TY - JOUR AU - Giannubilo, Stefano Raffaele AU - Cecati, Monia AU - Marzioni, Daniela AU - Ciavattini, Andrea TI - Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 SN - 1661-6596 DO - 10.3390/ijms25031418 UR - https://m2.mtmt.hu/api/publication/34538788 ID - 34538788 AB - In this review, we comprehensively present the literature on circulating microRNAs (miRNAs) associated with preeclampsia, a pregnancy-specific disease considered the primary reason for maternal and fetal mortality and morbidity. miRNAs are single-stranded non-coding RNAs, 20–24 nt long, which control mRNA expression. Changes in miRNA expression can induce a variation in the relative mRNA level and influence cellular homeostasis, and the strong presence of miRNAs in all body fluids has made them useful biomarkers of several diseases. Preeclampsia is a multifactorial disease, but the etiopathogenesis remains unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for a successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance in these molecular pathways can lead to severe placental lesions and pregnancy complications. We then discuss the role of miRNAs in trophoblast invasion and in the pathogenesis, diagnosis and prediction of preeclampsia. We also discuss the potential role of miRNAs from an epigenetic perspective with possible future therapeutic implications. LA - English DB - MTMT ER - TY - JOUR AU - Muse, Meghan E. AU - Armstrong, David A. AU - Hoen, Anne G. AU - Gilbert-Diamond, Diane AU - Gui, Jiang AU - Palys, Thomas J. AU - Kolling, Frederick W. AU - Christensen, Brock C. AU - Karagas, Margaret R. AU - Howe, Caitlin G. TI - Maternal–Infant Factors in Relation to Extracellular Vesicle and Particle miRNA in Prenatal Plasma and in Postpartum Human Milk JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 SN - 1661-6596 DO - 10.3390/ijms25031538 UR - https://m2.mtmt.hu/api/publication/34568040 ID - 34568040 AB - MicroRNAs (miRNA) in extracellular vesicles and particles (EVPs) in maternal circulation during pregnancy and in human milk postpartum are hypothesized to facilitate maternal–offspring communication via epigenetic regulation. However, factors influencing maternal EVP miRNA profiles during these two critical developmental windows remain largely unknown. In a pilot study of 54 mother–child dyads in the New Hampshire Birth Cohort Study, we profiled 798 EVP miRNAs, using the NanoString nCounter platform, in paired maternal second-trimester plasma and mature (6-week) milk samples. In adjusted models, total EVP miRNA counts were lower for plasma samples collected in the afternoon compared with the morning (p = 0.024). Infant age at sample collection was inversely associated with total miRNA counts in human milk EVPs (p = 0.040). Milk EVP miRNA counts were also lower among participants who were multiparous after delivery (p = 0.047), had a pre-pregnancy BMI > 25 kg/m2 (p = 0.037), or delivered their baby via cesarean section (p = 0.021). In post hoc analyses, we also identified 22 specific EVP miRNA that were lower among participants who delivered their baby via cesarean section (Q < 0.05). Target genes of delivery mode-associated miRNAs were over-represented in pathways related to satiety signaling in infants (e.g., CCKR signaling) and mammary gland development and lactation (e.g., FGF signaling, EGF receptor signaling). In conclusion, we identified several key factors that may influence maternal EVP miRNA composition during two critical developmental windows, which should be considered in future studies investigating EVP miRNA roles in maternal and child health. LA - English DB - MTMT ER - TY - JOUR AU - Song, Huichen AU - Ma, Lina AU - Sun, Benben AU - Shi, Huanhuan AU - Zhang, Yujing TI - The functions and applications of extracellular vesicles miRNAs in adverse pregnancy JF - EXRNA J2 - EXRNA VL - 6 PY - 2024 IS - 1 SN - 2398-0060 DO - 10.55092/exrna20240005 UR - https://m2.mtmt.hu/api/publication/34778022 ID - 34778022 LA - English DB - MTMT ER - TY - JOUR AU - Yaacoub, Serge AU - Boudaka, Ammar AU - AlKhatib, Ali AU - Pintus, Gianfranco AU - Sahebkar, Amirhossein AU - Kobeissy, Firas AU - Eid, Ali H. TI - The pharmaco-epigenetics of hypertension: a focus on microRNA JF - MOLECULAR AND CELLULAR BIOCHEMISTRY J2 - MOL CELL BIOCHEM VL - in press PY - 2024 SN - 0300-8177 DO - 10.1007/s11010-024-04947-9 UR - https://m2.mtmt.hu/api/publication/34722095 ID - 34722095 AB - Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, the prevalence of hypertension is projected to reach 1.5 billion people. The pathophysiology of this disease is multifaceted, as it involves nitric oxide and endothelin dysregulation, reactive oxygen species, vascular smooth muscle proliferation, and vessel wall calcification, among others. With the advent of new biomolecular techniques, various studies have elucidated a gaping hole in the etiology and mechanisms of hypertension. Indeed, epigenetics, DNA methylation, histone modification, and microRNA-mediated translational silencing appear to play crucial roles in altering the molecular phenotype into a hypertensive profile. Here, we critically review the experimentally determined associations between microRNA (miRNA) molecules and hypertension pharmacotherapy. Particular attention is given to the epigenetic mechanisms underlying the physiological responses to antihypertensive drugs like candesartan, and other relevant drugs like clopidogrel, aspirin, and statins among others. Furthermore, how miRNA affects the pharmaco-epigenetics of hypertension is especially highlighted. LA - English DB - MTMT ER - TY - JOUR AU - Yadav, Rajbala AU - Singh, AjayVir AU - Kushwaha, Shweta AU - Chauhan, DevendraSingh TI - Emerging role of exosomes as a liquid biopsy tool for diagnosis, prognosis & monitoring treatment response of communicable & non-communicable diseases JF - INDIAN JOURNAL OF MEDICAL RESEARCH J2 - INDIAN J MED RES VL - 159 PY - 2024 IS - 2 SN - 0971-5916 DO - 10.4103/ijmr.ijmr_2344_22 UR - https://m2.mtmt.hu/api/publication/34806786 ID - 34806786 LA - English DB - MTMT ER - TY - JOUR AU - Aharon, Anat AU - Rebibo-Sabbah, Annie AU - Ahmad, Rawan Sayed AU - Dangot, Ayelet AU - Bar-Lev, Tali Hana AU - Brenner, Benjamin AU - Cohen, Adi Halberthal AU - David, Chen Ben AU - Weiner, Zeev AU - Solt, Ido TI - Associations of maternal and placental extracellular vesicle miRNA with preeclampsia JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 11 PY - 2023 SN - 2296-634X DO - 10.3389/fcell.2023.1080419 UR - https://m2.mtmt.hu/api/publication/33661426 ID - 33661426 AB - Introduction: Gestational vascular complications (GVCs), including gestational hypertension and preeclampsia, are leading causes of maternal morbidity and mortality. Elevated levels of extracellular vesicles (EVs), in GVC have been linked to vascular injury. This study aims to characterize placental and circulating EV miRNA in GVCs, and explores the involvement of EV-miRNA in GVC, and whether they may be used to distinguish between placental and maternal pathologies. LA - English DB - MTMT ER - TY - JOUR AU - Al Darwish, Fatimah M. AU - Meijerink, Lotte AU - Coolen, Bram F. AU - Strijkers, Gustav J. AU - Bekker, Mireille AU - Lely, Titia AU - Terstappen, Fieke TI - From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes JF - CELLS J2 - CELLS-BASEL VL - 12 PY - 2023 IS - 16 SN - 2073-4409 DO - 10.3390/cells12162080 UR - https://m2.mtmt.hu/api/publication/34104586 ID - 34104586 AB - Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation. LA - English DB - MTMT ER - TY - CHAP AU - Chen, Lin AU - Yang, Jun AU - Xu, Guodong AU - Wu, Yuxiang ED - Tian, Geng ED - Yang, Jialiang ED - Huang, Tao TI - Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases T2 - Liquid Biopsies: Methods and Protocols PB - Springer US CY - New York, New York SN - 9781071633465 T3 - Methods in Molecular Biology, ISSN 1064-3745 ; 2695. PY - 2023 SP - 317 EP - 335 PG - 19 DO - 10.1007/978-1-0716-3346-5_22 UR - https://m2.mtmt.hu/api/publication/34064023 ID - 34064023 LA - English DB - MTMT ER - TY - JOUR AU - Dimik, Marko AU - Abeysinghe, Pevindu AU - Logan, Jayden AU - Mitchell, Murray TI - The exosome: a review of current therapeutic roles and capabilities in human reproduction JF - DRUG DELIVERY AND TRANSLATIONAL RESEARCH J2 - DRUG DELIV TRANSLAT RES VL - 13 PY - 2023 IS - 2 SP - 473 EP - 502 PG - 30 SN - 2190-393X DO - 10.1007/s13346-022-01225-3 UR - https://m2.mtmt.hu/api/publication/33059360 ID - 33059360 N1 - Összes idézések száma a WoS-ban: 0 AB - Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the human body and therefore are not prone to immunogenicity effects which would otherwise destroy unelicited foreign bodies. Clinically, they have been regarded as ideal candidates for applications relating to biomarker developments for the early detection of different diseases. Furthermore, exosomes may be of interest as potential drug delivery vehicles, which may improve factors such as bioavailability of loaded molecular cargo, side effect profiles, off-target effects, and pharmacokinetics of drug molecules. In this review, the therapeutic potential of exosomes and their use as clinical biomarkers for early diagnostics will be explored, alongside exosomes as therapeutic delivery vehicles. This review will evaluate techniques for cargo loading, and the capacity of loaded exosomes to improve various reproductive disease states. It becomes important, therefore, to consider factors such as loading efficiency, loading methods, cell viability, exosomal sources, exosome isolation, and the potential therapeutic benefits of exosomes. Issues related to targeted drug delivery will also be discussed. Finally, the variety of therapeutic cargo and the application of appropriate loading methods is explored, in the context of establishing clinical utility. LA - English DB - MTMT ER - TY - JOUR AU - Gallo, D.M. AU - Fitzgerald, W. AU - Romero, R. AU - Gomez-Lopez, N. AU - Gudicha, D.W. AU - Than, Nándor Gábor AU - Bosco, M. AU - Chaiworapongsa, T. AU - Jung, E. AU - Meyyazhagan, A. AU - Suksai, M. AU - Gotsch, F. AU - Erez, O. AU - Tarca, A.L. AU - Margolis, L. TI - Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death JF - JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE J2 - J MATERN-FETAL NEO M VL - 36 PY - 2023 IS - 1 PG - 20 SN - 1476-7058 DO - 10.1080/14767058.2023.2177529 UR - https://m2.mtmt.hu/api/publication/33682721 ID - 33682721 N1 - Cited By :1 Export Date: 15 December 2023 CODEN: JMNMA Correspondence Address: Margolis, L.; Section on Intercellular Interactions, 29 Lincoln Drive, 29B/1H16D, United States; email: margolil@mail.nih.gov LA - English DB - MTMT ER - TY - JOUR AU - Jusic, Amela AU - Junuzovic, Inela AU - Hujdurovic, Ahmed AU - Zhang, Lu AU - Vausort, Mélanie AU - Devaux, Yvan TI - A Machine Learning Model Based on microRNAs for the Diagnosis of Essential Hypertension JF - NON-CODING RNA J2 - NON-CODING RNA VL - 9 PY - 2023 IS - 6 SN - 2311-553X DO - 10.3390/ncrna9060064 UR - https://m2.mtmt.hu/api/publication/34224842 ID - 34224842 N1 - Funding Agency and Grant Number: European Union's Horizon 2020 research and innovation programme under the Marie Sklstrok;odowska-Curie Actions individual fellowship Funding text: The authors would like to thank Vesna Bratovcic, vice-rector for international relations at the University of Tuzla, Bosnia and Herzegovina, for the coordination of the blood sample transfer from the University of Tuzla to the Luxembourg Institute of Health. Thanks to Christelle Nicolas, a laboratory technician at the Cardiovascular Research Unit, LIH, for the great contribution to RT-qPCR experiments and Andrew Lumley, research engineer at the Cardiovascular Research Unit, LIH, for the critical reading of the manuscript. AB - Introduction: Hypertension is a major and modifiable risk factor for cardiovascular diseases. Essential, primary, or idiopathic hypertension accounts for 90–95% of all cases. Identifying novel biomarkers specific to essential hypertension may help in understanding pathophysiological pathways and developing personalized treatments. We tested whether the integration of circulating microRNAs (miRNAs) and clinical risk factors via machine learning modeling may provide useful information and novel tools for essential hypertension diagnosis and management. Materials and methods: In total, 174 participants were enrolled in the present observational case–control study, among which, there were 89 patients with essential hypertension and 85 controls. A discovery phase was conducted using small RNA sequencing in whole blood samples obtained from age- and sex-matched hypertension patients (n = 30) and controls (n = 30). A validation phase using RT-qPCR involved the remaining 114 participants. For machine learning, 170 participants with complete data were used to generate and evaluate the classification model. Results: Small RNA sequencing identified seven miRNAs downregulated in hypertensive patients as compared with controls in the discovery group, of which six were confirmed with RT-qPCR. In the validation group, miR-210-3p/361-3p/362-5p/378a-5p/501-5p were also downregulated in hypertensive patients. A machine learning support vector machine (SVM) model including clinical risk factors (sex, BMI, alcohol use, current smoker, and hypertension family history), miR-361-3p, and miR-501-5p was able to classify hypertension patients in a test dataset with an AUC of 0.90, a balanced accuracy of 0.87, a sensitivity of 0.83, and a specificity of 0.91. While five miRNAs exhibited substantial downregulation in hypertension patients, only miR-361-3p and miR-501-5p, alongside clinical risk factors, were consistently chosen in at least eight out of ten sub-training sets within the SVM model. Conclusions: This study highlights the potential significance of miRNA-based biomarkers in deepening our understanding of hypertension’s pathophysiology and in personalizing treatment strategies. The strong performance of the SVM model highlights its potential as a valuable asset for diagnosing and managing essential hypertension. The model remains to be extensively validated in independent patient cohorts before evaluating its added value in a clinical setting. LA - English DB - MTMT ER - TY - JOUR AU - Kubo, Ayane AU - Matsubara, Keiichi AU - Matsubara, Yuko AU - Nakaoka, Hirotomo AU - Sugiyama, Takashi TI - The Influence of Nicotine on Trophoblast-Derived Exosomes in a Mouse Model of Pathogenic Preeclampsia JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 13 SN - 1661-6596 DO - 10.3390/ijms241311126 UR - https://m2.mtmt.hu/api/publication/34066420 ID - 34066420 AB - Preeclampsia (PE) is a serious complication of pregnancy with a pathogenesis that is not fully understood, though it involves the impaired invasion of extravillous trophoblasts (EVTs) into the decidual layer during implantation. Because the risk of PE is actually decreased by cigarette smoking, we considered the possibility that nicotine, a critical component of tobacco smoke, might protect against PE by modifying the content of exosomes from EVTs. We investigated the effects of nicotine on our PE model mouse and evaluated blood pressure. Next, exosomes were extracted from nicotine-treated extravillous trophoblasts (HTR-8/SVneo), and the peptide samples were evaluated by DIA (Data Independent Acquisition) proteomic analysis following nano LC-MS/MS. Hub proteins were identified using bioinformatic analysis. We found that nicotine significantly reduced blood pressure in a PE mouse model. Furthermore, we identified many proteins whose abundance in exosomes was modified by nicotine treatment of EVTs, and we used bioinformatic annotation and network analysis to select five key hub proteins with potential roles in the pathogenesis or prevention of PE. EVT-derived exosomes might influence the pathogenesis of PE because the cargo delivered by exosomes can signal to and modify the receiving cells and their environment. LA - English DB - MTMT ER - TY - JOUR AU - Nguyen, Cong Minh AU - Sallam, Mohamed AU - Islam, Md Sajedul AU - Clack, Kimberley AU - Soda, Narshone AU - Nguyen, Nam-Trung AU - Shiddiky, Muhammad J. A. TI - Placental Exosomes as Biomarkers for Maternal Diseases: Current Advances in Isolation, Characterization, and Detection JF - ACS SENSORS J2 - ACS SENSORS VL - 8 PY - 2023 IS - 7 SP - 2493 EP - 2513 PG - 21 SN - 2379-3694 DO - 10.1021/acssensors.3c00689 UR - https://m2.mtmt.hu/api/publication/34065462 ID - 34065462 N1 - Queensland Micro- and Nanotechnology Centre (QMNC), Griffith University, Nathan, QLD 4111, Australia School of Environment and Science (ESC), Griffith University, Nathan, QLD 4111, Australia School of Medicine and Dentistry, Griffith University, Southport, QLD 4222, Australia Rural Health Research Institute, Charles Sturt University, Orange, NSW 2800, Australia Export Date: 5 September 2023 Correspondence Address: Shiddiky, M.J.A.; Queensland Micro- and Nanotechnology Centre (QMNC), Australia; email: mshiddiky@csu.edu.au LA - English DB - MTMT ER - TY - JOUR AU - Rao, Aishwarya AU - Shinde, Uma AU - Das, Dhanjit Kumar AU - Balasinor, Nafisa AU - Madan, Taruna TI - Early prediction of pre-eclampsia using circulating placental exosomes. Newer insights. TS - Newer insights. JF - INDIAN JOURNAL OF MEDICAL RESEARCH J2 - INDIAN J MED RES VL - 158 PY - 2023 IS - 4 SP - 385 EP - 396 PG - 12 SN - 0971-5916 DO - 10.4103/ijmr.ijmr_2143_22 UR - https://m2.mtmt.hu/api/publication/34403802 ID - 34403802 N1 - Department of Innate Immunity, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai, Maharashtra, India Department of Neuroendocrinology, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai, Maharashtra, India Department of Stem Cell Biology, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai, Maharashtra, India Export Date: 07 December 2023 AB - Pre-eclampsia (PE), a multifactorial de novo hypertensive pregnancy disorder, is one of the leading causes of foeto-maternal morbidity and mortality. Currently, antihypertensive drugs are the first-line therapy for PE and evidence suggests that low-dose aspirin initiated early in high risk pregnancies may reduce the risk of development or severity of PE. However, an early prediction of this disorder remains an unmet clinical challenge. Several potential serum biomarkers associated with maternal immunoregulation and placental angiogenesis have been evaluated but are ineffective and inconsistent for early prediction. Although placental biomarkers would be more specific and sensitive in predicting the risk of PE, accessing the placenta during pregnancy is not feasible. Circulating placental exosomes (pEXO), originating from foeto-maternal interface, are being evaluated as the placenta's surrogate and the best source of non-invasive placental biomarkers. pEXO appear in the maternal circulation starting from six weeks of gestation and its dynamic biological cargo across pregnancy is associated with successful pregnancy outcomes. Therefore, monitoring changes in pEXO expression profiles could provide new insights into the prediction, diagnosis and treatment of PE. This narrative review comprehensively summarizes the available literature on the candidate predictive circulating biomarkers evaluated for PE to date. In particular, the review elucidates the current knowledge of distinct molecular signatures emanating from pEXO in pre-eclamptic women to support the discovery of novel early predictive biomarkers for effective intervention and management of the disease. LA - English DB - MTMT ER - TY - CHAP AU - Wang, Peiyu AU - Yuan, Yuyao AU - Qiu, Mantang ED - Tian, Geng ED - Yang, Jialiang ED - Huang, Tao TI - Identification of Plasma Metabolites Associated with Lung Cancer Survival T2 - Liquid Biopsies: Methods and Protocols PB - Springer US CY - New York, New York SN - 9781071633465 T3 - Methods in Molecular Biology, ISSN 1064-3745 ; 2695. PY - 2023 SP - 181 EP - 193 PG - 13 DO - 10.1007/978-1-0716-3346-5_12 UR - https://m2.mtmt.hu/api/publication/34091236 ID - 34091236 LA - English DB - MTMT ER - TY - JOUR AU - Xiong, Jiali AU - Fan, Yaotian AU - Wang, Yuxuan AU - Luo, Junyi AU - Chen, Ting AU - Sun, Jiajie AU - Xi, Qianyun AU - Zhang, Yongliang TI - New signaling kid on the block in the endocrine system: the role of extracellular vesicles JF - ENDOCRINOLOGY J2 - ENDOCRINOLOGY VL - 164 PY - 2023 IS - 8 SN - 0013-7227 DO - 10.1210/endocr/bqad099 UR - https://m2.mtmt.hu/api/publication/34047720 ID - 34047720 LA - English DB - MTMT ER - TY - JOUR AU - ALTINTAŞ, Nuray AU - TONK, Onur AU - SARICA YILMAZ, Özge TI - Effects of microRNAs in hypertension disease JF - EUROPEAN RESEARCH JOURNAL J2 - EUR RES J VL - 8 PY - 2022 IS - 1 SP - 131 EP - 138 PG - 8 SN - 2149-3189 DO - 10.18621/eurj.855796 UR - https://m2.mtmt.hu/api/publication/32636372 ID - 32636372 LA - English DB - MTMT ER - TY - JOUR AU - Barranco, Isabel AU - Salas-Huetos, Albert AU - Berlanga, Angel AU - Spinaci, Marcella AU - Yeste, Marc AU - Ribas-Maynou, Jordi TI - Involvement of extracellular vesicle-encapsulated miRNAs in human reproductive disorders: a systematic review JF - REPRODUCTION FERTILITY AND DEVELOPMENT J2 - REPROD FERT DEVELOP VL - 34 PY - 2022 IS - 11 SP - 751 EP - 755 PG - 5 SN - 1031-3613 DO - 10.1071/RD21301 UR - https://m2.mtmt.hu/api/publication/32836977 ID - 32836977 LA - English DB - MTMT ER - TY - JOUR AU - Brown, Paul A. TI - Differential and targeted vesiculation: pathologic cellular responses to elevated arterial pressure JF - MOLECULAR AND CELLULAR BIOCHEMISTRY J2 - MOL CELL BIOCHEM VL - 477 PY - 2022 IS - 4 SP - 1023 EP - 1040 PG - 18 SN - 0300-8177 DO - 10.1007/s11010-021-04351-7 UR - https://m2.mtmt.hu/api/publication/32605459 ID - 32605459 N1 - Cited By :4 Export Date: 9 June 2023 CODEN: MCBIB Correspondence Address: Brown, P.A.; Department of Basic Medical Sciences, Mona, Jamaica; email: paul.brown02@uwimona.edu.jm LA - English DB - MTMT ER - TY - JOUR AU - Das, Kaushik AU - Rao, L. Vijaya Mohan TI - The Role of microRNAs in Inflammation JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 24 SN - 1661-6596 DO - 10.3390/ijms232415479 UR - https://m2.mtmt.hu/api/publication/33298784 ID - 33298784 AB - Inflammation is a biological response of the immune system to various insults, such as pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro- and anti-inflammatory factors and their direction towards inflammation often leads to the development and progression of various inflammation-associated diseases. The role of small non-coding RNAs (small ncRNAs) in inflammation has gained much attention in the past two decades for their regulation of inflammatory gene expression at multiple levels and their potential to serve as biomarkers and therapeutic targets in various diseases. One group of small ncRNAs, microRNAs (miRNAs), has become a key regulator in various inflammatory disease conditions. Their fine-tuning of target gene regulation often turns out to be an important factor in controlling aberrant inflammatory reactions in the system. This review summarizes the biogenesis of miRNA and the mechanisms of miRNA-mediated gene regulation. The review also briefly discusses various pro- and anti-inflammatory miRNAs, their targets and functions, and provides a detailed discussion on the role of miR-10a in inflammation. LA - English DB - MTMT ER - TY - JOUR AU - Ghafourian, Mehri AU - Mahdavi, Roya AU - Akbari Jonoush, Zahra AU - Sadeghi, Mahvash AU - Ghadiri, Nooshin AU - Farzaneh, Maryam AU - Mousavi Salehi, Abdolah TI - The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets JF - CELL COMMUNICATION AND SIGNALING J2 - CELL COMM SIGN VL - 20 PY - 2022 IS - 1 SN - 1478-811X DO - 10.1186/s12964-022-00853-z UR - https://m2.mtmt.hu/api/publication/32781783 ID - 32781783 LA - English DB - MTMT ER - TY - JOUR AU - Gupta, Shweta AU - Mazumder, P.B. TI - Exosomes as diagnostic tools JF - ADVANCES IN CLINICAL CHEMISTRY J2 - ADV CLIN CHEM VL - 110 PY - 2022 SP - 117 EP - 144 PG - 28 SN - 0065-2423 DO - 10.1016/bs.acc.2022.06.004 UR - https://m2.mtmt.hu/api/publication/33077919 ID - 33077919 AB - Exosomes have evolved into novel candidates as diagnostic tools due to their composition of proteins and nucleic acids and ability to cross hypoxic regions, the systemic circulation and blood vessel barriers. Exosomes are nano-sized extracellular vesicles that contain information from their source cells and are found in almost all body fluids. In this chapter, we have focused on basic biogenesis, contents, and functions of these unique particles, and provide a comprehensive discussion on their usefulness as novel diagnostic tools in various diseases. In addition, these unique features make them potential candidates for development of advanced therapeutics and monitoring thereof. © 2022 Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - Gusar, Vladislava AU - Timofeeva, Angelika AU - Chagovets, Vitaliy AU - Kan, Nataliya AU - Vysokikh, Mikhail AU - Marey, Maria AU - Karapetyan, Anna AU - Baev, Oleg AU - Sukhikh, Gennadiy TI - Diagnostic Potential of Exosomal HypoxamiRs in the Context of Hypoxia–Sumoylation–HypoxamiRs in Early Onset Preeclampsia at the Preclinical Stage JF - LIFE-BASEL J2 - LIFE-BASEL VL - 12 PY - 2022 IS - 1 SN - 2075-1729 DO - 10.3390/life12010101 UR - https://m2.mtmt.hu/api/publication/32595696 ID - 32595696 LA - English DB - MTMT ER - TY - JOUR AU - Howe, Caitlin G AU - Foley, Helen B AU - Kennedy, Elizabeth M AU - Eckel, Sandrah P AU - Chavez, Thomas a AU - Faham, Dema AU - Grubbs, Brendan H AU - Al-Marayati, Laila AU - Lerner, Deborah AU - Suglia, Shakira AU - Bastain, Theresa M AU - Marsit, Carmen J AU - Breton, Carrie V TI - Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study JF - EPIGENETICS J2 - EPIGENETICS-US VL - 17 PY - 2022 IS - 3 SP - 269 EP - 285 PG - 17 SN - 1559-2294 DO - 10.1080/15592294.2021.1899887 UR - https://m2.mtmt.hu/api/publication/32011224 ID - 32011224 N1 - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States Gangarosa Department of Environmental Health, Emory Rollins School of Public Health, Atlanta, GA, United States Department of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, CA, United States Eisner Health, Los Angeles, CA, United States Department of Epidemiology, Emory Rollins School of Public Health, Atlanta, GA, United States Export Date: 19 December 2021 Correspondence Address: Howe, C.G.; Department of Epidemiology, Lebanon; email: Caitlin.G.Howe@Dartmouth.edu LA - English DB - MTMT ER - TY - JOUR AU - Jiang, Hongxia AU - Zhao, Hanqiu AU - Zhang, Mengzhe AU - He, Yuanzhou AU - Li, Xiaochen AU - Xu, Yongjian AU - Liu, Xiansheng TI - Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 13 PY - 2022 SN - 1664-3224 DO - 10.3389/fimmu.2022.824188 UR - https://m2.mtmt.hu/api/publication/32802661 ID - 32802661 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [81973987, 81700051, 81700052] Funding text: This study was funded by grants from the National Natural Science Foundation of China (No. 81973987, 81700051 and 81700052). LA - English DB - MTMT ER - TY - JOUR AU - Kazemzadeh, Mohammadrahim AU - Martinez-Calderon, Miguel AU - Paek, Song Y. AU - Lowe, MoiMoi AU - Aguergaray, Claude AU - Xu, Weiliang AU - Chamley, Lawrence W. AU - Broderick, Neil G. R. AU - Hisey, Colin L. TI - Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser Fabricated Nanoplasmonic Sensors JF - ACS SENSORS J2 - ACS SENSORS VL - 7 PY - 2022 IS - 6 SP - 1698 EP - 1711 PG - 14 SN - 2379-3694 DO - 10.1021/acssensors.2c00378 UR - https://m2.mtmt.hu/api/publication/33034176 ID - 33034176 N1 - Funding Agency and Grant Number: Health Research Council of New Zealand; Auckland Medical Research Foundation; Goodfellow Fund for the Support of Urological Research Funding text: The authors would like to thank the Photon Factory and the Hub for Extracellular Vesicle Investigations at the University of Auckland, and the LEGACY postdoctoral scholars program at The Ohio State University for their continued support. This work was funded by The Health Research Council of New Zealand, Auckland Medical Research Foundation, and the Goodfellow Fund for the Support of Urological Research. LA - English DB - MTMT ER - TY - JOUR AU - Li, Yuanyuan AU - Han, Xinning AU - Yu, Lin TI - Study of serum miR-518 and its correlation with inflammatory factors in patients with gestational diabetes mellitus complicated with hypertensive disorder complicating pregnancy JF - EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY J2 - EUR J OBSTET GYN R B (EJOG) VL - 272 PY - 2022 SP - 198 EP - 205 PG - 8 SN - 0301-2115 DO - 10.1016/j.ejogrb.2022.03.005 UR - https://m2.mtmt.hu/api/publication/32723312 ID - 32723312 LA - English DB - MTMT ER - TY - JOUR AU - Ortega, Miguel A. AU - Fraile-Martínez, Oscar AU - García-Montero, Cielo AU - Paradela, Alberto AU - Asunción Sánchez-Gil, María AU - Rodriguez-Martin, Sonia AU - De León-Luis, Juan A. AU - Pereda-Cerquella, Claude AU - Bujan, Julia AU - Guijarro, Luis G. AU - Alvarez-Mon, Melchor AU - García-Honduvilla, Natalio TI - Unfolding the role of placental-derived Extracellular Vesicles in Pregnancy: From homeostasis to pathophysiology JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 10 PY - 2022 SP - 1 SN - 2296-634X DO - 10.3389/fcell.2022.1060850 UR - https://m2.mtmt.hu/api/publication/33262577 ID - 33262577 N1 - Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain Cancer Registry and Pathology Department, Principe de Asturias University Hospital, Alcala de Henares, Spain Proteomics Core Facility, CNB-CSIC, Madrid, Spain University Defense Center of Madrid (CUD), Madrid, Spain Service of Pediatric, Hospital Universitario Principe de Asturias, Alcalá de Henares, Spain Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, Madrid, Spain Health Research Institute Gregorio Marañón, Madrid, Spain Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Ma-drid, Madrid, Spain Unit of Biochemistry and Molecular Biology, Centro de Investigación Biomédica en Red en El Área Temática de Enfermedades Hepáticas (CIBEREHD), Department of System Biology, University of Alcalá, Alcala de Henares, Spain Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine, Centro de Investigación Biomédica en Red en El Área Temática de Enfermedades Hepáticas (CIBEREHD), University Hospital Príncipe de Asturias, Alcala de Henares, Spain Cited By :6 Export Date: 1 December 2023 Correspondence Address: Ortega, M.A.; Department of Medicine and Medical Specialities, Spain; email: miguel.angel.ortega92@gmail.com AB - The human placenta is a critical structure with multiple roles in pregnancy, including fetal nutrition and support, immunological, mechanical and chemical barrier as well as an endocrine activity. Besides, a growing body of evidence highlight the relevance of this organ on the maternofetal wellbeing not only during gestation, but also from birth onwards. Extracellular vesicles (EVs) are complex macromolecular structures of different size and content, acting as carriers of a diverse set of molecules and information from donor to recipient cells. Since its early development, the production and function of placental-derived EVs are essential to ensure an adequate progress of pregnancy. In turn, the fetus receives and produce their own EVs, highlighting the importance of these components in the maternofetal communication. Moreover, several studies have shown the clinical relevance of EVs in different obstetric pathologies such as preeclampsia, infectious diseases or gestational diabetes, among others, suggesting that they could be used as pathophysiological biomarkers of these diseases. Overall, the aim of this article is to present an updated review of the published basic and translational knowledge focusing on the role of placental-derived EVs in normal and pathological pregnancies. We suggest as well future lines of research to take in this novel and promising field. LA - English DB - MTMT ER - TY - JOUR AU - Powell, Juliana S. AU - Gandley, Robin E. AU - Lackner, Emily AU - Dolinish, Andrea AU - Ouyang, Yingshi AU - Powers, Robert W. AU - Morelli, Adrian E. AU - Hubel, Carl A. AU - Sadovsky, Yoel TI - Small extracellular vesicles from plasma of women with preeclampsia increase myogenic tone and decrease endothelium-dependent relaxation of mouse mesenteric arteries JF - PREGNANCY HYPERTENSION J2 - PREGNANCY HYPERTENS VL - 28 PY - 2022 SP - 66 EP - 73 PG - 8 SN - 2210-7789 DO - 10.1016/j.preghy.2022.02.005 UR - https://m2.mtmt.hu/api/publication/32690510 ID - 32690510 N1 - Funding Agency and Grant Number: Eunice Kennedy Shriver NICHD [P01HD030367, R37HD086916]; NIAID [R01AI148690]; Pennsylvania Department of Health Formula Research Funds; American Heart Association Go Red for Women Strategically Focused Research Network [16SFRN28340000]; Margaret Ritchie R. Battle Family Charitable Fund Funding text: The project was supported by Eunice Kennedy Shriver NICHD grant R37HD086916 (to Y.S.) , NIAID grant R01AI148690 (to A.M. and Y.S.) , Eunice Kennedy Shriver NICHD grant P01HD030367 (to C.A.H., R.W.P., and R.E.G.) , Pennsylvania Department of Health Formula Research Funds (to C.A.H., R.W.P., and R.E.G,) , American Heart Association Go Red for Women Strategically Focused Research Network grant 16SFRN28340000 (to C.A.H., R.W.P., and R.E.G.) , and the Margaret Ritchie R. Battle Family Charitable Fund (to C.A.H. and Y.S.) . LA - English DB - MTMT ER - TY - JOUR AU - Quadri, Zainuddin AU - Elsherbini, Ahmed AU - Bieberich, Erhard TI - Extracellular vesicles in pharmacology: Novel approaches in diagnostics and therapy JF - PHARMACOLOGICAL RESEARCH J2 - PHARMACOL RES VL - 175 PY - 2022 SN - 1043-6618 DO - 10.1016/j.phrs.2021.105980 UR - https://m2.mtmt.hu/api/publication/32543517 ID - 32543517 N1 - Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, United States Veterans Affairs Medical Center, Lexington, KY 40502, United States Export Date: 19 December 2021 CODEN: PHMRE Correspondence Address: Bieberich, E.; Department of Physiology, 780 Rose St. Room MS519, United States; email: Erhard.bieberich@uky.edu LA - English DB - MTMT ER - TY - JOUR AU - Zarkovic, Milena AU - Hufsky, Franziska AU - Markert, Udo R. AU - Marz, Manja TI - The Role of Non-Coding RNAs in the Human Placenta JF - CELLS J2 - CELLS-BASEL VL - 11 PY - 2022 IS - 9 SN - 2073-4409 DO - 10.3390/cells11091588 UR - https://m2.mtmt.hu/api/publication/32908724 ID - 32908724 N1 - Funding Agency and Grant Number: DFG, German Research Foundation [MA1550/12-1, MA5082/9-1]; Landesprogramm ProDigital [DigLeben-5575/10-9] Funding text: We thank the DFG, German Research Foundation (MA1550/12-1, MA5082/9-1) and the Landesprogramm ProDigital (DigLeben-5575/10-9) for financial support. LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Ji-Ru AU - Sun, Hai-Jian TI - Extracellular Vesicle-Mediated Vascular Cell Communications in Hypertension: Mechanism Insights and Therapeutic Potential of ncRNAs JF - CARDIOVASCULAR DRUGS AND THERAPY J2 - CARDIOVASC DRUG THER VL - 36 PY - 2022 IS - 1 SP - 157 EP - 172 PG - 16 SN - 0920-3206 DO - 10.1007/s10557-020-07080-z UR - https://m2.mtmt.hu/api/publication/31612542 ID - 31612542 LA - English DB - MTMT ER - TY - JOUR AU - Cooke, William R. AU - Jones, Gabriel D. AU - Redman, Christopher W.G. AU - Vatish, Manu TI - Syncytiotrophoblast Derived Extracellular Vesicles in Relation to Preeclampsia JF - MATERNAL-FETAL MEDICINE J2 - MATERNAL-FETAL MEDICINE VL - 3 PY - 2021 IS - 2 SP - 151 EP - 160 PG - 10 SN - 2096-6954 DO - 10.1097/FM9.0000000000000093 UR - https://m2.mtmt.hu/api/publication/32001774 ID - 32001774 N1 - Export Date: 19 December 2021 Correspondence Address: Cooke, W.R.; Nuffield Department of Women's and Reproductive Health, United Kingdom; email: william.cooke@wrh.ox.ac.uk LA - English DB - MTMT ER - TY - JOUR AU - Hashimoto, Ayako AU - Sugiura, Kei AU - Hoshino, Ayuko TI - Impact of exosome-mediated feto-maternal interactions on pregnancy maintenance and development of obstetric complications JF - JOURNAL OF BIOCHEMISTRY J2 - J BIOCHEM-TOKYO VL - 169 PY - 2021 IS - 2 SP - 163 EP - 171 PG - 9 SN - 0021-924X DO - 10.1093/jb/mvaa137 UR - https://m2.mtmt.hu/api/publication/31778443 ID - 31778443 N1 - Export Date: 19 December 2021 CODEN: JOBIA Correspondence Address: Hashimoto, A.; Department of Obstetrics and Gynecology, Hongo 7-3-1, Japan; email: hashimotoa-gyn@h.u-tokyo.ac.jp Correspondence Address: Hoshino, A.; School of Life Science and Technology, Nagatsuta-cho 4259, Japan; email: ayukohoshino@bio.titech.ac.jp LA - English DB - MTMT ER - TY - JOUR AU - Jin, Yan AU - Jia, Tingting AU - Wu, Xueling AU - Wang, Yanyan AU - Sun, Wenwen AU - Chen, Yajun AU - Wu, Guimei TI - The predictive value of microRNA in early hypertensive disorder complicating pregnancy (HDCP). JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 13 PY - 2021 IS - 6 SP - 7288 EP - 7293 PG - 6 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/32116691 ID - 32116691 N1 - Obstetrics Department I, Cangzhou Central Hospital, Cangzhou, China Obstetrics Department III, Cangzhou Central Hospital, Cangzhou, China Export Date: 19 December 2021 AB - To examine the predictive value of microRNA (miRNA) in hypertensive disorder complicating pregnancy (HDCP).102 pregnant women with HDCP admitted to our hospital from March 2017 to June 2019 were recruited as the study cohort and randomly divided into an HDCP group, a mild preeclampsia group, and a severe preeclampsia group, with 34 patients in each group. In addition, 34 healthy pregnant women who underwent pregnancy tests in our hospital were recruited as the normal group. The relative expressions of plasma miR-19a, miR-126, and miRNA-210 in were measured. A Pearson correlation analysis was used to analyze the correlations between the miR-19a, miR-181b, and miRNA-210 expressions and the severity of HDCP. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of the miR-19a, miR-126, and miRNA-210 expressions.The miR-19a and miRNA-210 expressions were higher in the HDCP group, the mild preeclampsia group, and the severe preeclampsia group than they were in the normal group, and the miR-126 expression was lower (all P<0.05). The miR-19a, miR-126, and miRNA-210 expressions were different among the four groups (P<0.05). The miR-19a and miRNA-210 expression levels in the severe preeclampsia group were higher than they were in the HDCP group, and the miR-126 expression was lower (P<0.05). A Pearson correlation analysis showed the miR-19a and miR-210 levels in the HDCP patients were positively correlated with the severity of the disease (P<0.05), and the miR-126 level is negatively correlated with disease severity (P<0.05). Our ROC curve analysis demonstrated that the miR-19a, miR-126, and miR-210 levels have a predictive value for HDCP. The areas under the curve were 0.800, 0.633, and 0.723, the sensitivities were 81.2%, 71.4%, and 80.2%, and the specificities were 73.5%, 67.5%, 81.5%. Additionally, the area under the curve of the combination of the three was 0.896, and the sensitivity and specificity were 90.5% and 93.9% respectively.miR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically. LA - English DB - MTMT ER - TY - JOUR AU - Kolkova, Zuzana AU - Holubekova, Veronika AU - Grendar, Marian AU - Nachajova, Marcela AU - Zubor, Pavol AU - Pribulova, Terezia AU - Loderer, Dusan AU - Zigo, Imrich AU - Biringer, Kamil AU - Hornakova, Andrea TI - Association of Circulating miRNA Expression with Preeclampsia, Its Onset, and Severity JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 11 PY - 2021 IS - 3 SP - 476 SN - 2075-4418 DO - 10.3390/diagnostics11030476 UR - https://m2.mtmt.hu/api/publication/31908674 ID - 31908674 N1 - Funding Agency and Grant Number: VEGA from the Ministry of Education of The Slovak Republic [1/0272/19]; Project Centre of Excellence for Research in Personalised Therapy (CEVYPET) [26220120053]; EU; European Regional Development Fund Funding text: The present study was supported by VEGA (grant no. 1/0272/19) from the Ministry of Education of The Slovak Republic and by the Project Centre of Excellence for Research in Personalised Therapy (CEVYPET) (ITMS code: 26220120053), co-funded from the EU sources and European Regional Development Fund. LA - English DB - MTMT ER - TY - THES AU - Kovács, Árpád Ferenc TI - A terhességi immuntolerancia mechanizmusának vizsgálatai PY - 2021 DO - 10.14753/SE.2021.2430 UR - https://m2.mtmt.hu/api/publication/31778438 ID - 31778438 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pankiewicz, K. AU - Fijałkowska, A. AU - Issat, T. AU - Maciejewski, T.M. TI - Insight into the key points of preeclampsia pathophysiology: Uterine artery remodeling and the role of micrornas JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 6 PG - 14 SN - 1661-6596 DO - 10.3390/ijms22063132 UR - https://m2.mtmt.hu/api/publication/31932623 ID - 31932623 N1 - Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Department of Cardiology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Export Date: 26 March 2021 Correspondence Address: Pankiewicz, K.; Department of Obstetrics and Gynecology, Kasprzaka 17a, Poland; email: katarzynahak@wp.pl Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Department of Cardiology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Export Date: 30 March 2021 Correspondence Address: Pankiewicz, K.; Department of Obstetrics and Gynecology, Kasprzaka 17a, Poland; email: katarzynahak@wp.pl Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Department of Cardiology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland Export Date: 16 May 2021 Correspondence Address: Pankiewicz, K.; Department of Obstetrics and Gynecology, Kasprzaka 17a, Poland; email: katarzynahak@wp.pl AB - Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregnancy and is thought to be impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries that leads to reduced placental perfusion and release of numerous biological factors causing endothelial damage and development of acute maternal syndrome with systemic multiorgan failure (stage 2—the onset of maternal clinical symptoms, maternal stage). Recently, in the light of the vast body of evidence, two-stage model of preeclampsia has been updated with a few novel pathways leading to clinical manifestation in the second part of pregnancy. This paper reviews current state of knowledge about pathophysiology of preeclampsia and places particular focus on the recent advances in understanding of uterine artery remodeling alterations, as well as the role of microRNAs in preeclampsia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. LA - English DB - MTMT ER - TY - THES AU - Pirogova, M. M. TI - Роль неивазивных методов диагностики в оптимизации акушерской тактики при врастании и предлежании плаценты PY - 2021 UR - https://m2.mtmt.hu/api/publication/32513996 ID - 32513996 LA - Russian DB - MTMT ER - TY - JOUR AU - Wang, Zengfang AU - Yang, Ruizhen AU - Zhang, Jiaojiao AU - Wang, Pingping AU - Wang, Zengyan AU - Gao, Jian AU - Liu, Xue AU - Gu, Bingjie TI - Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance JF - MEDIATORS OF INFLAMMATION J2 - MEDIAT INFLAMM VL - 2021 PY - 2021 SN - 0962-9351 DO - 10.1155/2021/5558048 UR - https://m2.mtmt.hu/api/publication/32077778 ID - 32077778 N1 - Department of Gynecology and Obstetrics, Maternal and Child Health Hospital, Weifang Medical University, Weifang, 261000, China Operating Room, Zhucheng People's Hospital, Zhucheng, 262200, China Central Laboratory of Weifang People's Hospital, Weifang, 261000, China Department of Paediatrics, Maternal and Child Health Care Hospital of Weifang, Weifang, 261000, China Export Date: 5 November 2021 CODEN: MNFLE Correspondence Address: Liu, X.; Operating Room, China; email: rmyyliuxue@163.com Correspondence Address: Gao, J.; Department of Paediatrics, China; email: gaojian1650@126.com LA - English DB - MTMT ER - TY - JOUR AU - Xu, Peng AU - Ma, Yeling AU - Wu, Hongyu AU - Wang, Yan-Ling TI - Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 9 PY - 2021 SN - 2296-634X DO - 10.3389/fcell.2021.646326 UR - https://m2.mtmt.hu/api/publication/31934967 ID - 31934967 N1 - Export Date: 19 December 2021 Correspondence Address: Wang, Y.-L.; State Key Laboratory of Stem Cell and Reproductive Biology, China; email: wangyl@ioz.ac.cn Correspondence Address: Wang, Y.-L.; Beijing Institute for Stem Cell and Regenerative MedicineChina; email: wangyl@ioz.ac.cn Correspondence Address: Wang, Y.-L.; University of Chinese Academy of SciencesChina; email: wangyl@ioz.ac.cn LA - English DB - MTMT ER - TY - JOUR AU - Aplin, John D. AU - Myers, Jenny E. AU - Timms, Kate AU - Westwood, Melissa TI - Tracking placental development in health and disease JF - NATURE REVIEWS ENDOCRINOLOGY J2 - NAT REV ENDOCRINOL VL - 16 PY - 2020 IS - 9 SP - 479 EP - 494 PG - 16 SN - 1759-5029 DO - 10.1038/s41574-020-0372-6 UR - https://m2.mtmt.hu/api/publication/31367020 ID - 31367020 N1 - Maternal and Fetal Health Group, Manchester Academic Health Sciences Centre, St Mary’s Hospital, Manchester, United Kingdom Lydia Becker Institute of Inflammation and Immunology, The University of Manchester, Manchester, United Kingdom Cited By :16 Export Date: 14 May 2021 Correspondence Address: Aplin, J.D.; Maternal and Fetal Health Group, United Kingdom; email: john.aplin@manchester.ac.uk LA - English DB - MTMT ER - TY - JOUR AU - Buca, Danilo AU - Bologna, Giuseppina AU - D’Amico, Alice AU - Cugini, Sara AU - Musca, Francesca AU - Febbo, Melania AU - D’Arcangelo, Dolores AU - Buca, Davide AU - Simeone, Pasquale AU - Liberati, Marco AU - Vitacolonna, Ester AU - Miscia, Sebastiano AU - D’Antonio, Francesco AU - Lanuti, Paola TI - Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 6 SN - 1661-6596 DO - 10.3390/ijms21062120 UR - https://m2.mtmt.hu/api/publication/31256520 ID - 31256520 N1 - Department of Obstetrics and Gynecology, University of Chieti, Chieti, 66100, Italy Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, 66100, Italy Centre on Aging Sciences and Translational Medicine (Ce.S.I.-Me.T.), University “G. D’Annunzio” of Chieti-Pescara, Chieti, 66100, Italy School of Medicine and Health Science, G. d’Annunzio University of Chieti-Pescara, Chieti, 66100, Italy Department of Molecular Medicine and Development, University of Siena, Siena, 53100, Italy Fetal Medicine Unit, Department of Medical and Surgical Sciences, Department of Obstetrics and Gynecology, University of Foggia, Foggia, 71121, Italy Cited By :2 Export Date: 29 November 2020 Correspondence Address: Buca, D.; Department of Obstetrics and Gynecology, University of ChietiItaly; email: danilobuca@gmail.com LA - English DB - MTMT ER - TY - THES AU - Frazier, S. E. TI - Investigating Placental MicroRNAs in Preeclampsia and Optimising a Gene Therapy Strategy for Targeting the Placenta PY - 2020 UR - https://m2.mtmt.hu/api/publication/31871968 ID - 31871968 LA - English DB - MTMT ER - TY - JOUR AU - Gao, Xuelin AU - Shao, Lulu AU - Ge, Xinying AU - Zhang, Long AU - Chen, Dexin AU - He, Rongxia TI - The Potential Role of Serum Exosomes in Preeclampsia JF - CURRENT DRUG METABOLISM J2 - CURR DRUG METAB VL - 21 PY - 2020 IS - 5 SP - 352 EP - 356 PG - 5 SN - 1389-2002 DO - 10.2174/1389200221666200525152441 UR - https://m2.mtmt.hu/api/publication/31407098 ID - 31407098 LA - English DB - MTMT ER - TY - JOUR AU - Hornakova, A. AU - Kolkova, Z. AU - Holubekova, V. AU - Loderer, D. AU - Lasabova, Z. AU - Biringer, K. AU - Halasova, E. TI - Diagnostic Potential of MicroRNAs as Biomarkers in the Detection of Preeclampsia JF - GENETIC TESTING AND MOLECULAR BIOMARKERS J2 - GENET TEST MOL BIOMA VL - 24 PY - 2020 IS - 6 SP - 321 EP - 327 PG - 7 SN - 1945-0265 DO - 10.1089/gtmb.2019.0264 UR - https://m2.mtmt.hu/api/publication/31350673 ID - 31350673 N1 - Export Date: 18 June 2020 Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, 036 01, Slovakia Department of Molecular Biology and Genomics and Jessenius, Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia Export Date: 16 July 2020 Correspondence Address: Hornakova, A.; Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaSlovakia; email: a.mendelova@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Konečná, Barbora AU - Vlková, Barbora AU - Repiská, Gabriela AU - Tóthová, Ľubomíra TI - Transfection of maternal cells with placental extracellular vesicles in preeclampsia JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 141 PY - 2020 SN - 0306-9877 DO - 10.1016/j.mehy.2020.109721 UR - https://m2.mtmt.hu/api/publication/31336439 ID - 31336439 N1 - Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, Bratislava, Slovakia Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 2, Bratislava, Slovakia Export Date: 19 December 2021 CODEN: MEHYD Correspondence Address: Konečná, B.; Institute of Molecular Biomedicine, Sasinkova 4, Slovakia; email: barbora.konecna@imbm.sk LA - English DB - MTMT ER - TY - JOUR AU - Li, Hui AU - Ouyang, Yingshi AU - Sadovsky, Elena AU - Parks, W. Tony AU - Chu, Tianjiao AU - Sadovsky, Yoel TI - Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia JF - HYPERTENSION J2 - HYPERTENSION VL - 75 PY - 2020 IS - 3 SP - 762 EP - 771 PG - 10 SN - 0194-911X DO - 10.1161/HYPERTENSIONAHA.119.14081 UR - https://m2.mtmt.hu/api/publication/31143904 ID - 31143904 N1 - Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of PittsburghPA, United States Department of Microbiology and Molecular Genetics, University of PittsburghPA, United States Reproductive Department of Xiangya Hospital, Central South University, Changsha, Hunan, China Third Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of TorontoON, Canada Cited By :28 Export Date: 5 November 2021 CODEN: HPRTD Correspondence Address: Sadovsky, Y.; Magee-Womens Research Institute, 204 Craft Ave, United States; email: ysadovsky@mwri.magee.edu LA - English DB - MTMT ER - TY - JOUR AU - Li, Jun AU - Wu, Yan AU - Liu, Hui TI - Expression and role of miR‑338‑3p in peripheral blood and placenta of patients with pregnancy‑induced hypertension JF - EXPERIMENTAL AND THERAPEUTIC MEDICINE J2 - EXP THER MED VL - 20 PY - 2020 IS - 1 SP - 418 EP - 426 PG - 9 SN - 1792-0981 DO - 10.3892/etm.2020.8719 UR - https://m2.mtmt.hu/api/publication/31306484 ID - 31306484 LA - English DB - MTMT ER - TY - JOUR AU - Pérez-Roncero, Gonzalo R. AU - López-Baena, María T. AU - Pérez-López, Faustino R. AU - Escobar-Valdivieso, Gustavo S. AU - Chedraui, Peter AU - Hidalgo, Luis TI - Syncytiotrophoblast-derived extracellular products associated with preeclampsia JF - European Gynecology and Obstetrics J2 - EGO VL - 2 PY - 2020 IS - 2 SP - 90 EP - 93 PG - 4 SN - 2710-2580 UR - https://m2.mtmt.hu/api/publication/32514006 ID - 32514006 LA - English DB - MTMT ER - TY - JOUR AU - Wang, Hui AU - Wang, Lin AU - Zhou, Xiaocheng AU - Luo, Xinyue AU - Liu, Ke AU - Jiang, Erhui AU - Chen, Yang AU - Shao, Zhe AU - Shang, Zhengjun TI - OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2020 PY - 2020 PG - 13 SN - 2314-6133 DO - 10.1155/2020/2125656 UR - https://m2.mtmt.hu/api/publication/31377934 ID - 31377934 N1 - Export Date: 19 December 2021 Correspondence Address: Shang, Z.; State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), China; email: shangzhengjun@whu.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Yang, H. AU - Ma, Q. AU - Wang, Y. AU - Tang, Z. TI - Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities JF - JOURNAL OF TRANSLATIONAL MEDICINE J2 - J TRANSL MED VL - 18 PY - 2020 IS - 1 SN - 1479-5876 DO - 10.1186/s12967-020-02227-w UR - https://m2.mtmt.hu/api/publication/31167001 ID - 31167001 N1 - Export Date: 9 February 2020 Correspondence Address: Yang, H.; Department of Laboratory Medicine, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityChina; email: haiouyang2006@126.com LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Jiayin AU - Li, Haibo AU - Fan, Boyue AU - Xu, Wenrong AU - Zhang, Xu TI - Extracellular vesicles in normal pregnancy and pregnancy‐related diseases JF - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J2 - J CELL MOL MED VL - 24 PY - 2020 IS - 8 SP - 4377 EP - 4388 PG - 12 SN - 1582-1838 DO - 10.1111/jcmm.15144 UR - https://m2.mtmt.hu/api/publication/31252712 ID - 31252712 N1 - Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China Department of Clinical Laboratory, Nantong Maternal and Child Health Care Hospital, Nantong, China Export Date: 19 December 2021 Correspondence Address: Zhang, X.; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, China; email: xuzhang@ujs.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Zhou, Biting AU - Xu, Kailun AU - Zheng, Xi AU - Chen, Ting AU - Wang, Jian AU - Song, Yongmao AU - Shao, Yingkuan AU - Zheng, Shu TI - Application of exosomes as liquid biopsy in clinical diagnosis JF - SIGNAL TRANSDUCTION AND TARGETED THERAPY J2 - SIGNAL TRANSDUCT TAR VL - 5 PY - 2020 IS - 1 SN - 2095-9907 DO - 10.1038/s41392-020-00258-9 UR - https://m2.mtmt.hu/api/publication/31397044 ID - 31397044 N1 - Cited By :1 Export Date: 18 October 2020 Cited By :1 Export Date: 12 November 2020 Cited By :6 Export Date: 8 January 2021 Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Cited By :17 Export Date: 7 March 2021 Correspondence Address: Shao, Y.; Cancer Institute, China; email: ykshao@zju.edu.cn Correspondence Address: Zheng, S.; Cancer Institute, China; email: zhengshu@zju.edu.cn Chemicals/CAS: alkaline phosphatase, 9001-78-9; creatine kinase, 9001-15-4 Funding details: 2016YFC1302803 Funding details: National Natural Science Foundation of China, NSFC Funding details: Natural Science Foundation of Zhejiang Province, LY19H030012 Funding details: National Natural Science Foundation of China-Yunnan Joint Fund, NSFC-Yunnan Joint Fund, 81500115, 81672342 Funding text 1: This work was supported by National Key R&D Program of China (No. 2016YFC1302803), National Natural Science Foundation of China (No.81500115, No. 81672342), and Zhejiang Provincial Natural Science Foundation of China (No. LY19H030012). Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Cited By :28 Export Date: 21 April 2021 Correspondence Address: Shao, Y.; Cancer Institute, China; email: ykshao@zju.edu.cn Correspondence Address: Zheng, S.; Cancer Institute, China; email: zhengshu@zju.edu.cn Chemicals/CAS: alkaline phosphatase, 9001-78-9; creatine kinase, 9001-15-4 Funding details: 2016YFC1302803 Funding details: National Natural Science Foundation of China, NSFC Funding details: Natural Science Foundation of Zhejiang Province, LY19H030012 Funding details: National Natural Science Foundation of China-Yunnan Joint Fund, NSFC-Yunnan Joint Fund, 81500115, 81672342 Funding text 1: This work was supported by National Key R&D Program of China (No. 2016YFC1302803), National Natural Science Foundation of China (No.81500115, No. 81672342), and Zhejiang Provincial Natural Science Foundation of China (No. LY19H030012). Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China Cited By :51 Export Date: 7 September 2021 Correspondence Address: Shao, Y.; Cancer Institute, China; email: ykshao@zju.edu.cn Correspondence Address: Zheng, S.; Cancer Institute, China; email: zhengshu@zju.edu.cn Chemicals/CAS: alkaline phosphatase, 9001-78-9; creatine kinase, 9001-15-4 Funding details: 2016YFC1302803 Funding details: National Natural Science Foundation of China, NSFC Funding details: Natural Science Foundation of Zhejiang Province, LY19H030012 Funding details: National Natural Science Foundation of China-Yunnan Joint Fund, NSFC-Yunnan Joint Fund, 81500115, 81672342 Funding text 1: This work was supported by National Key R&D Program of China (No. 2016YFC1302803), National Natural Science Foundation of China (No.81500115, No. 81672342), and Zhejiang Provincial Natural Science Foundation of China (No. LY19H030012). LA - English DB - MTMT ER - TY - CHAP AU - Kovács, Árpád Ferenc ED - Juanita, F. Lafon TI - Current Trends on Exploring the Multifaceted Role of Extracellular Vesicles in Human Pregnancy T2 - Extracellular Vesicles PB - Nova Science Publishers CY - Hauppauge, New York SN - 9781536164664 PY - 2019 SP - 37 EP - 60 PG - 24 UR - https://m2.mtmt.hu/api/publication/30859819 ID - 30859819 LA - English DB - MTMT ER - TY - JOUR AU - Biró, Orsolya AU - Fóthi, Ábel AU - Alasztics, Bálint AU - Nagy, Bálint AU - Orbán, Tamás I. AU - Rigó, János TI - Circulating exosomal and Argonaute-bound microRNAs in preeclampsia JF - GENE J2 - GENE VL - 692 ET - 0 PY - 2019 SP - 138 EP - 144 PG - 7 SN - 0378-1119 DO - 10.1016/j.gene.2019.01.012 UR - https://m2.mtmt.hu/api/publication/30401681 ID - 30401681 AB - Introduction microRNAs (miRNAs) play important role in the regulation of placental development, and abnormal miRNA expression is associated with preeclampsia (PE). miRNAs are released from trophoblast cells to maternal blood flow, where they are highly stable, being encapsulated inside extracellular vesicles, like exosomes or bound to Argonaute proteins. In PE, placental dysfunction leads to aberrant extracellular miRNA secretion. hsa-miR-210 is a hypoxia-sensitive miRNA found to be upregulated in PE; however, it is unknown whether it is the cause or the consequence of the disease. Objective Our aim was to analyze the expression of several miRNAs, including hsa-miR-210 in placenta, exosome and Ago-bound fractions comparing normal (N) and PE pregnancies. We performed in vitro analyses of extracellular hsa-miR-210 secretion of trophoblast cell cultures (of villous and extravillous origin) under hypoxic condition. Methods PE and N placenta samples were collected from C-sections, and blood samples were drawn from each pregnant woman in the third trimester. HTR-8 and JAR cell lines were cultured in exosome-free media and treated with hypoxia-mimetic agents. Exosome and Ago-bound fractions were isolated by membrane affinity spin column method from plasma and cell media. Short RNAs were extracted from exosomes and vesicle-free fractions, and total-RNA was isolated from the placenta samples. The RNA purity and concentration were measured by spectrophotometry. Expression analysis was carried out by qPCR with specific primers to target and reference miRNAs. Results The level of hsa-miR-210 was significantly higher in PE placentas, which could cause a minor increase of exosomal and a high elevation of Ago-bound miR-210 in circulation. Hypoxia lead to intracellular hsa-miR-210 upregulation in trophoblast cell lines. In extravillous cell (HTR-8) media, only the level of exosomal hsa-miR-210 was increased but no change in Ago-bound hsa-miR-210 level was observed. In contrast, in villous cell (JAR) media, the level of exosomal hsa-miR-210 was increased and enhanced release of Ago-bound hsa-miR-210 was also observed. Conclusion Based on our data, we postulate that in PE, exosomal hsa-miR-210 is secreted actively from the trophoblast, and by intercellular communication, it may have a role in disease etiology. In addition, there is a passive release of Ago-bound hsa-miR-210 into the circulation, which may represent by-products of cell-death and is thereby a possible consequence of the disease. LA - English DB - MTMT ER - TY - THES AU - Biró, Orsolya TI - A mikroRNS-ek patogenetikai szerepe és expressziós mintázata praeeclampsiában PY - 2019 DO - 10.14753/SE.2019.2269 UR - https://m2.mtmt.hu/api/publication/30859380 ID - 30859380 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Duan, Y. AU - Jiang, L. AU - Li, L. AU - Li, Q. TI - The roles of placenta-derived miRNAs in the occurrence and development of preeclampsia and their clinical values JF - CHINESE JOURNAL OF LABORATORY MEDICINE J2 - CHIN J LAB MED VL - 42 PY - 2019 IS - 7 SP - 575 EP - 580 PG - 6 SN - 1009-9158 DO - 10.3760/cma.j.issn.1009-9158.2019.07.015 UR - https://m2.mtmt.hu/api/publication/31381570 ID - 31381570 N1 - Export Date: 16 July 2020 Correspondence Address: Li, Q.; Department of Clinical Laboratory, Shanghai First People’s Hospital Baoshan BranchChina; email: aqianmerry@163.com AB - Preeclampsia (PE) is a serious disease that threatens the health of maternal and newborn. However, the etiology and pathogenesis of PE remains elusive. Micro-RNA, a class of noncoding small single stranded RNA, plays an important role in the physiologic and pathophysiologic process of PE. In recent years, some researchers classified the placenta-derived miRNAs and investigated their roles in the occurrence of PE and their potential value in the PE early diagnosis. These findings are summarized in the review. Copyright © 2019 by the Chinese Medical Association. LA - Chinese DB - MTMT ER - TY - JOUR AU - Guan, Yinuo AU - Song, Xianjing AU - Sun, Wei AU - Wang, Yiran AU - Liu, Bin TI - Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV VL - 2019 PY - 2019 PG - 12 SN - 1942-0900 DO - 10.1155/2019/4727283 UR - https://m2.mtmt.hu/api/publication/30683358 ID - 30683358 N1 - Export Date: 9 February 2020 Correspondence Address: Liu, B.; Department of Cardiology, Second Hospital of Jilin UniversityChina; email: liubin3333@vip.sina.com LA - English DB - MTMT ER - TY - JOUR AU - Huang, Xiaohao AU - Wu, Lan AU - Zhang, Guoying AU - Tang, Ranran AU - Zhou, Xue TI - Elevated MicroRNA-181a-5p Contributes to Trophoblast Dysfunction and Preeclampsia. JF - REPRODUCTIVE SCIENCES J2 - REPROD SCI VL - 26 PY - 2019 IS - 8 SP - 1121 EP - 1129 PG - 9 SN - 1933-7191 DO - 10.1177/1933719118808916 UR - https://m2.mtmt.hu/api/publication/30329471 ID - 30329471 N1 - Export Date: 9 February 2020 Correspondence Address: Tang, R.; Department of Obstetrics and Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care HospitalChina; email: 13190186401@163.com AB - It has been demonstrated that preeclampsia is associated with alterations in placental microRNA expression. Previous reports have shown that hsa-miR-181a-5p is overexpressed in human preeclamptic placenta compared with normotensive placenta. The purpose of this study was to explore whether upregulated hsa-miR-181a-5p expression is involved in the ontogenesis of preeclampsia.Twenty preeclamptic placentas and 20 normotensive placentas were obtained from nulliparous women by cesarean section. Expression of hsa-miR-181a-5p in placenta tissues and human trophoblast cell lines was analyzed by reverse transcription polymerase chain reaction. The trophoblast cell lines (HTR-8/SVneo and JAR) were transfected with specific oligonucleotides to upregulate miR-181a-5p expression. The effect of miR-181a-5p expression on proliferation, cell cycle, apoptosis, and invasion in HTR-8/SVneo and JAR cells was then investigated.It was demonstrated that hsa-miR-181a-5p expression was upregulated in preeclamptic placentas and that it may trigger antiproliferation and inhibition of cell cycle progression, induce apoptosis, and suppress invasion in HTR-8/SVneo and JAR cells.Anomalously upregulated hsa-miR-181a-5p expression could contribute to trophoblast dysfunction and may be a crucial factor in the pathogenesis of preeclampsia. LA - English DB - MTMT ER - TY - JOUR AU - Jafari, Davod AU - Malih, Sara AU - Eslami, Seyed Sadegh AU - Jafari, Rasool AU - Darzi, Leila AU - Tarighi, Parastoo AU - Samadikuchaksaraei, Ali TI - The relationship between molecular content of mesenchymal stem cells derived exosomes and their potentials: opening the way for exosomes based therapeutics JF - BIOCHIMIE J2 - BIOCHIMIE VL - 165 PY - 2019 SP - 76 EP - 89 PG - 14 SN - 0300-9084 DO - 10.1016/j.biochi.2019.07.009 UR - https://m2.mtmt.hu/api/publication/30740414 ID - 30740414 N1 - Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Export Date: 4 August 2019 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Export Date: 23 August 2019 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir Funding details: Iran University of Medical Sciences, IUMS Funding text 1: This work was supported by Iran University of Medical Sciences , Tehran, Iran. Export Date: 9 February 2020 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir Funding Agency and Grant Number: Iran University of Medical Sciences, Tehran, Iran Funding text: This work was supported by Iran University of Medical Sciences, Tehran, Iran. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Export Date: 21 February 2020 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Cited By :1 Export Date: 3 March 2020 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir Funding details: Iran University of Medical Sciences, IUMS Funding text 1: This work was supported by Iran University of Medical Sciences , Tehran, Iran. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Cited By :1 Export Date: 13 June 2020 CODEN: BICMB Correspondence Address: Tarighi, P.; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical SciencesIran; email: tarighi.p@iums.ac.ir LA - English DB - MTMT ER - TY - JOUR AU - Kamrani, Amin AU - Alipourfard, Iraj AU - Ahmadi-Khiavi, Homayoon AU - Yousefi, Mehdi AU - Rostamzadeh, Davood AU - Izadi, Morteza AU - Ahmadi, Majid TI - The role of epigenetic changes in preeclampsia JF - BIOFACTORS J2 - BIOFACTORS VL - 45 PY - 2019 IS - 5 SP - 712 EP - 724 PG - 13 SN - 0951-6433 DO - 10.1002/biof.1542 UR - https://m2.mtmt.hu/api/publication/30770243 ID - 30770243 N1 - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Center of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Reproductive Biology Department, Tabriz University of Medical Sciences, Tabriz, Iran Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Cited By :4 Export Date: 16 July 2020 CODEN: BIFAE Correspondence Address: Izadi, M.; Health Research Center, Baqiyatallah University of Medical SciencesIran; email: morteza_izadi@yahoo.com AB - Preeclampsia (PE) is a disorder affecting 2-10% of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be related to different diseases such as PE. Abnormal DNA methylation during placentation is the most important epigenetic factor correlated with PE. Moreover, changes in histone modification like acetylation and also the effect of overregulation or low regulation of miRNAs or long noncoding RNAs on variety signaling pathways can be resulted in PE. The aim of this review is to describe of studies about epigenetic changes in PE and its therapeutic strategies. LA - English DB - MTMT ER - TY - JOUR AU - Konecna, Barbora AU - Tothova, Lubomira AU - Repiska, Gabriela TI - Exosomes-Associated DNA-New Marker in Pregnancy Complications? JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 20 PY - 2019 IS - 12 PG - 15 SN - 1661-6596 DO - 10.3390/ijms20122890 UR - https://m2.mtmt.hu/api/publication/30920237 ID - 30920237 N1 - Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81108, Slovakia Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81372, Slovakia Cited By :39 Export Date: 15 February 2024 Chemicals/CAS: alkaline phosphatase, 9001-78-9; ciprofloxacin, 85721-33-1; DNA, 9007-49-2; nuclease, 9026-81-7; Biomarkers; Cell-Free Nucleic Acids Funding details: Vedecká Grantová Agentúra MŠVVaŠ SR a SAV, VEGA, 1/0064/17 Funding text 1: Funding: This work was supported by the Slovak research and grant agency VEGA through the contract 1/0064/17. AB - Despite a large number of studies, the etiology of pregnancy complications remains unknown. The involvement of cell-free DNA or fetal cell-free DNA in the pathogenesis of pregnancy complications is currently being hypothesized. Cell-free DNA occurs in different forms-free; part of neutrophil extracellular traps; or as recently discovered, carried by extracellular vesicles. Cell-free DNA is believed to activate an inflammatory pathway, which could possibly cause pregnancy complications. It could be hypothesized that DNA in its free form could be easily degraded by nucleases to prevent the inflammatory activation. However, recently, there has been a growing interest in the role of exosomes, potential protectors of cell-free DNA, in pregnancy complications. Most of the interest from recent years is directed towards the micro RNA carried by exosomes. However, exosome-associated DNA in relation to pregnancy complications has not been truly studied yet. DNA, as an important cargo of exosomes, has been so far studied mostly in cancer research. This review collects all the known information on the topic of not only exosome-associated DNA but also some information on vesicles-associated DNA and the studies regarding the role of exosomes in pregnancy complications from recent years. It also suggests possible analysis of exosome-associated DNA in pregnancy from plasma and emphasizes the importance of such analysis for future investigations of pregnancy complications. A major obstacle to the advancement in this field is the proper uniformed technique for exosomes isolation. Similarly, the sensitivity of methods analyzing a small fraction of DNA, potentially fetal DNA, carried by exosomes is variable. LA - English DB - MTMT ER - TY - JOUR AU - Lv, Yan AU - Lu, Cheng AU - Ji, Xiaohong AU - Miao, Zhijing AU - Long, Wei AU - Ding, Hongjuan AU - Lv, Mingming TI - Roles of microRNAs in preeclampsia JF - JOURNAL OF CELLULAR PHYSIOLOGY J2 - J CELL PHYSIOL VL - 234 PY - 2019 IS - 2 SP - 1052 EP - 1061 PG - 10 SN - 0021-9541 DO - 10.1002/jcp.27291 UR - https://m2.mtmt.hu/api/publication/27706006 ID - 27706006 LA - English DB - MTMT ER - TY - JOUR AU - Xu, Huiying AU - Du, Yu AU - He, Jing AU - Wang, Liping AU - Sun, Gaogao TI - MicroRNA-378 protects human umbilical vein endothelial cells from injuries by soluble CD226 through down-regulating the expression of soluble CD226 in natural killer cells JF - BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT J2 - BIOTECHNOL BIOTEC EQ VL - 33 PY - 2019 IS - 1 SP - 1097 EP - 1107 PG - 11 SN - 1310-2818 DO - 10.1080/13102818.2019.1640075 UR - https://m2.mtmt.hu/api/publication/30738986 ID - 30738986 N1 - Export Date: 9 February 2020 Correspondence Address: Xu, H.; Department of Obstetrics and Gynecology, The First People’s Hospital of Lanzhou City, No. 1 West Wujiayuan Road, China; email: sdhy147@163.com LA - English DB - MTMT ER - TY - JOUR AU - Yu, You AU - Min, Zou AU - Zhou Zhihang, ZHIhang AU - Linhong, Mao AU - Tao, Ran AU - Yan, Liu AU - Song, He TI - Hypoxia-induced exosomes promote hepatocellular carcinoma proliferation and metastasis via miR-1273f transfer JF - EXPERIMENTAL CELL RESEARCH J2 - EXP CELL RES VL - 385 PY - 2019 IS - 1 PG - 10 SN - 0014-4827 DO - 10.1016/j.yexcr.2019.111649 UR - https://m2.mtmt.hu/api/publication/30859131 ID - 30859131 AB - Exosomes are present within the local hypoxic tumor microenvironment, where they are able to transfer microRNAs between cells, thereby, effectively mediating cell-cell communication. Hypoxia plays a pivotal role in the progression of many tumor types such as hepatocellular carcinoma (HCC), but how hypoxia-induced exosomes in HCC affect HCC cells remains uncertain. In the present study, we found that hypoxic conditions induced increased exosomal production by HCC cells, and these exosomes, in turn, enhanced the proliferation, migration, and invasiveness in addition to epithelial-to-mesenchymal transition (EMT) in HCC cells under normoxic conditions. When we analyzed these exosomes, we found that miR-1273f were present at higher levels under hypoxic conditions, and we determined that this miRNA was responsible for directly replicating the effects of hypoxic exosomes within HCC cells, in addition to activating the Wnt/β-catenin signaling. We finally identified LHX6, which is a known inhibitor of the Wnt/β-catenin pathway, to be a miR-1273f target. These results, thus, provide evidence that hypoxic conditions can lead HCC cells to express increased exosomes that facilitate miR-1273f expression in normoxic cells, thereby enhancing their malignant phenotype at least in part by targeting LHX6 for downregulation. LA - English DB - MTMT ER - TY - JOUR AU - ZHAO, Le AU - YANG, Haili AU - ZHANG, Rong AU - YANG, Yongheng AU - LI, Jialu AU - ZHOU, Heming AU - WANG, Pan AU - ZHAO, Yongju TI - The Regulation Role of Exosomes in Mammalian Pregnancy JF - ACTA VETERINARIA ET ZOOTECHNICA SINICA / XUMU SHOUYI XUEBAO J2 - ACTA VET ZOOTECH SIN VL - 50 PY - 2019 IS - 12 SP - 2371 EP - 2378 PG - 8 SN - 0366-6964 UR - https://m2.mtmt.hu/api/publication/32513992 ID - 32513992 LA - Chinese DB - MTMT ER - TY - JOUR AU - 赵得雄, . AU - 靳紫薇, . AU - 李宗英, . AU - 王烈宏, . AU - 谢玲, . TI - 妊娠期高血压患者中miRNA210表达与尿微量白蛋白/肌酐比的相关性研究 JF - Chinese Journal of Clinical Obstetrics and Gynecology J2 - Chinese Journal of Clinical Obstetrics and Gynecology VL - 20 PY - 2019 IS - 6 SP - 551 EP - 552 PG - 2 SN - 1672-1861 UR - https://m2.mtmt.hu/api/publication/32613885 ID - 32613885 LA - Chinese DB - MTMT ER - TY - JOUR AU - Biró, Orsolya AU - Rigó, János TI - A mikro-RNS-ek patogenetikai szerepe és expressziós mintázata praeeclampsiában JF - ORVOSI HETILAP J2 - ORV HETIL VL - 159 PY - 2018 IS - 14 SP - 547 EP - 556 PG - 10 SN - 0030-6002 DO - 10.1556/650.2018.31025 UR - https://m2.mtmt.hu/api/publication/3357249 ID - 3357249 AB - Preeclampsia is the leading cause of maternal and fetal morbidity and mortality that affects 3-8% of pregnancies worldwide. Its main symptoms include new onset of high blood pressure and proteinuria after 20 weeks of pregnancy. The cause of the disease is still debated. microRNAs are short, non-coding RNA molecules that play a pivotal part in the posttranscriptional regulation of eukaryotic genes. They are involved in fine-tuning of vital physiological processes such as cell cycle, proliferation, differentiation and cell death. In genomic studies, hundreds of microRNAs were detected in the placenta, which are supposed to regulate placental development and contribute to uncomplicated pregnancy. Several studies have reported changes in the expression of microRNAs in pregnancy. Abnormal microRNA expression may have a role in the development of preeclampsia as it affects the proliferation, migration, and invasion of the trophoblast cells, spiral artery remodeling, and angiogenesis. Some placental microRNAs (e.g., the C19MC microRNA cluster) are able to reach the maternal circulation through their release via exosomes from the trophoblast layer. These 'circulating' microRNA molecules can be applied as biomarkers for the detection of various placental disorders owing to their stability and specificity. Orv Hetil. 2018; 159(14): 547-556. LA - Hungarian DB - MTMT ER - TY - THES AU - Chu, Wing Hong TI - Maternal Folic Acid Supplementation and Its Effects on Metabolic and Epigenetic Regulatory Gene Networks in Offspring PY - 2018 UR - https://m2.mtmt.hu/api/publication/30859220 ID - 30859220 LA - English DB - MTMT ER - TY - JOUR AU - Fitzgerald, Wendy AU - Gomez-Lopez, Nardhy AU - Erez, Offer AU - Romero, Roberto AU - Margolis, Leonid TI - Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors JF - AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY J2 - AM J REPROD IMMUNOL VL - 80 PY - 2018 IS - 1 PG - 21 SN - 1046-7408 DO - 10.1111/aji.12860 UR - https://m2.mtmt.hu/api/publication/27516581 ID - 27516581 N1 - Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, United States Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, United States Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, United States Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine, Detroit, MI, United States Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Export Date: 23 August 2019 CODEN: AAJID Correspondence Address: Romero, R.; Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human ServicesUnited States; email: prbchiefstaff@med.wayne.edu Chemicals/CAS: C reactive protein, 9007-41-4; colony stimulating factor 1, 81627-83-0; gamma interferon, 82115-62-6; gamma interferon inducible protein 10, 97741-20-3; interleukin 13, 148157-34-0; interleukin 18, 189304-55-0; interleukin 2, 85898-30-2; interleukin 8, 114308-91-7; lactoferrin, 55599-62-7 Funding details: Wayne State University Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD Funding details: National Institutes of Health, NIH Funding details: HHSN275201300006C Funding details: U.S. Department of Health and Human Services, HHS Funding text 1: This research was supported, in part, by the Perinatology Research Branch (PRB), Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), and, in part, with federal funds from the NICHD/NIH/DHHS under Contract No. HHSN275201300006C. N.G-L was also supported by the Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health. We thank the physicians and nurses from the Center for Advanced Obstetrical Care and Research and the Intrapartum Unit, as well as the research assistants from the PRB Clinical Laboratory, for their help in collecting samples. In addition, we thank Suzanne M. Jacques, M.D., and Faisal Qureshi, M.D., for analysis of histological sections of tissue explants. This work was supported by an NICHD Intramural Program. Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, United States Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, United States Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, United States Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine, Detroit, MI, United States Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Export Date: 22 October 2019 CODEN: AAJID Correspondence Address: Romero, R.; Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human ServicesUnited States; email: prbchiefstaff@med.wayne.edu Export Date: 9 February 2020 CODEN: AAJID Correspondence Address: Romero, R.; Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human ServicesUnited States; email: prbchiefstaff@med.wayne.edu Funding Agency and Grant Number: Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [HHSN275201300006C]; Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health Funding text: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: HHSN275201300006C; Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, United States Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, United States Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, United States Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine, Detroit, MI, United States Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Cited By :1 Export Date: 3 March 2020 CODEN: AAJID Correspondence Address: Romero, R.; Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human ServicesUnited States; email: prbchiefstaff@med.wayne.edu Chemicals/CAS: C reactive protein, 9007-41-4; colony stimulating factor 1, 81627-83-0; gamma interferon, 82115-62-6; gamma interferon inducible protein 10, 97741-20-3; interleukin 13, 148157-34-0; interleukin 18, 189304-55-0; interleukin 2, 85898-30-2; interleukin 8, 114308-91-7; lactoferrin, 55599-62-7 Funding details: Wayne State University Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD Funding details: National Institutes of Health, NIH Funding details: HHSN275201300006C Funding details: U.S. Department of Health and Human Services, HHS Funding text 1: This research was supported, in part, by the Perinatology Research Branch (PRB), Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), and, in part, with federal funds from the NICHD/NIH/DHHS under Contract No. HHSN275201300006C. N.G-L was also supported by the Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health. We thank the physicians and nurses from the Center for Advanced Obstetrical Care and Research and the Intrapartum Unit, as well as the research assistants from the PRB Clinical Laboratory, for their help in collecting samples. In addition, we thank Suzanne M. Jacques, M.D., and Faisal Qureshi, M.D., for analysis of histological sections of tissue explants. This work was supported by an NICHD Intramural Program. Section of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, United States Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, United States Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, United States Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine, Detroit, MI, United States Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States Cited By :2 Export Date: 1 June 2020 CODEN: AAJID Correspondence Address: Romero, R.; Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human ServicesUnited States; email: prbchiefstaff@med.wayne.edu Chemicals/CAS: C reactive protein, 9007-41-4; colony stimulating factor 1, 81627-83-0; gamma interferon, 82115-62-6; gamma interferon inducible protein 10, 97741-20-3; interleukin 13, 148157-34-0; interleukin 18, 189304-55-0; interleukin 2, 85898-30-2; interleukin 8, 114308-91-7; lactoferrin, 55599-62-7 Funding details: Wayne State University Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD Funding details: National Institutes of Health, NIH Funding details: HHSN275201300006C Funding details: U.S. Department of Health and Human Services, HHS Funding text 1: This research was supported, in part, by the Perinatology Research Branch (PRB), Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), and, in part, with federal funds from the NICHD/NIH/DHHS under Contract No. HHSN275201300006C. N.G-L was also supported by the Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health. We thank the physicians and nurses from the Center for Advanced Obstetrical Care and Research and the Intrapartum Unit, as well as the research assistants from the PRB Clinical Laboratory, for their help in collecting samples. In addition, we thank Suzanne M. Jacques, M.D., and Faisal Qureshi, M.D., for analysis of histological sections of tissue explants. This work was supported by an NICHD Intramural Program. LA - English DB - MTMT ER - TY - JOUR AU - Mavreli, D AU - Papantoniou, N AU - Kolialexi, A TI - miRNAs in pregnancy-related complications: an update JF - EXPERT REVIEW OF MOLECULAR DIAGNOSTICS J2 - EXPERT REV MOL DIAGN VL - 18 PY - 2018 IS - 7 SP - 587 EP - 589 PG - 3 SN - 1473-7159 DO - 10.1080/14737159.2018.1480939 UR - https://m2.mtmt.hu/api/publication/27546979 ID - 27546979 N1 - OA gold_or_bronze 3rd Department of Obstetrics & Gynecology, Athens University School of Medicine, Athens, Greece Department of Medical Genetics, Athens University School of Medicine, Athens, Greece Cited By :1 Export Date: 23 August 2019 CODEN: ERMDC Correspondence Address: Kolialexi, A.; Department of Medical Genetics, Aghia Sofia Children’s HospitalGreece; email: akolial@med.uoa.gr Chemicals/CAS: Biomarkers; MicroRNAs Export Date: 9 February 2020 CODEN: ERMDC Correspondence Address: Kolialexi, A.; Department of Medical Genetics, Aghia Sofia Children’s HospitalGreece; email: akolial@med.uoa.gr LA - English DB - MTMT ER -