@article{MTMT:34560236, title = {Epidemiology of Traumatic Brain Injury in Abu-Dhabi, UAE}, url = {https://m2.mtmt.hu/api/publication/34560236}, author = {Alqaydi, K. and Ghazanfar, O. and Madhi, A. and Avila, N. and Fares, S.}, doi = {10.2174/0250688205666230906092948}, journal-iso = {EMIRATES MED J}, journal = {EMIRATES MEDICAL JOURNAL}, volume = {5}, unique-id = {34560236}, issn = {0250-6882}, year = {2024} } @article{MTMT:34307884, title = {Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke}, url = {https://m2.mtmt.hu/api/publication/34307884}, author = {Au, Ngan Pan Bennett and Wu, Tan and Kumar, Gajendra and Jin, Yuting and Li, Yolanda Yuen Tung and Chan, Shun Lam and Lai, Joseph Ho Chi and Chan, Kannie Wai Yan and Yu, Kwan Ngok and Wang, Xin and Ma, Chi Him Eddie}, doi = {10.1016/j.bbi.2023.09.015}, journal-iso = {BRAIN BEHAV IMMUN}, journal = {BRAIN BEHAVIOR AND IMMUNITY}, volume = {115}, unique-id = {34307884}, issn = {0889-1591}, abstract = {Traumatic brain injury (TBI) and stroke share a common pathophysiology that worsens over time due to sec-ondary tissue injury caused by sustained inflammatory response. However, studies on pharmacological in-terventions targeting the complex secondary injury cascade have failed to show efficacy. Here, we demonstrated that low-dose ionizing radiation (LDIR) reduced lesion size and reversed motor deficits after TBI and photo -thrombotic stroke. Magnetic resonance imaging demonstrated significant reduction of infarct volume in LDIR-treated mice after stroke. Systems-level transcriptomic analysis showed that genes upregulated in LDIR-treated stoke mice were enriched in pathways associated with inflammatory and immune response involving micro-glia. LDIR induced upregulation of anti-inflammatory-and phagocytosis-related genes, and downregulation of key pro-inflammatory cytokine production. These findings were validated by live-cell assays, in which microglia exhibited higher chemotactic and phagocytic capacities after LDIR. We observed substantial microglial clustering at the injury site, glial scar clearance and reversal of motor deficits after stroke. Cortical microglia/macrophages depletion completely abolished the beneficial effect of LDIR on motor function recovery in stroke mice. LDIR promoted axonal projections (brain rewiring) in motor cortex and recovery of brain activity detected by elec-troencephalography recordings months after stroke. LDIR treatment delayed by 8 h post-injury still maintained full therapeutic effects on motor recovery, indicating that LDIR is a promising therapeutic strategy for TBI and stroke.}, keywords = {traumatic brain injury; low-dose ionizing radiation; photothrombotic stroke; Microglia polarization}, year = {2024}, eissn = {1090-2139}, pages = {43-63}, orcid-numbers = {Au, Ngan Pan Bennett/0000-0003-0245-9096} } @article{MTMT:34555885, title = {Clinical outcomes for various benign paroxysmal positional vertigo (BPPV) diagnoses in adolescents and young adults with recent concussions}, url = {https://m2.mtmt.hu/api/publication/34555885}, author = {Bowman, Thomas G. and Thibault, Rachel and Radack, Benjamin M. and Davis, Anissa and Elam, Penelope}, doi = {10.1016/j.ptsp.2023.12.004}, journal-iso = {PHYS THER SPORT}, journal = {PHYSICAL THERAPY IN SPORT}, volume = {65}, unique-id = {34555885}, issn = {1466-853X}, abstract = {Objective: Determine how positive BPPV findings in adolescents and young adults following concussion impacted the total number of treatments required and time until discharge. Setting: Outpatient physical therapy clinic.Participants: 167 individuals who were diagnosed with concussion or brain injury.Design: Retrospective chart review. Main measures: Total number of treatments and days until discharge were compared for various BPPV diagnoses (anterior canal, posterior canal, horizontal canal, and combination) and for individuals with and without BPPV.Results: Fifty-one out of 167 cases (30.54%) were diagnosed with BPPV. The total number of treatments provided was statistically different across BPPV diagnoses (P = .004). However, days until discharge were not statistically different between BPPV diagnoses (P = .28). There was no significant difference between time to discharge between those with BPPV (median = 21 days, range = 7-126) and those without (median = 28 days, range = 7-84 days; P = .23, r = 0.09).Conclusion: To optimize outcomes, including symptom resolution and return to sport and/or work, early identification of BPPV and subsequent intervention should be prioritized for individuals who have concussion symptoms that suggest vestibular dysfunction.}, keywords = {Therapy; rehabilitation; rehabilitation; vestibular dysfunction; concussion; BPPV}, year = {2024}, pages = {90-94} } @article{MTMT:34560215, title = {Traumatic brain injury is common and undertreated in the orthopaedic trauma population}, url = {https://m2.mtmt.hu/api/publication/34560215}, author = {Boyapati, R.M. and Nehrbas, J. and Yarboro, S.R. and Hadeed, M.M.}, doi = {10.1016/j.injury.2024.111325}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {55}, unique-id = {34560215}, issn = {0020-1383}, year = {2024}, eissn = {1879-0267} } @article{MTMT:34560209, title = {The value of computed tomography angiography in predicting the surgical effect and prognosis of severe traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34560209}, author = {Chen, J. and Zhao, W. and Zhu, X. and Yang, L. and Geng, C. and Zhang, X. and Wang, Y.}, doi = {10.1038/s41598-024-52385-w}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34560209}, issn = {2045-2322}, year = {2024}, eissn = {2045-2322} } @article{MTMT:34560222, title = {The neuroprotection of controlled decompression after traumatic epidural intracranial hypertension through suppression of autophagy via PI3K/Akt signaling pathway}, url = {https://m2.mtmt.hu/api/publication/34560222}, author = {Che, Y. and Wu, W. and Qian, X. and Sheng, Z. and Zhang, W. and Zheng, J. and Chen, J. and Wang, Y.}, doi = {10.1016/j.heliyon.2023.e23753}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34560222}, year = {2024}, eissn = {2405-8440} } @article{MTMT:34560219, title = {Inflammation, brain connectivity, and neuromodulation in post-traumatic headache}, url = {https://m2.mtmt.hu/api/publication/34560219}, author = {da, Silva Fiorin F. and do, Espírito Santo C.C. and Da, Silva J.T. and Chung, M.-K.}, doi = {10.1016/j.bbih.2024.100723}, journal-iso = {BRAIN BEHAVIOR IMMUNITY - HEALTH}, journal = {BRAIN BEHAVIOR IMMUNITY - HEALTH}, volume = {35}, unique-id = {34560219}, year = {2024}, eissn = {2666-3546} } @article{MTMT:34559958, title = {Long-Term Follow-Up of Critically Ill Patients With Traumatic Brain Injury: From Intensive Care Parameters to Patient and Caregiver-Reported Outcome}, url = {https://m2.mtmt.hu/api/publication/34559958}, author = {Domensino, A.-F. and Tas, J. and Donners, B. and Kooyman, J. and van, der Horst I.C.C. and Haeren, R. and Ariës, M.J.H. and van, Heugten C.}, doi = {10.1089/neu.2022.0474}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {41}, unique-id = {34559958}, issn = {0897-7151}, year = {2024}, eissn = {1557-9042}, pages = {123-134} } @article{MTMT:34560218, title = {Pituitary dysfunction following mild traumatic brain injury in female athletes}, url = {https://m2.mtmt.hu/api/publication/34560218}, author = {Eggertsdóttir, Claessen L.Ó. and Kristjánsdóttir, H. and Jónsdóttir, M.K. and Lund, S.H. and Kristensen, I.U. and Sigurjónsdóttir, H.Á.}, doi = {10.1530/EC-23-0363}, journal-iso = {ENDOCR CONNECT}, journal = {ENDOCRINE CONNECTIONS}, volume = {13}, unique-id = {34560218}, issn = {2049-3614}, year = {2024}, eissn = {2049-3614} } @article{MTMT:34555881, title = {Longitudinal motor system changes from acute to chronic spinal cord injury}, url = {https://m2.mtmt.hu/api/publication/34555881}, author = {Emmenegger, Tim M. and Pfyffer, Dario and Curt, Armin and Schading-Sassenhausen, Simon and Hupp, Markus and Ashburner, John and Friston, Karl and Weiskopf, Nikolaus and Thompson, Alan and Freund, Patrick}, doi = {10.1111/ene.16196}, journal-iso = {EUR J NEUROL}, journal = {EUROPEAN JOURNAL OF NEUROLOGY}, unique-id = {34555881}, issn = {1351-5101}, abstract = {Background and purposeIn acute spinal cord injury (SCI), magnetic resonance imaging (MRI) reveals tissue bridges and neurodegeneration for 2 years. This 5-year study aims to track initial lesion changes, subsequent neurodegeneration, and their impact on recovery.MethodsThis prospective longitudinal study enrolled acute SCI patients and healthy controls who were assessed clinically-and by MRI-regularly from 3 days postinjury up to 60 months. We employed histologically cross-validated quantitative MRI sequences sensitive to volume, myelin, and iron changes, thereby reflecting indirectly processes of neurodegeneration and neuroinflammation. General linear models tracked lesion and remote changes in volume, myelin- and iron-sensitive magnetic resonance indices over 5 years. Associations between lesion, degeneration, and recovery (using the Spinal Cord Independence Measure [SCIM] questionnaire and the International Standards for Neurological Classification of Spinal Cord Injury total motor score) were assessed.ResultsPatients' motor scores improved by an average of 12.86 (95% confidence interval [CI] = 6.70-19.00) points, and SCIM by 26.08 (95% CI = 17.00-35.20) points. Within 3-28 days post-SCI, lesion size decreased by more than two-thirds (3 days: 302.52 +/- 185.80 mm2, 28 days: 76.77 +/- 88.62 mm2), revealing tissue bridges. Cervical cord and corticospinal tract volumes transiently increased in SCI patients by 5% and 3%, respectively, accompanied by cervical myelin decreases and iron increases. Over time, progressive atrophy was observed in both regions, which was linked to early lesion dynamics. Tissue bridges, reduced swelling, and myelin content decreases were predictive of long-term motor score recovery and improved SCIM score.ConclusionsStudying acute changes and their impact on longer follow-up provides insights into SCI trajectory, highlighting the importance of acute intervention while indicating the potential to influence outcomes in the later stages. Neurodegeneration and lesion characteristics in spinal cord injury (SCI) patients were clinically and MRI-assessed at intervals of 3 days, 1 month, 3 months, 6 months, 12 months, 24 months, and 60 months post-injury, revealing insights into their association with clinical recovery.image}, keywords = {RECOVERY; IRON; MRI; Clinical Neurology; Acute spinal cord injury; lesion core}, year = {2024}, eissn = {1468-1331}, orcid-numbers = {Pfyffer, Dario/0000-0002-2406-9251} } @article{MTMT:34560216, title = {The Role of Neuropsychology in Traumatic Brain Injury: Comprehensive Literature Review}, url = {https://m2.mtmt.hu/api/publication/34560216}, author = {Halalmeh, D.R. and Salama, H.Z. and LeUnes, E. and Feitosa, D. and Ansari, Y. and Sachwani-Daswani, G.R. and Moisi, M.D.}, doi = {10.1016/j.wneu.2023.12.069}, journal-iso = {WORLD NEUROSURG}, journal = {WORLD NEUROSURGERY}, volume = {183}, unique-id = {34560216}, issn = {1878-8750}, year = {2024}, eissn = {1878-8769}, pages = {128-143} } @article{MTMT:34555884, title = {The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications}, url = {https://m2.mtmt.hu/api/publication/34555884}, author = {Hasan, Gulam Mustafa and Anwar, Saleha and Shamsi, Anas and Sohal, Sukhwinder Singh and Hassan, Md. Imtaiyaz}, doi = {10.3389/fphar.2023.1330098}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {14}, unique-id = {34555884}, abstract = {Traumatic brain injury (TBI) leads to brain damage, comprising both immediate primary damage and a subsequent cascade of secondary injury mechanisms. The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins. TBI disrupts molecular signaling, cell structures, and functions. In addition to physical tissue damage, such as axonal injuries, contusions, and haemorrhages, TBI interferes with brain functioning, impacting cognition, decision-making, memory, attention, and speech capabilities. Despite a deep understanding of the pathophysiology of TBI, an intensive effort to evaluate the underlying mechanisms with effective therapeutic interventions is imperative to manage the repercussions of TBI. Studies have commenced to explore the potential of employing natural compounds as therapeutic interventions for TBI. These compounds are characterized by their low toxicity and limited interactions with conventional drugs. Moreover, many natural compounds demonstrate the capacity to target various aspects of the secondary injury process. While our understanding of the pathophysiology of TBI, there is an urgent need for effective therapeutic interventions to mitigate its consequences. Here, we aimed to summarize the mechanism of action and the role of phytochemicals against TBI progression. This review discusses the therapeutic implications of various phytonutrients and addresses primary and secondary consequences of TBI. In addition, we highlighted the roles of emerging phytochemicals as promising candidates for therapeutic intervention of TBI. The review highlights the neuroprotective roles of phytochemicals against TBI and the mechanistic approach. Furthermore, our efforts focused on the underlying mechanisms, providing a better understanding of the therapeutic potential of phytochemicals in TBI therapeutics.}, keywords = {glutamate; traumatic brain injury; SUBARACHNOID HEMORRHAGE; ANIMAL-MODELS; INDUCED OXIDATIVE STRESS; ENERGY HOMEOSTASIS; Blood-brain barrier (BBB); INDUCED NEUROTOXICITY; Therapeutic intervention; Functional outcomes; Phytonutrients; ACID PHENETHYL ESTER; multi-targeted therapies; secondary injury cascades (SIC); AMELIORATES COGNITIVE DEFICITS}, year = {2024}, eissn = {1663-9812} } @article{MTMT:34474356, title = {Blood biomarkers for traumatic brain injury: A narrative review of current evidence}, url = {https://m2.mtmt.hu/api/publication/34474356}, author = {Hossain, I. and Marklund, N. and Czeiter, Endre and Hutchinson, P. and Büki, András}, doi = {10.1016/j.bas.2023.102735}, journal-iso = {BRAIN SPINE}, journal = {BRAIN AND SPINE}, volume = {4}, unique-id = {34474356}, issn = {2772-5294}, year = {2024}, orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944} } @article{MTMT:34555882, title = {Long-term survival after primary decompressive craniectomy for severe traumatic brain injury: an observational study from 1 to 17 years}, url = {https://m2.mtmt.hu/api/publication/34555882}, author = {Huang, Yu-Hua and Lee, Tsung-Han}, doi = {10.1007/s10143-024-02289-0}, journal-iso = {NEUROSURG REV}, journal = {NEUROSURGICAL REVIEW}, volume = {47}, unique-id = {34555882}, issn = {0344-5607}, abstract = {Primary decompressive craniectomy (DC) is carried out to prevent intracranial hypertension after removal of mass lesions resulting from traumatic brain injury (TBI). While primary DC can be a life-saving intervention, significant mortality risks persist during the follow-up period. This study was undertaken to investigate the long-term survival rate and ascertain the risk factors of mortality in TBI patients who underwent primary DC. We enrolled 162 head-injured patients undergoing primary DC in this retrospective study. The primary focus was on long-term mortality, which was monitored over a range of 12 to 209 months post-TBI. We compared the clinical parameters of survivors and non-survivors, and used a multivariate logistic regression model to adjust for independent risk factors of long-term mortality. For the TBI patients who survived the initial hospitalization period following surgery, the average duration of follow-up was 106.58 +/- 65.45 months. The recorded long-term survival rate of all patients was 56.2% (91/162). Multivariate logistic regression analysis revealed that age (odds ratio, 95% confidence interval = 1.12, 1.07-1.18; p < 0.01) and the status of basal cisterns (absent versus normal; odds ratio, 95% confidence interval = 9.32, 2.05-42.40; p < 0.01) were the two independent risk factors linked to long-term mortality. In conclusion, this study indicated a survival rate of 56.2% for patients subjected to primary DC for TBI, with at least a one-year follow-up. Key risk factors associated with long-term mortality were advanced age and absent basal cisterns, critical considerations for developing effective TBI management strategies.}, keywords = {AGE; MORTALITY; diagnosis; IMPACT; traumatic brain injury; OUTCOMES; HEAD-INJURY; PREDICTORS; LONG-TERM MORTALITY; Clinical Neurology; INTRACRANIAL-PRESSURE; MASS LESIONS; primary decompressive craniectomy}, year = {2024}, eissn = {1437-2320} } @article{MTMT:34560033, title = {Consensus-Based Development of a Global Registry for Traumatic Brain Injury: Establishment, Protocol, and Implementation}, url = {https://m2.mtmt.hu/api/publication/34560033}, author = {Joannides, A.J. and Korhonen, T.K. and Clark, D. and Gnanakumar, S. and Venturini, S. and Mohan, M. and Bashford, T. and Baticulon, R. and Bhagavatula, I.D. and Esene, I. and Fernández-Méndez, R. and Figaji, A. and Gupta, D. and Khan, T. and Laeke, T. and Martin, M. and Menon, D. and Paiva, W. and Park, K.B. and Pattisapu, J.V. and Rubiano, A.M. and Sekhar, V. and Shabani, H.K. and Sichizya, K. and Solla, D. and Tirsit, A. and Tripathi, M. and Turner, C. and Depreitere, B. and Iaccarino, C. and Lippa, L. and Reisner, A. and Rosseau, G. and Servadei, F. and Trivedi, R.A. and Waran, V. and Kolias, A. and Hutchinson, P.}, doi = {10.1227/neu.0000000000002661}, journal-iso = {NEUROSURGERY}, journal = {NEUROSURGERY}, volume = {94}, unique-id = {34560033}, issn = {0148-396X}, year = {2024}, eissn = {1524-4040}, pages = {278-288} } @article{MTMT:34625110, title = {Treatment with Rapamycin in Animal Models of Traumatic Brain Injuries; a Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34625110}, author = {Kiah, Mohammad and Azimi, Amir and Hajisoltani, Razieh and Yousefifard, Mahmoud}, doi = {10.22037/aaem.v12i1.2150}, journal-iso = {ARCH ACAD EMERG MED}, journal = {ARCHIVES OF ACADEMIC EMERGENCY MEDICINE}, volume = {12}, unique-id = {34625110}, keywords = {MODELS; animal; Meta-analysis; Brain Injuries; systematic review; traumatic}, year = {2024}, eissn = {2645-4904} } @article{MTMT:34560063, title = {The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review}, url = {https://m2.mtmt.hu/api/publication/34560063}, author = {Lember, L.-M. and Ntikas, M. and Mondello, S. and Wilson, L. and Di, Virgilio T.G. and Hunter, A.M. and Kobeissy, F. and Mechref, Y. and Donaldson, D.I. and Ietswaart, M.}, doi = {10.1186/s40798-023-00665-6}, journal-iso = {SPORT MED-OPEN}, journal = {SPORTS MEDICINE-OPEN}, volume = {10}, unique-id = {34560063}, issn = {2199-1170}, year = {2024}, eissn = {2198-9761} } @article{MTMT:34560232, title = {Mapping general anesthesia states based on electro-encephalogram transition phases}, url = {https://m2.mtmt.hu/api/publication/34560232}, author = {Loison, V. and Voskobiynyk, Y. and Lindquist, B. and Necula, D. and Longrois, D. and Paz, J. and Holcman, D.}, doi = {10.1016/j.neuroimage.2023.120498}, journal-iso = {NEUROIMAGE}, journal = {NEUROIMAGE}, volume = {285}, unique-id = {34560232}, issn = {1053-8119}, year = {2024}, eissn = {1095-9572} } @article{MTMT:34625108, title = {Design recommendations for XR-based motor rehabilitation exergames at home}, url = {https://m2.mtmt.hu/api/publication/34625108}, author = {Lorenz, Emanuel A. and Stoen, Andreas Braten and Fridheim, Magnus Lie and Alsos, Ole Andreas}, doi = {10.3389/frvir.2024.1340072}, journal-iso = {Front. Virtual Real.}, journal = {Frontiers in Virtual Reality}, volume = {5}, unique-id = {34625108}, keywords = {Game design; virtual reality (VR); Co-design; Design recommendations; motor rehabilitation; Exergame; Extended Reality (XR); acquired brain injuries (ABI)}, year = {2024}, eissn = {2673-4192} } @article{MTMT:34555601, title = {Classification and Characterization of Traumatic Brain Injuries in the Northern Region of Sweden}, url = {https://m2.mtmt.hu/api/publication/34555601}, author = {Magnusson, Beatrice M. and Koskinen, Lars-Owe D.}, doi = {10.3390/jcm13010008}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {13}, unique-id = {34555601}, abstract = {Background: Traumatic brain injury (TBI) is a common cause of death and disability, the incidence of which in northern Sweden is not fully investigated. This study classifies and characterize epidemiological and demographic features of TBIs in a defined population in Umea county, Sweden. Specifically, to evaluate frequencies of (1) intracranial lesions detected with computed tomography (CT), (2) need for emergency intervention, and (3) hospital admission, in minimal, mild, moderate, and severe TBI, respectively. Methods: The data were gathered from 4057 TBI patients visiting our emergency room (ER) during a two-year period (2015-2016), of whom 56% were men and approximately 95% had minimal TBIs (Glasgow Coma Scale (GCS), score 15). Results: Of all injuries, 97.8% were mild (GCS 14-15), 1.7% were moderate (GCS 9-13), and 0.5% were severe (GCS < 9). CT scans were performed on 46% of the patients, with 28% being hospitalized. A high annual TBI incidence of 1350 cases per 100,000 citizens was found. The mortality rate was 0.5% with the majority as expected in the elderly group (>80 years). Conclusions: Minimal TBIs were not as mild as previously reported, with a relatively high frequency of abnormal CT findings and a high mortality rate. No emergency intervention was required in patients in the GCS 13-15 group with normal CT scans. These findings have implications for clinical practice in the ER with the suggestion to include biomarkers to reduce unnecessary CT scans.}, keywords = {MORTALITY; PREVENTION; MANAGEMENT; EPIDEMIOLOGY; traumatic brain injury; Glasgow coma scale; outcome; HEAD-INJURY; intervention; Demographics; ADMISSION; CT scan; CENTER-TBI; epidemiological}, year = {2024}, eissn = {2077-0383}, orcid-numbers = {Koskinen, Lars-Owe D./0000-0003-3528-8502} } @article{MTMT:34560228, title = {Provider Perceived Facilitators and Barriers to Identifying, Perceiving, and Seeking Healthcare for Chronic Pain after TBI: A Qualitative NIDILRR and VA TBI Model Systems Collaborative Project}, url = {https://m2.mtmt.hu/api/publication/34560228}, author = {Nakase-Richardson, R. and Cotner, B.A. and Agtarap, S.D. and Martin, A.M. and Ching, D. and O'Connor, D.R. and Tweed, A. and Haun, J.N. and Hanks, R.A. and Bergquist, T.F. and Hammond, F.M. and Zafonte, R.D. and Hoffman, J.M.}, doi = {10.1097/HTR.0000000000000922}, journal-iso = {J HEAD TRAUMA REHAB}, journal = {JOURNAL OF HEAD TRAUMA REHABILITATION}, volume = {39}, unique-id = {34560228}, issn = {0885-9701}, year = {2024}, eissn = {1550-509X}, pages = {E1-E14} } @article{MTMT:34625109, title = {Glial cells react to closed head injury in a distinct and spatiotemporally orchestrated manner}, url = {https://m2.mtmt.hu/api/publication/34625109}, author = {Nespoli, Ester and Hakani, Marsela and Hein, Tabea Melissa and May, Stephanie Nadine and Danzer, Karin and Wirth, Thomas and Baumann, Bernd and Dimou, Leda}, doi = {10.1038/s41598-024-52337-4}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34625109}, issn = {2045-2322}, year = {2024}, eissn = {2045-2322} } @article{MTMT:34560223, title = {Tranexamic acid in patients with traumatic brain injury: A meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34560223}, author = {Sarhan, R.M. and Boshra, M.S. and Abdelrahim, M.E.A. and Osama, H.}, doi = {10.1016/j.redar.2023.04.005}, journal-iso = {REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION}, journal = {REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION}, unique-id = {34560223}, issn = {0034-9356}, year = {2024}, eissn = {2340-3284} } @article{MTMT:34560212, title = {Incomplete accumulation of perilesional reactive astrocytes exacerbates wound healing after closed-head injury by increasing inflammation and BBB disruption}, url = {https://m2.mtmt.hu/api/publication/34560212}, author = {Sawant, N. and Watanabe, A. and Ueda, H. and Okano, H. and Morita, M.}, doi = {10.1016/j.expneurol.2024.114700}, journal-iso = {EXP NEUROL}, journal = {EXPERIMENTAL NEUROLOGY}, volume = {374}, unique-id = {34560212}, issn = {0014-4886}, year = {2024}, eissn = {1090-2430} } @article{MTMT:34560214, title = {A retrospective analysis of concussion and post-concussional syndrome diagnoses in Western Australian emergency departments}, url = {https://m2.mtmt.hu/api/publication/34560214}, author = {Thomas, E. and Chih, H. and Thorne, J. and Fitzgerald, M. and Cowen, G.}, doi = {10.1016/j.injury.2024.111333}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {55}, unique-id = {34560214}, issn = {0020-1383}, year = {2024}, eissn = {1879-0267} } @{MTMT:34560230, title = {Psychosocial Understanding of Sport-Related Concussion}, url = {https://m2.mtmt.hu/api/publication/34560230}, author = {Utley, J.J. and Schack-Dugré, J. and Menard, K.}, booktitle = {The Psychology of Sport Injury and Rehabilitation, Second Edition}, doi = {10.4324/9781003295709-6}, unique-id = {34560230}, year = {2024}, pages = {57-76} } @article{MTMT:34560224, title = {Treatment-limiting decisions in patients with severe traumatic brain injury in the Netherlands}, url = {https://m2.mtmt.hu/api/publication/34560224}, author = {van, Erp I.A.M. and van, Essen T.A. and Kompanje, E.J.O. and van, der Jagt M. and Moojen, W.A. and Peul, W.C. and van, Dijck J.T.J.M.}, doi = {10.1016/j.bas.2024.102746}, journal-iso = {BRAIN SPINE}, journal = {BRAIN AND SPINE}, volume = {4}, unique-id = {34560224}, issn = {2772-5294}, year = {2024} } @article{MTMT:34560235, title = {Changes in decision-making function in patients with subacute mild traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34560235}, author = {Wang, Y. and Chen, Q. and Zhang, X. and Wang, K. and Cheng, H. and Chen, X.}, doi = {10.1111/ejn.16195}, journal-iso = {EUR J NEUROSCI}, journal = {EUROPEAN JOURNAL OF NEUROSCIENCE}, volume = {59}, unique-id = {34560235}, issn = {0953-816X}, year = {2024}, eissn = {1460-9568}, pages = {69-81} } @article{MTMT:34560226, title = {Broadening horizons: ferroptosis as a new target for traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34560226}, author = {Wei, Z. and Yu, H. and Zhao, H. and Wei, M. and Xing, H. and Pei, J. and Yang, Y. and Ren, K.}, doi = {10.1093/burnst/tkad051}, journal-iso = {BURNS TRAUMA}, journal = {BURNS & TRAUMA}, volume = {12}, unique-id = {34560226}, issn = {2321-3868}, year = {2024}, eissn = {2321-3876} } @article{MTMT:34635170, title = {Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration}, url = {https://m2.mtmt.hu/api/publication/34635170}, author = {Xiong, Ye and Mahmood, Asim and Chopp, Michael}, doi = {10.4103/1673-5374.374143}, journal-iso = {NEUR REG RES}, journal = {NEURAL REGENERATION RESEARCH}, volume = {19}, unique-id = {34635170}, issn = {1673-5374}, keywords = {Biomarkers; traumatic brain injury; neuroprotection; neuroinflammation; Functional outcome; Neuroplasticity; Extracellular vesicles; mesenchymal stem/stromal cells}, year = {2024}, eissn = {1876-7958}, pages = {49-54} } @article{MTMT:34555880, title = {Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases}, url = {https://m2.mtmt.hu/api/publication/34555880}, author = {Zhang, Jun and Liu, Shengwen and Wu, Yaqi and Tang, Zhijian and Wu, Yasong and Qi, Yiwei and Dong, Fangyong and Wang, Yu}, doi = {10.1007/s10571-023-01440-7}, journal-iso = {CELL MOL NEUROBIOL}, journal = {CELLULAR AND MOLECULAR NEUROBIOLOGY}, volume = {44}, unique-id = {34555880}, issn = {0272-4340}, abstract = {The existence of lymphatic vessels or similar clearance systems in the central nervous system (CNS) that transport nutrients and remove cellular waste is a neuroscientific question of great significance. As the brain is the most metabolically active organ in the body, there is likely to be a potential correlation between its clearance system and the pathological state of the CNS. Until recently the successive discoveries of the glymphatic system and the meningeal lymphatics solved this puzzle. This article reviews the basic anatomy and physiology of the glymphatic system. Imaging techniques to visualize the function of the glymphatic system mainly including post-contrast imaging techniques, indirect lymphatic assessment by detecting increased perivascular space, and diffusion tensor image analysis along the perivascular space (DTI-ALPS) are discussed. The pathological link between glymphatic system dysfunction and neurological disorders is the key point, focusing on the enlarged perivascular space (EPVS) and the index of diffusivity along the perivascular space (ALPS index), which may represent the activity of the glymphatic system as possible clinical neuroimaging biomarkers of neurological disorders.Graphical AbstractThe pathological link between glymphatic system dysfunction and neurological disorders is the key point, focusing on the enlarged perivascular space (EPVS) and the index for of diffusivity along the perivascular space (ALPS index), which may represent the activity of the glymphatic system as possible clinical neuroimaging biomarkers of neurological disorders}, keywords = {ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; CELL BIOLOGY; Clearance; TRAUMATIC BRAIN-INJURY; SMALL VESSEL DISEASE; glymphatic system; glymphatic system; enlarged perivascular space; Diffusion tensor image analysis along the perivascular space; Index for diffusivity along the perivascular space}, year = {2024}, eissn = {1573-6830} } @article{MTMT:34555883, title = {Dynamic Changes and Effects of H2S, IGF-1, and GH in the Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/34555883}, author = {Zhang, Zhen and Wu, Xin and Kong, Yang and Zou, Peng and Wang, Yanbin and Zhang, Hongtao and Cui, Guangqiang and Zhu, Wei and Chen, Hongguang}, doi = {10.1007/s10528-023-10557-9}, journal-iso = {BIOCHEM GENET}, journal = {BIOCHEMICAL GENETICS}, unique-id = {34555883}, issn = {0006-2928}, abstract = {The aim of this study was to examine the expression changes of H2S, IGF-1, and GH in traumatic brain injury (TBI) patients and to detect their neuroprotective functions after TBI. In this study, we first collected cerebrospinal fluid (CSF) and plasma from TBI patients at different times after injury and evaluated the concentrations of H2S, IGF-1, and GH. In vitro studies were using the scratch-induced injury model and cell-cell interaction model (HT22 hippocampal neurons co-cultured with LPS-induced BV2 microglia cells). In vivo studies were using the controlled cortical impact (CCI) model in mice. Cell viability was assessed by CCK-8 assay. Pro-inflammatory cytokines expression was determined by qRT-PCR, ELISA, and nitric oxide production. Western blot was performed to assess the expression of CBS, CSE, IGF-1, and GHRH. Moreover, the recovery of TBI mice was evaluated for behavioral function by applying the modified Neurological Severity Score (mNSS), the Rotarod test, and the Morris water maze. We discovered that serum H2S, CSF H2S, and serum IGF-1 concentrations were all adversely associated with the severity of the TBI, while the concentrations of IGF-1 and GH in CSF and GH in the serum were all positively related to TBI severity. Experiments in vitro and in vivo indicated that treatment with NaHS (H2S donor), IGF-1, and MR-409 (GHRH agonist) showed protective effects after TBI. This study gives novel information on the functions of H2S, IGF-1, and GH in TBI.}, keywords = {Inflammation; ACTIVATION; GROWTH; PATHOPHYSIOLOGY; Mitochondria; traumatic brain injury; hypopituitarism; HYDROGEN-SULFIDE; IGF-1; Biochemistry & Molecular Biology; H2S}, year = {2024}, eissn = {1573-4927} } @article{MTMT:34560229, title = {Nomogram for Predicting Central Nervous System Infection Following Traumatic Brain Injury in the Elderly}, url = {https://m2.mtmt.hu/api/publication/34560229}, author = {Zhao, W. and Guo, S. and Xu, Z. and Wang, Y. and Kou, Y. and Tian, S. and Qi, Y. and Pang, J. and Zhou, W. and Wang, N. and Liu, J. and Zhai, Y. and Ji, P. and Jiao, Y. and Fan, C. and Chao, M. and Fan, Z. and Qu, Y. and Wang, L.}, doi = {10.1016/j.wneu.2023.10.088}, journal-iso = {WORLD NEUROSURG}, journal = {WORLD NEUROSURGERY}, unique-id = {34560229}, issn = {1878-8750}, year = {2024}, eissn = {1878-8769} } @article{MTMT:34560217, title = {sTBI-GAN: An adversarial learning approach for data synthesis on traumatic brain segmentation}, url = {https://m2.mtmt.hu/api/publication/34560217}, author = {Zhao, X. and Zang, D. and Wang, S. and Shen, Z. and Xuan, K. and Wei, Z. and Wang, Z. and Zheng, R. and Wu, X. and Li, Z. and Wang, Q. and Qi, Z. and Zhang, L.}, doi = {10.1016/j.compmedimag.2024.102325}, journal-iso = {COMPUT MED IMAG GRAP}, journal = {COMPUTERIZED MEDICAL IMAGING AND GRAPHICS}, volume = {112}, unique-id = {34560217}, issn = {0895-6111}, year = {2024}, eissn = {1879-0771} } @article{MTMT:34560429, title = {Outcomes and factors associated with mortality among Traumatic Brain injury patients admitted to the Intensive care units of comprehensive specialized hospitals in the Amhara Region, 2022. A Multi-center retrospective cross-sectional study}, url = {https://m2.mtmt.hu/api/publication/34560429}, author = {Abebe, Messelu M. and Ayenew, T. and Tadesse, Shibabaw A. and Berie, Mekonnen G. and Gashaw, Belayneh A. and Azene, Demile T. and Alemayehu, Getahun B. and Fekad, Getahun A. and Miretie, Dessie T.}, doi = {10.1016/j.ijans.2023.100603}, journal-iso = {INTERNATIONAL JOURNAL OF AFRICA NURSING SCIENCES}, journal = {INTERNATIONAL JOURNAL OF AFRICA NURSING SCIENCES}, volume = {19}, unique-id = {34560429}, issn = {2214-1391}, year = {2023} } @article{MTMT:34307971, title = {A role for protein arginine methyltransferase 7 in repetitive and mild traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34307971}, author = {Acosta, Christina H. and Clemons, Garrett A. and Citadin, Cristiane T. and Carr, William C. and Udo, Mariana Sayuri Berto and Tesic, Vesna and Sanicola, Henry W. and Freelin, Anne H. and Toms, Jamie B. and Jordan, J. Dedrick and Guthikonda, Bharat and Wu, Celeste Yin-Chieh and Lee, Reggie Hui -Chao and Lin, Hung Wen}, doi = {10.1016/j.neuint.2023.105524}, journal-iso = {NEUROCHEM INT}, journal = {NEUROCHEMISTRY INTERNATIONAL}, volume = {166}, unique-id = {34307971}, issn = {0197-0186}, abstract = {Mild traumatic brain injury affects the largest proportion of individuals in the United States and world-wide. Preclinical studies of repetitive and mild traumatic brain injury (rmTBI) have been limited in their ability to recapitulate human pathology (i.e. diffuse rotational injury). We used the closed-head impact model of engineered rotation acceleration (CHIMERA) to simulate rotational injury observed in patients and to study the pathological outcomes post-rmTBI using C57BL/6J mice. Enhanced cytokine production was observed in both the cortex and hippocampus to suggest neuroinflammation. Furthermore, microglia were assessed via enhanced iba1 protein levels and morphological changes using immunofluorescence. In addition, LC/MS analyses revealed excess glutamate production, as well as diffuse axonal injury via Bielschowsky's silver stain kit. Moreover, the heterogeneous nature of rmTBI has made it challenging to identify drug therapies that address rmTBI, therefore we sought to identify novel targets in the concurrent rmTBI pathology. The pathophysiological findings correlated with a time-dependent decrease in protein arginine methyltransferase 7 (PRMT7) protein expression and activity post-rmTBI along with dysregulation of PRMT upstream mediators s-adenosylmethionine and methionine adenosyltransferase 2 (MAT2) in vivo. In addition, inhibition of the upstream mediator MAT2A using the HT22 hippocampal neuronal cell line suggest a mechanistic role for PRMT7 via MAT2A in vitro. Collectively, we have identified PRMT7 as a novel target in rmTBI pathology in vivo and a mechanistic link between PRMT7 and upstream mediator MAT2A in vitro.}, keywords = {traumatic brain injury; S-adenosylmethionine; protein arginine methyltransferase; Methionine adenosyltransferase 2; PF-9366}, year = {2023}, eissn = {1872-9754} } @article{MTMT:34181776, title = {Data-driven approaches to reveal the pathobiological heterogeneity in patients with traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34181776}, author = {Åkerlund, C. and Ercole, A.}, doi = {10.1007/s00134-023-07156-y}, journal-iso = {INTENS CARE MED}, journal = {INTENSIVE CARE MEDICINE}, volume = {49}, unique-id = {34181776}, issn = {0342-4642}, year = {2023}, eissn = {1432-1238}, pages = {1107-1109} } @article{MTMT:34307939, title = {Role of music therapy in improving cognitive function post-traumatic brain injury: A systematic review}, url = {https://m2.mtmt.hu/api/publication/34307939}, author = {Alashram, Anas R. and Janada, Qusai and Ghrear, Tamara and Annino, Giuseppe}, doi = {10.1080/23279095.2023.2228951}, journal-iso = {APPL NEUROPSYCH-ADUL}, journal = {APPLIED NEUROPSYCHOLOGY-ADULT}, unique-id = {34307939}, issn = {2327-9095}, abstract = {Cognitive deficits are one of the most prevalent impairments in patients with traumatic brain injury (TBI). Music therapy has the potential to be a valuable intervention for improving cognitive function. This review aimed to investigate the effects of music therapy on cognitive function in patients with TBI. Scopus, PubMed, REHABDATA, PEDro, EMBASE, and web of science were searched for experimental trials examining the impacts of music therapy on cognition in patients with TBI from inception until December 2022. Physiotherapy Evidence Database (PEDro) scale was used to evaluate the methodological quality of the included studies. Five studies met the inclusion criteria. A total of 122 patients with TBI were included in this review, 32% of whom were females. The PEDro scores ranged from four to seven, with a median of five. The findings showed that music therapy could be effective in improving executive function post-TBI, with limited evidence for the effects on memory and attention. Music therapy might be safe in patients with TBI. The evidence for the effect of music therapy on executive function in patients with TBI is promising. Further studies with larger sample sizes and long-term follow-ups are strongly needed.}, keywords = {music therapy; cognition; Cognitive function; rehabilitation; EXECUTIVE FUNCTION}, year = {2023}, eissn = {2327-9109} } @article{MTMT:34247648, title = {Astrocytes in functional recovery following central nervous system injuries}, url = {https://m2.mtmt.hu/api/publication/34247648}, author = {Alhadidi, Qasim M. and Bahader, Ghaith A. and Arvola, Oiva and Kitchen, Philip and Shah, Zahoor A. and Salman, Mootaz M.}, doi = {10.1113/JP284197}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {In press}, unique-id = {34247648}, issn = {0022-3751}, abstract = {Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms critical for regulating neuronal plasticity following central nervous system (CNS) insults. Ischaemic stroke and traumatic brain injury are associated with high rates of disability and mortality. Depending on the context and type of injury, reactive astrocytes respond with diverse morphological, proliferative and functional changes collectively known as astrogliosis, which results in both pathogenic and protective effects. There is a large body of research on the negative consequences of astrogliosis following brain injuries. There is also growing interest in how astrogliosis might in some contexts be protective and help to limit the spread of the injury. However, little is known about how astrocytes contribute to the chronic functional recovery phase following traumatic and ischaemic brain insults. In this review, we explore the protective functions of astrocytes in various aspects of secondary brain injury such as oedema, inflammation and blood-brain barrier dysfunction. We also discuss the current knowledge on astrocyte contribution to tissue regeneration, including angiogenesis, neurogenesis, synaptogenesis, dendrogenesis and axogenesis. Finally, we discuss diverse astrocyte-related factors that, if selectively targeted, could form the basis of astrocyte-targeted therapeutic strategies to better address currently untreatable CNS disorders.imageAbstract figure legend The roles of astrocytes in CNS injuries.image}, keywords = {ASTROCYTES; regeneration; brain injury; Functional recovery; Traumatic CNS injury}, year = {2023}, eissn = {1469-7793}, orcid-numbers = {Kitchen, Philip/0000-0002-1558-4673; Salman, Mootaz M./0000-0002-5683-1706} } @article{MTMT:34560422, title = {Relationship between Folic Acid and Both Anxiety and Depression During Pregnancy}, url = {https://m2.mtmt.hu/api/publication/34560422}, author = {Ali, S.C. and Salam, W.A. and Saif, M.H.}, doi = {10.61336/appj/22-1-05}, journal-iso = {Azerbaijan Pharmaceutical and Pharmacotherapy Journal}, journal = {Azerbaijan Pharmaceutical and Pharmacotherapy Journal}, volume = {22}, unique-id = {34560422}, issn = {1994-1951}, year = {2023}, pages = {18-23} } @article{MTMT:33917202, title = {Traumatic Brain Injury in Select Low- and Middle-Income Countries: A Narrative Review of the Literature}, url = {https://m2.mtmt.hu/api/publication/33917202}, author = {Allen, Beddome C. and Cummer, Elaina and Sarma, Anand K.}, doi = {10.1089/neu.2022.0068}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {40}, unique-id = {33917202}, issn = {0897-7151}, abstract = {Low- and middle-income countries (LMICs) experience the majority of traumatic brain injuries (TBIs), yet few studies have examined the epidemiology and management strategies of TBI in LMICs. The objective of this narrative review is to discuss the epidemiology of TBI within LMICs, describe the adherence to Brain Trauma Foundation (BTF) guidelines for the management of severe TBI in LMICs, and document TBI management strategies currently used in LMICs. Articles from January 1, 2009 to September 30, 2021 that included patients with TBI greater than 18 years of age in low-, low middle-, and high middle-income countries were queried in PubMed. Search results demonstrated that TBI in LMICs mostly impacts young males involved in road traffic accidents. Within LMICs there are a myriad of approaches to managing TBI with few randomized controlled trials performed within LMICs to evaluate those interventions. More studies are needed in LMICs to establish the effectiveness and appropriateness of BTF guidelines for managing TBI and to help identify methods for managing TBI that are appropriate in low-resource settings. The problem of limited pre- and post-hospital care is a bigger challenge that needs to be considered while addressing management of TBI in LMICs.}, keywords = {Brain Trauma Foundation Guidelines; LMIC TBI; LMIC TBI challenges; pre- and post-hospital care; traumatic brain injury epidemiology}, year = {2023}, eissn = {1557-9042}, pages = {602-619} } @article{MTMT:34555915, title = {The Nociceptin/Orphanin FQ peptide receptor antagonist, SB-612111, improves cerebral blood flow in a rat model of traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34555915}, author = {Al, Yacoub Omar N. and Tarantini, Stefano and Zhang, Yong and Csiszar, Anna and Standifer, Kelly M.}, doi = {10.3389/fphar.2023.1272969}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {14}, unique-id = {34555915}, abstract = {Traumatic brain injury (TBI) affects more than 2.5 million people in the U.S. each year and is the leading cause of death and disability in children and adults ages 1 to 44. Approximately 90% of TBI cases are classified as mild but may still lead to acute detrimental effects such as impaired cerebral blood flow (CBF) that result in prolonged impacts on brain function and quality of life in up to 15% of patients. We previously reported that nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor antagonism reversed mild blast TBI-induced vestibulomotor deficits and prevented hypoxia. To explore mechanisms by which the NOP receptor-N/OFQ pathway modulates hypoxia and other TBI sequelae, the ability of the NOP antagonist, SB-612111 (SB), to reverse TBI-induced CBF and associated injury marker changes were tested in this study. Male Wistar rats randomly received sham craniotomy or craniotomy + TBI via controlled cortical impact. Injury severity was assessed after 1 h (modified neurological severity score (mNSS). Changes in CBF were assessed 2 h post-injury above the exposed cortex using laser speckle contrast imaging in response to the direct application of increasing concentrations of vehicle or SB (1, 10, and 100 mu M) to the brain surface. TBI increased mNSS scores compared to baseline and confirmed mild TBI (mTBI) severity. CBF was significantly impaired on the ipsilateral side of the brain following mTBI, compared to contralateral side and to sham rats. SB dose-dependently improved CBF on the ipsilateral side after mTBI compared to SB effects on the respective ipsilateral side of sham rats but had no effect on contralateral CBF or in uninjured rats. N/OFQ levels increased in the cerebral spinal fluid (CSF) following mTBI, which correlated with the percent decrease in ipsilateral CBF. TBI also activated ERK and cofilin within 3 h post-TBI; ERK activation correlated with increased CSF N/OFQ. In conclusion, this study reveals a significant contribution of the N/OFQ-NOP receptor system to TBI-induced dysregulation of cerebral vasculature and suggests that the NOP receptor should be considered as a potential therapeutic target for TBI.}, keywords = {TISSUE DISTRIBUTION; NITRIC-OXIDE; CDNA CLONING; MOLECULAR-CLONING; Mild traumatic brain injury; L-arginine; Mitogen-Activated Protein Kinases; cerebral blood flow; Controlled cortical impact; Controlled cortical impact; laser speckle contrast imaging; chromosomal localization; p38 MAPK; COFILIN PHOSPHORYLATION; cofilin-1; Nociceptin/orphanin FQ (N/OFQ)}, year = {2023}, eissn = {1663-9812} } @article{MTMT:33917163, title = {Testing the stability of a family resilience model at 2 and 5 years after traumatic brain injury or spinal cord injury: A longitudinal study}, url = {https://m2.mtmt.hu/api/publication/33917163}, author = {Anderson, Malcolm Ikin and Gopinath, Bamini and Jones, Kate Fiona and Morey, Peter and Simpson, Grahame Kenneth}, doi = {10.1016/j.rehab.2023.101734}, journal-iso = {ANN PHYS REHAB MED}, journal = {ANNALS OF PHYSICAL AND REHABILITATION MEDICINE}, volume = {66}, unique-id = {33917163}, issn = {1877-0657}, abstract = {Background: Recent studies have tested models of resilience and caregiver adjustment in individuals with traumatic brain injury (TBI) or spinal cord injury (SCI). Few studies have examined the role of adaptive varia-bles over time.Objective: Conduct a longitudinal study to test a model of caregiver resilience with caregiver outcomes at 2 -and 5-years post-injury. Method: Caregivers of relatives with TBI or SCI were surveyed at 2 years (Time 1) and 5 years (Time 2) post -injury. Stability of the resilience model across the 2 time-points was tested using structural equation model-ing with multi-group analysis. Measures included resilience related variables (Connor-Davidson Resilience Scale, General Self-Efficacy Scale, Herth Hope Scale, Social Support Survey) and outcome variables (Caregiver Burden Scale, General Health Questionnaire-28, Medical Outcome Study Short Form-36 [SF-36] and Positive and Negative Affect Scale).Results: In total, 100 caregivers were surveyed at both 2 and 5 years (TBI =77, SCI =23). Scores for resilience (Time 1, 75.9 SD 10.6; Time 2, 71.5 SD 12.6) and self-efficacy (Time 1, 32.51 SD 3.85; Time 2, 31.66 SD 4.28) showed significant minor declines, with other variables remaining stable. The resilience model for the pooled responses (Time 1+ Time 2) demonstrated a good fit (Goodness of Fit Index [GFI] = 0.971; Incremental Fit Index [IFI] = 0.986; Tucker-Lewis Index [TLI] = 0.971; Comparative Fit Index [CFI] = 0.985 and Root Mean Square Error of Approximation [RMSEA] = 0.051). Multi-group analysis then compared Time 1 to Time 2 responses and found that a variant (compared to invariant) model best fitted the data, with social support having stronger associations with mental health and positive affect at Time 2 than Time 1. Hope reduced from Time 1 to Time 2.Conclusions: The model suggests that resilience-related variables can play an important role in positive care-giver adjustment over time.(c) 2023 Elsevier Masson SAS. All rights reserved.}, keywords = {FAMILY; burden; spinal cord injury; caregiver; RESILIENCE; traumatic brain injuries}, year = {2023}, eissn = {1877-0665} } @article{MTMT:34181799, title = {Efforts to improve the quality of treatment for craniocerebral trauma}, url = {https://m2.mtmt.hu/api/publication/34181799}, author = {Anonymous, '}, doi = {10.3760/cma.j.cn112050-20230518-00146}, journal-iso = {CHINESE J NEUROSUR}, journal = {CHINESE JOURNAL OF NEUROSURGERY}, volume = {39}, unique-id = {34181799}, issn = {1001-2346}, year = {2023}, pages = {649-652} } @article{MTMT:33807149, title = {Association Between Admission Ionized Calcium Level and Neurological Outcome of Patients with Isolated Severe Traumatic Brain Injury: A Retrospective Cohort Study}, url = {https://m2.mtmt.hu/api/publication/33807149}, author = {Badarni, Karawan and Harush, Noi and Andrawus, Elias and Bahouth, Hany and Bar-Lavie, Yaron and Raz, Aeyal and Roimi, Michael and Epstein, Danny}, doi = {10.1007/s12028-023-01687-4}, journal-iso = {NEUROCRIT CARE}, journal = {NEUROCRITICAL CARE}, unique-id = {33807149}, issn = {1541-6933}, abstract = {BackgroundTraumatic brain injury (TBI) is a leading cause of death and disability worldwide. Pathophysiological processes following initial insult are complex and not fully understood. Ionized calcium (Ca++) is an essential cofactor in the coagulation cascade and platelet aggregation, and hypocalcemia may contribute to the progression of intracranial bleeding. On the other hand, Ca++ is an important mediator of cell damage after TBI and cellular hypocalcemia may have a neuroprotective effect after brain injury. We hypothesized that early hypocalcemia might have an adverse effect on the neurological outcome of patients suffering from isolated severe TBI. In this study, we aimed to evaluate the relationship between admission Ca++ level and the neurological outcome of these patients.MethodsThis was a retrospective, single-center, cohort study of all patients admitted between January 2014 and December 2020 due to isolated severe TBI, which was defined as head abbreviated injury score >= 4 and an absence of severe (abbreviated injury score > 2) extracranial injuries. The primary outcome was a favorable neurological status at discharge, defined by a modified Rankin Scale of 0-2. Multivariable logistic regression was performed to determine whether admission hypocalcemia (Ca++ < 1.16 mmol L-1) is an independent predictor of neurological status at discharge.ResultsThe final analysis included 201 patients. Hypocalcemia was common among patients with isolated severe TBI (73.1%). Most of the patients had mild hypocalcemia (1 < Ca++ < 1.16 mmol L-1), and only 13 (6.5%) patients had Ca++ <= 1.00 mmol L-1. In the entire cohort, hypocalcemia was independently associated with higher rates of good neurological status at discharge (adjusted odds ratio of 3.03, 95% confidence interval 1.11-8.33, p = 0.03). In the subgroup of 81 patients with an admission Glasgow Coma Scale > 8, 52 (64.2%) had hypocalcemia. Good neurological status at discharge was recorded in 28 (53.8%) of hypocalcemic patients compared with 14 (17.2%) of those with normal Ca++ (p = 0.002). In multivariate analyses, hypocalcemia was independently associated with good neurological status at discharge (adjusted odds ratio of 6.67, 95% confidence interval 1.39-33.33, p = 0.02).ConclusionsOur study demonstrates that among patients with isolated severe TBI, mild admission hypocalcemia is associated with better neurological status at hospital discharge. The prognostic value of Ca++ may be greater among patients with admission Glasgow Coma Scale > 8. Trials are needed to investigate the role of hypocalcemia in brain injury.}, keywords = {calcium; ARTERIAL; MORTALITY; PATTERNS; MANAGEMENT; traumatic brain injury; SUBARACHNOID HEMORRHAGE; stroke; GUIDELINES; Nimodipine; hypocalcemia; Neurotrauma; Critical Care Medicine}, year = {2023}, eissn = {1556-0961} } @article{MTMT:33868396, title = {Cerebrospinal Fluid and Blood Biomarkers in Patients with Post-Traumatic Disorders of Consciousness: A Scoping Review}, url = {https://m2.mtmt.hu/api/publication/33868396}, author = {Bagnato, Sergio and Boccagni, Cristina}, doi = {10.3390/brainsci13020364}, journal-iso = {BRAIN SCI}, journal = {BRAIN SCIENCES}, volume = {13}, unique-id = {33868396}, abstract = {(1) Background: Cerebrospinal fluid (CSF) and blood biomarkers are emerging tools used to obtain information on secondary brain damage and to improve diagnostic and prognostic accuracy for patients with prolonged post-traumatic disorders of consciousness (DoC). We synthesized available data from studies evaluating CSF and blood biomarkers in these patients. (2) Methods: A scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist to identify and synthesize data from relevant studies. Studies were identified by PubMed and manual searches. Those involving patients with unresponsive wakefulness syndrome or in a minimally conscious state for >28 days, evaluating CSF or blood biomarkers, and conducted on patients with traumatic brain injuries older than 16 years were included in the review. (3) Results: In total, 17 studies were included. Findings on neurofilament light chain, proteins, metabolites, lipids, amyloid-beta, tau, melatonin, thyroid hormones, microtubule-associated protein 2, neuron-specific enolase, and brain-derived neurotrophic factor were included in the qualitative synthesis. (4) Conclusions: The most promising applications for CSF and blood biomarkers are the monitoring of secondary neurodegeneration, support of DoC diagnoses, and refinement of prognoses, although current evidence remains too scarce to recommend such uses of these biomarkers in clinical practice.}, keywords = {Prognosis; diagnosis; PLASTICITY; traumatic brain injury; neurodegeneration; biomarker; minimally conscious state; neurofilament light chain; VEGETATIVE STATE; Unresponsive wakefulness syndrome}, year = {2023}, eissn = {2076-3425}, orcid-numbers = {Bagnato, Sergio/0000-0002-6289-1887} } @article{MTMT:33917190, title = {Neuronal differentiation and functional maturation of neurons from neural stem cells induced by bFGF-chitosan controlled release system}, url = {https://m2.mtmt.hu/api/publication/33917190}, author = {Bai, Tianyu and Duan, Hongmei and Zhang, Boya and Hao, Peng and Zhao, Wen and Gao, Yudan and Yang, Zhaoyang and Li, Xiaoguang}, doi = {10.1007/s13346-023-01322-x}, journal-iso = {DRUG DELIV TRANSLAT RES}, journal = {DRUG DELIVERY AND TRANSLATIONAL RESEARCH}, unique-id = {33917190}, issn = {2190-393X}, abstract = {Available methods for differentiating stem cells into neurons require a large number of cytokines and neurotrophic factors, with complex steps and slow processes, and are inefficient to produce functional neurons and form synaptic contacts, which is expensive and impractical in clinical application. Here, we demonstrated a bioactive material, basic fibroblast growth factor (bFGF)-chitosan controlled release system, for facilitating neuronal differentiation from NSCs and the functional maturation of the induced neurons with high efficiency. We illustrated by immunostaining that the neurons derived from NSCs expressed mature immunomarkers of interneurons and excitatory neurons. And we found by patch-clamp that the induced neurons exhibited diverse electrophysiological properties as well as formed functional synapses. In vivo, we implanted bFGF-chitosan into lesion area in traumatic brain injury (TBI) mice and similarly observed abundance of neuroblasts in SVZ and the presence of newborn functional neurons in injury area, which integrated into synaptic networks. Taken together, our efficient and rapid tissue engineering approach may be a potential method for the generation of functional neuronal lineage cells from stem cells and a therapy of brain injury and disease.}, keywords = {traumatic brain injury; NEURONAL DIFFERENTIATION; Neural Stem Cells; Functional maturation; Synaptic circuits; bFGF-chitosan}, year = {2023}, eissn = {2190-3948}, orcid-numbers = {Zhao, Wen/0000-0003-4566-5914} } @article{MTMT:34560342, title = {Progress in application of adult endogenous neurogenesis in brain injury repair}, url = {https://m2.mtmt.hu/api/publication/34560342}, author = {Bai, T.-Y. and Mu, J. and Hao, P. and Duan, H.-M. and Hao, F. and Zhao, W. and Gao, Y.-D. and Wang, Z.-J. and Yang, Z.-Y. and Li, X.-G.}, doi = {10.13294/j.aps.2023.0024}, journal-iso = {ACTA PHYSIOL SIN}, journal = {ACTA PHYSIOLOGICA SINICA}, volume = {75}, unique-id = {34560342}, issn = {0371-0874}, year = {2023}, pages = {231-240} } @{MTMT:34392774, title = {High-fat diets in traumatic brain injury: A ketogenic diet resolves what the Western diet messes up neuroinflammation and beyond}, url = {https://m2.mtmt.hu/api/publication/34392774}, author = {Bakkar, N.-M.Z. and Ibeh, S. and AlZaim, I. and El-Yazbi, A.F. and Kobeissy, F.}, booktitle = {Diet and Nutrition in Neurological Disorders}, doi = {10.1016/B978-0-323-89834-8.00022-2}, unique-id = {34392774}, year = {2023}, pages = {175-197} } @article{MTMT:33793521, title = {Timing matters: sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/33793521}, author = {Baskin, Britahny M and Logsdon, Aric F and Lee, Suhjung Janet and Foresi, Brian D and Peskind, Elaine and Banks, William A and Cook, David G and Schindler, Abigail G}, doi = {10.1016/j.bbi.2023.03.003}, journal-iso = {BRAIN BEHAV IMMUN}, journal = {BRAIN BEHAVIOR AND IMMUNITY}, volume = {110}, unique-id = {33793521}, issn = {0889-1591}, year = {2023}, eissn = {1090-2139}, pages = {222-236} } @article{MTMT:33218349, title = {Impact of Chronological Age and Biological Sex on Cerebrovascular Reactivity in Moderate/Severe Traumatic Brain Injury: A CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Study}, url = {https://m2.mtmt.hu/api/publication/33218349}, author = {Batson, Carleen and Froese, Logan and Sekhon, Mypinder and Griesdale, Donald and Gomez, Alwyn and Thelin, Eric P. and Raj, Rahul and Aries, Marcel and Gallagher, Clare and Bernard, Francis and Kramer, Andreas H. and Zeiler, Frederick A.}, doi = {10.1089/neu.2022.0293}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {40}, unique-id = {33218349}, issn = {0897-7151}, abstract = {Impaired cerebrovascular reactivity has emerged as an important associate with poor long-term outcome after moderate/severe traumatic brain injury (TBI). However, our understanding of what drives or modulates the degree of impaired cerebrovascular function remains poor. Age and biological sex remain important modifiers of cerebrovascular function in health and disease, yet their impact on cerebrovascular reactivity after TBI remains unclear. The aim of this study was to explore subgroup responses based on age and biological sex on cerebral physiology. Data from 283 TBI patients from the CAnadian High Resolution TBI (CAHR-TBI) Research Collaborative were evaluated. Cerebrovascular reactivity was determined using high-frequency cerebral physiology for the derivation of three intracranial pressure (ICP)-based indices: 1) pressure reactivity index (PRx)-correlation between ICP and mean arterial pressure (MAP); 2) pulse amplitude index (PAx)-correlation between pulse amplitude of ICP (AMP) and MAP; and 3) RAC-correlation between AMP and cerebral perfusion pressure (CPP). Insult burden (% time above clinically defined thresholds) were calculated for these indices. These cerebral physiology indices were studied for their relationship with age via linear regression, age trichotomization (< 40, 40 - 60, > 60), and decades of age (< 30, 30-39, 40-49, 50-59, 60-69, > 69) schemes. Similarly, differences based on biological sex were assessed. A statistically significant positive linear correlation was found between PAx, RAC, and age. In corollary, a statistically significant relationship was found between increasing age on trichotomized and decades of age analysis with PAx and RAC measures. PRx failed to demonstrate such relationships to advancing age. There was no clear difference in cerebrovascular reactivity profiles between biological sex categories. These findings suggest that AMP-based cerebrovascular reactivity indices may be better positioned to detect impairment in TBI patients with advancing age. Further investigation into the utility of PAx and RAC is required, as they may prove useful for certain subgroups of patients.}, keywords = {AGE; Cerebrovascular reactivity; Rac; biological sex; PRx; Pax}, year = {2023}, eissn = {1557-9042}, pages = {1098-1111}, orcid-numbers = {Raj, Rahul/0000-0003-4243-9591} } @article{MTMT:33917191, title = {Antioxidant and neuroprotective effects of dexpanthenol in rats induced with traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/33917191}, author = {Bektasoglu, Pinar Kuru and Koyuncuoglu, Turkan and Ozaydin, Dilan and Kandemir, Cansu and Akakin, Dilek and Yuksel, Meral and Gurer, Bora and Celikoglu, Erhan and Yegen, Berrak C.}, doi = {10.1016/j.injury.2023.02.025}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {54}, unique-id = {33917191}, issn = {0020-1383}, abstract = {Trauma-induced primary damage is followed by secondary damage, exacerbating traumatic brain injury (TBI). Dexpanthenol has been shown to protect tissues against oxidative damage in various inflammation models. This study aimed to investigate possible antioxidant and neuroprotective effects of dexpanthenol in TBI. Wistar albino male rats were randomly assigned to control ( n = 16), trauma ( n = 16) and dexpan-thenol (500 mg/kg; n = 14) groups. TBI was induced under anesthesia by dropping a 300 g weight from 70-cm height onto the skulls of the rats. Twenty-four hours after the trauma, the rats were decapitated and myeloperoxidase (MPO) levels, luminol-and lucigenin-enhanced chemiluminescence (CL), malondi-aldehyde (MDA) levels, superoxide dismutase (SOD) levels, and catalase (CAT) and caspase-3 activities were measured in brain tissues. Following transcardiac paraformaldehyde perfusion, histopathological damage was graded on hematoxylin-eosin-stained brain tissues. In the trauma group, MPO level, caspase-3 activity and luminol-lucigenin CL levels were elevated ( p < 0.05-0.001) when compared to controls; meanwhile in the dexpanthenol group these increases were not seen ( p < 0.05-0.001) and MDA levels were decreased ( p < 0.05). Decreased SOD and CAT activities ( p < 0.01) in the vehicle-treated TBI group were increased above control levels in the dexpanthenol group ( p < 0.05-0.001). in the dexpanthenol group there was relatively less neuronal damage observed micro-scopically in the cortices after TBI. Dexpanthenol reduced oxidative damage, suppressed apoptosis by stimulating antioxidant systems and alleviated brain damage caused by TBI. Further experimental and clinical investigations are needed to confirm that dexpanthenol can be administered in the early stages of TBI. (c) 2023 Elsevier Ltd. All rights reserved.}, keywords = {ANTIOXIDANT; traumatic brain injury; neuroprotection; anti-inflammatory; antiapoptotic; Dexpanthenol}, year = {2023}, eissn = {1879-0267}, pages = {1065-1070} } @{MTMT:34559908, title = {Head and Brain Trauma}, url = {https://m2.mtmt.hu/api/publication/34559908}, author = {Bertolini, G. and Cattani, L. and Iaccarino, C. and Fornaciari, A. and Picetti, E.}, booktitle = {Textbook of Emergency General Surgery}, doi = {10.1007/978-3-031-22599-4_39}, unique-id = {34559908}, year = {2023}, pages = {581-604} } @article{MTMT:34307946, title = {Glasgow coma scale pupil score (GCS-P) and the hospital mortality in severe traumatic brain injury: analysis of 1,066 Brazilian patients}, url = {https://m2.mtmt.hu/api/publication/34307946}, author = {Bertotti, Melina More and Martins, Evandro Tostes and Areas, Fernando Zanela and Vascouto, Helena Dresch and Rangel, Norma Beatriz and Melo, Hiago Murilo and Lin, Katia and Kupek, Emil and Dal Pizzol, Felipe and Golby, Alexandra J. and Walz, Roger}, doi = {10.1055/s-0043-1768671}, journal-iso = {ARQ NEURO-PSIQUIAT}, journal = {ARQUIVOS DE NEURO-PSIQUIATRIA}, volume = {81}, unique-id = {34307946}, issn = {0004-282X}, abstract = {Background Pupil reactivity and the Glasgow Coma Scale (GCS) score are the most clinically relevant information to predict the survival of traumatic brain injury (TBI) patients.Objective We evaluated the accuracy of the GCS-Pupil score (GCS-P) as a prognostic index to predict hospital mortality in Brazilian patients with severe TBI and compare it with a model combining GCS and pupil response with additional clinical and radiological prognostic factors.Methods Data from 1,066 patients with severe TBI from 5 prospective studies were analyzed. We determined the association between hospital mortality and the combination of GCS, pupil reactivity, age, glucose levels, cranial computed tomography (CT), or the GCS-P score by multivariate binary logistic regression.Results Eighty-five percent ( n = 908) of patients were men. The mean age was 35 years old, and the overall hospital mortality was 32.8%. The area under the receiver operating characteristic curve (AUROC) was 0.73 (0.70-0.77) for the model using the GCS-P score and 0.80 (0.77-0.83) for the model including clinical and radiological variables. The GCS-P score showed similar accuracy in predicting the mortality reported for the patients with severe TBI derived from the International Mission for Prognosis and Clinical Trials in TBI (IMPACT) and the Corticosteroid Randomization After Significant Head Injury (CRASH) studies.Conclusion Our results support the external validation of the GCS-P to predict hospital mortality following a severe TBI. The predictive value of the GCS-P for long-term mortality, functional, and neuropsychiatric outcomes in Brazilian patients with mild, moderate, and severe TBI deserves further investigation.}, keywords = {MORTALITY; Prognosis; Brain Injuries; Glasgow coma scale; Pupil; traumatic}, year = {2023}, eissn = {1678-4227}, pages = {452-459}, orcid-numbers = {Melo, Hiago Murilo/0000-0002-8152-7773; Lin, Katia/0000-0002-5401-7524; Kupek, Emil/0000-0001-6704-1673} } @article{MTMT:34181750, title = {Mining the contribution of intensive care clinical course to outcome after traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34181750}, author = {Bhattacharyay, S. and Caruso, P.F. and Åkerlund, C. and Wilson, L. and Stevens, R.D. and Menon, D.K. and Steyerberg, E.W. and Nelson, D.W. and Ercole, A.}, doi = {10.1038/s41746-023-00895-8}, journal-iso = {NPJ DIGIT MED}, journal = {NPJ DIGITAL MEDICINE}, volume = {6}, unique-id = {34181750}, year = {2023}, eissn = {2398-6352} } @article{MTMT:34288228, title = {Influence of Sociodemographic, Premorbid, and Injury-Related Factors on Post-Traumatic Stress, Anxiety, and Depression after Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/34288228}, author = {Bockhop, Fabian and Cunitz, Katrin and Zeldovich, Marina and Buchheim, Anna and Beissbarth, Tim and Hagmayer, York and von Steinbuechel, Nicole}, doi = {10.3390/jcm12123873}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {34288228}, abstract = {Psychopathological symptoms are common sequelae after traumatic brain injury (TBI), leading to increased personal and societal burden. Previous studies on factors influencing Post-traumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), and Major Depressive Disorder (MDD) after TBI have produced inconclusive results, partly due to methodological limitations. The current study investigated the influence of commonly proposed factors on the clinical impairment, occurrence, frequency, and intensity of symptoms of PTSD, GAD, and MDD after TBI. The study sample comprised 2069 individuals (65% males). Associations between psychopathological outcomes and sociodemographic, premorbid, and injury-related factors were analyzed using logistic regression, standard, and zero-inflated negative binomial models. Overall, individuals experienced moderate levels of PTSD, GAD, and MDD. Outcomes correlated with early psychiatric assessments across domains. The clinical impairment, occurrence, frequency, and intensity of all outcomes were associated with the educational level, premorbid psychiatric history, injury cause, and functional recovery. Distinct associations were found for injury severity, LOC, and clinical care pathways with PTSD; age and LOC:sex with GAD; and living situation with MDD, respectively. The use of suitable statistical models supported the identification of factors associated with the multifactorial etiology of psychopathology after TBI. Future research may apply these models to reduce personal and societal burden.}, keywords = {traumatic brain injury; generalized anxiety disorder; MAJOR DEPRESSIVE DISORDER; Post-Traumatic Stress Disorder; negative and zero-inflated negative binomial model}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Bockhop, Fabian/0000-0001-8892-896X; Cunitz, Katrin/0000-0001-5530-8190; Zeldovich, Marina/0000-0003-0172-9904; Buchheim, Anna/0000-0002-1339-5246; Beissbarth, Tim/0000-0001-6509-2143} } @{MTMT:34560419, title = {Functional Neuroradiology of Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/34560419}, author = {Boffa, G. and Raz, E. and Inglese, M.}, booktitle = {Functional Neuroradiology: Principles and Clinical Applications}, doi = {10.1007/978-3-031-10909-6_14}, unique-id = {34560419}, year = {2023}, pages = {355-371} } @article{MTMT:34307955, title = {Cardiac Point-of-Care Ultrasound in Pediatric Neurocritical Care: A Case Series}, url = {https://m2.mtmt.hu/api/publication/34307955}, author = {Boggs, Kaitlyn and Kirschen, Matthew and Glau, Christie and Chen, Shih-Shan Lang and Himebauch, Adam S. and Huh, Jimmy and Conlon, Thomas}, doi = {10.1016/j.pediatrneurol.2023.03.017}, journal-iso = {PEDIATR NEUROL}, journal = {PEDIATRIC NEUROLOGY}, volume = {144}, unique-id = {34307955}, issn = {0887-8994}, abstract = {Background: Pediatric brain injury is accompanied by hemodynamic perturbations complicating the optimization of cerebral physiology. Point-of-care ultrasound (POCUS) uses dynamic real-time imaging to complement the physical examination and identify hemodynamic abnormalities in preload, contractility, and afterload conditions, but the contribution of cardiac POCUS in the context of pediatric brain injury is unclear.Methods: We reviewed cardiac POCUS images integrated in clinical care to examine those with neuro-logical injury and hemodynamic abnormalities.Results: We discuss three children with acute brain injury and myocardial dysfunction identified using cardiac POCUS by bedside clinicians.Conclusions: Cardiac POCUS may have an important role in caring for children with neurologic injury. These patients received personalized care informed by POCUS data in attempts to stabilize hemodynamics and optimize clinical outcomes.(c) 2023 Elsevier Inc. All rights reserved.}, keywords = {Pediatrics; CARDIAC DYSFUNCTION; Neurological injury; POCUS; Point -of -care ultrasound}, year = {2023}, eissn = {1873-5150}, pages = {56-59}, orcid-numbers = {Boggs, Kaitlyn/0000-0003-4135-3809; Kirschen, Matthew/0000-0003-3585-2687; Glau, Christie/0000-0003-1583-4609; Conlon, Thomas/0000-0002-0703-484X} } @article{MTMT:34307973, title = {What Happens Next? Traumatic Brain Injury in the Community}, url = {https://m2.mtmt.hu/api/publication/34307973}, author = {Bragge, Peter and Wright, Breanna and Grundy, Emily and Goodwin, Denise and Gozt, Aleksandra and Clynes, Lucy and Calabritto, Mia and Fitzgerald, Melinda}, doi = {10.1097/HTR.0000000000000824}, journal-iso = {J HEAD TRAUMA REHAB}, journal = {JOURNAL OF HEAD TRAUMA REHABILITATION}, volume = {38}, unique-id = {34307973}, issn = {0885-9701}, abstract = {Traumatic brain injury (TBI) continues to substantially impact the lives of millions of people around the world annually. Community-based prevention and support of TBI are particularly challenging and underresearched aspects of TBI management. Ongoing cognitive, emotional, and other effects of TBI are not immediately obvious in community settings such as schools, workplaces, sporting clubs, aged care facilities, and support agencies providing homelessness or domestic violence support. This is compounded by a lack of guidance and support materials designed for nonmedical settings. Connectivity Australia, a not-for-profit organization promoting TBI awareness, research, and support, responded to this need by conducting a national survey and series of roundtables to deepen understanding of TBI awareness, challenges, and support needs across the community. The 48 survey respondents and 22 roundtable participants represented Australian departments of health; correctional services; homelessness and housing; Aboriginal and Torres Strait Islander health; community, school, and professional sports; allied healthcare and rehabilitation providers; insurance; and work health and safety. Three key themes were identified: Accessible, nationally consistent plain-language guidelines; Building research literacy; and Knowing your role in TBI identification and management. This commentary briefly describes these themes and their implications based on a publicly available full report detailing the study findings(www.connectivity.org.au/resources-for-researchers/connectivity-research).}, keywords = {Brain Injuries; traumatic brain injury; social services; community sports; jurisdictional services; management of brain injury}, year = {2023}, eissn = {1550-509X}, pages = {279-282}, orcid-numbers = {Fitzgerald, Melinda/0000-0002-4823-8179} } @article{MTMT:34023886, title = {Stress and traumatic brain injury: An inherent bi-directional relationship with temporal and synergistic complexities}, url = {https://m2.mtmt.hu/api/publication/34023886}, author = {Brand, J. and McDonald, S.J. and Gawryluk, J.R. and Christie, B.R. and Shultz, S.R.}, doi = {10.1016/j.neubiorev.2023.105242}, journal-iso = {NEUROSCI BIOBEHAV R}, journal = {NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS}, volume = {151}, unique-id = {34023886}, issn = {0149-7634}, abstract = {Traumatic brain injury (TBI) and stress are prevalent worldwide and can both result in life-altering health problems. While stress often occurs in the absence of TBI, TBI inherently involves some element of stress. Furthermore, because there is pathophysiological overlap between stress and TBI, it is likely that stress influences TBI outcomes. However, there are temporal complexities in this relationship (e.g., when the stress occurs) that have been understudied despite their potential importance. This paper begins by introducing TBI and stress and highlighting some of their possible synergistic mechanisms including inflammation, excitotoxicity, oxidative stress, hypothalamic-pituitary-adrenal axis dysregulation, and autonomic nervous system dysfunction. We next describe different temporal scenarios involving TBI and stress and review the available literature on this topic. In doing so we find initial evidence that in some contexts stress is a highly influential factor in TBI pathophysiology and recovery, and vice versa. We also identify important knowledge gaps and suggest future research avenues that will increase our understanding of this inherent bidirectional relationship and could one day result in improved patient care. © 2023 The Authors}, keywords = {glutamate; Cytokines; immune response; Reactive oxygen species; neuroinflammation; allostatic overload; ANS, HPA-axis microglia; Glucocorticoids, treatment}, year = {2023}, eissn = {1873-7528} } @article{MTMT:34555903, title = {Prediction of therapeutic intensity level from automatic multiclass segmentation of traumatic brain injury lesions on CT-scans}, url = {https://m2.mtmt.hu/api/publication/34555903}, author = {Brossard, Clement and Greze, Jules and de, Busschere Jules-Arnaud and Attye, Arnaud and Richard, Marion and Tornior, Florian Dhaussy and Acquitter, Clement and Payen, Jean-Francois and Barbier, Emmanuel L. and Bouzat, Pierre and Lemasson, Benjamin}, doi = {10.1038/s41598-023-46945-9}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34555903}, issn = {2045-2322}, abstract = {The prediction of the therapeutic intensity level (TIL) for severe traumatic brain injury (TBI) patients at the early phase of intensive care unit (ICU) remains challenging. Computed tomography images are still manually quantified and then underexploited. In this study, we develop an artificial intelligence-based tool to segment brain lesions on admission CT-scan and predict TIL within the first week in the ICU. A cohort of 29 head injured patients (87 CT-scans; Dataset1) was used to localize (using a structural atlas), segment (manually or automatically with or without transfer learning) 4 or 7 types of lesions and use these metrics to train classifiers, evaluated with AUC on a nested cross-validation, to predict requirements for TIL sum of 11 points or more during the 8 first days in ICU. The validation of the performances of both segmentation and classification tasks was done with Dice and accuracy scores on a sub-dataset of Dataset1 (internal validation) and an external dataset of 12 TBI patients (12 CT-scans; Dataset2). Automatic 4-class segmentation (without transfer learning) was not able to correctly predict the apparition of a day of extreme TIL (AUC=6023%). In contrast, manual quantification of volumes of 7 lesions and their spatial location provided a significantly better prediction power (AUC=89 +/- 17%). Transfer learning significantly improved the automatic 4-class segmentation (DICE scores 0.63 vs 0.34) and trained more efficiently a 7-class convolutional neural network (DICE=0.64). Both validations showed that segmentations based on transfer learning were able to predict extreme TIL with better or equivalent accuracy (83%) as those made with manual segmentations. Our automatic characterization (volume, type and spatial location) of initial brain lesions observed on CT-scan, publicly available on a dedicated computing platform, could predict requirements for high TIL during the first 8 days after severe TBI. Transfer learning strategies may improve the accuracy of CNN-based segmentation models.}, keywords = {CLASSIFICATION; SCALE}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Barbier, Emmanuel L./0000-0002-4952-1240} } @article{MTMT:34307927, title = {Who Would Have Thought It? Intestinal Surgery May Prove To Be the Most Effective Therapy For Traumatic Brain Injury (TBI): a Hypothesis and a Challenge}, url = {https://m2.mtmt.hu/api/publication/34307927}, author = {Buchwald, Henry and McGlennon, Tim and Roberts, Arthur and Ahnfeldt, Eric and Buchwald, Jane and Pories, Walter}, doi = {10.1007/s11695-023-06613-3}, journal-iso = {OBES SURG}, journal = {OBESITY SURGERY}, volume = {33}, unique-id = {34307927}, issn = {0960-8923}, year = {2023}, eissn = {1708-0428}, pages = {2629-2631} } @article{MTMT:34307958, title = {High risk and low prevalence diseases: Blast injuries}, url = {https://m2.mtmt.hu/api/publication/34307958}, author = {Bukowski, Josh and Nowadly, Craig D. and Schauer, Steven G. and Koyfman, Alex and Long, Brit}, doi = {10.1016/j.ajem.2023.05.003}, journal-iso = {AM J EMERG MED}, journal = {AMERICAN JOURNAL OF EMERGENCY MEDICINE}, volume = {70}, unique-id = {34307958}, issn = {0735-6757}, abstract = {Introduction: Blast injury is a unique condition that carries a high rate of morbidity and mortality, often with mixed penetrating and blunt injuries. Objective: This review highlights the pearls and pitfalls of blast injuries, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence. Discussion: Explosions may impact multiple organ systems through several mechanisms. Patients with suspected blast injury and multisystem trauma require a systematic evaluation and resuscitation, as well as investigation for injuries specific to blast injuries. Blast injuries most commonly affect air -filled organs but can also result in se-vere cardiac and brain injury. Understanding blast injury patterns and presentations is essential to avoid misdi-agnosis and balance treatment of competing interests of patients with polytrauma. Management of blast victims can also be further complicated by burns, crush injury, resource limitation, and wound infection. Given the significant morbidity and mortality associated with blast injury, identification of various injury patterns and appropriate management are essential. Conclusions: An understanding of blast injuries can assist emergency clinicians in diagnosing and managing this potentially deadly disease. Published by Elsevier Inc.}, keywords = {explosion; wound; blast injury; improvised explosive device; IED; combat; military}, year = {2023}, eissn = {1532-8171}, pages = {46-56} } @article{MTMT:34560455, title = {Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/34560455}, author = {Cai, L.T. and Brett, B.L. and Palacios, E.M. and Yuh, E.L. and Bourla, I. and Wren-Jarvis, J. and Wang, Y. and Mac, Donald C. and Diaz-Arrastia, R. and Giacino, J.T. and Okonkwo, D.O. and Levin, H.S. and Robertson, C.S. and Temkin, N. and Markowitz, A.J. and Manley, G.T. and Stein, M.B. and McCrea, M.A. and Zafonte, R.D. and Nelson, L.D. and Mukherjee, P. and Ferguson, A.R. and Taylor, S.R. and Yue, J.K. and Jha, R. and Gopinath, S. and Jain, S. and Ngwenya, L.B. and Badjatia, N. and Gullapalli, R. and Korley, F.K. and Puccio, A.M. and Schnyer, D. and Madden, C. and Grandhi, R. and Dirk, Keene C. and Merchant, R. and TRACK-TBI, Investigators}, doi = {10.1016/j.bpsc.2022.08.015}, journal-iso = {BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGINING}, journal = {BIOLOGICAL PSYCHIATRY: COGNITIVE NEUROSCIENCE AND NEUROIMAGING}, unique-id = {34560455}, issn = {2451-9022}, year = {2023}, eissn = {2451-9030} } @article{MTMT:34560246, title = {Application of analgesia and sedation under BIS monitoring combined with hydraulic coupling intracranial pressure monitoring in severe craniocerebral injury}, url = {https://m2.mtmt.hu/api/publication/34560246}, author = {Cai, Y. and Dong, Z. and Zhong, X. and Wang, Y. and Yang, J. and Zhao, C. and Fei, Z. and Zhang, L. and Gu, H. and Yang, T.}, doi = {10.3760/cma.j.cn121430-20231023-00171}, journal-iso = {CHINESE CRITIC CARE MED}, journal = {CHINESE CRITICAL CARE MEDICINE}, volume = {35}, unique-id = {34560246}, issn = {2095-4352}, year = {2023}, pages = {1274-1280} } @article{MTMT:33917156, title = {The kinase inhibitory region of SOCS3 attenuates reactive astrogliosis and astroglial scar in mice after traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/33917156}, author = {Cai, Zhenlu and Zhang, Zixuan and Zhang, Liyun and Tan, Ruolan and Wang, Yu and Sun, Meiqi and Hu, Xiaoxuan and Ge, Qian and An, Jing and Lu, Haixia}, doi = {10.1016/j.jchemneu.2023.102273}, journal-iso = {J CHEM NEUROANAT}, journal = {JOURNAL OF CHEMICAL NEUROANATOMY}, volume = {131}, unique-id = {33917156}, issn = {0891-0618}, abstract = {Traumatic brain injury (TBI) leads to reactive astrogliosis that impedes neural repair/regeneration. It has been proven that SOCS3 attenuates astrocyte activation by inhibiting the JAK2-STAT3 pathway. However, whether the kinase inhibitory region (KIR) of SOCS3 can be directly applied to mediate astrocyte activation after TBI is not clear. The present study aimed at investigating the inhibitory effect of KIR on reactive astrogliosis and its potential neuroprotection after TBI insult. For this purpose, A TBI model was developed by the free impact of heavy objects in adult mice. KIR was linked to the TAT peptide (TAT-KIR) to facilitate cell membrane penetration and intracranially injected into the cerebral cortex adjacent to the TBI lesion. Then reactive astrogliosis, activity of JAK2-STAT3 pathway, neuron loss, and function deficit were observed. Our results showed a decrease in neuron loss and an improvement in neural function. Meanwhile, Intracranial injection of TAT-KIR in TBI mice demonstrated a reduction of GFAP-positive astrocytes as well as C3/GFAP double-labeled A1 reactive astrocytes. Western blot analysis illustrated that the activity of the JAK2-STAT3 pathway was significantly inhibited by TAT-KIR. We conclude that exogenous treatment TAT-KIR, through suppression of JAK2-STAT3 activity, inhibits TBI-induced reactive astrogliosis induced, thereby alleviating the loss of neurons and relieving the neural function deficit. This investigation suggests that TAT-KIR could be a potential therapeutic strategy for enhancing neural regeneration following}, keywords = {traumatic brain injury; STAT3; Reactive astrogliosis; Kinase inhibitory region; TAT-KIR}, year = {2023}, eissn = {1873-6300} } @article{MTMT:34555899, title = {Use of Virtual Reality in Patients with Acquired Brain Injury: A Systematic Review}, url = {https://m2.mtmt.hu/api/publication/34555899}, author = {Calderone, Andrea and Carta, Diamante and Cardile, Davide and Quartarone, Angelo and Rifici, Carmela and Calabro, Rocco Salvatore and Corallo, Francesco}, doi = {10.3390/jcm12247680}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {34555899}, abstract = {Background and Objectives: ABI is found in all societies as the most severe, disabling neurological disorder. A cognitive rehabilitation program is essential for the clinical recovery of these patients, improving functional outcomes and quality of life. Modern technologies such as virtual reality (VR) offer several advantages over traditional therapies, including the ability to engage people in simulated performance of functional tasks. This review will examine the studies in which virtual reality has been used as an aid, technique, or intervention in patients with acquired brain injury. Materials and Methods: Studies were identified from an online search of PubMed, Cochrane Library, and Web of Science databases. Results: We found that TBI patients responded positively to VR treatment depending on the damaged or impaired cognitive and motor functions they acquired. It is now a tool that is available in the rehabilitation of these patients and supports the recovery of various motor and cognitive functions. Conclusions: This review has shown that VR is an intervention technique that increasingly exists in clinical rehabilitation practice for ABI patients. The device uses advanced technologies that can cause general changes in cognitive, motor, and psychological aspects and create a simulated environment that can partially restore these functions and behaviors, as well as the behaviors of everyday life.}, keywords = {Therapy; Reliability; Exercise; Cognitive function; TASK; STROKE PATIENTS; rehabilitation; PEOPLE; cognitive rehabilitation; Neurorehabilitation; traumatic brain injuries; Acquired brain injuries}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Cardile, Davide/0000-0003-2052-0970} } @article{MTMT:34265352, title = {Repetitive, but Not Single, Mild Blast TBI Causes Persistent Neurological Impairments and Selective Cortical Neuronal Loss in Rats}, url = {https://m2.mtmt.hu/api/publication/34265352}, author = {Campos-Pires, Rita and Ong, Bee Eng and Koziakova, Mariia and Ujvari, Eszter and Fuller, Isobel and Boyles, Charlotte and Sun, Valerie and Ko, Andy and Pap, Daniel and Lee, Matthew and Gomes, Lauren and Gallagher, Kate and Mahoney, Peter F. and Dickinson, Robert}, doi = {10.3390/brainsci13091298}, journal-iso = {BRAIN SCI}, journal = {BRAIN SCIENCES}, volume = {13}, unique-id = {34265352}, abstract = {Exposure to repeated mild blast traumatic brain injury (mbTBI) is common in combat soldiers and the training of Special Forces. Evidence suggests that repeated exposure to a mild or subthreshold blast can cause serious and long-lasting impairments, but the mechanisms causing these symptoms are unclear. In this study, we characterise the effects of single and tightly coupled repeated mbTBI in Sprague–Dawley rats exposed to shockwaves generated using a shock tube. The primary outcomes are functional neurologic function (unconsciousness, neuroscore, weight loss, and RotaRod performance) and neuronal density in brain regions associated with sensorimotor function. Exposure to a single shockwave does not result in functional impairments or histologic injury, which is consistent with a mild or subthreshold injury. In contrast, exposure to three tightly coupled shockwaves results in unconsciousness, along with persistent neurologic impairments. Significant neuronal loss following repeated blast was observed in the motor cortex, somatosensory cortex, auditory cortex, and amygdala. Neuronal loss was not accompanied by changes in astrocyte reactivity. Our study identifies specific brain regions particularly sensitive to repeated mbTBI. The reasons for this sensitivity may include exposure to less attenuated shockwaves or proximity to tissue density transitions, and this merits further investigation. Our novel model will be useful in elucidating the mechanisms of sensitisation to injury, the temporal window of sensitivity and the evaluation of new treatments.}, year = {2023}, eissn = {2076-3425}, pages = {1298} } @article{MTMT:34404374, title = {Post-Concussion Symptoms and Disability in Adults With Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34404374}, author = {Cancelliere, C. and Verville, L. and Stubbs, J.L. and Yu, H. and Hincapié, C.A. and Cassidy, J.D. and Wong, J.J. and Shearer, H.M. and Connell, G. and Southerst, D. and Howitt, S. and Guist, B. and Silverberg, N.D.}, doi = {10.1089/neu.2022.0185}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {40}, unique-id = {34404374}, issn = {0897-7151}, year = {2023}, eissn = {1557-9042}, pages = {1045-1059} } @article{MTMT:34408000, title = {Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study}, url = {https://m2.mtmt.hu/api/publication/34408000}, author = {Cardoso, Maira Gloria de Freitas and de, Barros Joao Luis Vieira Monteiro and de, Queiroz Rafael Alves Bonfim and Rocha, Natalia Pessoa and Silver, Carlisa and da, Silva Agnes Stephanie and da, Silva Ewelin Wasner Machado and Roque, Isadora Goncalves and Carvalho, Julia de Lima and dos, Santos Laura Ferreira and Cota, Leticia Bitencourt and Lemos, Lucas Miranda and Miranda, Mariana Figueiredo and Miranda, Millena Figueiredo and Vianna, Pedro Parenti and Oliveira, Rafael Arantes and Furlam, Tiago de Oliveira and Soares, Tulio Safar Sarquis and Pedroso, Vinicius Sousa Pietra and Faleiro, Rodrigo Moreira and Vieira, Erica Leandro Marciano and Teixeira, Antonio Lucio and de, Souza Leonardo Cruz and de, Miranda Aline Silva}, doi = {10.1016/j.bbr.2023.114457}, journal-iso = {BEHAV BRAIN RES}, journal = {BEHAVIOURAL BRAIN RESEARCH}, volume = {449}, unique-id = {34408000}, issn = {0166-4328}, abstract = {Very few studies have investigated cognition and impulsivity following mild traumatic brain injury (mTBI) in the general population. Furthermore, the neurobiological mechanisms underlying post-TBI neurobehavioral syn-dromes are complex and remain to be fully clarified. Herein, we took advantage of machine learning based -modeling to investigate potential biomarkers of mTBI-associated impulsivity. Twenty-one mTBI patients were assessed within one-month post-TBI and their data were compared to 19 healthy controls on measures of impulsivity (Barratt Impulsiveness Scale - BIS), executive functioning, episodic memory, self-report cognitive failures and blood biomarkers of inflammation, vascular and neuronal damage. mTBI patients were significantly more impulsive than controls in BIS total and subscales. Serum levels of sCD40L, Cathepsin D, IL-4, Neuropilin-1, IFN-alpha 2, and Copeptin were associated with impulsivity in mTBI patients. Besides showing that mTBI are asso-ciated with impulsivity in non-military people, we unveiled different pathophysiological pathways potentially implicated in mTBI-related impulsivity.}, keywords = {Inflammation; SERUM; ASSOCIATION; IMPULSIVITY; diagnosis; anxiety; Behavioral Sciences; INHIBITORY CONTROL; mTBI; blood biomarkers; MIGRATION INHIBITORY FACTOR; Neuron-specific enolase; COPEPTIN; GELATINASE-ASSOCIATED LIPOCALIN}, year = {2023}, eissn = {1872-7549} } @article{MTMT:34307961, title = {Dietary (Poly)phenols in Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/34307961}, author = {Carecho, Rafael and Carregosa, Diogo and Ratilal, Bernardo Oliveira and Figueira, Ines and Angeles Avila-Galvez, Maria and dos Santos, Claudia Nunes and Loncarevic-Vasiljkovic, Natasa}, doi = {10.3390/ijms24108908}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34307961}, issn = {1661-6596}, abstract = {Traumatic brain injury (TBI) remains one of the leading causes of death and disability in young adults worldwide. Despite growing evidence and advances in our knowledge regarding the multifaceted pathophysiology of TBI, the underlying mechanisms, though, are still to be fully elucidated. Whereas initial brain insult involves acute and irreversible primary damage to the brain, the processes of subsequent secondary brain injury progress gradually over months to years, providing a window of opportunity for therapeutic interventions. To date, extensive research has been focused on the identification of druggable targets involved in these processes. Despite several decades of successful pre-clinical studies and very promising results, when transferred to clinics, these drugs showed, at best, modest beneficial effects, but more often, an absence of effects or even very harsh side effects in TBI patients. This reality has highlighted the need for novel approaches that will be able to respond to the complexity of the TBI and tackle TBI pathological processes on multiple levels. Recent evidence strongly indicates that nutritional interventions may provide a unique opportunity to enhance the repair processes after TBI. Dietary (poly)phenols, a big class of compounds abundantly found in fruits and vegetables, have emerged in the past few years as promising agents to be used in TBI settings due to their proven pleiotropic effects. Here, we give an overview of the pathophysiology of TBI and the underlying molecular mechanisms, followed by a state-of-the-art summary of the studies that have evaluated the efficacy of (poly)phenols administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. The current limitations on our knowledge concerning (poly)phenol effects in TBI in the pre-clinical studies are also discussed.}, keywords = {Inflammation; neurodegeneration; secondary brain injury; Oxidative stress}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Carregosa, Diogo/0000-0002-1396-3039; Figueira, Ines/0000-0003-4639-6883; Loncarevic-Vasiljkovic, Natasa/0000-0002-8350-1390} } @article{MTMT:33911648, title = {Serum assessment of traumatic axonal injury: the correlation of GFAP, t-Tau, UCH-L1, and NfL levels with diffusion tensor imaging metrics and its prognosis utility}, url = {https://m2.mtmt.hu/api/publication/33911648}, author = {Castano-Leon, Ana M. and Carabias, Cristina Sanchez and Hilario, Amaya and Ramos, Ana and Navarro-Main, Blanca and Paredes, Igor and Munarriz, Pablo M. and Panero, Irene and Fernandez, Carla Eiriz and Garcia-Perez, Daniel and Moreno-Gomez, Luis Miguel and Esteban-Sinovas, Olga and Posadas, Guillermo Garcia and Gomez, Pedro A. and Lagares, Alfonso}, doi = {10.3171/2022.5.JNS22638}, journal-iso = {J NEUROSURG}, journal = {JOURNAL OF NEUROSURGERY}, volume = {138}, unique-id = {33911648}, issn = {0022-3085}, abstract = {OBJECTIVE Diagnosis of traumatic axonal injury (TAI) is challenging because of its underestimation by conventional MRI and the technical requirements associated with the processing of diffusion tensor imaging (DTI). Serum biomark-ers seem to be able to identify patients with abnormal CT scanning findings, but their potential role to assess TAI has seldomly been explored.METHODS Patients with all severities of traumatic brain injury (TBI) were prospectively included in this study between 2016 and 2021. They underwent blood extraction within 24 hours after injury and imaging assessment, including DTI. Serum concentrations of glial fibrillary acidic protein, total microtubule-associated protein (t-Tau), ubiquitin C-terminal hydrolase L1 (UCH-L1), and neurofilament light chain (NfL) were measured using an ultrasensitive Simoa multiplex assay panel, a digital form of enzyme-linked immunosorbent assay. The Glasgow Outcome Scale-Extended score was determined at 6 months after TBI. The relationships between biomarker concentrations, volumetric analysis of corpus callosum (CC) lesions, and fractional anisotropy (FA) were analyzed by nonparametric tests. The prognostic utility of the biomarker was determined by calculating the C-statistic and an ordinal regression analysis.RESULTS A total of 87 patients were included. Concentrations of all biomarkers were significantly higher for patients compared with controls. Although the concentration of the biomarkers was affected by the presence of mass lesions, FA of the CC was an independent factor influencing levels of UCH-L1 and NfL, which positioned these two biomarkers as better surrogates of TAI. Biomarkers also performed well in determining patients who would have had unfavorable outcome. NfL and the FA of the CC are independent complementary factors related to outcome.CONCLUSIONS UCH-L1 and NfL seem to be the biomarkers more specific to detect TAI. The concentration of NfL combined with the FA of the CC might help predict long-term outcome. https://thejns.org/doi/abs/10.3171/2022.5.JNS22638 KEYWORDS serum; biomarker; traumatic axonal injury; fractional anisotropy; outcome; trauma; traumatic brain injury}, keywords = {SERUM; traumatic brain injury; TRAUMA; biomarker; outcome; fractional anisotropy; traumatic axonal injury}, year = {2023}, eissn = {1933-0693}, pages = {454-464}, orcid-numbers = {Gomez, Pedro A./0000-0002-4185-5238} } @article{MTMT:33917193, title = {Prolonged and intense neuroinflammation after severe traumatic brain injury assessed by cerebral microdialysis with 300 kDa membranes}, url = {https://m2.mtmt.hu/api/publication/33917193}, author = {Cederberg, David and Visse, Edward and Marklund, Niklas and Siesjo, Peter}, doi = {10.1016/j.jneuroim.2023.578020}, journal-iso = {J NEUROIMMUNOL}, journal = {JOURNAL OF NEUROIMMUNOLOGY}, volume = {377}, unique-id = {33917193}, issn = {0165-5728}, abstract = {Background: A neuroinflammatory response that may lead to edema and secondary brain damage is elicited in severe traumatic brain injury (TBI). Previous studies using microdialysis (MD) membranes with 100 k Dalton (kDa) cut-off found a transient intracerebral release of cytokines and chemokines without significant correlations to clinical course, intracranial pressure (ICP) or metabolites. In this study, a (300 kDa) MD probe was used to measure the levels of cytokines and chemokines in relation to ICP and metabolites.Methods: Seven patients with severe TBI received 2 MD catheters. In four patients sufficient dialysate could be retrieved for analysis from both catheters. MD samples were analyzed bedside, then frozen and analyzed for chemokines and cytokines using a multiplex assay (Mesoscale Discovery).Results: MD sampling was performed from 9 to 350 h. In total, 17 chemokines and cytokines were detected. Of these, IL-6, IL-8, IP-10, MCP-1 and MIP-1 beta were consistently elevated, and investigated further in relation to metabolites, and ICP. Levels of chemokines and cytokines were higher than previously reported from TBI pa-tients, and partially higher than those reported in patients with cytokine release syndrome. There were no significant differences between the two catheters regarding cytokine/chemokine concentrations, except for IL-6 which was higher in the peri-contusional area. No correlation with metabolites and ICP was observed. No significant increase or decline of chemokine or cytokine secretion was observed during the study period.Conclusion: Our data suggest that cytokine and chemokine levels reflect a perpetual, potent and pan-cerebebral inflammatory response that persists beyond 15 days following TBI.}, keywords = {Brain Injuries; neuroinflammation; brain metabolism; MICRODIALYSIS; Traumatic/pathology}, year = {2023}, eissn = {1872-8421} } @article{MTMT:34238146, title = {Equity considerations in clinical practice guidelines for traumatic brain injury and homelessness: a systematic review}, url = {https://m2.mtmt.hu/api/publication/34238146}, author = {Chan, Vincy and Estrella, Maria Jennifer and Hanafy, Sara and Colclough, Zoe and Joyce, Julie Michele and Babineau, Jessica and Colantonio, Angela}, doi = {10.1016/j.eclinm.2023.102152}, journal-iso = {ECLINICALMEDICINE}, journal = {ECLINICALMEDICINE}, volume = {63}, unique-id = {34238146}, issn = {2589-5370}, abstract = {Background Clinical practice guidelines (CPGs) predominantly prioritise treatment and cost-effectiveness, which encourages a universal approach that may not address the circumstances of disadvantaged groups. We aimed to advance equity and quality of care for individuals experiencing homelessness and traumatic brain injury (TBI) by assessing the extent to which homelessness and TBI are integrated in CPGs for TBI and CPGs for homelessness, respectively, and the extent to which equity, including consideration of disadvantaged populations and the PROGRESS-Plus framework, is considered in these CPGs.Methods For this systematic review, CPGs for TBI or homelessness were identified from electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), targeted websites, Google Search, and reference lists of eligible CPGs on November 16, 2021 and March 16, 2023. The proportion of CPGs that integrated evidence regarding TBI and homelessness was identified and qualitative content analysis was conducted to understand how homelessness is integrated in CPGs for TBI and vice versa. Equity assessment tools were utilised to understand the extent to which equity was considered in these CPGs. This review is registered with PROSPERO (CRD42021287696).Findings Fifty-eight CPGs for TBI and two CPGs for homelessness met inclusion criteria. Only three CPGs for TBI integrated evidence regarding homelessness by recognizing the prevalence of TBI in individuals experiencing homelessness and identifying housing as a consideration in the assessment and management of TBI. The two CPGs for homelessness acknowledged TBI as prevalent and recognised individuals experiencing TBI and homelessness as a disadvantaged population that should be prioritised in guideline development. Equity was rarely considered in the content and development of CPGs for TBI.Interpretation Considerations for equity in CPGs for homelessness and TBI are lacking. To ensure that CPGs reflect and address the needs of individuals experiencing homelessness and TBI, we have identified several guideline development priorities. Namely, there is a need to integrate evidence regarding homelessness and TBI in CPGs for TBI and CPGs for homelessness, respectively and engage disadvantaged populations in all stages of guideline development. Further, this review highlights an urgent need to conduct research focused on and with disadvantaged populations.}, keywords = {Health; traumatic brain injury; inequity; Evidence-Based Practice; concussion; Clinical practice guideline; homeless; Knowledge synthesis; disadvantaged populations}, year = {2023}, eissn = {2589-5370} } @article{MTMT:34307956, title = {Rehabilitation among individuals with traumatic brain injury who intersect with the criminal justice system: A scoping review}, url = {https://m2.mtmt.hu/api/publication/34307956}, author = {Chan, Vincy and Estrella, Maria Jennifer and Syed, Shazray and Lopez, Allison and Shah, Riya and Colclough, Zoe and Babineau, Jessica and Beaulieu-Dearman, Zacharie and Colantonio, Angela}, doi = {10.3389/fneur.2022.1052294}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {13}, unique-id = {34307956}, issn = {1664-2295}, abstract = {Traumatic brain injury (TBI), a leading cause of morbidity and mortality globally, is highly prevalent among individuals who intersect with the criminal justice system (CJS). It is well-established that TBI negatively impacts individuals' interactions both within the CJS and upon release and is associated with serious disciplinary charges and higher recidivism rates. Although rehabilitation is fundamental to TBI recovery, it is not known to what extent rehabilitation is available to, or used by, individuals who intersect with the CJS. This scoping review explores the availability and extent of rehabilitation for individuals with TBI who intersect with the CJS, based on available literature. A systematic search of electronic databases (MEDLINE, Embase, Cochrane CENTRAL Register of Clinical Trials, CINAHL, APA PsycINFO, Applied Social Sciences Index and Abstracts, and Proquest Nursing and Allied Health), relevant organizations' websites, and reference lists of eligible articles identified 22 peer-reviewed articles and 2 gray literature reports that met predetermined eligibility criteria. Extracted data were synthesized through a descriptive numerical summary and qualitative content analysis. This review provides evidence that existing rehabilitation interventions are already serving individuals with TBI with a history of CJS involvement; however, they rarely consider or acknowledge TBI or CJS in their interventions. Findings also suggest opportunities to integrate rehabilitation for individuals with TBI who intersect with the CJS through TBI screening, education on TBI within CJS settings, and linkages to the community to facilitate continuity of care. This review also highlights significant gaps in knowledge regarding sex, gender, and other intersecting factors. Research to understand how these experiences impact the rehabilitation process throughout the CJS is urgently needed to enable timely and appropriate rehabilitation and continuity of care for diverse individuals with TBI who intersect with the CJS.}, keywords = {traumatic brain injury; rehabilitation; concussion; criminal justice; Knowledge synthesis}, year = {2023}, eissn = {1664-2295} } @article{MTMT:34560407, title = {Posttraumatic stress disorder and mild traumatic brain injury – common consequences of war: Issues of pathogenesis and differential diagnosis (review)}, url = {https://m2.mtmt.hu/api/publication/34560407}, author = {Chebotaryova, L.L. and Kovalenko, O.Ye. and Solonovych, A.S. and Solonovych, O.S.}, doi = {10.30841/2786-720X.2.2023.282496}, journal-iso = {Fam. Med. Eur. Prac.}, journal = {Family Medicine. European Practices}, volume = {2023}, unique-id = {34560407}, issn = {2786-720X}, year = {2023}, pages = {64-72} } @article{MTMT:34307941, title = {Probucol treatment after traumatic brain injury activates BDNF/TrkB pathway, promotes neuroregeneration and ameliorates functional deficits in mice}, url = {https://m2.mtmt.hu/api/publication/34307941}, author = {Chen, Chen-Mei and Gung, Pei-Yu and Ho, Yen-Chun and Hamdin, Candra D. D. and Yet, Shaw-Fang}, doi = {10.1111/bph.16157}, journal-iso = {BR J PHARMACOL}, journal = {BRITISH JOURNAL OF PHARMACOLOGY}, volume = {180}, unique-id = {34307941}, issn = {0007-1188}, abstract = {Background and PurposeTraumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide, yet pharmacotherapies for TBI are currently lacking. Neuroregeneration is important in brain repair and functional recovery. In this study, probucol, a cholesterol-lowering drug with established safety profiles, was examined for its therapeutic effects and neuroregenerative actions in TBI. Experimental ApproachMale mice were subjected to the controlled cortical impact model of TBI, followed by daily administration of probucol. Neurological and cognitive functions were evaluated. Histological analyses of the neocortex and hippocampus were performed to detect the lesion, dendritic degeneration (microtubule-associated protein 2), synaptic density (synaptophysin), neurogenesis (doublecortin), brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) activation. Involvement of BDNF/TrkB pathway in probucol-mediated effects was examined in primary cultures of cortical neurons. Key ResultsProbucol reduced brain lesion volume, enhanced the recovery of body symmetry, improved motor function and attenuated memory dysfunction after TBI. Meanwhile, probucol promoted post-injury dendritic growth and synaptogenesis and increased hippocampal proliferating neuronal progenitor cells, along with the formation as well as the survival of newborn neurons. Moreover, probucol enhances BDNF expression and TrkB activation. In vitro, probucol promoted neurite outgrowth, which was inhibited by a selective TrkB antagonist ANA-12. Conclusions and ImplicationsProbucol enhanced functional restoration and ameliorated cognitive impairment after TBI by promoting post-injury neuronal remodelling and neurogenesis. Increased activation of BDNF/TrkB pathway by probucol, at least in part, contributed to the neuroregenerative effects of probucol. Together, it may be promising to repurpose probucol for TBI.}, keywords = {MEMORY; traumatic brain injury; BDNF; NEUROGENESIS; Neuroplasticity; brain regeneration; probucol}, year = {2023}, eissn = {1476-5381}, pages = {2605-2622}, orcid-numbers = {Yet, Shaw-Fang/0000-0001-9097-3962} } @article{MTMT:34307957, title = {Understanding the Barriers of Implementing a Self-Awareness Assessment in Occupational Therapy Practice within a Brain Injury Population: An Exploratory Study}, url = {https://m2.mtmt.hu/api/publication/34307957}, author = {Cheng, Anika and Tsow, Rebecca and Schmidt, Julia}, doi = {10.1155/2023/3933995}, journal-iso = {OCCUP THER INT}, journal = {OCCUPATIONAL THERAPY INTERNATIONAL}, volume = {2023}, unique-id = {34307957}, issn = {0966-7903}, abstract = {Background. Self-awareness is seldom formally assessed by occupational therapists among individuals with traumatic brain injury (TBI). However, impaired self-awareness is prevalent and has a significant impact on rehabilitation outcomes. There is a need to understand clinician perspectives on self-awareness assessments and promote evidence-based practice in clinical settings. Aims. (1) Explore how an education session impacts knowledge and use of self-awareness assessments in occupational therapists working with people with TBI; (2) Understand the barriers that occupational therapists experience when assessing self-awareness in clinical practice. Materials and Methods. A single-group pre-post session design with an integrated knowledge translation approach was used. Occupational therapists working in neurorehabilitation were recruited from two rehabilitation centres through convenience sampling. Participants completed questionnaires before, after, and three months following an education session about the Self-Awareness of Deficits (SADI) assessment. Results. 14 occupational therapists participated in this study. A statistically significant increase in knowledge and confidence in using the SADI was observed both post-session and at 3-month follow-up. Conclusion. Targeted and ongoing education promotes confidence and knowledge retention among occupational therapists. Further research should explore strategies to promote behaviour change. Significance. The barriers identified in this study can provide insights for knowledge translation across clinical contexts.}, year = {2023}, eissn = {1557-0703}, orcid-numbers = {Tsow, Rebecca/0009-0005-0712-289X; Schmidt, Julia/0000-0003-2004-4871} } @article{MTMT:33917194, title = {Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice}, url = {https://m2.mtmt.hu/api/publication/33917194}, author = {Cheng, Hao and Wang, Pengfei and Wang, Ning and Dong, Wenwen and Chen, Ziyuan and Wu, Mingzhe and Wang, Ziwei and Yu, Ziqi and Guan, Dawei and Wang, Linlin and Zhao, Rui}, doi = {10.3390/antiox12030731}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {12}, unique-id = {33917194}, abstract = {Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI) outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and neuroinflammation in TBI, but its role in iron-induced post-TBI damage is unclear. We investigated ferroptotic neuronal damage in the injured cortex and observed neurological deficits post-TBI. These were ameliorated by the iron chelator deferoxamine (DFO) in wild-type mice. In Nrf2-knockout (Nrf2(-/-)) mice, more sever ferroptosis and neurological deficits were detected. Dimethyl fumarate (DMF)-mediated NRF2 activation alleviated neural dysfunction in TBI mice, partly due to TBI-induced ferroptosis mitigation. Additionally, FTH-FTL and FSP1 protein levels, associated with iron metabolism and the ferroptotic redox balance, were highly NRF2-dependent post-TBI. Thus, NRF2 is neuroprotective against TBI-induced ferroptosis through both the xCT-GPX4- and FTH-FTL-determined free iron level and the FSP1-regulated redox status. This yields insights into the neuroprotective role of NRF2 in TBI-induced neuronal damage and its potential use in TBI treatment.}, keywords = {ANTIOXIDANT; Nrf2; Ferroptosis; Traumatic brain injury (TBI); FREE IRON}, year = {2023}, eissn = {2076-3921} } @article{MTMT:33917227, title = {Systemic immune inflammation index and peripheral blood carbon dioxide concentration at admission predict poor prognosis in patients with severe traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/33917227}, author = {Chen, Li and Xia, Shaohuai and Zuo, Yi and Lin, Yinghong and Qiu, Xianshen and Chen, Qizuan and Feng, Tianshun and Xia, Xuewei and Shao, Qixiang and Wang, Shousen}, doi = {10.3389/fimmu.2022.1034916}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {13}, unique-id = {33917227}, issn = {1664-3224}, abstract = {BackgroundRecent studies have shown that systemic inflammation responses and hyperventilation are associated with poor outcomes in patients with severe traumatic brain injury (TBI). The aim of this retrospective study was to investigate the relationships between the systemic immune inflammation index (SII = platelet x neutrophil/lymphocyte) and peripheral blood CO2 concentration at admission with the Glasgow Outcome Score (GOS) at 6 months after discharge in patients with severe TBI. MethodsWe retrospectively analyzed the clinical data for 1266 patients with severe TBI at three large medical centers from January 2016 to December 2021, and recorded the GOS 6 months after discharge. The receiver operating characteristic (ROC) curve was used to determine the best cutoff values for SII, CO2, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and chi-square tests were used to evaluate the relationships among SII, CO2 and the basic clinical characteristics of patients with TBI. Multivariate logistic regression analysis was used to determine the independent prognostic factors for GOS in patients with severe TBI. Finally, ROC curve, nomogram, calibration curve and decision curve analyses were used to evaluate the value of SII and coSII-CO2 in predicting the prognosis of patients with severe TBI. And we used the multifactor regression analysis method to build the CRASH model and the IMPACT model. The CRASH model included age, GCS score (GCS, Glasgow Coma Scale) and Pupillary reflex to light: one, both, none. The IMPACT model includes age, motor score and Pupillary reflex to light: one, both, none. ResultsThe ROC curves indicated that the best cutoff values of SII, CO2, PLR, NLR and LMR were 2651.43x10(9), 22.15mmol/L, 190.98x10(9), 9.66x10(9) and 1.5x10(9), respectively. The GOS at 6 months after discharge of patients with high SII and low CO2 were significantly poorer than those with low SII and high CO2. Multivariate logistic regression analysis revealed that age, systolic blood pressure (SBP), pupil size, subarachnoid hemorrhage (SAH), SII, PLR, serum potassium concentration [K+], serum calcium concentration [Ca2+], international normalized ratio (INR), C-reactive protein (CRP) and co-systemic immune inflammation index combined with carbon dioxide (coSII-CO2) (P < 0.001) were independent prognostic factors for GOS in patients with severe TBI. In the training group, the C-index was 0.837 with SII and 0.860 with coSII-CO2. In the external validation group, the C-index was 0.907 with SII and 0.916 with coSII-CO2. Decision curve analysis confirmed a superior net clinical benefit with coSII-CO2 rather than SII in most cases. Furthermore, the calibration curve for the probability of GOS 6 months after discharge showed better agreement with the observed results when based on the coSII-CO2 rather than the SII nomogram. According to machine learning, coSII-CO2 ranked first in importance and was followed by pupil size, then SII. ConclusionsSII and CO2 have better predictive performance than NLR, PLR and LMR. SII and CO2 can be used as new, accurate and objective clinical predictors, and coSII-CO2, based on combining SII with CO2, can be used to improve the accuracy of GOS prediction in patients with TBI 6 months after discharge.}, keywords = {Prognosis; Carbon Dioxide; traumatic brain injury; Glasgow Outcome Scale; nomogram; system immune inflammation index}, year = {2023}, eissn = {1664-3224} } @article{MTMT:33917210, title = {Risk of Migraine after Traumatic Brain Injury and Effects of Injury Management Levels and Treatment Modalities: A Nationwide Population-Based Cohort Study in Taiwan}, url = {https://m2.mtmt.hu/api/publication/33917210}, author = {Chen, Mei-Hui and Sung, Yueh-Feng and Chien, Wu-Chien and Chung, Chi-Hsiang and Chen, Jeng-Wen}, doi = {10.3390/jcm12041530}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {33917210}, abstract = {Traumatic brain injury (TBI) causes several long-term disabilities, particularly headaches. An association between TBI and subsequent migraine has been reported. However, few longitudinal studies have explained the link between migraine and TBI. Moreover, the modifying effects of treatment remain unknown. This retrospective cohort study used records from Taiwan's Longitudinal Health Insurance Database 2005 to evaluate the risk of migraine among patients with TBI and to determine the effects of different treatment modalities. Initially, 187,906 patients, aged >= 18 years, who were diagnosed as TBI in 2000, were identified. In total, 151,098 patients with TBI and 604,394 patients without TBI were matched at a 1:4 ratio according to baseline variables during the same observation period. At the end of follow-up, 541 (0.36%) and 1491 (0.23%) patients in the TBI and non-TBI groups, respectively, developed migraine. The TBI group exhibited a higher risk of migraine than the non-TBI group (adjusted HR: 1.484). Major trauma (Injury Severity Score, ISS >= 16) was associated with a higher migraine risk than minor trauma (ISS < 16) (adjusted HR: 1.670). However, migraine risk did not differ significantly after surgery or occupational/physical therapy. These findings highlight the importance of long-term follow-up after TBI onset and the need to investigate the underlying pathophysiological link between TBI and subsequent migraine.}, keywords = {MIGRAINE; EPIDEMIOLOGY; headache; traumatic brain injury; treatment modalities}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Chien, Wu-Chien/0000-0002-3286-0780; Chen, Jeng-Wen/0000-0003-3635-4815} } @article{MTMT:34307893, title = {Exosomes from ADSCs ameliorate nerve damage in the hippocampus caused by post traumatic brain injury via the delivery of circ-Scmh1 promoting microglial M2 polarization}, url = {https://m2.mtmt.hu/api/publication/34307893}, author = {Chen, Songyu and Wang, Xuewei and Qian, Zhouqi and Wang, Mingsheng and Zhang, Feng and Zeng, Tao and Li, Lei and Gao, Liang}, doi = {10.1016/j.injury.2023.110927}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {54}, unique-id = {34307893}, issn = {0020-1383}, abstract = {Background: Traumatic brain injury (TBI) is an urgent global health issue. Neuroinflammation, due partially to microglia, can worsen or even cause neuropsychiatric disorders after a TBI. An increasing number of studies have found that adipose-derived stem cell (ADSC) derived exosomes can alleviate many diseases by delivering noncoding RNAs including circRNA and miRNAs, but the mechanism of action remains unclear.Methods: In the present investigation, we produced a TBI mouse model and isolated exosomes from their ADSCs before and after an hypoxic pretreatment. We then used next generation sequencing (NGS) to identify differentially expressed circRNAs and luciferase report assays to determine the relationship between the different noncoding RNAs (miRNA, circRNA and mRNA).Results: The results show that we successfully isolated ADSCs which possessed a multidirectional differentiation potential. We then isolated exosomes from untreated ADSCs (Exos) and from hypoxia pretreated ADSCs (HExos). The HExos significantly decreased hippocampal nerve injury after TBI by decreasing M1 microglia mediated inflammatory cytokine expression and caused recovery of cognitive function. NGS data revealed that abnormal circ-Scmh1 expression plays a role in HExo mediated brain tissue preservation after TBI. Furthermore, luciferase report analysis found that miR-154-5p and STAT6 were the targets for circ-Scmh1. Interestingly, miR-154-5p overexpression or STAT6 inhibition reversed the circ-Scmh1 induced M2 microglial polarization. Overexpression of circ-Scmh1 increased the therapeutic effect of Exo on hippocampal nerve injury after TBI by promotion of M2 microglial polarization and decreased inflammatory induced hippocampal nerve injury. Conclusion: Taken together, we found that exosomes from ADSCs ameliorate nerve damage in the hippocampus post TBI through the delivery of circ-Scmh1 and the promotion of microglial M2 polarization.}, keywords = {traumatic brain injury; Exosomes; adipose-derived mesenchymal stem cells; Microglial M2 polarization; circ-Scmh1}, year = {2023}, eissn = {1879-0267} } @article{MTMT:34555523, title = {Plasma D-dimer levels are a biomarker for in-hospital complications and long-term mortality in patients with traumatic brain injury}, url = {https://m2.mtmt.hu/api/publication/34555523}, author = {Chen, Xinli and Wang, Xiaohua and Liu, Yingchao and Guo, Xiumei and Wu, Fan and Yang, Yushen and Hu, Weipeng and Zheng, Feng and He, Hefan}, doi = {10.3389/fnmol.2023.1276726}, journal-iso = {FRONT MOL NEUROSCI}, journal = {FRONTIERS IN MOLECULAR NEUROSCIENCE}, volume = {16}, unique-id = {34555523}, issn = {1662-5099}, abstract = {Introduction: Traumatic brain injury (TBI) is a major health concern worldwide. D-dimer levels, commonly used in the diagnosis and treatment of neurological diseases, may be associated with adverse events in patients with TBI. However, the relationship between D-dimer levels, TBI-related in-hospital complications, and long-term mortality in patients with TBI has not been investigated. Here, examined whether elevated D-dimer levels facilitate the prediction of in-hospital complications and mortality in patients with TBI.Methods: Overall, 1,338 patients with TBI admitted to our institute between January 2016 and June 2022 were retrospectively examined. D-dimer levels were assessed within 24 h of admission, and propensity score matching was used to adjust for baseline characteristics.Results: Among the in-hospital complications, high D-dimer levels were associated with electrolyte metabolism disorders, pulmonary infections, and intensive care unit admission (p < 0.05). Compared with patients with low (0.00-1.54 mg/L) D-dimer levels, the odds of long-term mortality were significantly higher in all other patients, including those with D-dimer levels between 1.55 mg/L and 6.35 mg/L (adjusted hazard ratio [aHR] 1.655, 95% CI 0.9632.843), 6.36 mg/L and 19.99 mg/L (aHR 2.38, 95% CI 1.416-4.000), and >20 mg/L (aHR 3.635, 95% CI 2.195-6.018; p < 0.001). D-dimer levels were positively correlated with the risk of death when the D-dimer level reached 6.82 mg/L.Conclusion: Overall, elevated D-dimer levels at admission were associated with adverse outcomes and may predict poor prognosis in patients with TBI. Our findings will aid in the acute diagnosis, classification, and management of TBI.}, keywords = {COAGULATION; traumatic brain injury; biomarker; Mild; D-dimer; coagulopathy; LONG-TERM MORTALITY; In-hospital complications; Progressive hemorrhagic injury}, year = {2023}, eissn = {1662-5099} } @article{MTMT:34297002, title = {Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice}, url = {https://m2.mtmt.hu/api/publication/34297002}, author = {Chen, Yuhua and Chen, Junhui and Wei, Hong and Gong, Kai and Meng, Jiao and Long, Tianlin and Guo, Jianfeng and Hong, Jun and Yang, Lingjian and Qiu, Junling and Xiong, Kun and Wang, Zhanxiang and Xu, Quanhua}, doi = {10.3389/fimmu.2023.1172710}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {14}, unique-id = {34297002}, issn = {1664-3224}, abstract = {IntroductionGut-microbiota-brain axis is a potential treatment to decrease the risk of chronic traumatic encephalopathy following traumatic brain injury (TBI). Phosphoglycerate mutase 5 (PGAM5), a mitochondrial serine/threonine protein phosphatase, resides in mitochondrial membrane and regulates mitochondrial homeostasis and metabolism. Mitochondria mediates intestinal barrier and gut microbiome. ObjectivesThis study investigated the association between PGAM5 and gut microbiota in mice with TBI. MethodsThe controlled cortical impact injury was established in mice with genetically-ablated Pgam5 (Pgam5(-/-)) or wild type, and WT male mice were treated with fecal microbiota transplantation (FMT) from male Pgam5(-/-) mice or Akkermansia muciniphila (A. muciniphila). Then the gut microbiota abundance, blood metabolites, neurological function, and nerve injury were detected. ResultsTreated with antibiotics for suppressing gut microbiota in Pgam5(-/-) mice partially relieved the role of Pgam5 deficiency in the improvement of initial inflammatory factors and motor dysfunction post-TBI. Pgam5 knockout exhibited an increased abundance of A. muciniphila in mice. FMT from male Pgam5(-/-) mice enabled better maintenance of amino acid metabolism and peripherial environment than that in TBI-vehicle mice, which suppressed neuroinflammation and improved neurological deficits, and A. muciniphila was negatively associated with intestinal mucosal injury and neuroinflammation post-TBI. Moreover, A. muciniphila treatment ameliorated neuroinflammation and nerve injury by regulating Nlrp3 inflammasome activation in cerebral cortex with TBI. ConclusionThus, the present study provides evidence that Pgam5 is involved in gut microbiota-mediated neuroinflammation and nerve injury, with A. muciniphila-Nlrp3 contributing to peripheral effects.}, keywords = {neuroprotection; TBI; Akkermansia muciniphila; NLRP3; PGAM5; Gut-microbiota-brain axis}, year = {2023}, eissn = {1664-3224} } @article{MTMT:34560381, title = {Adolescent traumatic brain injury leads to incremental neural impairment in middle-aged mice: role of persistent oxidative stress and neuroinflammation}, url = {https://m2.mtmt.hu/api/publication/34560381}, author = {Chen, Z. and Wang, P. and Cheng, H. and Wang, N. and Wu, M. and Wang, Z. and Wang, Z. and Dong, W. and Guan, D. and Wang, L. and Zhao, R.}, doi = {10.3389/fnins.2023.1292014}, journal-iso = {FRONT NEUROSCI-SWITZ}, journal = {FRONTIERS IN NEUROSCIENCE}, volume = {17}, unique-id = {34560381}, issn = {1662-4548}, year = {2023}, eissn = {1662-453X} } @article{MTMT:34560364, title = {EPIDEMIOLOGICAL FEATURES OF TRAUMATIC BRAIN INJURIES FROM A FIRST LEVEL TRAUMA CARE NATIONAL MEDICAL CENTER IN GEORGIA}, url = {https://m2.mtmt.hu/api/publication/34560364}, author = {Chikhladze, N. and Halliday, F. and Pitskhelauri, N. and Tsiskaridze, A.}, doi = {10.38045/ohrm.2023.2.01}, journal = {One Health & Risk Management}, volume = {4}, unique-id = {34560364}, issn = {2587-3458}, year = {2023}, pages = {5-11} } @article{MTMT:34025667, title = {Longitudinal in vivo monitoring of axonal degeneration after brain injury}, url = {https://m2.mtmt.hu/api/publication/34025667}, author = {Chornyy, S. and Borovicka, J.A. and Patel, D. and Shin, M.-K. and Vázquez-Rosa, E. and Miller, E. and Wilson, B. and Pieper, A.A. and Dana, H.}, doi = {10.1016/j.crmeth.2023.100481}, journal-iso = {CELL REP METH}, journal = {CELL REPORTS METHODS}, volume = {3}, unique-id = {34025667}, abstract = {Traumatic brain injury (TBI)-induced axonal degeneration leads to acute and chronic neuropsychiatric impairment, neuronal death, and accelerated neurodegenerative diseases of aging, including Alzheimer's and Parkinson's diseases. In laboratory models, axonal degeneration is traditionally studied through comprehensive postmortem histological evaluation of axonal integrity at multiple time points. This requires large numbers of animals to power for statistical significance. Here, we developed a method to longitudinally monitor axonal functional activity before and after injury in vivo in the same animal over an extended period. Specifically, after expressing an axonal-targeting genetically encoded calcium indicator in the mouse dorsolateral geniculate nucleus, we recorded axonal activity patterns in the visual cortex in response to visual stimulation. In vivo aberrant axonal activity patterns after TBI were detectable from 3 days after injury and persisted chronically. This method generates longitudinal same-animal data that substantially reduces the number of required animals for preclinical studies of axonal degeneration. © 2023 The Author(s)}, keywords = {Female; Male; calcium; ARTICLE; MOUSE; controlled study; nonhuman; animal experiment; animal cell; Histopathology; Electroencephalogram; in vivo study; traumatic brain injury; Signal processing; visual acuity; neurodegeneration; Parkinson's disease; Alzheimer's disease; neuromodulation; brain injury; nerve fiber degeneration; visual stimulation; C57BL 6 mouse; geniculate nucleus; Genetically encoded calcium indicators; multiphoton microscopy; AXONAL DEGENERATION; visual processing; CP: Neuroscience; GCaMP6-axon}, year = {2023}, eissn = {2667-2375} } @article{MTMT:33917212, title = {Effects of short-term hyperoxemia on cerebral autoregulation and tissue oxygenation in acute brain injured patients}, url = {https://m2.mtmt.hu/api/publication/33917212}, author = {Ciliberti, Pietro and Cardim, Danilo and Giardina, Alberto and Groznik, Matjaz and Ball, Lorenzo and Giovannini, Martina and Battaglini, Denise and Beqiri, Erta and Matta, Basil and Smielewski, Peter and Czosnyka, Marek and Pelosi, Paolo and Robba, Chiara}, doi = {10.3389/fphys.2023.1113386}, journal-iso = {FRONT PHYSIOL}, journal = {FRONTIERS IN PHYSIOLOGY}, volume = {14}, unique-id = {33917212}, abstract = {Introduction: Potential detrimental effects of hyperoxemia on outcomes have been reported in critically ill patients. Little evidence exists on the effects of hyperoxygenation and hyperoxemia on cerebral physiology. The primary aim of this study is to assess the effect of hyperoxygenation and hyperoxemia on cerebral autoregulation in acute brain injured patients. We further evaluated potential links between hyperoxemia, cerebral oxygenation and intracranial pressure (ICP).Methods: This is a single center, observational, prospective study. Acute brain injured patients [traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH)] undergoing multimodal brain monitoring through a software platform (ICM+) were included. Multimodal monitoring consisted of invasive ICP, arterial blood pressure (ABP) and near infrared spectrometry (NIRS). Derived parameters of ICP and ABP monitoring included the pressure reactivity index (PRx) to assess cerebral autoregulation. ICP, PRx, and NIRS-derived parameters (cerebral regional saturation of oxygen, changes in concentration of regional oxy- and deoxy-hemoglobin), were evaluated at baseline and after 10 min of hyperoxygenation with a fraction of inspired oxygen (FiO(2)) of 100% using repeated measures t-test or paired Wilcoxon signed-rank test. Continuous variables are reported as median (interquartile range).Results: Twenty-five patients were included. The median age was 64.7 years (45.9-73.2), and 60% were male. Thirteen patients (52%) were admitted for TBI, 7 (28%) for SAH, and 5 (20%) patients for ICH. The median value of systemic oxygenation (partial pressure of oxygen-PaO2) significantly increased after FiO(2) test, from 97 (90-101) mm Hg to 197 (189-202) mm Hg, p < 0.0001. After FiO(2) test, no changes were observed in PRx values (from 0.21 (0.10-0.43) to 0.22 (0.15-0.36), p = 0.68), nor in ICP values (from 13.42 (9.12-17.34) mm Hg to 13.34 (8.85-17.56) mm Hg, p = 0.90). All NIRS-derived parameters reacted positively to hyperoxygenation as expected. Changes in systemic oxygenation and the arterial component of cerebral oxygenation were significantly correlated (respectively delta PaO2 and delta O(2)Hbi; r = 0.49 (95% CI = 0.17-0.80).Conclusion: Short-term hyperoxygenation does not seem to critically affect cerebral autoregulation.}, keywords = {Intracranial Pressure; brain injury; Cerebral autoregulation; CEREBRAL OXYGENATION; hyperoxygenation}, year = {2023}, eissn = {1664-042X} } @article{MTMT:34307887, title = {How do Individuals With and Without Traumatic Brain Injury Interpret Emoji? Similarities and Differences in Perceived Valence, Arousal, and Emotion Representation}, url = {https://m2.mtmt.hu/api/publication/34307887}, author = {Clough, Sharice and Tanguay, Annick F. N. and Mutlu, Bilge and Turkstra, Lyn S. and Duff, Melissa C.}, doi = {10.1007/s10919-023-00433-w}, journal-iso = {J NONVERBAL BEHAV}, journal = {JOURNAL OF NONVERBAL BEHAVIOR}, volume = {47}, unique-id = {34307887}, issn = {0191-5886}, abstract = {Impaired facial affect recognition is common after traumatic brain injury (TBI) and linked to poor social outcomes. We explored whether perception of emotions depicted by emoji is also impaired after TBI. Fifty participants with TBI and 50 non-injured peers generated free-text labels to describe emotions depicted by emoji and rated their levels of valence and arousal on nine-point rating scales. We compared how the two groups' valence and arousal ratings were clustered and examined agreement in the words participants used to describe emoji. Hierarchical clustering of affect ratings produced four emoji clusters in the non-injured group and three emoji clusters in the TBI group. Whereas the non-injured group had a strongly positive and a moderately positive cluster, the TBI group had a single positive valence cluster, undifferentiated by arousal. Despite differences in cluster numbers, hierarchical structures of the two groups' emoji ratings were significantly correlated. Most emoji had high agreement in the words participants with and without TBI used to describe them. Participants with TBI perceived emoji similarly to non-injured peers, used similar words to describe emoji, and rated emoji similarly on the valence dimension. Individuals with TBI showed small differences in perceived arousal for a minority of emoji. Overall, results suggest that basic recognition processes do not explain challenges in computer-mediated communication reported by adults with TBI. Examining perception of emoji in context by people with TBI is an essential next step for advancing our understanding of functional communication in computer-mediated contexts after brain injury.}, keywords = {arousal; traumatic brain injury; emotion; VALENCE; computer-mediated communication; emoji}, year = {2023}, eissn = {1573-3653}, pages = {489-511} } @article{MTMT:34560412, title = {Traumatic Head Injuries in Moldova: a Cross-Sectional Analysis of Medical Registry Data}, url = {https://m2.mtmt.hu/api/publication/34560412}, author = {Cociu, S. and Hamann, C.J. and Cebanu, S. and Cazacu-Stratu, A. and Coman, M.A. and Peek-Asa, C.}, doi = {10.3897/folmed.65.e91262}, journal-iso = {FOLIA MED}, journal = {FOLIA MEDICA}, volume = {65}, unique-id = {34560412}, issn = {0204-8043}, year = {2023}, eissn = {1314-2143}, pages = {775-782} } @article{MTMT:34307907, title = {The Toronto Concussion Study: a prospective investigation of characteristics in a cohort of adults from the general population seeking care following acute concussion, 2016-2020}, url = {https://m2.mtmt.hu/api/publication/34307907}, author = {Comper, Paul and Foster, Evan and Chandra, Tharshini and Langer, Laura and Wiseman-Hakes, Catherine and Mochizuki, George and Ruttan, Lesley and Lawrence, David W. and Inness, Elizabeth L. and Gladstone, Jonathan and Saverino, Cristina and Tam, Alan and Kam, Alice and Al-Rawi, Firas and Bayley, Mark Theodore}, doi = {10.3389/fneur.2023.1152504}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {14}, unique-id = {34307907}, issn = {1664-2295}, abstract = {Purpose There is limited research regarding the characteristics of those from the general population who seek care following acute concussion.Methods To address this gap, a large cohort of 473 adults diagnosed with an acute concussion (female participants = 287; male participants = 186) was followed using objective measures prospectively over 16 weeks beginning at a mean of 5.1 days post-injury.Results Falls were the most common mechanism of injury (MOI) (n = 137, 29.0%), followed by sports-related recreation (n = 119, 25.2%). Male participants were more likely to be injured playing recreational sports or in a violence-related incident; female participants were more likely to be injured by falling. Post-traumatic amnesia (PTA) was reported by 80 participants (16.9 %), and loss of consciousness (LOC) was reported by 110 (23.3%). In total, 54 participants (11.4%) reported both PTA and LOC. Male participants had significantly higher rates of PTA and LOC after their injury compared to their female counterparts. Higher initial symptom burden was associated with a longer duration of recovery for both male and female participants. Female participants had more symptoms and higher severity of symptoms at presentation compared to male participants. Female participants were identified to have a longer recovery duration, with a mean survival time of 6.50 weeks compared to 5.45 weeks in male participants (p < 0.0001). A relatively high proportion of female and male participants in this study reported premorbid diagnoses of depression and anxiety compared to general population characteristics.Conclusion Although premorbid diagnoses of depression and/or anxiety were associated with higher symptom burden at the initial visit, the duration of symptoms was not directly associated with a pre-injury history of psychological/psychiatric disturbance. This cohort of adults, from the general population, seeking care for their acute concussion attained clinical and functional recovery over a period of 4-12 weeks.}, keywords = {sex differences; Characteristics; mild TBI; Symptom reporting; ACUTE CONCUSSION}, year = {2023}, eissn = {1664-2295}, orcid-numbers = {Wiseman-Hakes, Catherine/0000-0001-8441-884X} } @article{MTMT:34560431, title = {Is transcranial direct current stimulation (tDCS) effective to improve cognition and functionality after severe traumatic brain injury? A perspective article and hypothesis}, url = {https://m2.mtmt.hu/api/publication/34560431}, author = {Cordeiro, B.N.D.L. and Kuster, E. and Thibaut, A. and Rodrigues, Nascimento L. and Gonçalves, J.V. and Arêas, G.P.T. and Paiva, W.S. and Arêas, F.Z.D.S.}, doi = {10.3389/fnhum.2023.1162854}, journal-iso = {FRONT HUM NEUROSCI}, journal = {FRONTIERS IN HUMAN NEUROSCIENCE}, volume = {17}, unique-id = {34560431}, issn = {1662-5161}, year = {2023}, eissn = {1662-5161} } @article{MTMT:34307950, title = {Recovery of clinical, cognitive and cortical activity measures following mild traumatic brain injury (mTBI): A longitudinal investigation}, url = {https://m2.mtmt.hu/api/publication/34307950}, author = {Coyle, Hannah L. and Bailey, Neil W. and Ponsford, Jennie and Hoy, Kate E.}, doi = {10.1016/j.cortex.2023.04.009}, journal-iso = {CORTEX}, journal = {CORTEX: A JOURNAL DEVOTED TO THE STUDY OF THE NERVOUS SYSTEM AND BEHAVIOR}, volume = {165}, unique-id = {34307950}, issn = {0010-9452}, abstract = {The mechanisms that underpin recovery following mild traumatic brain injury (mTBI) remain poorly understood. Identifying neurophysiological markers and their functional significance is necessary to develop diagnostic and prognostic indicators of recovery. The current study assessed 30 participants in the subacute phase of mTBI (10-31 days post-injury) and 28 demographically matched controls. Participants also completed 3 month (mTBI: N = 21, control: N = 25) and 6 month (mTBI: N = 15, control: N = 25) follow up sessions to track recovery. At each time point, a battery of clinical, cognitive, and neuro-physiological assessments was completed. Neurophysiological measures included resting-state electroencephalography (EEG) and transcranial magnetic stimulation combined with EEG (TMS-EEG). Outcome measures were analysed using mixed linear models (MLM). Group differences in mood, post-concussion symptoms and resting-state EEG resolved by 3 months, and recovery was maintained at 6 months. On TMS-EEG derived neurophysio-logical measures of cortical reactivity, group differences ameliorated at 3 months but re-emerged at 6 months, while on measures of fatigue, group differences persisted across all time points. Persistent neurophysiological changes and greater fatigue in the absence of measurable cognitive impairment may suggest the impact of mTBI on neuronal commu-nication may leads to increased neural effort to maintain efficient function. Neurophysi-ological measures to track recovery may help identify both temporally optimal windows and therapeutic targets for the development of new treatments in mTBI.(c) 2023 Elsevier Ltd. All rights reserved.}, keywords = {cognition; Electroencephalography (EEG); transcranial magnetic stimulation; post-concussion symptoms; mild traumatic brain injury (mTBI); (TMS)}, year = {2023}, eissn = {1973-8102}, pages = {14-25} } @article{MTMT:34307921, title = {Enhancement of the liver's neuroprotective role ameliorates traumatic brain injury pathology}, url = {https://m2.mtmt.hu/api/publication/34307921}, author = {Dai, Yongfeng and Dong, Jinghua and Wu, Yu and Zhu, Minzhen and Xiong, Wenchao and Li, Huanyu and Zhao, Yulu and Hammock, Bruce D. and Zhu, Xinhong}, doi = {10.1073/pnas.2301360120}, journal-iso = {P NATL ACAD SCI USA}, journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, volume = {120}, unique-id = {34307921}, issn = {0027-8424}, abstract = {Traumatic brain injury (TBI) is a pervasive problem worldwide for which no effective treatment is currently available. Although most studies have focused on the pathology of the injured brain, we have noted that the liver plays an important role in TBI. Using two mouse models of TBI, we found that the enzymatic activity of hepatic soluble epoxide hydrolase (sEH) was rapidly decreased and then returned to normal levels following TBI, whereas such changes were not observed in the kidney, heart, spleen, or lung. Interestingly, genetic downregulation of hepatic Ephx2 (which encodes sEH) ameliorates TBI-induced neurological deficits and promotes neurological function recovery, whereas overexpression of hepatic sEH exacerbates TBI-associated neurological impairments. Furthermore, hepatic sEH ablation was found to promote the generation of A2 pheno-type astrocytes and facilitate the production of various neuroprotective factors associated with astrocytes following TBI. We also observed an inverted V-shaped alteration in the plasma levels of four EET (epoxyeicosatrienoic acid) isoforms (5,6-, 8,9- ,11,12-, and 14,15- EET) following TBI which were negatively correlated with hepatic sEH activity. However, hepatic sEH manipulation bidirectionally regulates the plasma levels of 14,15- EET, which rapidly crosses the blood-brain barrier. Additionally, we found that the application of 14,15- EET mimicked the neuroprotective effect of hepatic sEH ablation, while 14,15-epoxyeicosa- 5(Z)- enoic acid blocked this effect, indicating that the increased plasma levels of 14,15- EET mediated the neuroprotective effect observed after hepatic sEH ablation. These results highlight the neuroprotective role of the liver in TBI and suggest that targeting hepatic EET signaling could represent a promising therapeutic strategy for treating TBI.}, keywords = {LIVER; ASTROCYTES; traumatic brain injury; SOLUBLE EPOXIDE HYDROLASE; 14; 15-epoxyeicosatrienoic acid}, year = {2023}, eissn = {1091-6490} } @article{MTMT:34181805, title = {Traumatic brain injury as a chronic disease: insights from the United States Traumatic Brain Injury Model Systems Research Program}, url = {https://m2.mtmt.hu/api/publication/34181805}, author = {Dams-O'Connor, K. and Juengst, S.B. and Bogner, J. and Chiaravalloti, N.D. and Corrigan, J.D. and Giacino, J.T. and Harrison-Felix, C.L. and Hoffman, J.M. and Ketchum, J.M. and Lequerica, A.H. and Marwitz, J.H. and Miller, A.C. and Nakase-Richardson, R. and Rabinowitz, A.R. and Sander, A.M. and Zafonte, R. and Hammond, F.M.}, doi = {10.1016/S1474-4422(23)00065-0}, journal-iso = {LANCET NEUROL}, journal = {LANCET NEUROLOGY}, volume = {22}, unique-id = {34181805}, issn = {1474-4422}, year = {2023}, eissn = {1474-4465}, pages = {517-528} } @article{MTMT:34782829, title = {Saliva cortisol levels and physiological parameter fluctuations in mild traumatic brain injury patients compared to controls}, url = {https://m2.mtmt.hu/api/publication/34782829}, author = {Daneva, E. and Makris, K. and Korompeli, A. and Muurlink, O. and Kaklamanos, I. and Fildissis, G. and Vlachos, K. and Myrianthefs, P.}, doi = {10.1080/00207454.2021.1951264}, journal-iso = {INT J NEUROSCI}, journal = {INTERNATIONAL JOURNAL OF NEUROSCIENCE}, volume = {133}, unique-id = {34782829}, issn = {0020-7454}, year = {2023}, eissn = {1563-5279}, pages = {612-620} } @article{MTMT:34148951, title = {The kynurenine pathway in traumatic brain injuries and concussion}, url = {https://m2.mtmt.hu/api/publication/34148951}, author = {Dehhaghi, M. and Heng, B. and Guillemin, G.J.}, doi = {10.3389/fneur.2023.1210453}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {14}, unique-id = {34148951}, issn = {1664-2295}, year = {2023}, eissn = {1664-2295} } @inproceedings{MTMT:34560433, title = {Mapping care pathways in children with TBI using Markov Models}, url = {https://m2.mtmt.hu/api/publication/34560433}, author = {Deken, V.-J.D. and Putman, K. and Cools, W. and Barbe, K. and Deynse, H.V.}, booktitle = {2023 IEEE International Symposium on Medical Measurements and Applications (MeMeA)}, doi = {10.1109/MeMeA57477.2023.10171883}, unique-id = {34560433}, year = {2023} } @article{MTMT:34307966, title = {Incidence and predictors of mortality among traumatic brain injury patients admitted to Amhara region Comprehensive Specialized Hospitals, northwest Ethiopia, 2022}, url = {https://m2.mtmt.hu/api/publication/34307966}, author = {Demlie, Tiruye Azene and Alemu, Mahlet Temesgen and Messelu, Mengistu Abebe and Wagnew, Fasil and Mekonen, Enyew Getaneh}, doi = {10.1186/s12873-023-00823-9}, journal-iso = {BMC EMERG MED}, journal = {BMC EMERGENCY MEDICINE}, volume = {23}, unique-id = {34307966}, issn = {1471-227X}, abstract = {IntroductionTraumatic brain injury is a substantial cause of mortality and morbidity with a higher burden in low and middle-income countries due to healthcare systems that are unable to deliver effectively the acute and long-term care the patients require. Besides its burden, there is little information on traumatic brain injury-related mortality in Ethiopia, especially in the region. Therefore, this study aimed to assess the incidence and predictors of mortality among traumatic brain injury patients admitted to comprehensive specialized hospitals in the Amhara region, northwest Ethiopia, 2022.MethodsAn institution-based retrospective follow-up study was conducted among 544 traumatic brain injury patients admitted from January 1, 2021, to December 31, 2021. A simple random sampling method was used. Data were extracted using a pre-tested and structured data abstraction sheet. Data were entered, coded, and cleaned into EPi-info version 7.2.0.1 software and exported to STATA version 14.1 for analysis. The Weibull regression model was fitted to determine the association between time to death and covariates. Variables with a P-value < 0.05 were declared statistically significant.ResultsThe overall incidence of mortality among traumatic brain injury patients was 1.23 per 100 person-day observation [95% (CI: 1.0, 1.5)] with a median survival time of 106 (95% CI: 60, 121) days. Age [AHR: 1.08 (95% CI; 1.06, 1.1)], severe traumatic brain injury [AHR: 10 (95% CI; 3.55, 28.2)], moderate traumatic brain injury [AHR: 9.2 (95% CI 2.97, 29)], hypotension [AHR: 6.9 (95% CI; 2.8, 17.1)], coagulopathy [AHR: 2.55 (95% CI: 1.27, 5.1)], hyperthermia [AHR: 2.79 (95% CI; 1.4, 5.5)], and hyperglycemia [AHR: 2.28 (95% CI; 1.13, 4.6)] were positively associated with mortality while undergoing neurosurgery were negatively associated with mortality [AHR: 0.47 (95% CI; 0.27-0 0.82)].ConclusionThe overall incidence of mortality was found to be high. Age, severe and moderate traumatic brain injury, hypotension at admission, coagulopathy, presence of associated aspiration pneumonia, undergoing a neurosurgical procedure, episode of hyperthermia, and hyperglycemia during hospitalization were the independent predictors of time to death. Therefore, interventions to reduce mortality should focus on the prevention of primary injury and secondary brain injury.}, keywords = {MORTALITY; Incidence; traumatic brain injury; Ethiopia}, year = {2023}, eissn = {1471-227X} } @article{MTMT:34559983, title = {Traumatic Brain Injury: Intraoperative Management and Intensive Care Unit Multimodality Monitoring}, url = {https://m2.mtmt.hu/api/publication/34559983}, author = {Denchev, K. and Gomez, J. and Chen, P. and Rosenblatt, K.}, doi = {10.1016/j.anclin.2022.11.003}, journal-iso = {ANESTHESIOLOGY CLINICS}, journal = {ANESTHESIOLOGY CLINICS}, volume = {41}, unique-id = {34559983}, issn = {1932-2275}, year = {2023}, pages = {39-78} }