TY - JOUR AU - Bajaj, A. AU - Tsukamoto, T. TI - Evolution of D-amino acid oxidase inhibitors: From concept to clinic JF - ADVANCES IN PHARMACOLOGY J2 - ADV PHARMACOL PY - 2024 SN - 1054-3589 DO - 10.1016/bs.apha.2024.10.016 UR - https://m2.mtmt.hu/api/publication/35636255 ID - 35636255 LA - English DB - MTMT ER - TY - JOUR AU - Das, Kuladeep AU - Balaram, Hemalatha AU - Sanyal, Kaustuv TI - Amino Acid Chirality: Stereospecific Conversion and Physiological Implications JF - ACS OMEGA J2 - ACS OMEGA VL - 9 PY - 2024 IS - 5 SP - 5084 EP - 5099 PG - 16 SN - 2470-1343 DO - 10.1021/acsomega.3c08305 UR - https://m2.mtmt.hu/api/publication/34627085 ID - 34627085 N1 - Cited By :2 Export Date: 13 December 2024 Correspondence Address: Das, K.; Molecular Biology and Genetics Unit, Jakkur, India; email: kuladeep@jncasr.ac.in Correspondence Address: Balaram, H.; Molecular Biology and Genetics Unit, Jakkur, India; email: hb@jncasr.ac.in Correspondence Address: Sanyal, K.; Molecular Biology and Genetics Unit, Jakkur, India; email: sanyal@jncasr.ac.in LA - English DB - MTMT ER - TY - JOUR AU - Liu, Qi AU - Liu, Xuyi AU - Li, Yazhou AU - Zhou, Yu AU - Zhao, Linxiang AU - Liang, Xuewu AU - Liu, Hong TI - Construction of Diversified Penta-Spiro-Heterocyclic and Fused-Heterocyclic Frameworks with Potent Antitumor Activity JF - CHEMISTRY-A EUROPEAN JOURNAL J2 - CHEM-EUR J VL - 29 PY - 2023 IS - 54 PG - 7 SN - 0947-6539 DO - 10.1002/chem.202301553 UR - https://m2.mtmt.hu/api/publication/34311239 ID - 34311239 N1 - State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Liaoning, Shenyang, 110016, China Export Date: 6 February 2024 CODEN: CEUJE Correspondence Address: Liang, X.; State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, China; email: liangxuewu0714@simm.ac.cn Correspondence Address: Liu, H.; State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, China; email: hliu@simm.ac.cn AB - Multiple-spiro/fused-heterocyclic frameworks containing indazolone are structurally unique and represent a class of potentially dominant skeletons. In this work, we successfully fulfilled Rh(III)-catalyst mediated substrate- and pH- controlled strategies to construct four novel types of complicated penta-spiro/fused-heterocyclic frameworks via C-H activation/[4+1] and [4+2] annulation cascades. This method had mild reaction conditions, a broad scope of substrates, moderate to good yields, and valuable applications, which could realize for the first time the generation of the novel di-spiro-heterocyclic and multiple fused-heterocyclic products with unique structures. More importantly, novel spiro[cyclohexane-indazolo[1,2-a]indazole] scaffold constructed by this method exhibited potent antitumor activity against a variety of refractory solid tumors and hematological malignancies in vitro. Overall, our work provided new insights into the construction of complex and diverse multiple spiro/fused-heterocyclic systems and offered novel valuable lead compounds for the discovery of antitumor drugs. LA - English DB - MTMT ER - TY - JOUR AU - Chen, Shao‐Yong AU - Zheng, Yi‐Chuan AU - Liu, Xu‐Ge AU - Song, Jia‐Lin AU - Shu, Bing AU - Zheng, Tao AU - Xiao, Lin AU - Zhang, Shang‐Shi AU - Cao, Hua TI - Indazolones Directed Rh(III)‐Catalyzed C−H Amidation of Arenes JF - ADVANCED SYNTHESIS & CATALYSIS J2 - ADV SYNTH CATAL VL - 364 PY - 2022 IS - 18 SP - 3302 EP - 3309 PG - 8 SN - 1615-4150 DO - 10.1002/adsc.202200570 UR - https://m2.mtmt.hu/api/publication/33092116 ID - 33092116 N1 - School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan, 528458, China Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, China School of Pharmacy, Henan University, Henan, Kaifeng, 475004, China Cited By :3 Export Date: 6 February 2024 CODEN: ASCAF Correspondence Address: Cao, H.; School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, China; email: caohua@gdpu.edu.cn Correspondence Address: Zhang, S.-S.; Center for Drug Research and Development, China; email: zhangshangshi@gdpu.edu.cn Correspondence Address: Liu, X.-G.; School of Pharmacy, Henan, China; email: liuxg7@henu.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Lefin, R. AU - Petzer, A. AU - Cloete, S.J. AU - Petzer, J.P. TI - Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of D-amino acid oxidase JF - RESULTS IN CHEMISTRY J2 - RESULT CHEM VL - 4 PY - 2022 SN - 2211-7156 DO - 10.1016/j.rechem.2021.100278 UR - https://m2.mtmt.hu/api/publication/32688772 ID - 32688772 N1 - Export Date: 19 February 2022 Correspondence Address: Petzer, J.P.; Pharmaceutical Chemistry, South Africa; email: jacques.petzer@nwu.ac.za LA - English DB - MTMT ER - TY - JOUR AU - Medvedev, A. AU - Buneeva, O. TI - Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 16 PY - 2022 SN - 1662-5153 DO - 10.3389/fnbeh.2022.922274 UR - https://m2.mtmt.hu/api/publication/33032577 ID - 33032577 N1 - Export Date: 29 July 2022 Correspondence Address: Medvedev, A.; Laboratory of Pharmacoproteomics, Russian Federation; email: professor57@yandex.ru Funding details: 122030100170-5, 2021-2030 Funding text 1: The work performed within the framework of the Program for Basic Research in the Russian Federation for a long-term period (2021-2030) (No. 122030100170-5). AB - Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the indole nucleus. Although these stages require concerted action of bacterial and host enzymes, there are two pathways of isatin formation: the host and bacterial pathways. Isatin acts as a neuroprotector in different experimental models of neurodegeneration. Its effects are realized via up- and downregulation of isatin-responsive genes and via interaction with numerous isatin-binding proteins identified in the brain. The effect of isatin on protein-protein interactions in the brain may be important for realization of weak inhibition of multiple receptor targets. Copyright © 2022 Medvedev and Buneeva. LA - English DB - MTMT ER - TY - JOUR AU - Pippione, A.C. AU - Sainas, S. AU - Boschi, D. AU - Lolli, M.L. TI - Hydroxyazoles as acid isosteres and their drug design applications—Part 2: Bicyclic systems JF - ADVANCES IN HETEROCYCLIC CHEMISTRY J2 - ADV HETEROCYCL CHEM VL - 134 PY - 2021 SP - 273 EP - 311 PG - 39 SN - 0065-2725 DO - 10.1016/bs.aihch.2020.12.002 UR - https://m2.mtmt.hu/api/publication/31917464 ID - 31917464 AB - Hydroxyazoles are acidic systems that are considered isosteres of the carboxylic acid group; because of their efficacy in exploring chemical space, they are considered an efficient bioisosteric tool for designing optimized compounds with added IP value. Recently, we and other groups applied such systems in the framework of hit-to-lead optimization processes. Having already covered in this volume (Sainas et al., 2020) the chemo-physical properties, synthetic methodologies and drug design application of monocyclic hydro-xyazoles, in this chapter we complete the scenario focusing on the parent bicyclic hydroxyazole systems. © 2021 Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - Grishin, D. V. AU - Zhdanov, D. D. AU - Pokrovskaya, M. V. AU - Sokolov, N. N. TI - D-amino acids in nature, agriculture and biomedicine JF - FRONTIERS IN LIFE SCIENCE J2 - FRONT LIFE SCI VL - 13 PY - 2020 IS - 1 SP - 11 EP - 22 PG - 12 SN - 2155-3769 DO - 10.1080/21553769.2019.1622596 UR - https://m2.mtmt.hu/api/publication/31125935 ID - 31125935 N1 - Institute of Biomedical Chemistry, Moscow, Russian Federation Peoples Friendship University of Russia, Moscow, Russian Federation Cited By :2 Export Date: 22 July 2020 Correspondence Address: Grishin, D.V.; Institute of Biomedical ChemistryRussian Federation; email: molbiol_ibm@inbox.ru LA - English DB - MTMT ER - TY - JOUR AU - Wolosker, H. AU - Balu, D.T. TI - d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 10 PY - 2020 IS - 1 SN - 2158-3188 DO - 10.1038/s41398-020-00870-x UR - https://m2.mtmt.hu/api/publication/31386329 ID - 31386329 N1 - Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 31096, Israel Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States Translational Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, United States Export Date: 22 July 2020 Correspondence Address: Balu, D.T.; Department of Psychiatry, Harvard Medical SchoolUnited States; email: dbalu@mclean.harvard.edu LA - English DB - MTMT ER - TY - JOUR AU - Liao, Bohong AU - Peng, Lingrong AU - Zhou, Jin AU - Mo, Huiting AU - Zhao, Jialan AU - Yang, Zike AU - Guo, Xiaowen AU - Zhang, Peiquan AU - Zhang, Xin AU - Zhu, Zhibo TI - Synthesis and Activity Evaluation of Nasopharyngeal Carcinoma Inhibitors Based on 6‐(Pyrimidin‐4‐yl)‐1 H ‐indazole JF - CHEMISTRY & BIODIVERSITY J2 - CHEM BIODIVERS VL - 16 PY - 2019 IS - 5 SN - 1612-1872 DO - 10.1002/cbdv.201800598 UR - https://m2.mtmt.hu/api/publication/30644667 ID - 30644667 N1 - Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13# Shiliugang Road, Haizhu District, Guangzhou, 510315, China Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China Cited By :3 Export Date: 19 February 2022 CODEN: CBHIA Correspondence Address: Zhu, Z.; Integrated Hospital of Traditional Chinese Medicine, 13# Shiliugang Road, Haizhu District, China; email: zhuzb676@smu.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Szilágyi, Bence AU - Ferenczy, György AU - Keserű, György Miklós TI - Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies JF - EXPERT OPINION ON DRUG DISCOVERY J2 - EXPERT OPIN DRUG DIS VL - 13 ET - 0 PY - 2018 IS - 10 SP - 973 EP - 982 PG - 10 SN - 1746-0441 DO - 10.1080/17460441.2018.1524459 UR - https://m2.mtmt.hu/api/publication/30353690 ID - 30353690 N1 - Export Date: 3 January 2019 Correspondence Address: Keserű, G.M.; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: keseru.gyorgy@ttk.mta.hu Funding details: KTIA NAP_13-2014-0009 Funding text 1: This work was supported by the National Brain Research Program [grant number KTIA NAP_13-2014-0009]. Cited By :4 Export Date: 22 July 2020 Correspondence Address: Keserű, G.M.; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: keseru.gyorgy@ttk.mta.hu AB - Introduction: D-amino-acid oxidase (DAAO) degrades D-serine, a co-agonist of the NMDA receptor whose dysfunction is involved in the positive, negative, and cognitive symptoms of schizophrenia. The inhibition of DAAO appears to be a viable strategy to increase D-serine level and to have therapeutic potential in schizophrenia. Areas covered: This review describes the efforts to develop DAAO inhibitors and to optimize their in vitro and in vivo effects in preclinical settings. The structural evolution of DAAO inhibitors is presented from simple carboxylic acid derivatives via small, planar compounds with carboxylic acid mimetics to extended compounds whose binding is possible owing to DAAO flexibility. Inhibitory potency and pharmacokinetic properties are discussed in the context of compounds’ ability to increase D-serine level and to show efficacy in animal models of schizophrenia. Expert opinion: The accumulated knowledge on the structural requirements of DAAO inhibitors and on their in vitro and in vivo effects provides appropriate basis to develop inhibitors with optimized potency, selectivity and pharmacokinetic profile including blood-brain penetration. In addition, the validation of DAAO inhibition therapy in alleviating the symptoms of schizophrenia requires further studies on the efficacy of DAAO inhibitors in behavioral assays of animals and on the species differences in D-serine metabolism. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. LA - English DB - MTMT ER -