@article{MTMT:31655754, title = {Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model}, url = {https://m2.mtmt.hu/api/publication/31655754}, author = {Brunner, Szilvia and Tőkés, Tünde and Szabó, Emilia Rita and Polanek, Róbert and Szabó, Zoltán Imre and Reisz, Zita and Konczné Gubán, Barbara and Szijártó, András Lajos and Michael, Brand and Stefan, Hans and Leonhard, Karsch and Elisabeth, Lessmann and Jörg, Pawelke and Michael, Schürer and Elke, Beyreuther and Hideghéty, Katalin}, doi = {10.21873/anticanres.14633}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {40}, unique-id = {31655754}, issn = {0250-7005}, year = {2020}, eissn = {1791-7530}, pages = {6123-6135}, orcid-numbers = {Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Szabó, Zoltán Imre/0000-0001-8278-8038; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:30732651, title = {11 Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy}, url = {https://m2.mtmt.hu/api/publication/30732651}, author = {Hideghéty, Katalin and Brunner, Szilvia and Cheesman, Andrew and Szabó, Emilia Rita and Polanek, Róbert and Margarone, Daniele and Tőkés, Tünde and Mogyorósi, Károly}, doi = {10.21873/anticanres.13343}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {39}, unique-id = {30732651}, issn = {0250-7005}, year = {2019}, eissn = {1791-7530}, pages = {2265-2276}, orcid-numbers = {Hideghéty, Katalin/0000-0001-7080-2365; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tőkés, Tünde/0000-0002-0587-7886} } @article{MTMT:30913045, title = {Selection of gamma analysis acceptance criteria in IMRT QA using Gafchromic EBT3 film dosimetry}, url = {https://m2.mtmt.hu/api/publication/30913045}, author = {Khan, Muhammad Isa and Shakil, Muhammad and Tahir, Muhammad Bilal and Rafique, Muhammad and Iqbal, Tahir and Zahoor, Aliza and Rehman, Jalil Ur and Iqbal, Khalid and Chow, James C. L.}, doi = {10.1017/S1460396918000602}, journal-iso = {J RADIOTHER PRACT}, journal = {JOURNAL OF RADIOTHERAPY IN PRACTICE}, volume = {18}, unique-id = {30913045}, issn = {1460-3969}, abstract = {Background and purpose This study reported the justification and selection of acceptable gamma criteria with respect to low (6 MV) and high (15 MV) photon beams for intensity-modulated radiation therapy quality assurance (IMRT QA) using the Gafchromic external beam therapy 3 (EBT3) film. Materials and methods Five-field step-and-shoot IMRT was used to treat 16 brain IMRT patients using the dual-energy DHX-S linear accelerator (Varian Medical System, Palo Alto, CA, USA). Dose comparisons between computed values of the treatment planning system (TPS) and Gafchromic EBT3 film were evaluated based on gamma analysis using the Film QA Pro software. The dose distribution was analysed with gamma area histograms (GAHs) generated using different gamma criteria (3%/2 mm, 3%/3 mm and 5%/3 mm) for the 6 and 15 MV photon beams, to optimise the best distance-to-agreement (DTA) criteria with respect to the beam energy. Results From the comparison between the dose distributions acquired from the TPS and EBT3 film, a DTA criterion of 3%/2 mm showed less dose differences (DDs) with passing rates up to 93% for the 6 MV photon beams, while for the 15 MV a relaxed DTA criterion of 5%/3 mm was consistent with the DD acceptability criteria with a 95% passing rate. Conclusions Our results suggested that high-energy photon beams required relaxed DTA criteria for the brain IMRT QA, while low-energy photon beams showed better results even with tight DTA criteria.}, keywords = {Quality assurance; IMRT; Gafchromic EBT3 film; gamma analysis}, year = {2019}, eissn = {1467-1131}, pages = {127-131}, orcid-numbers = {Tahir, Muhammad Bilal/0000-0002-0495-0236} } @article{MTMT:30518757, title = {Diagnostics and Dosimetry Solutions for Multidisciplinary Applications at the ELIMAIA Beamline}, url = {https://m2.mtmt.hu/api/publication/30518757}, author = {Scuderi, Valentina and Amato, Antonino and Amico, Antonio Giuseppe and Borghesi, Marco and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Fajstavr, Antonin and Giuffrida, Lorenzo and Grepl, Filip and Korn, Georg and Larosa, Giuseppina and Leanza, Renata and Margarone, Daniele and Milluzzo, Giuliana and Petringa, Giada and Pipek, Jan and Russo, Antonio and Schillaci, Francesco and Velyhan, Andriy and Romano, Francesco}, doi = {10.3390/app8091415}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {8}, unique-id = {30518757}, abstract = {ELI (Extreme Light Infrastructure) multidisciplinary applications of laser-ion acceleration (ELIMAIA) is one the user facilities beamlines of the ELI-Beamlines facility in Prague. It will be dedicated to the transport of laser-driven ion beams and equipped with detectors for diagnostics and dosimetry, in order to carry out experiments for a broad range of multidisciplinary applications. One of the aims of the beamline is also to demonstrate the feasibility of these peculiar beams for possible medical applications, which means delivering controllable and stable beams, properly monitoring their transport parameters and accurately measuring the dose per shot. To fulfil this task, innovative systems of charged particle beam diagnostics have been realized and alternative approaches for relative and absolute dosimetry have been proposed. Concerning the first one, real-time diagnostic solutions have been adopted, involving the use of time-of-flight techniques and Thomson parabola spectrometry for an on-line characterization of the ion beam parameters, as well as radiochromic films, nuclear track detectors (typically CR39), and image plates for single shot measurements. For beam dosimetry, real-time beam/dose monitoring detectors have been realized, like the secondary emission monitor and a double-gap ionization chamber, which can be cross calibrated against a Faraday cup, used for absolute dosimetry. The main features of these detectors are reported in this work together with a description of their working principle and some preliminary tests.}, keywords = {Dosimetry; Medical application; laser-driven ion; on-line diagnostics; multidisciplinary application}, year = {2018}, eissn = {2076-3417} }