https://m2.mtmt.hu/ hun 2026-07-21 09:41 true true 1 2 2 20 100 1 2 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 34470059 VALIDATED true College of Animal Science and Technology, JLAU-Borui Dairy Science and Technology R&D Center, Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, Jilin Agricultural University, Changchun, 130118, China Postdoctoral Scientific Research Workstation, Feed Engineering Technology Research Center of Jilin Province, Changchun Borui Science & Technology Co., Ltd, Changchun, 130118, China College of Life Science, Jilin Agricultural University, Changchun, 130118, China Export Date: 9 February 2024 CODEN: JHMAD Correspondence Address: Wang, T.; College of Animal Science and Technology, China; email: cagewang@163.com 0 false 2024-06-14T05:22:43.295+0000 2024-06-14T05:21:01.997+0000 2024-01-01T12:53:41.354+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2024-06-14T05:21:00.880+0000 2024-06-14T05:21:01.106+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dong, Jia-nan Impact of deoxynivalenol on rumen function, production, and health of dairy cows: Insights from metabolomics and microbiota analysis true true /api/journal/2535 REVIEWED true false 2535 false 2535 true 0304-3894 1873-3336 Journal FOREIGN 465 133376 133376 2024 true true 2024 true true true false false false NONE 2024-06-14 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 D1 A false false false false 2024-03-31T11:53:49.076+0000 4 28 0 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 113563360 /api/authorship/113563360 1 0.083333336 true false false Dong Jia-nan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563361 /api/authorship/113563361 2 0.083333336 false false false Zhao Zhi-kun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563362 /api/authorship/113563362 3 0.083333336 false false false Wang Zhan-qing true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563363 /api/authorship/113563363 4 0.083333336 false false false Li Song-ze true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563364 /api/authorship/113563364 5 0.083333336 false false false Zhang Yong-peng true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563365 /api/authorship/113563365 6 0.083333336 false false false Sun Zhe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563366 /api/authorship/113563366 7 0.083333336 false false false Qin Gui-xin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563367 /api/authorship/113563367 8 0.083333336 false false false Zhang Xue-feng true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563368 /api/authorship/113563368 9 0.083333336 false false false Zhao Wei true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563369 /api/authorship/113563369 10 0.083333336 false false false Aschalew Natnael Demelash true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563370 /api/authorship/113563370 11 0.083333336 false false false Wang Tao true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113563371 /api/authorship/113563371 12 0.083333336 false true false Zhen Yu-guo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25196680 /api/publicationidentifier/25196680 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.jhazmat.2023.133376 https://doi.org/10.1016/j.jhazmat.2023.133376 false true PublicationIdentifier 26619124 /api/publicationidentifier/26619124 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001165914300001 https://www.webofscience.com/wos/woscc/full-record/001165914300001 false true PublicationIdentifier 25449315 /api/publicationidentifier/25449315 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true SjrRating 11463273 /api/sjrrating/11463273 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2304 /api/classificationexternal/2304 true 2304 true D1 FROM_LAST_YEAR true true /api/publication/34470059 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dong Jia-nan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhao Zhi-kun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wang Zhan-qing </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li Song-ze </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Yong-peng </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sun Zhe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Qin Gui-xin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Xue-feng </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhao Wei </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aschalew Natnael Demelash </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wang Tao </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhen Yu-guo </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34470059" target="_blank">Impact of deoxynivalenol on rumen function, production, and health of dairy cows: Insights from metabolomics and microbiota analysis</a></div> <div> <span class="journal-title">JOURNAL OF HAZARDOUS MATERIALS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0304-3894">0304-3894</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3336">1873-3336</a>)</span>: <span class="journal-volume">465</span> <span class="page"> Paper 133376. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jhazmat.2023.133376" target="_blank" href="https://doi.org/10.1016/j.jhazmat.2023.133376"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001165914300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001165914300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85181586313" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85181586313"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://linkinghub.elsevier.com/retrieve/pii/S0304389423026602" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S0304389423026602"> Egyéb URL </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34470059&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34470059</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.06.14. 07:21 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: College of Animal Science and Technology, JLAU-Borui Dairy Science and Technology R&D Center, Key Laboratory of Animal Nutrition and Feed Science of Jilin Province, Key Laboratory of Animal Production Product Quality and Security Ministry of Education, Jilin Agricultural University, Changchun, 130118, China Postdoctoral Scientific Research Workstation, Feed Engineering T...</pre> </div></div> PublicationOther 34521339 VALIDATED true 0 false 2025-12-02T13:00:32.450+0000 2025-09-08T06:15:17.466+0000 2024-01-22T07:38:37.806+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2025-09-08T06:15:09.208+0000 2025-09-08T06:15:09.208+0000 2025-09-08T06:15:17.625+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther true 10000361 Publication in repository true 29 29 /api/publicationtype/29 PublicationType 15 true 29 PublicationOther /api/subtype/10000361 Csak repozitóriumban hozzáférhető közlemény SubType 1582 true 10000361 true 1 /api/category/1 Category true 1 Tamás, Bakos mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions 2024 Messenger RNA-containing lipid nanoparticles (mRNA-LNPs) enabled widespread COVID-19 vaccination with a small fraction of vaccine recipients displaying acute or sub-acute inflammatory symptoms. The molecular mechanism of these adverse events (AEs) remains undetermined. Here we report that the mRNA-LNP vaccine, Comirnaty, triggers low-level complement (C) activation and production of inflammatory cytokines, which may be key underlying processes of inflammatory AEs. In serum, Comirnaty and the control PEGylated liposome (Doxebo) caused different rises of C split products, C5a, sC5b-9, Bb and C4d, indicating stimulation of the classical pathway of C activation mainly by the liposomes, while a stronger stimulation of the alternative pathway was equal with the vaccine and the liposomes. Spikevax had similar C activation as Comirnaty, but viral or synthetic mRNAs had no such effect. In autologous serum-supplemented peripheral blood mononuclear cell (PBMC) cultures, Comirnaty caused increases in the levels of sC5b-9 and proinflammatory cytokines in the following order: IL-1α < IFN-γ < IL-1β < TNF-α < IL-6 < IL-8, whereas heatinactivation of serum prevented the rises of IL-1α, IL-1β, and TNF-α. Clinical C inhibitors, Soliris and Berinert, suppressed vaccine-induced C activation in serum but did not affect cytokine production when applied individually. These findings suggest that the PEGylated lipid coating of mRNA-LNP nanoparticles can trigger C activation mainly via the alternative pathway, which may be causally related to the induction of some, but not all inflammatory cytokines. While innate immune stimulation is essential for the vaccine’s efficacy, concurrent production of C- and PBMC-derived inflammatory mediators may contribute to some of the AEs. Pharmacological attenuation of harmful cytokine production using C inhibitors likely requires blocking the C cascade at multiple points. true true 2024 true false false true false NONE 2025-12-02 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 false 10027489 false false false 2024-02-08T07:50:11.051+0000 Nanomedicina Kutató és Oktató Központ (SE / AOK / I / TMI); Transzlációs Medicina Intézet (SE / AOK / I) 8 36 2 14 0 BioRxiv Now published in International Journal of Molecular Sciences doi: 10.3390/ijms25073595 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 114015248 /api/authorship/114015248 1 0.071428575 true false Author 10070223 /api/author/10070223 Bakos Tamás true true Tamás Bakos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015249 /api/authorship/114015249 2 0.071428575 false false Author 10064003 /api/author/10064003 Mészáros Tamás true 10064003 true Tamás Mészáros true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015250 /api/authorship/114015250 3 0.071428575 false false Author 10024742 /api/author/10024742 Kozma Gergely Tibor true 10024742 true Gergely Tibor Kozma true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015251 /api/authorship/114015251 4 0.071428575 false false Petra Berényi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015252 /api/authorship/114015252 5 0.071428575 false false Author 10083173 /api/author/10083173 Facskó Réka true true Réka Facskó true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015253 /api/authorship/114015253 6 0.071428575 false false Henriette Farkas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015254 /api/authorship/114015254 7 0.071428575 false false Author 10005165 /api/author/10005165 Dézsi László true 10005165 true László Dézsi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015255 /api/authorship/114015255 8 0.071428575 false false Carlo Heirman true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015256 /api/authorship/114015256 9 0.071428575 false false Stefaan de Koker true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015257 /api/authorship/114015257 10 0.071428575 false false Raymond Schiffelers true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015258 /api/authorship/114015258 11 0.071428575 false false Kathryn Anne Glatter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015259 /api/authorship/114015259 12 0.071428575 false false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Tamás Radovits true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015260 /api/authorship/114015260 13 0.071 false true Author 10027489 /api/author/10027489 Szénási Gábor true 10027489 true Gábor Szénási true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 114015261 /api/authorship/114015261 14 0.071 false true true Author 10003266 /api/author/10003266 Szebeni János true 10003266 true János Szebeni true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25449333 /api/publicationidentifier/25449333 PlainSource 10006 /api/publicationsource/10006 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Preprint DOI Preprint DOI https://doi.org/@@@ true true 10006 true IDENTICAL 10.1101/2024.01.12.575122 https://doi.org/10.1101/2024.01.12.575122 false true /api/publication/34521339 <div class="PublicationOther Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070223"><a href="/gui2/?type=authors&mode=browse&sel=10070223" target="_blank">Tamás Bakos (<span class="authorship-author-name">Bakos Tamás</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064003"><a href="/gui2/?type=authors&mode=browse&sel=10064003" target="_blank">Tamás Mészáros (<span class="authorship-author-name">Mészáros Tamás</span> <span class="authorAux-mtmt"> nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024742"><a href="/gui2/?type=authors&mode=browse&sel=10024742" target="_blank">Gergely Tibor Kozma (<span class="authorship-author-name">Kozma Gergely Tibor</span> <span class="authorAux-mtmt"> Immunológia, Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Petra Berényi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083173"><a href="/gui2/?type=authors&mode=browse&sel=10083173" target="_blank">Réka Facskó (<span class="authorship-author-name">Facskó Réka</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Henriette Farkas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005165"><a href="/gui2/?type=authors&mode=browse&sel=10005165" target="_blank">László Dézsi (<span class="authorship-author-name">Dézsi László</span> <span class="authorAux-mtmt"> Elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Carlo Heirman </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stefaan de Koker </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raymond Schiffelers </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kathryn Anne Glatter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Tamás Radovits (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027489"><a href="/gui2/?type=authors&mode=browse&sel=10027489" target="_blank">Gábor Szénási<sup>**</sup> (<span class="authorship-author-name">Szénási Gábor</span> <span class="authorAux-mtmt"> kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003266"><a href="/gui2/?type=authors&mode=browse&sel=10003266" target="_blank">János Szebeni ✉ (<span class="authorship-author-name">Szebeni János</span> <span class="authorAux-mtmt"> Klinikai orvostudomány, immunológia, nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34521339" target="_blank">mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions</a></div> <div class="description"> <div class="description0">BioRxiv</div> <div class="description1">Now published in International Journal of Molecular Sciences doi: 10.3390/ijms25073595</div> </div> <div class="country"> Megjelenés: <span class="publishedYear">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1101/2024.01.12.575122" target="_blank" href="https://doi.org/10.1101/2024.01.12.575122"> Preprint DOI </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34521339&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34521339</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Egyéb ( Csak repozitóriumban hozzáférhető közlemény ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.09.08. 08:15 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> </div></div>