TY  - JOUR
AU  - Huttin, Olivier
AU  - Xhaard, Constance
AU  - Dandine-Roulland, Claire
AU  - Le, Floch Edith
AU  - Bacq-Daian, Delphine
AU  - Lamiral, Zohra
AU  - Bozec, Erwan
AU  - Deleuze, Jean-Francois
AU  - Zannad, Faiez
AU  - Rossignol, Patrick
AU  - Girerd, Nicolas
TI  - Layer myocardial strain is the most heritable echocardiographic trait
JF  - EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
J2  - EUR HEART J-CARD IMG
VL  - 24
PY  - 2023
IS  - 10
SP  - 1394
EP  - 1403
PG  - 10
SN  - 2047-2404
DO  - 10.1093/ehjci/jead146
UR  - https://m2.mtmt.hu/api/publication/34066276
ID  - 34066276
AB  - Aims Myocardial deformation assessed by strain analysis represents a significant advancement in our assessment of cardiac mechanics. However, whether this variable is genetically heritable or whether all/most of its variability is related to environmental factors is currently unknown. We sought to determine the heritability of echocardiographically determined cardiac mechanics indices in a population setting. Methods and results A total of 1357 initially healthy subjects (women 51.6%; 48.2 & PLUSMN; 14.1 years) were included in this study from 20-year follow-up after the fourth visit of the longitudinal familial STANISLAS cohort (Lorraine, France). Data were acquired using state-of-the-art cardiac ultrasound equipment, using acquisition and measurement protocols recommended by the EACVI (European Association of Cardiovascular Imaging)/ASE (American Society of Echocardiography)/Industry Task Force. Layer-specific global longitudinal strain (GLS) and global circumferential strain (full-wall, subendocardial, and subepicardial) and conventional structural and functional cardiac parameters and their potential heritability were assessed using restricted maximum likelihood analysis, with genetic relatedness matrix calculated from genome-wide association data. Indices of longitudinal/circumferential myocardial function and left ventricular (LV) ejection fraction had low heritability (ranging from 10% to 20%). Diastolic and standard LV function parameters had moderate heritability (ranging from 20% to 30%) except for end-systolic and end-diastolic volumes (30% and 45%, respectively). In contrast, global longitudinal subendocardial strain (GLSEndo)/global longitudinal subepicardial strain (GLSEpi) ratio had a high level of heritability (65%). Except for GLSEndo/GLSEpi ratio, a large percentage of variance remained unexplained (>50%). Conclusions In our population cohort, GLSEndo/GLSEpi ratio had a high level of heritability, whereas other classical and mechanical LV function parameters did not. Given the increasing recognition of GLSEndo/GLSEpi ratio as an early/sensitive imaging biomarker of systolic dysfunction, our results suggest the possible existence of individual genetic predispositions to myocardial decline.
LA  - English
DB  - MTMT
ER  -