TY - JOUR AU - Rafaqat, S. AU - Vujacic, I. Radoman AU - Gluscevic, S. AU - Sharif, S. AU - Klisic, A. TI - Biomarkers of diabetes: role in the pathogenesis of atrial fibrillation JF - EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES J2 - EUR REV MED PHARMACOL SCI VL - 28 PY - 2024 IS - 4 SP - 1524 EP - 1540 PG - 17 SN - 1128-3602 DO - 10.26355/eurrev_202402_35482 UR - https://m2.mtmt.hu/api/publication/34956375 ID - 34956375 LA - English DB - MTMT ER - TY - JOUR AU - Rafaqat, Saira AU - Gluscevic, Sanja AU - Patoulias, Dimitrios AU - Sharif, Saima AU - Klisic, Aleksandra TI - The Association between Coagulation and Atrial Fibrillation JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 2 PG - 22 SN - 2227-9059 DO - 10.3390/biomedicines12020274 UR - https://m2.mtmt.hu/api/publication/34956376 ID - 34956376 LA - English DB - MTMT ER - TY - JOUR AU - Aarnink, E. AU - Zabern, M. AU - Boersma, L. AU - Glikson, M. TI - Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 20 SN - 2077-0383 DO - 10.3390/jcm12206491 UR - https://m2.mtmt.hu/api/publication/34289743 ID - 34289743 N1 - Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, 21100, Italy Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, 9103102, Israel Department of Cardiology, Amsterdam University Medical Center, Amsterdam, 1105 AZ, Netherlands Export Date: 10 November 2023 Correspondence Address: Glikson, M.; Jesselson Integrated Heart Center, Israel; email: mglikson@szmc.org.il AB - Atrial fibrillation (AF) is the most common arrhythmia in adults worldwide and represents an important burden for patients, physicians, and healthcare systems. AF is associated with substantial mortality and morbidity, due to the disease itself and its specific complications, such as the increased risk of stroke and thromboembolic events associated with AF. The temporal relation between AF episodes and stroke is nonetheless incompletely understood. The factors associated with an increased thromboembolic risk remain unclear, as well as the stroke risk stratification. Therefore, in this review, we intend to expose the mechanisms and physiopathology leading to intracardiac thrombus formation and stroke in AF patients, together with the evidence supporting the causal hypothesis. We also expose the risk factors associated with increased risk of stroke, the current different risk stratification tools as well as future prospects for improving this risk stratification. © 2023 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Elias, Adi AU - Khoury, Yara AU - Shehadeh, Faheem AU - Ron, Gilat AU - Boulos, Monther AU - Nashashibi, Jeries AU - Zukermann, Robert AU - Elias, Mazen AU - Gepstein, Lior AU - Suleiman, Mahmoud TI - Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation JF - RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS J2 - Res Pract Thromb Haemost VL - 7 PY - 2023 IS - 2 PG - 7 SN - 2475-0379 DO - 10.1016/j.rpth.2023.100127 UR - https://m2.mtmt.hu/api/publication/34130757 ID - 34130757 AB - Background: Atrial Fibrillation (AF) is the most common sustained tachi-arrhythmia. Thrombus formation in the left atrial appendage (LAA) increases the risk of stroke and systemic embolism in patients with AF.Objectives: The aim of this study was to compare thrombin generation in the LAA to the LA among patients with AF. Methods: A cross-sectional study of consecutive patients with AF undergoing pulmonary veins catheter ablation. Blood samples from the femoral vein (FV), right atrium (RA), left atrium (LA), and LAA were collected during the catheter ablation procedures. Thrombin generation was assessed by a Calibrated Automated Thrombogram. The LAA-calibrated automated thrombogram parameters were compared with the RA, LA, and FV.Results: A total of 47 consecutive patients were enrolled in the study. The endogenous thrombin potential and peak height were significantly higher in the LAA compared with the LA, the mean differences and 95% CI between the LA and LAA were-378.9 (-680.5,-77.2) (nM*min) and-66.7 (-119.6,-13.8) (nM) in the endogenous thrombin potential and peak height respectively. Conclusion: In patients with AF undergoing catheter ablation, the LAA demonstrated increased thrombin generation compared with the LA. This finding might contribute to the understanding of why the LAA is more predisposed to thrombus formation than the LA. Clinical Trials Registration: NCT03795883 LA - English DB - MTMT ER - TY - JOUR AU - Friebel, J. AU - Witkowski, M. AU - Wegner, M. AU - Blöbaum, L. AU - Lammel, S. AU - Schencke, P.-A. AU - Jakobs, K. AU - Puccini, M. AU - Reißner, D. AU - Steffens, D. AU - Moos, V. AU - Schutheiss, H.-P. AU - Landmesser, U. AU - Rauch, U. TI - Cytotoxic CD8+ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation JF - CELLS J2 - CELLS-BASEL VL - 12 PY - 2023 IS - 1 SN - 2073-4409 DO - 10.3390/cells12010141 UR - https://m2.mtmt.hu/api/publication/33604611 ID - 33604611 N1 - Charité Center 11—Department of Cardiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, 12203, Germany Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 10785, Germany Department of Cardiac Anesthesiology and Intensive Care Medicine, German Heart Center, Berlin, 13353, Germany Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States Medical Department I, Gastroenterology, Infectious Diseases and Rheumatology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, 12203, Germany Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, 12203, Germany Export Date: 30 January 2023 Correspondence Address: Rauch, U.; Charité Center 11—Department of Cardiology, Germany; email: ursula.rauch@charite.de Chemicals/CAS: phenacyl chloride, 532-27-4; thrombin, 9002-04-4, 869858-13-9; thromboplastin, 9035-58-9 AB - Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8+ T lymphocytes in patients presenting with first-diagnosed AF (FDAF). Methods: A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (n = 160), cardiac tissue from patients with paroxysmal AF (n = 32) and 20 controls. Results: During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8+) circulated more frequently when compared to patients with chronic cardiovascular disease but without AF, accompanied by elevated plasma levels of CD8+ effector molecules, which corresponded to biomarkers of adverse cardiac remodelling and atrial dysfunction. Activation of tissue factor (TF) and PAR1 was associated with pro-inflammatory and cytotoxic effector functions. PAR1-related CD8+ cell activation was more frequent in FDAF patients that experienced a MACE. Conclusions: In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8+ T cells. Intervening in this cascade might be a promising synergistic approach to reducing disease progression and the vascular complications of AF. © 2022 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Hardy, Michael AU - Douxfils, Jonathan AU - Dincq, Anne-Sophie AU - Sennesael, Anne-Laure AU - Xhaet, Olivier AU - Mullier, Francois AU - Lessire, Sarah TI - Uninterrupted DOACs Approach for Catheter Ablation of Atrial Fibrillation: Do DOACs Levels Matter? JF - FRONTIERS IN CARDIOVASCULAR MEDICINE J2 - FRONT CARDIOVASC MED VL - 9 PY - 2022 PG - 8 SN - 2297-055X DO - 10.3389/fcvm.2022.864899 UR - https://m2.mtmt.hu/api/publication/33045551 ID - 33045551 AB - Most patients present for catheter ablation of atrial fibrillation (CAAF) with residual or full effect of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). In daily practice, it has been observed that the activated clotting time (ACT) was actually poorly sensitive to the effect of DOACs and that patients on DOACs required more unfractionated heparin (UFH) to achieve the ACT target of 300 s during the procedure, leading some authors to worry about potential overdosing. Conversely, we hypothesize that these higher doses of UFH are necessary to achieve adequate hemostasis during CAAF regardless of the residual effect of DOACs. During CAAF, thrombosis is promoted mainly by the presence of thrombogenic sheaths and catheters in the bloodstream. Preclinical data suggest that only high doses of DOACs are able to mitigate catheter-induced thrombin generation, whereas low dose UFH already do so. In addition, the effect of UFH seems to be lower in patients on DOACs, compared to patients on VKAs, explaining part of the differences observed in heparin requirements. Clinical studies could not identify increased bleeding risk in patients on DOACs compared to those on VKAs despite similar efficacy during CAAF procedures. Moreover, targeting a lower ACT was associated with an increased periprocedural thrombotic risk for both DOAC and VKA patients. Therefore, the low sensitivity of the ACT to the residual effect of DOACs should not be a major concern in its use in the interventional cardiology laboratory. LA - English DB - MTMT ER - TY - JOUR AU - Litwinowicz, Radoslaw AU - Natorska, Joanna AU - Zabczyk, Michal AU - Kapelak, Boguslaw AU - Lakkireddy, Dhanunjaya AU - Vuddanda, Venkat AU - Bartus, Krzysztof TI - Changes in fibrinolytic activity and coagulation factors after epicardial left atrial appendage closure in patients with atrial fibrillation JF - JOURNAL OF THORACIC DISEASE J2 - J THORACIC DISEASE VL - 14 PY - 2022 IS - 11 SP - 4226 EP - 4235 PG - 10 SN - 2072-1439 DO - 10.21037/jtd-21-1093 UR - https://m2.mtmt.hu/api/publication/33263413 ID - 33263413 AB - Background: The left atrial appendage (LAA) is known to be the primary source of thrombus formation in atrial fibrillation (AF). We investigate whether epicardial LAA occlusion (LAAO) from the cardiovascular system has an effect on coagulation and prothrombotic status in AF.Methods: Twenty-two patients with nonvalvular AF, who were not currently receiving oral anticoagulation (OAC) therapy, participated in a single-center prospective study. We measured fibrinogen and plasminogen levels along with plasma fibrin clot permeability, clot lysis time (CLT) and endogenous thrombin potential (ETP) before the LAAO procedure, at discharge and 1 month afterward.Results: One month after the LAAO procedure, plasma fibrin clot permeability improved by 39.3% as measured by clots prepared from peripheral blood (P=0.019) and also after adjustment for fibrinogen (P=0.027). Higher plasma fibrin clot permeability was associated with improved clot susceptibility to lysis (r=-0.67, P=0.013). CLT was reduced by 10.3% (P=0.0020), plasminogen activator inhibitor-1 antigen levels were reduced by 52% (P=0.023) and plasminogen activity was increased by 8.9% (P=0.0077). A trend toward decreased thrombin generation, reflected by a decreased ETP and peak thrombin generated was also observed 1 month after LAAO procedure (P=0.072 and P=0.087, respectively). No differences were observed in tissue-type plasminogen activator and thrombin-activatable fibrinolysis inhibitor plasma levels (both P>0.05).Conclusions: Obtained results seem to confirm that LAA plays a key role in thrombogenesis. Elimination of LAA from the circulatory system may improve fibrin clot permeability and susceptibility to fibrinolysis in peripheral blood. LA - English DB - MTMT ER - TY - JOUR AU - Gue, Ying X. AU - Ding, Wern Yew AU - Lip, Gregory Y. H. AU - Gorog, Diana A. TI - Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out? JF - SN APPLIED SCIENCES J2 - SN APPL SCI VL - 3 PY - 2021 IS - 5 SN - 2523-3963 DO - 10.1007/s42452-021-04517-4 UR - https://m2.mtmt.hu/api/publication/31979058 ID - 31979058 LA - English DB - MTMT ER - TY - JOUR AU - Negreva, Mariya N. AU - Prodanova, Krasimira S. AU - Vitlianova, Katerina D. TI - Paroxysmal atrial fibrillation is associated with early coagulation activity regardless of risk factors for embolism JF - MINERVA CARDIOLOGY AND ANGIOLOGY J2 - MINERVA CARDIOL ANGIOL VL - 69 PY - 2021 IS - 3 SP - 269 EP - 276 PG - 8 SN - 2724-5683 DO - 10.23736/S2724-5683.20.05209-3 UR - https://m2.mtmt.hu/api/publication/32237254 ID - 32237254 N1 - Export Date: 16 May 2022 Correspondence Address: Negreva, M.N.; Section of Cardiology, Hr. Smirnenski bul. 1, Bulgaria; email: mnegreva@abv.bg Chemicals/CAS: blood clotting factor 10, 9001-29-0; blood clotting factor 5, 9001-24-5, 9013-23-4; prothrombin, 9001-26-7; thromboplastin, 9035-58-9; Prothrombin Tradenames: VACUETTE, Greiner, United States; Vacutainer Manufacturers: Greiner, United States AB - BACKGROUND: Paroxysmal atrial fibrillation (PAF) is associated with an increased incidence of embolic events, even in patients with no embologenic risk factors. This fact raises the question for the hypercoagulability in PAF as a state closely related to the arrhythmia itself independent of other well established embologenic risk factors. The scarce data on that topic predisposed our aim that was to study coagulation activity in the early hours (up to the twenty-fourth hour) of the disease.METHODS: Fifty-one non-anticoagulated patients (26 men, 25 women; mean age 59.84 +/- 1.60 years) and 52 controls (26 men, 26 women; mean age 59.50 +/- 1.46 years) were consequently selected for the study. Plasma coagulation activity of factor II (FII), factor V (FV) and factor X (FX) was examined.RESULTS: In the PAF group, there was a higher activity of FlI (167.81 +/- 9.12% vs. 100.43 +/- 5.77%, P<0.001), FV (198.47 +/- 10.88% vs. 121.53 +/- 4.79%, P<0.001) and FX (193.20 +/- 11.85 vs. 116.20 +/- 5.86, P<0.001). The deviations were independent of age, sex, body mass index, presence of hypertension and CHA(2)DS(2)-VASc risk score (P>0.05). PAF duration was a significant predictor of FII activity (r=0.83, P<0.001) but no correlation was established between FV and FX activity and the arrhythmia duration (r=0.10, P>0.05; r=0.11, P>0.05, respectively).CONCLUSIONS: We established high coagulation activity during the first twenty-four hours of PAF. The observed deviations in the studied parameters give us reason to consider PAF a procoagulant state independent of the well-established prothrombotic risk factors, even in its early clinical manifestation. LA - English DB - MTMT ER - TY - JOUR AU - Orbán-Kálmándi, Rita Angéla AU - Szegedi, István AU - Sarkady, Ferenc AU - Fekete, István AU - Fekete, Klára AU - Vasas, Nikolett AU - Berényi, Ervin László AU - Csiba, László AU - Bagoly, Zsuzsa TI - A modified in vitro clot lysis assay predicts outcomes and safety in acute ischemic stroke patients undergoing intravenous thrombolysis JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-021-92041-1 UR - https://m2.mtmt.hu/api/publication/32073172 ID - 32073172 LA - English DB - MTMT ER - TY - JOUR AU - Wu, Dan AU - Liu, Yong'e TI - FM Combined With NIHSS Score Contributes to Early AIS Diagnosis and Differential Diagnosis of Cardiogenic and Non-Cardiogenic AIS JF - CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS J2 - CLIN APPL THROMB-HEM VL - 27 PY - 2021 PG - 6 SN - 1076-0296 DO - 10.1177/10760296211000129 UR - https://m2.mtmt.hu/api/publication/31978589 ID - 31978589 AB - A growing researchers have suggested that fibrin monomer (FM) plays an important role in early diagnosis of thrombotic diseases. We explored the application of FM in the diagnosis and classification of acute ischemic stroke (AIS). The differences in FM, D-dimer, and NIHSS scores between different TOAST (Trial of ORG 10172 in Acute Stroke Treatment) types were analyzed with one-way ANOVA; the correlation between FM, D-dimer and NIHSS score in patients with different TOAST classification was analyzed by Pearson linear correlation. The ROC curve was utilized to analyze the diagnostic performance. 1. FM was more effective in diagnosing patients with AIS than D-dimer. 2. The FM level in cardiogenic AIS was significantly different from that in non-cardiogenic patients (P < 0.05); the NIHSS score in cardiogenic stroke was significantly higher than in atherosclerotic and unexplained stroke group. Whereas, no statistical difference was observed in the D-dimer level between these groups (P > 0.05). 3. The correlation between FM and NIHSS scores in the cardiogenic (r = 0.3832) and atherosclerotic (r = 0.3144) groups was statistically significant. 4. FM exhibited the highest diagnostic efficacy for cardiogenic AIS; furthermore, FM combined with the NIHSS score was more conducive to the differential diagnosis of cardiogenic and non-cardiogenic AIS. FM detection contributes to the early diagnosis of AIS, and is important for the differential diagnosis of different TOAST types of AIS. Moreover, FM combined with the NIHSS score is valuable in the differential diagnosis of cardiogenic and non-cardiogenic AIS. LA - English DB - MTMT ER - TY - JOUR AU - Xu, Buyun AU - Du, Ye AU - Xu, Chao AU - Sun, Yong AU - Peng, Fang AU - Wang, Shengkai AU - Pan, Jie AU - Lou, Yuanqing AU - Xing, Yangbo TI - Left Atrial Appendage Morphology and Local Thrombogenesis-Related Blood Parameters in Patients With Atrial Fibrillation JF - JOURNAL OF THE AMERICAN HEART ASSOCIATION J2 - J AM HEART ASSOC VL - 10 PY - 2021 IS - 12 PG - 14 SN - 2047-9980 DO - 10.1161/JAHA.120.020406 UR - https://m2.mtmt.hu/api/publication/32237255 ID - 32237255 N1 - Funding Agency and Grant Number: Department of Health of Zhejiang Province, China [2019RC084]; Department of Science and Technology of Zhejiang Province, China [LGF20H020002] Funding text: This work was supported by Department of Health of Zhejiang Province, China (grant number: 2019RC084), and Department of Science and Technology of Zhejiang Province, China (grant number: LGF20H020002). AB - BackgroundLeft atrial appendage (LAA) morphology predicts stroke risk in patients with atrial fibrillation. However, it is not precisely understood how LAA morphology influences stroke risk. The present study aimed to investigate the relationship between LAA morphology and local thrombogenesis-related blood parameters in LAA.Methods and ResultsWe enrolled 205 patients undergoing catheter ablation of atrial fibrillation. The prevalence of chicken wing-, cactus-, windsock-, and cauliflower-type LAAs were 23.9%, 32.7%, 29.3%, and 14.1%, respectively. Blood samples were collected from the femoral vein, left atrium, and LAA in each patient. The levels of blood parameters were tested for each blood sample. The cauliflower-type LAA was associated with elevated platelet P-selectin expression, and interleukin-6 levels and with lower NO levels in LAA blood samples (P<0.05) independent of LAA flow velocity and LAA volume. LAA flow velocity, which was lowest in the cauliflower-type LAA, was the only independent predictor of von Willebrand factor antigen and plasminogen activator inhibitor-1 levels in LAA blood samples. In femoral vein blood samples, no significant difference was detected in the above blood parameters among the four LAA morphological types. In all blood samples, the levels of thrombin-antithrombin complex, D-dimer, fibrinogen, and tissue plasminogen activator were comparable among the four LAA morphological types.ConclusionsIn patients with atrial fibrillation, LAA morphological types might be associated with local platelet activity, fibrinolysis function, endothelial dysfunction, and inflammation. LA - English DB - MTMT ER - TY - JOUR AU - Bagoly, Zsuzsa AU - Hajas, Orsolya AU - Urbancsek, Réka AU - Kiss, Alexandra AU - Fiak, Edit AU - Sarkady, Ferenc AU - Tóth, Noémi Klára AU - Orbán-Kálmándi, Rita Angéla AU - Kovács, Kitti Bernadett AU - Nagy, László Tibor AU - Nagy, Attila Csaba AU - Kappelmayer, János AU - Csiba, László AU - Csanádi, Zoltán TI - Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 9 PY - 2020 IS - 9 PG - 13 SN - 2077-0383 DO - 10.3390/jcm9093050 UR - https://m2.mtmt.hu/api/publication/31610168 ID - 31610168 LA - English DB - MTMT ER - TY - JOUR AU - Bartus, Krzysztof AU - Litwinowicz, Radoslaw AU - Natorska, Joanna AU - Zabczyk, Michal AU - Undas, Anetta AU - Kapelak, Boguslaw AU - Lakkireddy, Dhanunjaya AU - Lee, Randall J TI - Coagulation factors and fibrinolytic activity in the left atrial appendage and other heart chambers in patients with atrial fibrillation. is there a local intracardiac prothrombotic state? (HEART-CLOT study). TS - is there a local intracardiac prothrombotic state? (HEART-CLOT study). JF - INTERNATIONAL JOURNAL OF CARDIOLOGY J2 - INT J CARDIOL VL - 301 PY - 2020 SP - 103 EP - 107 PG - 5 SN - 0167-5273 DO - 10.1016/j.ijcard.2019.09.053 UR - https://m2.mtmt.hu/api/publication/31202413 ID - 31202413 AB - Atrial fibrillation (AF), a risk factor for stroke and systemic thromboembolism, is associated with unfavorable fibrin clot properties and increased thrombus formation in peripheral blood. The left atrial appendage (LAA) is known to be the primary site of thrombus formation.We investigated the relative differences in plasma fibrin clot features including plasma fibrin clot permeability (Ks) and clot lysis time (CLT) between the right atrium (RA), right ventricle (RV), left atrium (LA), left ventricle (LV), LAA, and peripheral blood.Sixteen patients with nonvalvular AF who stopped oral anticoagulant therapy at least 2 days before a LARIAT procedure participated in a single-center prospective study. We measured fibrinogen and plasminogen levels along with Ks, CLT, and endogenous thrombin potential (ETP) during the LARIAT procedure in blood obtained from the right femoral vein, RA, RV, LA, LV and LAA.LAA clot porosity was reduced by 16.2% compared to peripheral blood (p = 0.026), also after adjustment for fibrinogen levels (p = 0.038). Ks was similar for the RA, RV, LA, LV, and LAA (all p > 0.05). We found 14.7% prolonged CLT for clots prepared from blood samples obtained from the LAA compared to those prepared from peripheral blood, but no differences between the RA, RV, LA and LV (all p > 0.05) were found. There were no significant differences in other parameters, including ETP, between heart chambers.Patients with AF are characterised by a local prothrombotic state as reflected by formation of compact fibrin clots in the LAA compared to peripheral blood, which may contribute to LAA thrombus formation and device-related thrombi. LA - English DB - MTMT ER - TY - JOUR AU - Hajas, Orsolya AU - Bagoly, Zsuzsa AU - Tóth, Noémi Klára AU - Urbancsek, Réka AU - Kiss, Alexandra AU - Kovács, Kitti Bernadett AU - Sarkady, Ferenc AU - Nagy, Attila Csaba AU - Vargáné Oláh, Anna AU - Nagy, László Tibor AU - Clemens, Marcell AU - Csiba, László AU - Csanádi, Zoltán TI - Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques JF - CARDIOLOGY RESEARCH AND PRACTICE J2 - CARDIOL RES PRAC VL - 2020 PY - 2020 PG - 8 SN - 2090-0597 DO - 10.1155/2020/1570483 UR - https://m2.mtmt.hu/api/publication/31143304 ID - 31143304 N1 - 281437 LA - English DB - MTMT ER - TY - JOUR AU - Hirano, Akemi AU - Suzuki, Yusuke AU - Umegaki, Hiroyuki AU - Hayashi, Toshio AU - Ina, Koichiro AU - Onishi, Joji AU - Hasegawa, Jun AU - Kuzuya, Masafumi TI - Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial JF - OBM GERIATRICS J2 - OBM GERIAT VL - 4 PY - 2020 IS - 1 SP - 1 SN - 2638-1311 DO - 10.21926/obm.geriatr.2001108 UR - https://m2.mtmt.hu/api/publication/32663605 ID - 32663605 LA - English DB - MTMT ER - TY - JOUR AU - Negreva, Mariya AU - Georgiev, Svetoslav AU - Zarkova, Ana TI - Fibrinolytic activity in atrial fibrillation JF - WORLD JOURNAL OF ADVANCED RESEARCH AND REVIEWS J2 - J ADV RES REV VL - 6 PY - 2020 IS - 2 SP - 193 EP - 200 PG - 8 SN - 2581-9615 DO - 10.30574/wjarr.2020.6.2.0156 UR - https://m2.mtmt.hu/api/publication/31355024 ID - 31355024 LA - English DB - MTMT ER - TY - JOUR AU - Negreva, Mariya AU - Prodanova, Krasimira AU - Vitlianova, Katerina AU - Madjova, Christiana TI - Paroxysmal atrial fibrillation: changes in factor VIII and von Willebrand factor impose early hypercoagulability JF - ARCHIVES OF MEDICAL SCIENCE - ATHEROSCLEROTIC DISEASES J2 - ARCH MED SC ATHEROSCL DIS VL - 5 PY - 2020 IS - 1 SP - 140 EP - 147 PG - 8 SN - 2451-0629 DO - 10.5114/amsad.2020.97101 UR - https://m2.mtmt.hu/api/publication/32097284 ID - 32097284 LA - English DB - MTMT ER - TY - JOUR AU - Undas, Anetta TI - Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications JF - EUROPACE J2 - EUROPACE VL - 22 PY - 2020 IS - 2 SP - 185 EP - 194 PG - 10 SN - 1099-5129 DO - 10.1093/europace/euz271 UR - https://m2.mtmt.hu/api/publication/30858830 ID - 30858830 N1 - Cited By :9 Export Date: 12 January 2023 CODEN: EUROC Correspondence Address: Undas, A.; Institute of Cardiology, 80 PrCrossed D sign dnicka Str., Poland; email: mmundas@cyf-kr.edu.pl LA - English DB - MTMT ER - TY - JOUR AU - Toru, MARUYAMA TI - Erythrocyte Deformability Is Impaired in Patients with Nonvalvular Atrial Fibrillation JF - JOURNAL OF CLINICAL PHYSIOLOGY J2 - J CLINIC PHYSIOL VL - 49 PY - 2019 IS - 2 SP - 65 SN - 0286-7052 UR - https://m2.mtmt.hu/api/publication/31529383 ID - 31529383 LA - Japanese DB - MTMT ER - TY - JOUR AU - Miguel Rivera-Caravaca, Jose AU - Roldan, Vanessa AU - Romera, Marta AU - Asuncion Esteve-Pastor, Maria AU - Valdes, Mariano AU - Lip, Gregory Y. H. AU - Vicente, Vicente AU - Marin, Francisco TI - Soluble Fibrin Monomer Complex and Prediction of Cardiovascular Events in Atrial Fibrillation: The Observational Murcia Atrial Fibrillation Project JF - JOURNAL OF GENERAL INTERNAL MEDICINE J2 - J GEN INTERN MED VL - 33 PY - 2018 IS - 6 SP - 847 EP - 854 PG - 8 SN - 0884-8734 DO - 10.1007/s11606-017-4279-4 UR - https://m2.mtmt.hu/api/publication/30499309 ID - 30499309 AB - BACKGROUND: Soluble fibrinmonomer complex (SFMC) is a biomarker of fibrin formation abnormally elevated in clinical situations of hypercoagulability. OBJECTIVE: We investigated the association and predictive performance of SFMC for stroke, adverse cardiovascular events, cardiovascular mortality and all-cause mortality in a cohort of patients with atrial fibrillation (AF) receiving vitamin K antagonist (VKA) anticoagulant therapy. DESIGN: During the second semester of 2007, we included 1226 AF outpatients stable on VKAs (INR 2.0-3.0) over a period of 6 months. SFMC levels were assessed at baseline. During 6.5 (IQR 4.4-8.0) years of follow-up, we recorded all ischemic strokes, adverse cardiovascular events (composite of stroke, acute heart failure, acute coronary syndrome and cardiovascular death), cardiovascular deaths and all-cause deaths. PARTICIPANTS: All patients were recruited consecutively. We excluded patients with rheumatic mitral valves, prosthetic heart valves, acute coronary syndrome, stroke, hemodynamic instability, hospital admissions or surgical interventions within the preceding 6 months. MAINMEASURES: SFMClevelsweremeasured in plasma by immunoturbidimetry in an automated coagulometer (STALiatestFM, Diagnostica Stago, Asnieres, France). KEY RESULTS: We recorded 121 (1.52%/year) ischemic strokes, 257 (3.23%/year) cardiovascular events, 67 (0.84%/year) cardiovascular deaths and 486 (6.10%/year) all-cause deaths. SFMC > 12 mu g/mL was not associated with stroke but was associated with higher risk of cardiovascular events (HR 1.72, 95% CI 1.31-2.26), cardiovascularmortality (HR 2.16, 95% CI 1.30-3.57) and all-cause mortality (HR 1.26, 95% CI 1.03-1.55). When SFMC > 12 mu g/mL was added to the CHA2DS2-VASc, there were significant improvements in predictive performance, sensitivity and reclassification for adverse cardiovascular events (c-index: 0.645 vs. 0.660, p = 0.010; IDI = 0.013, p< 0.001; NRI= 0.121, p< 0.001) and cardiovascular mortality (c-index: 0.661 vs. 0.691, p = 0.006; IDI = 0.009, p = 0.049; NRI = 0.217, p < 0.001), but decision curves demonstrated a similar net benefit and clinical usefulness. CONCLUSIONS: In AF patients taking VKAs, high SFMC levels were associated with the risk of adverse cardiovascular events, cardiovascularmortality and all-cause mortality. The addition of SFMC to the CHA2DS2-VASc score improved its predictive performance for these outcomes, but failed to show an improvement in clinical usefulness. LA - English DB - MTMT ER - TY - JOUR AU - Refaai, Majed A. AU - Riley, Paul AU - Mardovina, Tatsiana AU - Bell, Phoenix D. TI - The Clinical Significance of Fibrin Monomers JF - THROMBOSIS AND HAEMOSTASIS J2 - THROMB HAEMOSTASIS VL - 118 PY - 2018 IS - 11 SP - 1856 EP - 1866 PG - 11 SN - 0340-6245 DO - 10.1055/s-0038-1673684 UR - https://m2.mtmt.hu/api/publication/30571819 ID - 30571819 AB - Introduction: Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition. There are limited reports investigating the utility of FM in hyper-coagulable patients. LA - English DB - MTMT ER -