@article{MTMT:37105328,
	title = {Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model},
	url = {https://m2.mtmt.hu/api/publication/37105328},
	author = {Helwa‐Shalom, Omer and Nevo, Hani and Nasrawy, Tarek and Galiner, Masha and Yusef, Azraq and Ben‐David, Keren and Markowitz, Shany Ivon and Gellman, Yechiel N. and Beyth, Shaul and Sacks, Hagit and Blumenfeld, Anat and Haze, Amir},
	doi = {10.1002/jor.70190},
	journal-iso = {J ORTHOP RES},
	journal = {JOURNAL OF ORTHOPAEDIC RESEARCH},
	volume = {44},
	unique-id = {37105328},
	issn = {0736-0266},
	abstract = {Osteochondral injuries are common, painful, and lack natural healing abilities. Previous studies demonstrated that recombinant human amelogenin promotes osteochondral repair in rat knee injuries, including improved defect filling and formation of hyaline cartilage. Here, we aimed to evaluate the efficacy and safety of Remelix®, a novel recombinant human amelogenin–based product, in a large animal goat model. Acute osteochondral injuries were created in the weight‐bearing region of the medial femoral condyle in thirteen goats. Seven goats received Remelix® at a protein concentration of 0.5 mg/mL, with the contralateral knee applied with PX 407 carrier alone. An additional six goats received Remelix® at 0.25 mg/mL, while contralateral knees were treated with normal saline. Potential adverse effects, along with evaluation of osteochondral healing were assessed. Healing was assessed 24 weeks post‐treatment using magnetic resonance imaging (MRI), macroscopic evaluation, and histological and immunohistochemical analyses. No adverse effects were observed. Both Remelix® concentrations resulted in substantial healing of cartilage and subchondral bone. Histological analyses demonstrated improved tidemark formation, predominantly hyaline cartilage filling in the deeper layers of the defect with extension toward the superficial zone, and reduced subchondral bone abnormalities. MRI and macroscopic evaluations revealed a continuous repair surface with good integration at the defect margins. In contrast, PX 407 and saline‐treated control knees exhibited inferior repair, characterized by mainly fibrous cartilage, heterogeneous MRI signal intensity, and lower histological scores. Overall, Remelix® substantially improved osteochondral healing in a goat model without observable adverse effects, supporting its potential for further evaluation in human clinical studies.},
	year = {2026},
	eissn = {1554-527X},
	orcid-numbers = {Helwa‐Shalom, Omer/0000-0003-1538-0379; Nevo, Hani/0000-0002-8311-1341; Nasrawy, Tarek/0000-0002-7467-5305; Galiner, Masha/0000-0002-3103-0793; Yusef, Azraq/0000-0002-2239-8203; Ben‐David, Keren/0009-0007-8712-7387; Markowitz, Shany Ivon/0000-0003-3478-3843; Gellman, Yechiel N./0000-0003-4913-8812; Beyth, Shaul/0000-0002-1781-2916; Sacks, Hagit/0009-0008-5746-1488; Blumenfeld, Anat/0000-0002-1613-050X; Haze, Amir/0000-0002-7629-3431}
}

@article{MTMT:36792937,
	title = {Outcomes After Initial Non-Operative Treatment of Osteochondral Lesions of the Talus (OLT) in Skeletally Immature Patients: A Cross-Sectional Study},
	url = {https://m2.mtmt.hu/api/publication/36792937},
	author = {Steman, Jason A. H. and Buck, Tristan M. F. and Dahmen, Jari and Struijs, Peter A. A. and Stufkens, Sjoerd A. S. and Kerkhoffs, Gino M. M. J.},
	doi = {10.1177/19476035251357214},
	journal-iso = {CARTILAGE},
	journal = {CARTILAGE},
	unique-id = {36792937},
	issn = {1947-6035},
	keywords = {Cartilage; Ankle; osteochondral lesions of the talus; Non-operative; skeletally immature},
	year = {2025},
	eissn = {1947-6043}
}

@article{MTMT:34364573,
	title = {Epidemiology and Trends in Cartilage Surgery of the Foot and Ankle in Germany: An Analysis of National Healthcare Billing and Reporting Data from 2006 to 2020},
	url = {https://m2.mtmt.hu/api/publication/34364573},
	author = {Eidmann, Annette and Heinz, Tizian and Oberfeld, Jan and Weissenberger, Manuel and Rudert, Maximilian and Stratos, Ioannis},
	doi = {10.3390/medicina59071256},
	journal-iso = {MED LITH},
	journal = {MEDICINA-LITHUANIA},
	volume = {59},
	unique-id = {34364573},
	issn = {1010-660X},
	abstract = {Background and objectives: Cartilage surgery constitutes a standard intervention in foot and ankle procedures. Currently, there is a lack of epidemiological data on its frequency, age distribution, and surgical options for cartilage surgery. This study aimed to investigate the current landscape of cartilage surgery in Germany and identify the most common procedures from an epidemiological standpoint. Materials and methods: Medical billing and reporting data from the Federal Statistical Office of Germany, encompassing the period 2006-2020, was examined, including all foot and ankle cartilage surgical procedures (summarized under OPS codes 5-812 and 5-801). The dataset incorporated information on the affected joint, patient age and sex, and surgery type. Each surgical procedure was categorized as "debridement", "regeneration" or "refixation". Linear and nonlinear regression analyses were employed, with a statistical significance threshold of 0.05. Results: From the total of 136,501 procedures conducted during the study period, the most frequently performed interventions were microfracture (58,252) and chondroplasty (56,135), and thus, debridement procedures were in the leading position. The use of acellular membranes was the most used regenerative technique (n = 11,414). At the ankle joint, interventions were mostly arthroscopic and in men, while foot cartilage surgeries were preferably performed via open surgery and mostly in women. Age distribution analysis revealed two primary peaks: the first in the 20-25-year-old group (ankle and foot) and the second in the 45-50-year-old group (ankle) and 55-60-year-old group (foot). Refixation and regenerative procedures were more frequent among younger individuals, while debriding procedures were more frequent among older individuals. Regenerative procedures, particularly in the ankle, significantly increased over time. Conclusions: Cartilage surgery of the foot and ankle was common, with two primary age groups predominantly affected. Notably, recent years have witnessed a considerable rise in cartilage regenerative procedures.},
	keywords = {Age Distribution; regenerative therapies; Epidemiological analysis; cartilage surgery; foot and ankle procedures},
	year = {2023},
	eissn = {1648-9144},
	orcid-numbers = {Weissenberger, Manuel/0000-0003-3551-3204; Rudert, Maximilian/0000-0003-4982-6594; Stratos, Ioannis/0000-0001-5522-0092}
}

@article{MTMT:35423366,
	title = {Physician preferences in diagnostics and treatment of juvenile osteochondritis dissecans are diverse across the knee, ankle and elbow: an ESSKA survey},
	url = {https://m2.mtmt.hu/api/publication/35423366},
	author = {Kemmeren, LAM and van, Bergen CJA and Reijman, M and Piscaer, TM},
	doi = {10.1007/s00167-023-07563-0},
	journal-iso = {KNEE SURG SPORT TR A},
	journal = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
	volume = {31},
	unique-id = {35423366},
	issn = {0942-2056},
	year = {2023},
	eissn = {1433-7347},
	pages = {5228-5237}
}