@article{MTMT:35019374, title = {Evaluation of telomere length and telomerase activity on predicting in vitro fertilization treatment outcomes}, url = {https://m2.mtmt.hu/api/publication/35019374}, author = {Fragkiadaki, Persefoni and Kouvidi, Elisavet and Angelaki, Anna and Nikolopoulou, Dimitra and Vakonaki, Elena and Tsatsakis, Aristidis}, doi = {10.1007/s10815-024-03117-6}, journal-iso = {J ASSIST REPROD GEN}, journal = {JOURNAL OF ASSISTED REPRODUCTION AND GENETICS}, unique-id = {35019374}, issn = {1058-0468}, keywords = {infertility; In vitro fertilization; Telomere length; Assisted reproductive technology; Telomerase activity}, year = {2024}, eissn = {1573-7330}, orcid-numbers = {Tsatsakis, Aristidis/0000-0003-3824-2462} } @article{MTMT:35205302, title = {Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome}, url = {https://m2.mtmt.hu/api/publication/35205302}, author = {Pańczyszyn, A. and Boniewska-Bernacka, E. and Wertel, I. and Sadakierska-Chudy, A. and Goc, A.}, doi = {10.3390/ijms25168652}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {35205302}, issn = {1661-6596}, abstract = {The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes. © 2024 by the authors.}, keywords = {Female; review; human; randomized controlled trial; biological marker; fertility; fertility; sirtuin 1; sirtuin 1; telomere; genomic instability; Cell Aging; infertility therapy; In vitro fertilization; gamete; Telomeres; Oxidative stress; Oxidative stress}, year = {2024}, eissn = {1422-0067} } @article{MTMT:34567763, title = {The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy}, url = {https://m2.mtmt.hu/api/publication/34567763}, author = {Chen, Yu and Yang, Jiahao and Zhang, Ling}, doi = {10.3390/antiox12122117}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {12}, unique-id = {34567763}, abstract = {Oocyte quality is a pivotal determinant of assisted reproductive outcomes. The quality of oocytes is intricately linked to their developmental microenvironment, particularly the levels of oxidative stress within the follicular fluid. Oxidative stress levels in follicular fluid may have a substantial influence on oocyte health, thereby impacting the outcomes of ART procedures. This review meticulously explores the intricate relationship between oxidative stress in follicular fluid and ART outcomes. Furthermore, it delves into strategies aimed at ameliorating the oxidative stress status of follicular fluid, with the overarching goal of enhancing the overall efficacy of ART. This research endeavors to establish a robust foundation and provide valuable guidance for clinical treatment approaches, particularly in the context of infertile women, including those of advanced maternal age.}, keywords = {WOMEN; SUPPLEMENTATION; fertilization; follicular fluid; Oocyte quality; IN-VITRO MATURATION; Biochemistry & Molecular Biology; Chemistry, Medicinal; embryo quality; porcine oocyte; Oxidative stress; PLUS MELATONIN; RESVERATROL IMPROVES}, year = {2023}, eissn = {2076-3921} }