@article{MTMT:35636255,
	title = {Evolution of D-amino acid oxidase inhibitors: From concept to clinic},
	url = {https://m2.mtmt.hu/api/publication/35636255},
	author = {Bajaj, A. and Tsukamoto, T.},
	doi = {10.1016/bs.apha.2024.10.016},
	journal-iso = {ADV PHARMACOL},
	journal = {ADVANCES IN PHARMACOLOGY},
	unique-id = {35636255},
	issn = {1054-3589},
	year = {2024}
}

@article{MTMT:34627085,
	title = {Amino Acid Chirality: Stereospecific Conversion and Physiological Implications},
	url = {https://m2.mtmt.hu/api/publication/34627085},
	author = {Das, Kuladeep and Balaram, Hemalatha and Sanyal, Kaustuv},
	doi = {10.1021/acsomega.3c08305},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {9},
	unique-id = {34627085},
	issn = {2470-1343},
	year = {2024},
	eissn = {2470-1343},
	pages = {5084-5099},
	orcid-numbers = {Sanyal, Kaustuv/0000-0002-6611-4073}
}

@article{MTMT:34311239,
	title = {Construction of Diversified Penta-Spiro-Heterocyclic and Fused-Heterocyclic Frameworks with Potent Antitumor Activity},
	url = {https://m2.mtmt.hu/api/publication/34311239},
	author = {Liu, Qi and Liu, Xuyi and Li, Yazhou and Zhou, Yu and Zhao, Linxiang and Liang, Xuewu and Liu, Hong},
	doi = {10.1002/chem.202301553},
	journal-iso = {CHEM-EUR J},
	journal = {CHEMISTRY-A EUROPEAN JOURNAL},
	volume = {29},
	unique-id = {34311239},
	issn = {0947-6539},
	abstract = {Multiple-spiro/fused-heterocyclic frameworks containing indazolone are structurally unique and represent a class of potentially dominant skeletons. In this work, we successfully fulfilled Rh(III)-catalyst mediated substrate- and pH- controlled strategies to construct four novel types of complicated penta-spiro/fused-heterocyclic frameworks via C-H activation/[4+1] and [4+2] annulation cascades. This method had mild reaction conditions, a broad scope of substrates, moderate to good yields, and valuable applications, which could realize for the first time the generation of the novel di-spiro-heterocyclic and multiple fused-heterocyclic products with unique structures. More importantly, novel spiro[cyclohexane-indazolo[1,2-a]indazole] scaffold constructed by this method exhibited potent antitumor activity against a variety of refractory solid tumors and hematological malignancies in vitro. Overall, our work provided new insights into the construction of complex and diverse multiple spiro/fused-heterocyclic systems and offered novel valuable lead compounds for the discovery of antitumor drugs.},
	keywords = {C‐H activation; antitumor; Spiro; fused-heterocyclic frameworks; substrate- and pH- controlled strategies; [4+1] and [4+2] annulation; indazolone},
	year = {2023},
	eissn = {1521-3765}
}

@article{MTMT:33092116,
	title = {Indazolones Directed Rh(III)‐Catalyzed C−H Amidation of Arenes},
	url = {https://m2.mtmt.hu/api/publication/33092116},
	author = {Chen, Shao‐Yong and Zheng, Yi‐Chuan and Liu, Xu‐Ge and Song, Jia‐Lin and Shu, Bing and Zheng, Tao and Xiao, Lin and Zhang, Shang‐Shi and Cao, Hua},
	doi = {10.1002/adsc.202200570},
	journal-iso = {ADV SYNTH CATAL},
	journal = {ADVANCED SYNTHESIS & CATALYSIS},
	volume = {364},
	unique-id = {33092116},
	issn = {1615-4150},
	year = {2022},
	eissn = {1615-4169},
	pages = {3302-3309},
	orcid-numbers = {Zhang, Shang‐Shi/0000-0002-9247-1373}
}

@article{MTMT:32688772,
	title = {Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of D-amino acid oxidase},
	url = {https://m2.mtmt.hu/api/publication/32688772},
	author = {Lefin, R. and Petzer, A. and Cloete, S.J. and Petzer, J.P.},
	doi = {10.1016/j.rechem.2021.100278},
	journal-iso = {RESULT CHEM},
	journal = {RESULTS IN CHEMISTRY},
	volume = {4},
	unique-id = {32688772},
	issn = {2211-7156},
	year = {2022},
	eissn = {2211-7156}
}

@article{MTMT:33032577,
	title = {Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin},
	url = {https://m2.mtmt.hu/api/publication/33032577},
	author = {Medvedev, A. and Buneeva, O.},
	doi = {10.3389/fnbeh.2022.922274},
	journal-iso = {FRONT BEHAV NEUROSCI},
	journal = {FRONTIERS IN BEHAVIORAL NEUROSCIENCE},
	volume = {16},
	unique-id = {33032577},
	issn = {1662-5153},
	abstract = {Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the indole nucleus. Although these stages require concerted action of bacterial and host enzymes, there are two pathways of isatin formation: the host and bacterial pathways. Isatin acts as a neuroprotector in different experimental models of neurodegeneration. Its effects are realized via up- and downregulation of isatin-responsive genes and via interaction with numerous isatin-binding proteins identified in the brain. The effect of isatin on protein-protein interactions in the brain may be important for realization of weak inhibition of multiple receptor targets. Copyright © 2022 Medvedev and Buneeva.},
	keywords = {Brain; protein–protein interactions; Molecular targets; interactome; tryptophan metabolites; gut-brain axis; isatin; isatin-binding proteins},
	year = {2022},
	eissn = {1662-5153}
}

@article{MTMT:31917464,
	title = {Hydroxyazoles as acid isosteres and their drug design applications—Part 2: Bicyclic systems},
	url = {https://m2.mtmt.hu/api/publication/31917464},
	author = {Pippione, A.C. and Sainas, S. and Boschi, D. and Lolli, M.L.},
	doi = {10.1016/bs.aihch.2020.12.002},
	journal-iso = {ADV HETEROCYCL CHEM},
	journal = {ADVANCES IN HETEROCYCLIC CHEMISTRY},
	volume = {134},
	unique-id = {31917464},
	issn = {0065-2725},
	abstract = {Hydroxyazoles are acidic systems that are considered isosteres of the carboxylic acid group; because of their efficacy in exploring chemical space, they are considered an efficient bioisosteric tool for designing optimized compounds with added IP value. Recently, we and other groups applied such systems in the framework of hit-to-lead optimization processes. Having already covered in this volume (Sainas et al., 2020) the chemo-physical properties, synthetic methodologies and drug design application of monocyclic hydro-xyazoles, in this chapter we complete the scenario focusing on the parent bicyclic hydroxyazole systems. © 2021 Elsevier Inc.},
	keywords = {DRUG DESIGN; phenol; Scaffold hopping; Carboxylic group; bioisosterism; bioisosteres; isosterism; Fused systems; Hydroxyazoles},
	year = {2021},
	eissn = {1557-8429},
	pages = {273-311}
}

@article{MTMT:31125935,
	title = {D-amino acids in nature, agriculture and biomedicine},
	url = {https://m2.mtmt.hu/api/publication/31125935},
	author = {Grishin, D. V. and Zhdanov, D. D. and Pokrovskaya, M. V. and Sokolov, N. N.},
	doi = {10.1080/21553769.2019.1622596},
	journal-iso = {FRONT LIFE SCI},
	journal = {FRONTIERS IN LIFE SCIENCE},
	volume = {13},
	unique-id = {31125935},
	issn = {2155-3769},
	year = {2020},
	eissn = {2155-3777},
	pages = {11-22},
	orcid-numbers = {Grishin, D. V./0000-0002-0756-1869}
}

@article{MTMT:31386329,
	title = {d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders},
	url = {https://m2.mtmt.hu/api/publication/31386329},
	author = {Wolosker, H. and Balu, D.T.},
	doi = {10.1038/s41398-020-00870-x},
	journal-iso = {TRANSL PSYCHIAT},
	journal = {TRANSLATIONAL PSYCHIATRY},
	volume = {10},
	unique-id = {31386329},
	issn = {2158-3188},
	year = {2020},
	eissn = {2158-3188}
}

@article{MTMT:30644667,
	title = {Synthesis and Activity Evaluation of Nasopharyngeal Carcinoma Inhibitors Based on 6‐(Pyrimidin‐4‐yl)‐1 H ‐indazole},
	url = {https://m2.mtmt.hu/api/publication/30644667},
	author = {Liao, Bohong and Peng, Lingrong and Zhou, Jin and Mo, Huiting and Zhao, Jialan and Yang, Zike and Guo, Xiaowen and Zhang, Peiquan and Zhang, Xin and Zhu, Zhibo},
	doi = {10.1002/cbdv.201800598},
	journal-iso = {CHEM BIODIVERS},
	journal = {CHEMISTRY & BIODIVERSITY},
	volume = {16},
	unique-id = {30644667},
	issn = {1612-1872},
	year = {2019},
	eissn = {1612-1880}
}

@article{MTMT:30353690,
	title = {Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies},
	url = {https://m2.mtmt.hu/api/publication/30353690},
	author = {Szilágyi, Bence and Ferenczy, György and Keserű, György Miklós},
	doi = {10.1080/17460441.2018.1524459},
	journal-iso = {EXPERT OPIN DRUG DIS},
	journal = {EXPERT OPINION ON DRUG DISCOVERY},
	volume = {13},
	unique-id = {30353690},
	issn = {1746-0441},
	abstract = {Introduction: D-amino-acid oxidase (DAAO) degrades D-serine, a co-agonist of the NMDA receptor whose dysfunction is involved in the positive, negative, and cognitive symptoms of schizophrenia. The inhibition of DAAO appears to be a viable strategy to increase D-serine level and to have therapeutic potential in schizophrenia. Areas covered: This review describes the efforts to develop DAAO inhibitors and to optimize their in vitro and in vivo effects in preclinical settings. The structural evolution of DAAO inhibitors is presented from simple carboxylic acid derivatives via small, planar compounds with carboxylic acid mimetics to extended compounds whose binding is possible owing to DAAO flexibility. Inhibitory potency and pharmacokinetic properties are discussed in the context of compounds’ ability to increase D-serine level and to show efficacy in animal models of schizophrenia. Expert opinion: The accumulated knowledge on the structural requirements of DAAO inhibitors and on their in vitro and in vivo effects provides appropriate basis to develop inhibitors with optimized potency, selectivity and pharmacokinetic profile including blood-brain penetration. In addition, the validation of DAAO inhibition therapy in alleviating the symptoms of schizophrenia requires further studies on the efficacy of DAAO inhibitors in behavioral assays of animals and on the species differences in D-serine metabolism. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.},
	keywords = {SCHIZOPHRENIA; D-SERINE; D-amino-acid oxidase},
	year = {2018},
	eissn = {1746-045X},
	pages = {973-982},
	orcid-numbers = {Ferenczy, György/0000-0002-5771-4616}
}