benzoxazole derivative: Synthesis, computational insights, and biological properties},
	url = {https://m2.mtmt.hu/api/publication/37397039},
	author = {Faydali, Nagihan and Arpaci, Ozlem Temiz and Al-Otaibi, Jamelha S. and Mary, Y. Sheena},
	doi = {10.1016/j.insi.2026.100513},
	journal-iso = {In Silico Research in Biomedicine},
	journal = {In Silico Research in Biomedicine},
	volume = {2},
	unique-id = {37397039},
	issn = {3050-7871},
	year = {2026},
	pages = {100513},
	orcid-numbers = {Al-Otaibi, Jamelha S./0009-0007-2304-1920}
}

@article{MTMT:37190452,
	title = {A comprehensive study of novel pregnenolone-isoxazole hybrids as selective inducers of mitochondrial apoptosis in breast cancer cells},
	url = {https://m2.mtmt.hu/api/publication/37190452},
	author = {Malakhova, Victoria and Scherbakov, Alexander and Salnikova, Diana and Khamidullina, Alvina and Sorokin, Danila and Vasilenko, Dmitry and Chernoburova, Elena and Averina, Elena and Zavarzin, Igor and Volkova, Yulia},
	doi = {10.1039/d6md00076b},
	journal-iso = {RSC MED CHEM},
	journal = {RSC MEDICINAL CHEMISTRY},
	volume = {17},
	unique-id = {37190452},
	year = {2026},
	eissn = {2632-8682},
	pages = {2963-2983}
}

@article{MTMT:36981014,
	title = {Mesyl chloride-mediated synthesis and in vitro anticancer evaluation of 2-carboxamide derivatives of estrone and estradiol},
	url = {https://m2.mtmt.hu/api/publication/36981014},
	author = {Novák, András and Molnár, Barnabás and Huliák, Ildikó and Árva, Hédi and Nagy, Eszter and Kele, Zoltán and Csontné Kiricsi, Mónika and Frank, Éva},
	doi = {10.1016/j.rechem.2026.103153},
	journal-iso = {RESULT CHEM},
	journal = {RESULTS IN CHEMISTRY},
	volume = {23},
	unique-id = {36981014},
	issn = {2211-7156},
	year = {2026},
	eissn = {2211-7156},
	orcid-numbers = {Kele, Zoltán/0000-0002-4401-0302; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Frank, Éva/0000-0002-1332-0551}
}

@article{MTMT:36241134,
	title = {Aromatic scaffold-integrated hybrids of estradiol and benzoxazol-2-ones: synthesis and in vitro anticancer activity of N-substituted regioisomeric pairs},
	url = {https://m2.mtmt.hu/api/publication/36241134},
	author = {Kovács, Ferenc and Huliák, Ildikó and Árva, Hédi and Kocsis, Marianna and Csontné Kiricsi, Mónika and Frank, Éva},
	doi = {10.1039/D5RA01977J},
	journal-iso = {RSC ADV},
	journal = {RSC ADVANCES},
	volume = {15},
	unique-id = {36241134},
	year = {2025},
	eissn = {2046-2069},
	pages = {23954-23965},
	orcid-numbers = {Csontné Kiricsi, Mónika/0000-0002-8416-2052; Frank, Éva/0000-0002-1332-0551}
}

@article{MTMT:35481472,
	title = {The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents},
	url = {https://m2.mtmt.hu/api/publication/35481472},
	author = {Di Martino, Simona and De Rosa, Maria},
	doi = {10.1007/s41061-024-00477-6},
	journal-iso = {TOP CURR CHEM (2016-)},
	journal = {TOPICS IN CURRENT CHEMISTRY},
	volume = {382},
	unique-id = {35481472},
	issn = {2365-0869},
	year = {2024},
	eissn = {2364-8961},
	orcid-numbers = {Di Martino, Simona/0000-0001-5817-751X; De Rosa, Maria/0000-0002-4087-2554}
}