@article{MTMT:34289743,
	title = {Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients},
	url = {https://m2.mtmt.hu/api/publication/34289743},
	author = {Aarnink, E. and Zabern, M. and Boersma, L. and Glikson, M.},
	doi = {10.3390/jcm12206491},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {12},
	unique-id = {34289743},
	abstract = {Atrial fibrillation (AF) is the most common arrhythmia in adults worldwide and represents an important burden for patients, physicians, and healthcare systems. AF is associated with substantial mortality and morbidity, due to the disease itself and its specific complications, such as the increased risk of stroke and thromboembolic events associated with AF. The temporal relation between AF episodes and stroke is nonetheless incompletely understood. The factors associated with an increased thromboembolic risk remain unclear, as well as the stroke risk stratification. Therefore, in this review, we intend to expose the mechanisms and physiopathology leading to intracardiac thrombus formation and stroke in AF patients, together with the evidence supporting the causal hypothesis. We also expose the risk factors associated with increased risk of stroke, the current different risk stratification tools as well as future prospects for improving this risk stratification. © 2023 by the authors.},
	keywords = {Stroke prevention; Atrial Fibrillation; LEFT ATRIAL APPENDAGE; Stroke prediction},
	year = {2023},
	eissn = {2077-0383}
}

@article{MTMT:34130757,
	title = {Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation},
	url = {https://m2.mtmt.hu/api/publication/34130757},
	author = {Elias, Adi and Khoury, Yara and Shehadeh, Faheem and Ron, Gilat and Boulos, Monther and Nashashibi, Jeries and Zukermann, Robert and Elias, Mazen and Gepstein, Lior and Suleiman, Mahmoud},
	doi = {10.1016/j.rpth.2023.100127},
	journal-iso = {Res Pract Thromb Haemost},
	journal = {RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS},
	volume = {7},
	unique-id = {34130757},
	abstract = {Background: Atrial Fibrillation (AF) is the most common sustained tachi-arrhythmia. Thrombus formation in the left atrial appendage (LAA) increases the risk of stroke and systemic embolism in patients with AF.Objectives: The aim of this study was to compare thrombin generation in the LAA to the LA among patients with AF. Methods: A cross-sectional study of consecutive patients with AF undergoing pulmonary veins catheter ablation. Blood samples from the femoral vein (FV), right atrium (RA), left atrium (LA), and LAA were collected during the catheter ablation procedures. Thrombin generation was assessed by a Calibrated Automated Thrombogram. The LAA-calibrated automated thrombogram parameters were compared with the RA, LA, and FV.Results: A total of 47 consecutive patients were enrolled in the study. The endogenous thrombin potential and peak height were significantly higher in the LAA compared with the LA, the mean differences and 95% CI between the LA and LAA were-378.9 (-680.5,-77.2) (nM*min) and-66.7 (-119.6,-13.8) (nM) in the endogenous thrombin potential and peak height respectively. Conclusion: In patients with AF undergoing catheter ablation, the LAA demonstrated increased thrombin generation compared with the LA. This finding might contribute to the understanding of why the LAA is more predisposed to thrombus formation than the LA. Clinical Trials Registration: NCT03795883},
	year = {2023},
	eissn = {2475-0379}
}

@article{MTMT:33604611,
	title = {Cytotoxic CD8+ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation},
	url = {https://m2.mtmt.hu/api/publication/33604611},
	author = {Friebel, J. and Witkowski, M. and Wegner, M. and Blöbaum, L. and Lammel, S. and Schencke, P.-A. and Jakobs, K. and Puccini, M. and Reißner, D. and Steffens, D. and Moos, V. and Schutheiss, H.-P. and Landmesser, U. and Rauch, U.},
	doi = {10.3390/cells12010141},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {12},
	unique-id = {33604611},
	abstract = {Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8+ T lymphocytes in patients presenting with first-diagnosed AF (FDAF). Methods: A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (n = 160), cardiac tissue from patients with paroxysmal AF (n = 32) and 20 controls. Results: During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8+) circulated more frequently when compared to patients with chronic cardiovascular disease but without AF, accompanied by elevated plasma levels of CD8+ effector molecules, which corresponded to biomarkers of adverse cardiac remodelling and atrial dysfunction. Activation of tissue factor (TF) and PAR1 was associated with pro-inflammatory and cytotoxic effector functions. PAR1-related CD8+ cell activation was more frequent in FDAF patients that experienced a MACE. Conclusions: In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8+ T cells. Intervening in this cascade might be a promising synergistic approach to reducing disease progression and the vascular complications of AF. © 2022 by the authors.},
	keywords = {Female; Male; Inflammation; THROMBIN; THROMBIN; MYOPATHY; ARTICLE; CYTOTOXICITY; human; major clinical study; controlled study; enzyme linked immunosorbent assay; Flow Cytometry; Gene Expression; cardiovascular disease; disease exacerbation; T cells; human tissue; acute heart infarction; blood sampling; CD8+ T lymphocyte; follow up; heart muscle fibrosis; Cardiovascular risk; acute coronary syndrome; thrombogenicity; TISSUE FACTOR; Atrial Fibrillation; Atrial Fibrillation; thromboplastin; proteinase activated receptor; heart tissue; Protease-activated receptor; PAR1; MACE; atrial myopathy; CD8; CHA2DS2-VASc score; thrombo-inflammation; phenacyl chloride},
	year = {2023},
	eissn = {2073-4409}
}

@article{MTMT:33045551,
	title = {Uninterrupted DOACs Approach for Catheter Ablation of Atrial Fibrillation: Do DOACs Levels Matter?},
	url = {https://m2.mtmt.hu/api/publication/33045551},
	author = {Hardy, Michael and Douxfils, Jonathan and Dincq, Anne-Sophie and Sennesael, Anne-Laure and Xhaet, Olivier and Mullier, Francois and Lessire, Sarah},
	doi = {10.3389/fcvm.2022.864899},
	journal-iso = {FRONT CARDIOVASC MED},
	journal = {FRONTIERS IN CARDIOVASCULAR MEDICINE},
	volume = {9},
	unique-id = {33045551},
	issn = {2297-055X},
	abstract = {Most patients present for catheter ablation of atrial fibrillation (CAAF) with residual or full effect of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). In daily practice, it has been observed that the activated clotting time (ACT) was actually poorly sensitive to the effect of DOACs and that patients on DOACs required more unfractionated heparin (UFH) to achieve the ACT target of 300 s during the procedure, leading some authors to worry about potential overdosing. Conversely, we hypothesize that these higher doses of UFH are necessary to achieve adequate hemostasis during CAAF regardless of the residual effect of DOACs. During CAAF, thrombosis is promoted mainly by the presence of thrombogenic sheaths and catheters in the bloodstream. Preclinical data suggest that only high doses of DOACs are able to mitigate catheter-induced thrombin generation, whereas low dose UFH already do so. In addition, the effect of UFH seems to be lower in patients on DOACs, compared to patients on VKAs, explaining part of the differences observed in heparin requirements. Clinical studies could not identify increased bleeding risk in patients on DOACs compared to those on VKAs despite similar efficacy during CAAF procedures. Moreover, targeting a lower ACT was associated with an increased periprocedural thrombotic risk for both DOAC and VKA patients. Therefore, the low sensitivity of the ACT to the residual effect of DOACs should not be a major concern in its use in the interventional cardiology laboratory.},
	keywords = {IN-VITRO; POLYMORPHONUCLEAR LEUKOCYTES; catheter ablation; radiofrequency ablation; UNFRACTIONATED HEPARIN; Oral anticoagulants; Thrombus formation; Atrial Fibrillation; FACTOR-XA; VITAMIN-K ANTAGONISTS; direct oral anticoagulant; ACTIVATED CLOTTING TIME; FACTOR-IXA},
	year = {2022},
	eissn = {2297-055X},
	orcid-numbers = {Douxfils, Jonathan/0000-0002-7644-5298}
}

@article{MTMT:33263413,
	title = {Changes in fibrinolytic activity and coagulation factors after epicardial left atrial appendage closure in patients with atrial fibrillation},
	url = {https://m2.mtmt.hu/api/publication/33263413},
	author = {Litwinowicz, Radoslaw and Natorska, Joanna and Zabczyk, Michal and Kapelak, Boguslaw and Lakkireddy, Dhanunjaya and Vuddanda, Venkat and Bartus, Krzysztof},
	doi = {10.21037/jtd-21-1093},
	journal-iso = {J THORACIC DISEASE},
	journal = {JOURNAL OF THORACIC DISEASE},
	volume = {14},
	unique-id = {33263413},
	issn = {2072-1439},
	abstract = {Background: The left atrial appendage (LAA) is known to be the primary source of thrombus formation in atrial fibrillation (AF). We investigate whether epicardial LAA occlusion (LAAO) from the cardiovascular system has an effect on coagulation and prothrombotic status in AF.Methods: Twenty-two patients with nonvalvular AF, who were not currently receiving oral anticoagulation (OAC) therapy, participated in a single-center prospective study. We measured fibrinogen and plasminogen levels along with plasma fibrin clot permeability, clot lysis time (CLT) and endogenous thrombin potential (ETP) before the LAAO procedure, at discharge and 1 month afterward.Results: One month after the LAAO procedure, plasma fibrin clot permeability improved by 39.3% as measured by clots prepared from peripheral blood (P=0.019) and also after adjustment for fibrinogen (P=0.027). Higher plasma fibrin clot permeability was associated with improved clot susceptibility to lysis (r=-0.67, P=0.013). CLT was reduced by 10.3% (P=0.0020), plasminogen activator inhibitor-1 antigen levels were reduced by 52% (P=0.023) and plasminogen activity was increased by 8.9% (P=0.0077). A trend toward decreased thrombin generation, reflected by a decreased ETP and peak thrombin generated was also observed 1 month after LAAO procedure (P=0.072 and P=0.087, respectively). No differences were observed in tissue-type plasminogen activator and thrombin-activatable fibrinolysis inhibitor plasma levels (both P>0.05).Conclusions: Obtained results seem to confirm that LAA plays a key role in thrombogenesis. Elimination of LAA from the circulatory system may improve fibrin clot permeability and susceptibility to fibrinolysis in peripheral blood.},
	keywords = {COAGULATION; Thrombus; Atrial fibrillation (AF); left atrial appendage (LAA); Left atrial appendage occlusion (LAAO)},
	year = {2022},
	eissn = {2077-6624},
	pages = {4226-4235}
}

@article{MTMT:31979058,
	title = {Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out?},
	url = {https://m2.mtmt.hu/api/publication/31979058},
	author = {Gue, Ying X. and Ding, Wern Yew and Lip, Gregory Y. H. and Gorog, Diana A.},
	doi = {10.1007/s42452-021-04517-4},
	journal-iso = {SN APPL SCI},
	journal = {SN APPLIED SCIENCES},
	volume = {3},
	unique-id = {31979058},
	issn = {2523-3963},
	year = {2021},
	eissn = {2523-3971},
	orcid-numbers = {Gue, Ying X./0000-0001-9994-8915}
}

@article{MTMT:32237254,
	title = {Paroxysmal atrial fibrillation is associated with early coagulation activity regardless of risk factors for embolism},
	url = {https://m2.mtmt.hu/api/publication/32237254},
	author = {Negreva, Mariya N. and Prodanova, Krasimira S. and Vitlianova, Katerina D.},
	doi = {10.23736/S2724-5683.20.05209-3},
	journal-iso = {MINERVA CARDIOL ANGIOL},
	journal = {MINERVA CARDIOLOGY AND ANGIOLOGY},
	volume = {69},
	unique-id = {32237254},
	issn = {2724-5683},
	abstract = {BACKGROUND: Paroxysmal atrial fibrillation (PAF) is associated with an increased incidence of embolic events, even in patients with no embologenic risk factors. This fact raises the question for the hypercoagulability in PAF as a state closely related to the arrhythmia itself independent of other well established embologenic risk factors. The scarce data on that topic predisposed our aim that was to study coagulation activity in the early hours (up to the twenty-fourth hour) of the disease.METHODS: Fifty-one non-anticoagulated patients (26 men, 25 women; mean age 59.84 +/- 1.60 years) and 52 controls (26 men, 26 women; mean age 59.50 +/- 1.46 years) were consequently selected for the study. Plasma coagulation activity of factor II (FII), factor V (FV) and factor X (FX) was examined.RESULTS: In the PAF group, there was a higher activity of FlI (167.81 +/- 9.12% vs. 100.43 +/- 5.77%, P<0.001), FV (198.47 +/- 10.88% vs. 121.53 +/- 4.79%, P<0.001) and FX (193.20 +/- 11.85 vs. 116.20 +/- 5.86, P<0.001). The deviations were independent of age, sex, body mass index, presence of hypertension and CHA(2)DS(2)-VASc risk score (P>0.05). PAF duration was a significant predictor of FII activity (r=0.83, P<0.001) but no correlation was established between FV and FX activity and the arrhythmia duration (r=0.10, P>0.05; r=0.11, P>0.05, respectively).CONCLUSIONS: We established high coagulation activity during the first twenty-four hours of PAF. The observed deviations in the studied parameters give us reason to consider PAF a procoagulant state independent of the well-established prothrombotic risk factors, even in its early clinical manifestation.},
	keywords = {Risk Factors; embolism; Atrial Fibrillation},
	year = {2021},
	eissn = {2724-5772},
	pages = {269-276}
}

@article{MTMT:32073172,
	title = {A modified in vitro clot lysis assay predicts outcomes and safety in acute ischemic stroke patients undergoing intravenous thrombolysis},
	url = {https://m2.mtmt.hu/api/publication/32073172},
	author = {Orbán-Kálmándi, Rita Angéla and Szegedi, István and Sarkady, Ferenc and Fekete, István and Fekete, Klára and Vasas, Nikolett and Berényi, Ervin László and Csiba, László and Bagoly, Zsuzsa},
	doi = {10.1038/s41598-021-92041-1},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {11},
	unique-id = {32073172},
	issn = {2045-2322},
	year = {2021},
	eissn = {2045-2322},
	orcid-numbers = {Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279; Szegedi, István/0000-0003-4181-4361; Bagoly, Zsuzsa/0000-0001-5314-5607}
}

@article{MTMT:31978589,
	title = {FM Combined With NIHSS Score Contributes to Early AIS Diagnosis and Differential Diagnosis of Cardiogenic and Non-Cardiogenic AIS},
	url = {https://m2.mtmt.hu/api/publication/31978589},
	author = {Wu, Dan and Liu, Yong'e},
	doi = {10.1177/10760296211000129},
	journal-iso = {CLIN APPL THROMB-HEM},
	journal = {CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS},
	volume = {27},
	unique-id = {31978589},
	issn = {1076-0296},
	abstract = {A growing researchers have suggested that fibrin monomer (FM) plays an important role in early diagnosis of thrombotic diseases. We explored the application of FM in the diagnosis and classification of acute ischemic stroke (AIS). The differences in FM, D-dimer, and NIHSS scores between different TOAST (Trial of ORG 10172 in Acute Stroke Treatment) types were analyzed with one-way ANOVA; the correlation between FM, D-dimer and NIHSS score in patients with different TOAST classification was analyzed by Pearson linear correlation. The ROC curve was utilized to analyze the diagnostic performance. 1. FM was more effective in diagnosing patients with AIS than D-dimer. 2. The FM level in cardiogenic AIS was significantly different from that in non-cardiogenic patients (P < 0.05); the NIHSS score in cardiogenic stroke was significantly higher than in atherosclerotic and unexplained stroke group. Whereas, no statistical difference was observed in the D-dimer level between these groups (P > 0.05). 3. The correlation between FM and NIHSS scores in the cardiogenic (r = 0.3832) and atherosclerotic (r = 0.3144) groups was statistically significant. 4. FM exhibited the highest diagnostic efficacy for cardiogenic AIS; furthermore, FM combined with the NIHSS score was more conducive to the differential diagnosis of cardiogenic and non-cardiogenic AIS. FM detection contributes to the early diagnosis of AIS, and is important for the differential diagnosis of different TOAST types of AIS. Moreover, FM combined with the NIHSS score is valuable in the differential diagnosis of cardiogenic and non-cardiogenic AIS.},
	keywords = {Differential diagnosis; AIS; TOAST classification; Fm; NIHSS score},
	year = {2021},
	eissn = {1938-2723}
}

@article{MTMT:32237255,
	title = {Left Atrial Appendage Morphology and Local Thrombogenesis-Related Blood Parameters in Patients With Atrial Fibrillation},
	url = {https://m2.mtmt.hu/api/publication/32237255},
	author = {Xu, Buyun and Du, Ye and Xu, Chao and Sun, Yong and Peng, Fang and Wang, Shengkai and Pan, Jie and Lou, Yuanqing and Xing, Yangbo},
	doi = {10.1161/JAHA.120.020406},
	journal-iso = {J AM HEART ASSOC},
	journal = {JOURNAL OF THE AMERICAN HEART ASSOCIATION},
	volume = {10},
	unique-id = {32237255},
	issn = {2047-9980},
	abstract = {BackgroundLeft atrial appendage (LAA) morphology predicts stroke risk in patients with atrial fibrillation. However, it is not precisely understood how LAA morphology influences stroke risk. The present study aimed to investigate the relationship between LAA morphology and local thrombogenesis-related blood parameters in LAA.Methods and ResultsWe enrolled 205 patients undergoing catheter ablation of atrial fibrillation. The prevalence of chicken wing-, cactus-, windsock-, and cauliflower-type LAAs were 23.9%, 32.7%, 29.3%, and 14.1%, respectively. Blood samples were collected from the femoral vein, left atrium, and LAA in each patient. The levels of blood parameters were tested for each blood sample. The cauliflower-type LAA was associated with elevated platelet P-selectin expression, and interleukin-6 levels and with lower NO levels in LAA blood samples (P<0.05) independent of LAA flow velocity and LAA volume. LAA flow velocity, which was lowest in the cauliflower-type LAA, was the only independent predictor of von Willebrand factor antigen and plasminogen activator inhibitor-1 levels in LAA blood samples. In femoral vein blood samples, no significant difference was detected in the above blood parameters among the four LAA morphological types. In all blood samples, the levels of thrombin-antithrombin complex, D-dimer, fibrinogen, and tissue plasminogen activator were comparable among the four LAA morphological types.ConclusionsIn patients with atrial fibrillation, LAA morphological types might be associated with local platelet activity, fibrinolysis function, endothelial dysfunction, and inflammation.},
	keywords = {Inflammation; COAGULATION; endothelial dysfunction; Atrial Fibrillation; LEFT ATRIAL APPENDAGE},
	year = {2021},
	eissn = {2047-9980}
}

@article{MTMT:31610168,
	title = {Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation},
	url = {https://m2.mtmt.hu/api/publication/31610168},
	author = {Bagoly, Zsuzsa and Hajas, Orsolya and Urbancsek, Réka and Kiss, Alexandra and Fiak, Edit and Sarkady, Ferenc and Tóth, Noémi Klára and Orbán-Kálmándi, Rita Angéla and Kovács, Kitti Bernadett and Nagy, László Tibor and Nagy, Attila Csaba and Kappelmayer, János and Csiba, László and Csanádi, Zoltán},
	doi = {10.3390/jcm9093050},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {9},
	unique-id = {31610168},
	year = {2020},
	eissn = {2077-0383},
	orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350}
}

@article{MTMT:31202413,
	title = {Coagulation factors and fibrinolytic activity in the left atrial appendage and other heart chambers in patients with atrial fibrillation. is there a local intracardiac prothrombotic state? (HEART-CLOT study).},
	url = {https://m2.mtmt.hu/api/publication/31202413},
	author = {Bartus, Krzysztof and Litwinowicz, Radoslaw and Natorska, Joanna and Zabczyk, Michal and Undas, Anetta and Kapelak, Boguslaw and Lakkireddy, Dhanunjaya and Lee, Randall J},
	doi = {10.1016/j.ijcard.2019.09.053},
	journal-iso = {INT J CARDIOL},
	journal = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
	volume = {301},
	unique-id = {31202413},
	issn = {0167-5273},
	abstract = {Atrial fibrillation (AF), a risk factor for stroke and systemic thromboembolism, is associated with unfavorable fibrin clot properties and increased thrombus formation in peripheral blood. The left atrial appendage (LAA) is known to be the primary site of thrombus formation.We investigated the relative differences in plasma fibrin clot features including plasma fibrin clot permeability (Ks) and clot lysis time (CLT) between the right atrium (RA), right ventricle (RV), left atrium (LA), left ventricle (LV), LAA, and peripheral blood.Sixteen patients with nonvalvular AF who stopped oral anticoagulant therapy at least 2 days before a LARIAT procedure participated in a single-center prospective study. We measured fibrinogen and plasminogen levels along with Ks, CLT, and endogenous thrombin potential (ETP) during the LARIAT procedure in blood obtained from the right femoral vein, RA, RV, LA, LV and LAA.LAA clot porosity was reduced by 16.2% compared to peripheral blood (p = 0.026), also after adjustment for fibrinogen levels (p = 0.038). Ks was similar for the RA, RV, LA, LV, and LAA (all p > 0.05). We found 14.7% prolonged CLT for clots prepared from blood samples obtained from the LAA compared to those prepared from peripheral blood, but no differences between the RA, RV, LA and LV (all p > 0.05) were found. There were no significant differences in other parameters, including ETP, between heart chambers.Patients with AF are characterised by a local prothrombotic state as reflected by formation of compact fibrin clots in the LAA compared to peripheral blood, which may contribute to LAA thrombus formation and device-related thrombi.},
	year = {2020},
	eissn = {1874-1754},
	pages = {103-107}
}

@article{MTMT:31143304,
	title = {Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques},
	url = {https://m2.mtmt.hu/api/publication/31143304},
	author = {Hajas, Orsolya and Bagoly, Zsuzsa and Tóth, Noémi Klára and Urbancsek, Réka and Kiss, Alexandra and Kovács, Kitti Bernadett and Sarkady, Ferenc and Nagy, Attila Csaba and Vargáné Oláh, Anna and Nagy, László Tibor and Clemens, Marcell and Csiba, László and Csanádi, Zoltán},
	doi = {10.1155/2020/1570483},
	journal-iso = {CARDIOL RES PRAC},
	journal = {CARDIOLOGY RESEARCH AND PRACTICE},
	volume = {2020},
	unique-id = {31143304},
	issn = {2090-0597},
	year = {2020},
	eissn = {2090-8016},
	orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350}
}

@article{MTMT:32663605,
	title = {Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial},
	url = {https://m2.mtmt.hu/api/publication/32663605},
	author = {Hirano, Akemi and Suzuki, Yusuke and Umegaki, Hiroyuki and Hayashi, Toshio and Ina, Koichiro and Onishi, Joji and Hasegawa, Jun and Kuzuya, Masafumi},
	doi = {10.21926/obm.geriatr.2001108},
	journal-iso = {OBM GERIAT},
	journal = {OBM GERIATRICS},
	volume = {4},
	unique-id = {32663605},
	year = {2020},
	eissn = {2638-1311},
	pages = {1}
}

@article{MTMT:31355024,
	title = {Fibrinolytic activity in atrial fibrillation},
	url = {https://m2.mtmt.hu/api/publication/31355024},
	author = {Negreva, Mariya and Georgiev, Svetoslav and Zarkova, Ana},
	doi = {10.30574/wjarr.2020.6.2.0156},
	journal-iso = {J ADV RES REV},
	journal = {WORLD JOURNAL OF ADVANCED RESEARCH AND REVIEWS},
	volume = {6},
	unique-id = {31355024},
	year = {2020},
	eissn = {2581-9615},
	pages = {193-200}
}

@article{MTMT:32097284,
	title = {Paroxysmal atrial fibrillation: changes in factor VIII and von Willebrand factor impose early hypercoagulability},
	url = {https://m2.mtmt.hu/api/publication/32097284},
	author = {Negreva, Mariya and Prodanova, Krasimira and Vitlianova, Katerina and Madjova, Christiana},
	doi = {10.5114/amsad.2020.97101},
	journal-iso = {ARCH MED SC ATHEROSCL DIS},
	journal = {ARCHIVES OF MEDICAL SCIENCE - ATHEROSCLEROTIC DISEASES},
	volume = {5},
	unique-id = {32097284},
	year = {2020},
	eissn = {2451-0629},
	pages = {140-147}
}

@article{MTMT:30858830,
	title = {Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications},
	url = {https://m2.mtmt.hu/api/publication/30858830},
	author = {Undas, Anetta},
	doi = {10.1093/europace/euz271},
	journal-iso = {EUROPACE},
	journal = {EUROPACE},
	volume = {22},
	unique-id = {30858830},
	issn = {1099-5129},
	year = {2020},
	eissn = {1532-2092},
	pages = {185-194}
}

@article{MTMT:31529383,
	title = {Erythrocyte Deformability Is Impaired in Patients with Nonvalvular Atrial Fibrillation},
	url = {https://m2.mtmt.hu/api/publication/31529383},
	author = {Toru, MARUYAMA},
	journal-iso = {J CLINIC PHYSIOL},
	journal = {JOURNAL OF CLINICAL PHYSIOLOGY},
	volume = {49},
	unique-id = {31529383},
	issn = {0286-7052},
	year = {2019},
	eissn = {2435-1695},
	pages = {65}
}

@article{MTMT:30499309,
	title = {Soluble Fibrin Monomer Complex and Prediction of Cardiovascular Events in Atrial Fibrillation: The Observational Murcia Atrial Fibrillation Project},
	url = {https://m2.mtmt.hu/api/publication/30499309},
	author = {Miguel Rivera-Caravaca, Jose and Roldan, Vanessa and Romera, Marta and Asuncion Esteve-Pastor, Maria and Valdes, Mariano and Lip, Gregory Y. H. and Vicente, Vicente and Marin, Francisco},
	doi = {10.1007/s11606-017-4279-4},
	journal-iso = {J GEN INTERN MED},
	journal = {JOURNAL OF GENERAL INTERNAL MEDICINE},
	volume = {33},
	unique-id = {30499309},
	issn = {0884-8734},
	abstract = {BACKGROUND: Soluble fibrinmonomer complex (SFMC) is a biomarker of fibrin formation abnormally elevated in clinical situations of hypercoagulability. OBJECTIVE: We investigated the association and predictive performance of SFMC for stroke, adverse cardiovascular events, cardiovascular mortality and all-cause mortality in a cohort of patients with atrial fibrillation (AF) receiving vitamin K antagonist (VKA) anticoagulant therapy. DESIGN: During the second semester of 2007, we included 1226 AF outpatients stable on VKAs (INR 2.0-3.0) over a period of 6 months. SFMC levels were assessed at baseline. During 6.5 (IQR 4.4-8.0) years of follow-up, we recorded all ischemic strokes, adverse cardiovascular events (composite of stroke, acute heart failure, acute coronary syndrome and cardiovascular death), cardiovascular deaths and all-cause deaths. PARTICIPANTS: All patients were recruited consecutively. We excluded patients with rheumatic mitral valves, prosthetic heart valves, acute coronary syndrome, stroke, hemodynamic instability, hospital admissions or surgical interventions within the preceding 6 months. MAINMEASURES: SFMClevelsweremeasured in plasma by immunoturbidimetry in an automated coagulometer (STALiatestFM, Diagnostica Stago, Asnieres, France). KEY RESULTS: We recorded 121 (1.52%/year) ischemic strokes, 257 (3.23%/year) cardiovascular events, 67 (0.84%/year) cardiovascular deaths and 486 (6.10%/year) all-cause deaths. SFMC > 12 mu g/mL was not associated with stroke but was associated with higher risk of cardiovascular events (HR 1.72, 95% CI 1.31-2.26), cardiovascularmortality (HR 2.16, 95% CI 1.30-3.57) and all-cause mortality (HR 1.26, 95% CI 1.03-1.55). When SFMC > 12 mu g/mL was added to the CHA2DS2-VASc, there were significant improvements in predictive performance, sensitivity and reclassification for adverse cardiovascular events (c-index: 0.645 vs. 0.660, p = 0.010; IDI = 0.013, p< 0.001; NRI= 0.121, p< 0.001) and cardiovascular mortality (c-index: 0.661 vs. 0.691, p = 0.006; IDI = 0.009, p = 0.049; NRI = 0.217, p < 0.001), but decision curves demonstrated a similar net benefit and clinical usefulness. CONCLUSIONS: In AF patients taking VKAs, high SFMC levels were associated with the risk of adverse cardiovascular events, cardiovascularmortality and all-cause mortality. The addition of SFMC to the CHA2DS2-VASc score improved its predictive performance for these outcomes, but failed to show an improvement in clinical usefulness.},
	keywords = {THROMBOSIS; MORTALITY; Biomarkers; Anticoagulants; Atrial Fibrillation; soluble fibrin monomer complex},
	year = {2018},
	eissn = {1525-1497},
	pages = {847-854},
	orcid-numbers = {Roldan, Vanessa/0000-0002-4945-6602; Vicente, Vicente/0000-0002-4278-3264}
}

@article{MTMT:30571819,
	title = {The Clinical Significance of Fibrin Monomers},
	url = {https://m2.mtmt.hu/api/publication/30571819},
	author = {Refaai, Majed A. and Riley, Paul and Mardovina, Tatsiana and Bell, Phoenix D.},
	doi = {10.1055/s-0038-1673684},
	journal-iso = {THROMB HAEMOSTASIS},
	journal = {THROMBOSIS AND HAEMOSTASIS},
	volume = {118},
	unique-id = {30571819},
	issn = {0340-6245},
	abstract = {Introduction: Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition. There are limited reports investigating the utility of FM in hyper-coagulable patients.},
	keywords = {THROMBOSIS; venous thromboembolic event; D-dimers; fibrin split products; hyper-coagulation},
	year = {2018},
	eissn = {2567-689X},
	pages = {1856-1866}
}