TY - JOUR AU - Lundrigan, Travis AU - Tassone, Joseph P. AU - Stradiotto, Mark TI - Nickel-catalyzed N-arylation of optically pure amino acid esters with activated (hetero)aryl electrophiles JF - CANADIAN JOURNAL OF CHEMISTRY J2 - CAN J CHEM VL - 101 PY - 2023 IS - 5 SP - 275 EP - 283 PG - 9 SN - 0008-4042 DO - 10.1139/cjc-2022-0290 UR - https://m2.mtmt.hu/api/publication/33913826 ID - 33913826 AB - An efficient method for the C-N cross-coupling of (hetero)aryl (pseudo)halides with optically pure alpha-amino acid esters em-ploying a commercially available nickel catalyst and weak inorganic base was developed. This is the first example of Ni-catalyzed N-arylation of amino acid esters without the use of electrochemistry, which was shown to effectively couple a variety of amino acid tert-butyl esters with (hetero)aryl chlorides, bromides, and tosylates in high yields and excellent enantioreten-tion. Base-mediated racemization was revealed during control experiments, but increasing the steric bulk of the amino acid ester group limited the amount of racemization of the product. LA - English DB - MTMT ER - TY - JOUR AU - Mayer, Szabolcs AU - Herr, Dominika Mária AU - Nagy, Nóra AU - Donkó-Tóth, Viktória AU - Keglevich, Péter AU - Weber, Márton AU - Dékány, Miklós AU - Hazai, László TI - Synthesis and In Vitro Anticancer Evaluation of Chrysin Containing Hybrids and Other Chrysin Derivatives JF - PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING J2 - PERIOD POLYTECH CHEM ENG VL - 67 PY - 2023 IS - 2 SP - 316 EP - 336 PG - 21 SN - 0324-5853 DO - 10.3311/PPch.21919 UR - https://m2.mtmt.hu/api/publication/33856060 ID - 33856060 N1 - Funding Agency and Grant Number: European Union [RRF-2.3.1-21-2022-00015] Funding text: Project no. RRF-2.3.1-21-2022-00015 has been imple-mented with the support provided by the European Union. The authors thank Aron Szigetvari and Csaba Szantay Jr. for their contribution to the NMR results. AB - Chrysin, a well-known naturally occurring flavonoid having several biological effects including antiproliferative activity, was coupled with different pharmacophore structures. Coupling was carried out with spacers of different lengths and types. Structures selected for hybrid formation were amines, cyclic amino acid esters, and (hetero)aromatic compounds. In addition, vindoline, which is a Vinca alkaloid containing an indole skeleton, was also used. The alkylation of amines in the presence of carbonate base resulted in an interesting carbamate side product formation beside the expected amine. We also present the detailed structure elucidation of the carbamates. The in vitro anticancer activities of the synthesized derivatives were examined against 60 human tumor cell lines in National Cancer Institute (NCI, USA). LA - English DB - MTMT ER - TY - JOUR AU - Panova, Mariya A. AU - Shcherbakov, Konstantin V. AU - Zhilina, Ekaterina F. AU - Burgart, Yanina V. AU - Saloutin, Victor I. TI - Synthesis of Mono- and Polyazole Hybrids Based on Polyfluoroflavones JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 2 PG - 23 SN - 1420-3049 DO - 10.3390/molecules28020869 UR - https://m2.mtmt.hu/api/publication/33913827 ID - 33913827 AB - The possibility of functionalization of 2-(polyfluorophenyl)-4H-chromen-4-ones, with them having different numbers of fluorine atoms, with 1,2,4-triazole or imidazole under conditions of base-promoted nucleophilic aromatic substitution has been shown. A high selectivity of mono-substitution was found with the use of an azole (1.5 equiv.)/NaOBut(1.5 equiv.)/MeCN system. The structural features of fluorinated mono(azolyl)-substituted flavones in crystals were established using XRD analysis. The ability of penta- and tetrafluoroflavones to form persubstituted products with triazole under azole (6 equiv.)/NaOBut(6 equiv.)/DMF conditions was found in contrast to similar transformations with imidazole. On the basis of mono(azolyl)-containing polyfluoroflavones in reactions with triazole and pyrazole, polynuclear hybrid compounds containing various azole fragments were obtained. For poly(pyrazolyl)-substituted flavones, green emission in the solid state under UV-irradiation was found, and for some derivatives, weak fungistatic activity was found. LA - English DB - MTMT ER - TY - JOUR AU - Pereira, Ana Margarida AU - Cidade, Honorina AU - Tiritan, Maria Elizabeth TI - Stereoselective Synthesis of Flavonoids: A Brief Overview JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 1 PG - 33 SN - 1420-3049 DO - 10.3390/molecules28010426 UR - https://m2.mtmt.hu/api/publication/33841551 ID - 33841551 AB - Stereoselective synthesis has been emerging as a resourceful tool because it enables the obtaining of compounds with biological interest and high enantiomeric purity. Flavonoids are natural products with several biological activities. Owing to their biological potential and aiming to achieve enantiomerically pure forms, several methodologies of stereoselective synthesis have been implemented. Those approaches encompass stereoselective chalcone epoxidation, Sharpless asymmetric dihydroxylation, Mitsunobu reaction, and the cycloaddition of 1,4-benzoquinone. Chiral auxiliaries, organo-, organometallic, and biocatalysis, as well as the chiral pool approach were also employed with the goal of obtaining chiral bioactive flavonoids with a high enantiomeric ratio. Additionally, the employment of the Diels-Alder reaction based on the stereodivergent reaction on a racemic mixture strategy or using catalyst complexes to synthesise pure enantiomers of flavonoids was reported. Furthermore, biomimetic pathways displayed another approach as illustrated by the asymmetric coupling of 2-hydroxychalcones driven by visible light. Recently, an asymmetric transfer hydrogen-dynamic kinetic resolution was also applied to synthesise (R,R)-cis-alcohols which, in turn, would be used as building blocks for the stereoselective synthesis of flavonoids. LA - English DB - MTMT ER - TY - JOUR AU - Wang, Jia-yi AU - Zhou, Wei-yu AU - Huang, Xiao-xiao AU - Song, Shao-jiang TI - Flavonoids with antioxidant and tyrosinase inhibitory activity from corn silk (Stigma maydis) JF - NATURAL PRODUCT RESEARCH J2 - NAT PROD RES VL - 37 PY - 2023 IS - 5 SP - 835 EP - 839 PG - 5 SN - 1478-6419 DO - 10.1080/14786419.2022.2089986 UR - https://m2.mtmt.hu/api/publication/33340240 ID - 33340240 AB - Corn silk (Stigma maydis), being the styles and stigmas of maize, is a famous traditional medicine and functional tea in China. Research into the chemical composition of corn silk led to the identification of an unreported flavone (1, silkone A), accompanying with three known flavonoids (2-4). And their structures were elucidated through comprehensive spectroscopic analysis. Each obtained compound was evaluated for antioxidant capacity by DPPH, ABTS and FRAP assays. As a result, all tested compounds exhibited stronger radicals scavenging activities than Trolox in ABTS radical assay and displayed relatively weak antioxidant capacity in the other two experiments. Tyrosinase inhibitory activities of compounds 1-4 were also investigated, and compounds 3 and 4 demonstrated moderate inhibitory activities to tyrosinase with IC50 values of 0.49 and 0.21 mM, respectively, which was further investigated through molecular docking calculation. These results may contribute to the development of novel antioxidants and tyrosinase inhibitors from corn silk. LA - English DB - MTMT ER - TY - JOUR AU - Campos, Joana F. AU - Berteina-Raboin, Sabine TI - Eucalyptol, an All-Purpose Product JF - CATALYSTS J2 - CATALYSTS VL - 12 PY - 2022 IS - 1 PG - 22 SN - 2073-4344 DO - 10.3390/catal12010048 UR - https://m2.mtmt.hu/api/publication/33340241 ID - 33340241 AB - Eucalyptus plants have attracted the attention of researchers and environmentalists worldwide because they are a rapidly growing source of wood and a source of oil used for multiple purposes. The main and the most important oil component is 1,8-cineole (eucalyptol: 60-85%). This review summarizes the literature reported to date involving the use of 1,8-cineole for the treatment of disorders. Additionally, we describe our efforts in the use of eucalyptol as a solvent for the synthesis of O,S,N-heterocycles. Solvents used in chemistry are a fundamental element of the environmental performance of processes in corporate and academic laboratories. Their influence on costs, safety and health cannot be neglected. Green solvents such as bio-based systems hold considerable additional promise to reduce the environmental impact of organic chemistry. The first section outlines the process leading to our discovery of an unprecedented solvent and its validation in the first coupling reactions. This section continues with the description of its properties and characteristics and its reuse as reported in the various studies conducted. The second section highlights the use of eucalyptol in a series of coupling reactions (i.e., Suzuki-Miyaura, Sonogashira-Hagihara, Buchwald-Hartwig, Migita-Kosugi-Stille, Hiyama and cyanation) that form O,S,N-heterocycles. We describe the optimization process applied to reach the ideal conditions. We also show that eucalyptol can be a good alternative to build heterocycles that contain oxygen, sulfur and nitrogen. These studies allowed us to demonstrate the viability and potential that bio solvents can have in synthesis laboratories. LA - English DB - MTMT ER - TY - JOUR AU - Elagamy, Amr AU - Elghoneimy, Laila K. AU - Arafa, Reem K. AU - Pratap, Ramendra TI - Synthesis of functionalized flavones from 3-halo-2-(methylthio)-4H-chromen-4-ones JF - TETRAHEDRON LETTERS J2 - TETRAHEDRON LETT VL - 100 PY - 2022 PG - 5 SN - 0040-4039 DO - 10.1016/j.tetlet.2022.153882 UR - https://m2.mtmt.hu/api/publication/33340239 ID - 33340239 AB - A simple and efficient method for the synthesis of flavones was achieved by selective sulfide LiebeskindSrogl cross-coupling reaction of 2-(methylthio)-4H-chromen-4-ones and 3-halo-2-(methylthio)-4H-chromen-4-ones with arylboronic acids. This method is the first example of employing Liebeskind-Srogl coupling for the synthesis of flavones. Various aryl groups can be directly installed to the chromone ring. The structure of all the synthesized compounds were assigned by spectroscopic analysis. (C) 2022 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Thorat, Nitin M. M. AU - Khodade, Vinnayak S. S. AU - Ingale, Ajit P. P. AU - Lokwani, Deepak K. K. AU - Sarkate, Aniket P. P. AU - Thopate, Shankar R. R. TI - Molecular Docking Studies and Application of 6-(1-Arylmethanamino)-2-Phenyl-4H-Chromen-4-Ones as Potent Antibacterial Agents JF - POLYCYCLIC AROMATIC COMPOUNDS J2 - POLYCYCL AROMAT COMP PY - 2022 PG - 14 SN - 1040-6638 DO - 10.1080/10406638.2022.2150238 UR - https://m2.mtmt.hu/api/publication/33897419 ID - 33897419 AB - The present article depicts the synthesis of the series of 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones and their antibacterial activity against the S. aureus. 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones (1a-1n) were obtained via reductive amination reaction of 6-aminoflavone with various commercially available aldehydes. Synthesized compounds and 6-aminoflavone (1) were assessed for their antimicrobial activities against the S. aureus. 6-aminoflavone (1) was found to have an MIC of 2 mu g/mL. The compounds with side chains 4-fluorobenzyl (1a), 4-chlorobenzyl (1b), 4-nitrobenzyl (1e), 4-methoxybenzyl (1g) and (quinolin-2-yl)methyl (1n) were found to have an MIC of 2 mu g/mL. We have demonstrated that 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones are easily accessible via reductive amination reaction. These compounds are found to have antibacterial effect against S. aureus. LA - English DB - MTMT ER - TY - JOUR AU - Ichitsuka, Tomohiro AU - Komatsuzaki, Shingo AU - Masuda, Koichiro AU - Koumura, Nagatoshi AU - Sato, Kazuhiko AU - Kobayashi, Shu TI - Stereoretentive N-Arylation of Amino Acid Esters with Cyclohexanones Utilizing a Continuous-Flow System JF - CHEMISTRY-A EUROPEAN JOURNAL J2 - CHEM-EUR J VL - 27 PY - 2021 IS - 42 SP - 10844 EP - 10848 PG - 5 SN - 0947-6539 DO - 10.1002/chem.202101439 UR - https://m2.mtmt.hu/api/publication/32442026 ID - 32442026 AB - The N-arylation of chiral amino acid esters with minimal racemization is a challenging transformation because of the sensitivity of the alpha-stereocenter. A versatile synthetic method was developed to prepare N-arylated amino acid esters using cyclohexanones as aryl sources under continuous-flow conditions. The designed flow system, which consists of a coil reactor and a packed-bed reactor containing a Pd(OH)(2)/C catalyst, efficiently afforded the desired N-arylated amino acids without significant racemization, accompanied by only small amounts of easily removable co-products (i. e., H2O and alkanes). The efficiency and robustness of this method allowed for the continuous synthesis of the desired product in very high yield and enantiopurity with high space-time yield (74.1 g L-1 h(-1)) and turnover frequency (5.9 h(-1)) for at least 3 days. LA - English DB - MTMT ER - TY - JOUR AU - Pinto, Claudia AU - Cidade, Honorina AU - Pinto, Madalena AU - Tiritan, Maria Elizabeth TI - Chiral Flavonoids as Antitumor Agents JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 12 PG - 29 SN - 1424-8247 DO - 10.3390/ph14121267 UR - https://m2.mtmt.hu/api/publication/33340242 ID - 33340242 AB - Flavonoids are a group of natural products with a great structural diversity, widely distributed in plant kingdom. They play an important role in plant growth, development and defense against aggressors. Flavonoids show a huge variety of biological activities such as antioxidant, anti-inflammatory, anti-mutagenic, antimicrobial and antitumor, being able to modulate a large diversity of cellular enzymatic activities. Among natural flavonoids, some classes comprise chiral molecules including flavanones, flavan-3-ols, isoflavanones, and rotenoids, which have one or more stereogenic centers. Interestingly, in some cases, individual compounds of enantiomeric pairs have shown different antitumor activity. In nature, these compounds are mainly biosynthesized as pure enantiomers. Nevertheless, they are often isolated as racemates, being necessary to carry out their chiral separation to perform enantioselectivity studies. Synthetic chiral flavonoids with promising antitumor activity have also been obtained using diverse synthetic approaches. In fact, several new chiral bioactive flavonoids have been synthesized by enantioselective synthesis. Particularly, flavopiridol was the first cyclin-dependent kinase (CDK) inhibitor which entered clinical trials. The chiral pool approaches using amino acid as chiral building blocks have also been reported to achieve small libraries of chrysin derivatives with more potent in vitro growth inhibitory effect than chrysin, reinforcing the importance of the introduction of chiral moieties to improve antitumor activity. In this work, a literature review of natural and synthetic chiral flavonoids with antitumor activity is reported for the first time. LA - English DB - MTMT ER - TY - JOUR AU - Akhila, Vijayan R. AU - Priya, Maheswari R. AU - Sherin, Daisy R. AU - Krishnapriya, Girija K. AU - Keerthi, Sreerekha V. AU - Manojkumar, Thanathu K. AU - Rajasekharan, Kallikat N. TI - Mechanochemical Synthesis, in vitro Evaluation and Molecular Docking Studies of 4-Amino-2-arylamino-5-(benzofuran-2-oyl)thiazoles as Antidiabetic Agents JF - LETTERS IN ORGANIC CHEMISTRY J2 - LETT ORG CHEM VL - 16 PY - 2019 IS - 7 SP - 560 EP - 568 PG - 9 SN - 1570-1786 DO - 10.2174/1570178615666180815124425 UR - https://m2.mtmt.hu/api/publication/31067372 ID - 31067372 AB - The synthesis of 4-amino-2-arylamino-5-(benzofuran-2-oyl)thiazoles 4a-h, as example of 2,4-diaminothiazole-benzofuran hybrids and an evaluation of their antidiabetic activity, by in vitro and computational methods, are reported. The synthesis of these diaminothiazoles was achieved mechano chemically by a rapid solvent-less method. Their antidiabetic activity was assessed by alpha-glucosidase and alpha-amylase inhibition assays. The, IC50 value for alpha-glucosidase inhibition by 4-amino-5-(benzofuran-2-oyl)-2-(4-methoxyphenylamino)thiazole (4d) was found to be 20.04 mu M and the IC50 value for alpha-amylase inhibition, 195.03 mu M whereas the corresponding values for reference acarbose were 53.38 mu M and 502.03 mu M, respectively. Molecular docking studies at the active sites of alpha-glucosidase and alpha-amylase showed that among the diaminothiazoles 4a-h now studied, 4-amino-5-(benzofuran-2-oyl)-2-(4-methoxyphenylamino)thiazole (4d) has the highest D-scores of -8.63 and -8.08 for alpha-glucosidase and for alpha-amylase, with binding energies -47.76 and -19.73 kcal/mol, respectively. LA - English DB - MTMT ER - TY - JOUR AU - Campos, Joana E. AU - Berteina-Raboin, Sabine TI - Eucalyptol as a Bio-Based Solvent for Buchwald-Hartwig Reaction on O,S,N-Heterocycles JF - CATALYSTS J2 - CATALYSTS VL - 9 PY - 2019 IS - 10 PG - 11 SN - 2073-4344 DO - 10.3390/catal9100840 UR - https://m2.mtmt.hu/api/publication/31067370 ID - 31067370 AB - We report here the use of eucalyptol as a bio-based solvent for the Buchwald-Hartwig reaction on O,S,N-heterocycles. These heterocycles containing oxygen, sulfur and nitrogen were chosen as targets or as starting materials. Once again, eucalyptol demonstrated to be a possible sustainable alternative to common solvents. LA - English DB - MTMT ER - TY - JOUR AU - Ghiasbeigi, Elahe AU - Soleiman-Beigi, Mohammad TI - Copper Immobilized on Isonicotinic Acid Hydrazide Functionalized Nano-Magnetite as a Novel Recyclable Catalyst for Direct Synthesis of Phenols and Anilines JF - CHEMISTRYSELECT J2 - CHEMISTRYSELECT VL - 4 PY - 2019 IS - 12 SP - 3611 EP - 3619 PG - 9 SN - 2365-6549 DO - 10.1002/slct.201803770 UR - https://m2.mtmt.hu/api/publication/31067373 ID - 31067373 AB - A new nano-catalyst which contains a core of magnetic Fe3O4 nanoparticles (NPs) has been fabricated. It is covered via isonicotinic acid hydrazide and copper (Cu). In this sense, Isonicotinic acid hydrazide (INH) is applied because of its ability as a bidendental ligand and pharmaceutical activity in order to be used for the complexion and connection of Cu on Fe3O4 surface for the synthesis of Fe3O4@INH@Cu (INH= Isonicotinic acid hydrazide). In this regard, Fe3O4@INH@Cu as a heterogeneous nanocatalyst for the cross-coupling of aryl halides with potassium hydroxide (KOH) as the hydroxide source and ammonium acetate (NH4OAc), as the amine source in the presence of cesium carbonate (Cs2CO3) in polyethylene glycol (PEG-400), has been applied. The catalyst is a new magnetically recyclable catalytic system with easy preparation and purification, high activity, eco-friendly and economic advantages. LA - English DB - MTMT ER - TY - JOUR AU - Scattolin, Thomas AU - Bouayad-Gervais, Samir AU - Schoenebeck, Franziska TI - Straightforward access to N-trifluoromethyl amides, carbamates, thiocarbamates and ureas JF - NATURE J2 - NATURE VL - 573 PY - 2019 IS - 7772 SP - 102 EP - 107 PG - 7 SN - 0028-0836 DO - 10.1038/s41586-019-1518-3 UR - https://m2.mtmt.hu/api/publication/31067371 ID - 31067371 AB - Amides and related carbonyl derivatives are of central importance across the physical and life sciences(1,2). As a key biological building block, the stability and conformation of amides affect the structures of peptides and proteins as well as their biological function. In addition, amide-bond formation is one of the most frequently used chemical transformations(3,4). Given their ubiquity, a technology that is capable of modifying the fundamental properties of amides without compromising on stability may have considerable potential in pharmaceutical, agrochemical and materials science. In order to influence the physical properties of organic molecules-such as solubility, lipophilicity, conformation, pK(a) and (metabolic) stability-fluorination approaches have been widely adopted(5-7). Similarly, site-specific modification with isosteres and peptidomimetics(8), or in particular by N-methylation(9), has been used to improve the stability, physical properties, bioactivities and cellular permeabilities of compounds. However, the N-trifluoromethyl carbonyl motif-which combines both N-methylation and fluorination approaches-has not yet been explored, owing to a lack of efficient methodology to synthesize it. Here we report a straightforward method to access N-trifluoromethyl analogues of amides and related carbonyl compounds. The strategy relies on the operationally simple preparation of bench-stable carbamoyl fluoride building blocks, which can be readily diversified to the corresponding N-CF3 amides, carbamates, thiocarbamates and ureas. This method tolerates rich functionality and stereochemistry, and we present numerous examples of highly functionalized compounds-including analogues of widely used drugs, antibiotics, hormones and polymer units. LA - English DB - MTMT ER - TY - JOUR AU - Shcherbakov, Konstantin V. AU - Artemyeva, Mariya A. AU - Burgart, Yanina V. AU - Evstigneeva, Natalya P. AU - Gerasimova, Natalya A. AU - Zilberberg, Natalia V. AU - Kungurov, Nicolai V. AU - Saloutin, Victor I. AU - Chupakhin, Oleg N. TI - Transformations of 3-acyl-4H-polyfluorochromen-4-ones under the action of amino acids and biogenic amines JF - JOURNAL OF FLUORINE CHEMISTRY J2 - J FLUORINE CHEM VL - 226 PY - 2019 PG - 13 SN - 0022-1139 DO - 10.1016/j.jfluchem.2019.109354 UR - https://m2.mtmt.hu/api/publication/31067369 ID - 31067369 AB - For the first time 6,7,8-trifluoro- and 5,6,7,8-tetrafluorinated 3-benzoylflavones have been obtained. Their reactions with amino acids and biogenic amines were studied in comparison with polyfluorinated 3-acetyl-2-methylchromones. For chromones, reactions at the C-2 are preferred, which lead to the pyrone ring opening to form N-substituted aminoenketones. Whereas in the case of flavones the main route is the nucleophilic aromatic substitution of the fluorine atom at the C-7. Flavones and chromones react in the same way both with dopamine to give aminoenketones, and with proline to form 7-amino-substituted chromen-4-ones. All the reactions of chromen-4-ones are accompanied by deacylation, except ones of flavones with proline. Among the synthesized aminoenketones, compounds with high antimycotic and antibacterial action were found. LA - English DB - MTMT ER - TY - JOUR AU - Yuen, On Ying AU - Pang, Wai Hang AU - Chen, Xiangmeng AU - Chen, Zicong AU - Kwong, Fuk Yee AU - So, Chau Ming TI - Synthesis of Flavone Derivatives through Versatile Palladium-Catalyzed Cross-Coupling Reactions of Tosyloxy- and Mesyloxyflavones JF - SYNLETT J2 - SYNLETT VL - 30 PY - 2019 IS - 6 SP - 731 EP - 737 PG - 7 SN - 0936-5214 DO - 10.1055/s-0037-1611742 UR - https://m2.mtmt.hu/api/publication/30965445 ID - 30965445 AB - Tosyloxy- and mesyloxyflavones derived from abundant and biologically important hydroxyflavones were used to synthesize a series of functionalized flavones through versatile palladium-catalyzed cross-coupling reactions. A Pd(OAc) (2) /2-[2-(dicyclohexylphosphino)phenyl]-1-methyl-1 H -indole system effectively catalyzed the reactions of a broad range of tosyloxy- and mesyloxyflavones as electrophilic coupling partners with various nucleophiles to give the corresponding products in good to excellent yields. Catalyst loadings of as little as 0.1 mol% Pd were successfully used. Importantly, we demonstrated that this protocol provided a significantly improved efficiency in the synthesis of a potential chromen-4-one-based analogue of a potent inhibitor of DNA-dependent protein kinase. LA - English DB - MTMT ER - TY - JOUR AU - Heravi, Majid M AU - Kheilkordi, Zohreh AU - Zadsirjan, Vahideh AU - Heydari, Masumeh AU - Malmir, Masoumeh TI - Buchwald-Hartwig reaction: An overview JF - JOURNAL OF ORGANOMETALLIC CHEMISTRY J2 - J ORGANOMET CHEM VL - 861 PY - 2018 SP - 17 EP - 104 PG - 88 SN - 0022-328X DO - 10.1016/j.jorganchem.2018.02.023 UR - https://m2.mtmt.hu/api/publication/27351924 ID - 27351924 N1 - Cited By :42 Export Date: 6 November 2019 CODEN: JORCA Correspondence Address: Heravi, M.M.; Department of Chemistry, Department of Chemistry, Alzahra University, Vanak, Iran; email: mmh1331@yahoo.com LA - English DB - MTMT ER - TY - JOUR AU - Shcherbakov, Konstantin V AU - Burgart, Yanina V AU - Saloutin, Victor I AU - Chupakhin, Oleg N TI - Modification of Polyfluoro-Containing 3-(Ethoxycarbonyl)flavones by Biogenic Amines and Amino Acids JF - CURRENT ORGANIC SYNTHESIS J2 - CURR ORG SYNTH VL - 15 PY - 2018 IS - 5 SP - 707 EP - 714 PG - 8 SN - 1570-1794 DO - 10.2174/1570179415666180405120706 UR - https://m2.mtmt.hu/api/publication/27607161 ID - 27607161 LA - English DB - MTMT ER - TY - JOUR AU - Shelke, Yogesh G. AU - Yashmeen, Afsana AU - Gholap, Aniket V. A. AU - Gharpure, Santosh J. AU - Kapdi, Anant R. TI - Homogeneous Catalysis: A Powerful Technology for the Modification of Important Biomolecules JF - CHEMISTRY-AN ASIAN JOURNAL J2 - CHEM-ASIAN J VL - 13 PY - 2018 IS - 20 SP - 2991 EP - 3013 PG - 23 SN - 1861-4728 DO - 10.1002/asia.201801020 UR - https://m2.mtmt.hu/api/publication/30391897 ID - 30391897 N1 - Funding Agency and Grant Number: Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Science and Educational Research Board (SERB) [EMR/2016/005439]; Council for Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) - India [02(0298)/17/EMR-II] Funding text: A.R.K. acknowledges the Alexander von Humboldt Foundation for an equipment grant. A.R.K. also thanks the Science and Educational Research Board (SERB) for a research grant (EMR/2016/005439) and the Council for Scientific and Industrial Research (CSIR) through the EMR scheme (02(0298)/17/EMR-II), as well as research fellowships for Y.G.S. and A.V.A.G. Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Mumbai, Matunga 400019, India Department of Chemistry, Indian Institute of Technology, Bombay, Main Gate Road, Mumbai, Powai 400076, India Cited By :3 Export Date: 24 May 2021 CODEN: CAAJB Correspondence Address: Gharpure, S.J.; Department of Chemistry, Main Gate Road, India; email: sjgharpure@chem.iitb.ac.in Funding details: EMR/ 2016/005439 Funding details: Alexander von Humboldt-Stiftung Funding details: Department of Science and Technology, Ministry of Science and Technology, India, DST Funding details: Bangladesh Council of Scientific and Industrial Research, BCSIR, 02(0298)/17/EMR-II Funding text 1: A.R.K. acknowledges the Alexander von Humboldt Foundation for an equipment grant. A.R.K. also thanks the Science and Educational Research Board (SERB) for a research grant (EMR/ 2016/005439) and the Council for Scientific and Industrial Research (CSIR) through the EMR scheme (02(0298)/17/EMR-II), as well as research fellowships for Y.G.S. and A.V.A.G. Funding text 2: versity of Mumbai (M.Sc. 2002) and the Uni- versity of York (M.Sc. 2005; Prof. Ian J. S. Fair- lamb). He completed his Ph.D. in 2008 under the supervision of Prof. Fairlamb at the Uni- versity of York, U.K., before undertaking post- doctoral work in the research group of Prof. Lutz Ackermann at the Georg-August Univer- sität Gçttingen as an Alexander von Hum- boldt Fellow. After returning to India in 2010, he was successful in securing the prestigious DST Fast Track fellowship and the DST Inspire faculty award. He is currently an UGC-FRP As- sistant Professor at the Institute of Chemical Technology, Mumbai. The central theme of his research is the application of palladium catalysis for the sustainable synthesis of important heterocyclic molecules, including pharmaceutical drugs, as well as the modification of several bioactive molecules. AB - Homogeneous catalysis plays an important and ubiquitous role in the synthesis of simple and complex molecules, including drug compounds, natural products, and agrochemicals. In recent years, the wide-reaching importance of homogeneous catalysis has made it an indispensable tool for the modification of biomolecules, such as carbohydrates (sugars), amino acids, peptides, nucleosides, nucleotides, and steroids. Such a synthetic strategy offers several advantages, which have led to the development of new molecules of biological relevance at a rapid rate relative to the number of available synthetic methods. Given the powerful nature of homogeneous catalysis in effecting these synthetic transformations, this Focus Review has been compiled to highlight these important developments. LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Zoltán AU - Kónya, Krisztina TI - Synthesis of 1,3-Azol-2-yl O-Heterocycles by Microwave-Irradiation-Assisted Direct C–H Functionalization JF - SYNLETT J2 - SYNLETT VL - 29 PY - 2018 IS - 18 SP - 2412 EP - 2416 PG - 5 SN - 0936-5214 DO - 10.1055/s-0037-1611012 UR - https://m2.mtmt.hu/api/publication/30322288 ID - 30322288 N1 - Funding Agency and Grant Number: EUEuropean Union (EU); European Development Fund [GINOP-2.3.2-15-2016-00008] Funding text: This research was financially supported by the EU and co-financed by the European Development Fund under the project GINOP-2.3.2-15-2016-00008. AB - A microwave-irradiation-assisted synthesis of novel 1,3-azol-2-yl-substituted O-heterocycles, namely flavones, chromones, coumarins, and chromanones, is reported. Starting from the appropriate bromo derivatives and 1,3-azoles, this palladium and copper co-catalyzed method provides moderate to good yields and excellent regioselectivity. The ligand- and base-free method can be a useful, generally applicable synthetic tool in the formation of new O-heterocycles. LA - English DB - MTMT ER -