@article{MTMT:34081254, title = {Oral Health Knowledge and Habits of Hungarian Monozygotic and Dizygotic Twins: A Pilot Study}, url = {https://m2.mtmt.hu/api/publication/34081254}, author = {Lipták, Klaudia Margit and Lipták, Laura Mária and Rózsa, Noémi Katinka and Hermann, Péter and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Végh, Dániel}, doi = {10.1016/j.identj.2023.06.012}, journal-iso = {INT DENT J}, journal = {INTERNATIONAL DENTAL JOURNAL}, volume = {74}, unique-id = {34081254}, issn = {0020-6539}, abstract = {ABSTRACT Objective The aim of this research was to collate and analyse the data on the oral health knowledge and the related habits of a Hungarian cohort of monozygotic (MZ) and dizygotic (DZ) twins using the newly developed World Health Organisation Oral Health Questionnaire for Adults (Annex 7). Method A total of 15 sets of MZ twins and 14 sets of DZ twins (58 individuals) aged between 18 and 71 years were enrolled in the study. Each participant had to fill out a web-based questionnaire which comprised 23 questions (Google Forms). The data were collated and the oral health/hygiene habits of MZ and DZ twins were compared. Results No significant differences were detected between MZ and DZ twins with regards to their daily tooth-cleaning habits or the tooth-cleaning products used by the 2 groups. For instance, when asked how often they clean their teeth, 80% of MZ twins and 71% of DZ twins responded similarly. Further, both groups provided similar responses when questioned about the use of fluoride toothpaste, frequency of dental visits, and dental counselling received as well as a number of other parameters such as snacking of sweets and fear of visiting dentists. Conclusions Our pilot analysis of the questionnaire responses from MZ and DZ twins in Hungary did not indicate any significant differences in their oral care habits in general. Further studies with a large cohort are required to confirm or refute our findings.}, keywords = {public health; health education; Oral Health; ADVOCACY; monozygotic twin; Dizygotic twin}, year = {2024}, eissn = {1875-595X}, pages = {66-70}, orcid-numbers = {Lipták, Klaudia Margit/0009-0003-5177-1390; Lipták, Laura Mária/0009-0009-5470-3469; Rózsa, Noémi Katinka/0000-0002-8510-7047; Hermann, Péter/0000-0002-9148-0139; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Végh, Dániel/0000-0002-2836-6747} } @article{MTMT:35358121, title = {Mediation effect of gut microbiota on the relationship between physical activity and carotid plaque}, url = {https://m2.mtmt.hu/api/publication/35358121}, author = {Ouyang, Wenbin and Tang, Bei and He, Yongmei and Wu, Hao and Yang, Pingting and Yin, Lu and Li, Xiaohui and Li, Ying and Huang, Xin}, doi = {10.3389/fmicb.2024.1432008}, journal-iso = {FRONT MICROBIOL}, journal = {FRONTIERS IN MICROBIOLOGY}, volume = {15}, unique-id = {35358121}, keywords = {physical activity; MEDIATION; phylogenetic tree; gut microbiota; Carotid plaque}, year = {2024}, eissn = {1664-302X} } @article{MTMT:34946766, title = {Role of gut microbiota in cardiovascular diseases - a comprehensive review}, url = {https://m2.mtmt.hu/api/publication/34946766}, author = {Rashid, Safia and Sado, Abdulmaleek Idanesimhe and Afzal, Muhammad Sohaib and Ahmed, Amna and Almaalouli, Bsher and Waheed, Tallha and Abid, Rabia and Majumder, Koushik and Kumar, Vikash and Tejwaney, Usha and Kumar, Sarwan}, doi = {10.1097/MS9.0000000000001419}, journal-iso = {ANN MED SURG}, journal = {ANNALS OF MEDICINE AND SURGERY}, volume = {86}, unique-id = {34946766}, issn = {2049-0801}, keywords = {cardiovascular diseases; gut microbiota; CARDIAC OUTCOMES}, year = {2024}, pages = {1483-1489} } @article{MTMT:34349746, title = {Characterization of gut microbiota in adults with coronary atherosclerosis}, url = {https://m2.mtmt.hu/api/publication/34349746}, author = {Dong, Yu and Xu, Rui and Chen, Xiaowei and Yang, Chuanli and Jiang, Fei and Shen, Yan and Li, Qiong and Fang, Fujin and Li, Yongjun and Shen, Xiaobing}, doi = {10.7717/peerj.15245}, journal-iso = {PEERJ}, journal = {PEERJ}, volume = {11}, unique-id = {34349746}, issn = {2167-8359}, abstract = {Background. Cardiovascular disease, which is mainly caused by coronary atheroscle-rosis, is one of the leading causes of death and disability worldwide. Gut microbiota likely play an important role in coronary atherosclerosis. This study aims to investigate the microbiota profile of adults with coronary atherosclerosis to provide a theoretical basis for future research.Methods. Fecal samples were collected from 35 adult patients diagnosed with coronary atherosclerosis and 32 healthy adults in Nanjing, China, and the V3-V4 region of 16S rDNA genes was sequenced using high-throughput sequencing. Differences in alpha diversity, beta diversity, and gut microbiota composition between the two groups were then compared.Results. A beta diversity analysis revealed significant differences between adults with coronary atherosclerosis and controls, but there was no statistical difference in alpha diversity between the two groups. There were also differences in the composition of the gut microbiota between the two groups. The genera, Megamonas, Streptococcus, Veillonella, Ruminococcus_torques_group, Prevotella_2, Tyzzerella_4, were identified as potential biomarkers for coronary atherosclerosis.Conclusion. There are some differences in the gut microbiota of adults with coronary atherosclerosis compared to healthy adults. The insights from this study could be used to explore microbiome-based mechanisms for coronary atherosclerosis.}, keywords = {16S rDNA; gut microbiota; Coronary atherosclerosis}, year = {2023}, eissn = {2167-8359} } @article{MTMT:34499729, title = {Comparison of microvascular flow imaging and contrast-enhanced ultrasound for blood flow analysis of cervical lymph node lesions}, url = {https://m2.mtmt.hu/api/publication/34499729}, author = {Wang, T. and Xu, M. and Xu, C. and Wu, Y. and Dong, X.}, doi = {10.3233/CH-231860}, journal-iso = {CLIN HEMORHEOL MICRO}, journal = {CLINICAL HEMORHEOLOGY AND MICROCIRCULATION}, volume = {85}, unique-id = {34499729}, issn = {1386-0291}, abstract = {OBJECTIVE: To compare the diagnostic value of microvascular flow imaging (MVFI) with that of contrast-enhanced ultrasound (CEUS) for the analysis of blood flow in benign and malignant cervical lymph nodes. MATERIAL AND METHODS: As a prospective study, 95 cervical enlarged lymph nodes (43 benign and 52 malignant) were observed in 95 patients using conventional ultrasonography (including gray and Color Doppler Flow Imaging), CEUS, and MVFI. Two researchers evaluated vascular parameters of MVFI (vascular distribution, internal vascular features, vascular index) and CEUS (enhancement mode, enhancement type) and compared the diagnostic effects of MVFI and CEUS.All results were compared with pathological findings. RESULTS: There were significant differences in the vascular distribution and internal vascular features of benign and malignant lymph nodes on MVFI (P < 0.05). The vascular distribution of benign lymph nodes was mainly of the central and avascular types, the internal blood vessels were mostly normal, the vascular distribution of malignant lymph nodes was mainly mixed, the internal vessels were mainly tortuous and displaced. The optimal cut-off value of the benign and malignant lymph node vascular index (VI) was 15.55%, and the area under the receiver operating characteristic curve (AUC) of the VI was 0.876. There were also significant differences in the enhancement mode and types of benign and malignant lymph nodes in CEUS (P < 0.05). The benign lymph nodes showed centrifugal perfusion, and the enhancement types were mostly type I and type II. Most malignant lymph nodes showed centripetal or mixed perfusion, and the enhancement types were usually type III and type IV. The accuracy, sensitivity, and specificity of CEUS in the diagnosis of lymph node lesions were 84.2%, 84.6% and 83.7%, respectively, and the AUC was 0.845. The accuracy, sensitivity, and specificity of MVFI in the diagnosis of lymph node lesions were 85.3%, 84.6%, and 86.0%, respectively, and the AUC was 0.886. CONCLUSION: Both CEUS and MVFI are valuable in differentiating benign and malignant lesions of lymph nodes and have a similar diagnostic performance; however, MVFI is less invasive and simpler than CEUS. Therefore it is preferred for auxiliary examination of enlarged lymph nodes that are difficult to diagnose by conventional ultrasound. © 2023 – IOS Press. All rights reserved.}, keywords = {Adult; Female; Middle Aged; Male; Humans; PREDICTIVE VALUE; ARTICLE; human; Prospective Studies; Diagnosis, Differential; Sensitivity and Specificity; Sensitivity and Specificity; major clinical study; controlled study; pathology; Diagnostic Imaging; tuberculosis; image analysis; prospective study; Contrast Media; contrast medium; contrast medium; Hyperplasia; Differential diagnosis; LYMPHOMA; echography; Lymph Nodes; Lymph Nodes; lymphadenopathy; cancer staging; blood flow; Ultrasonography; Lymph node metastasis; lymph node; lymph node; flow measurement; Sulfur Hexafluoride; procedures; Contrast-enhanced ultrasound; Contrast-enhanced ultrasound; medical procedures; Narrow band imaging; color Doppler flowmetry; cervical lymph node; cervical lymphadenopathy; conventional ultrasound; Microvascular flow imaging; Microvascular flow imaging}, year = {2023}, eissn = {1875-8622}, pages = {249-259} } @article{MTMT:32687570, title = {Gut Microbiome in Patients with Obstructive Sleep Apnoea}, url = {https://m2.mtmt.hu/api/publication/32687570}, author = {Bikov, András and Szabó, Helga and Piroska, Márton and Kunos, László and Szily, Marcell and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.3390/app12042007}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {12}, unique-id = {32687570}, year = {2022}, eissn = {2076-3417}, orcid-numbers = {Bikov, András/0000-0002-8983-740X; Piroska, Márton/0000-0002-6000-5044; Szily, Marcell/0000-0003-3298-9231; Szabó, Dóra/0000-0002-8601-3923; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:33368228, title = {Neck circumference predicts development of carotid intima-media thickness and carotid plaque: A community-based longitudinal study}, url = {https://m2.mtmt.hu/api/publication/33368228}, author = {Cao, Weijie and Xu, Yiting and Shen, Yun and Hu, Tingting and Wang, Yufei and Ma, Xiaojing and Bao, Yuqian}, doi = {10.1016/j.numecd.2022.03.027}, journal-iso = {NUTR METAB CARDIOVAS}, journal = {NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES}, volume = {32}, unique-id = {33368228}, issn = {0939-4753}, abstract = {Background and aims: Carotid intima-media thickness (C-IMT) is an important index for evaluating subclinical atherosclerosis. Neck circumference (NC), a new anthropometric index of the upper body fat, is closely related to cardiovascular disease (CVD) and CVD risk factors. This study investigated the relationship between NC, C-IMT, and carotid plaque in a community based cohort. Methods and results: Participants recruited from Shanghai communities were followed up for 1.1-2.9 years. All participants underwent anthropometric and biochemical measurements. Elevated NC was defined as NC > 38.5 cm and NC > 34.5 cm in men and women, respectively. Elevated CIMT, determined by ultrasound, was defined as a level higher than the 75th percentile in the study population (>0.75 mm). In total, 1189 participants without carotid plaque at baseline were included, with an average age of 59.6 +/- 7.3 years. After a mean follow-up of 2.1 +/- 0.2 years, 203 participants developed carotid plaques. After adjusting for various atherosclerosis risk factors, the logistic regression showed that the higher NC group had a significantly greater risk of developing carotid plaque than the lower NC group (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.12-2.14; P = 0.008). Of those without carotid plaque at follow-up, 495 participants developed elevated C-IMT. Compared to the lower NC group, the higher NC group had a significantly increased risk of elevated C-IMT (OR, 1.49; 95% CI, 1.14-1.95; P = 0.003). Conclusion: Higher NC was significantly positively correlated with the risk of carotid plaque and elevated C-IMT. (c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.}, keywords = {longitudinal study; Carotid intima-media thickness; Neck circumference; Carotid plaque}, year = {2022}, eissn = {1590-3729}, pages = {1627-1634}, orcid-numbers = {Shen, Yun/0000-0002-9850-122X} } @article{MTMT:33919129, title = {Natural products against inflammation and atherosclerosis: Targeting on gut microbiota}, url = {https://m2.mtmt.hu/api/publication/33919129}, author = {Deng, Bing and Tao, Liyu and Wang, Yiru}, doi = {10.3389/fmicb.2022.997056}, journal-iso = {FRONT MICROBIOL}, journal = {FRONTIERS IN MICROBIOLOGY}, volume = {13}, unique-id = {33919129}, abstract = {The gut microbiota (GM) has become recognized as a crucial element in preserving human fitness and influencing disease consequences. Commensal and pathogenic gut microorganisms are correlated with pathological progress in atherosclerosis (AS). GM may thus be a promising therapeutic target for AS. Natural products with cardioprotective qualities might improve the inflammation of AS by modulating the GM ecosystem, opening new avenues for researches and therapies. However, it is unclear what components of natural products are useful and what the actual mechanisms are. In this review, we have summarized the natural products relieving inflammation of AS by regulating the GM balance and active metabolites produced by GM.}, keywords = {Inflammation; ATHEROSCLEROSIS; natural products; Immune; gut microbiota}, year = {2022}, eissn = {1664-302X} } @article{MTMT:34499733, title = {Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review}, url = {https://m2.mtmt.hu/api/publication/34499733}, author = {Grammatopoulos, K. and Antoniou, V.-D. and Mavrothalassitis, E. and Mouziouras, D. and Argyris, A.A. and Emmanouil, E. and Vlachopoulos, C. and Protogerou, A.D.}, doi = {10.1016/j.ahjo.2022.100219}, journal-iso = {AM HEART J PLUS}, journal = {AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE}, volume = {23}, unique-id = {34499733}, abstract = {Study objective: The present systematic review investigates the hypothesis that specific components of the intestinal microbiome and/or their metabolites are associated with early stages of subclinical arterial damage (SAD). Design: Based on the MOOSE criteria, we conducted a systematic review of the literature (Scopus, Medline) investigating the potential association between gut microbiota and the most widely applied arterial biomarkers of SAD. Participants: All studies included individuals without established cardiovascular disease, either with or without SAD. Intervention: No interventions were made. Main outcome measures: Association between exposure (components/metabolites of microbiota) and outcome (presence of SAD). Results: Fourteen articles met the predefined criteria. Due to the large heterogeneity, their meta-analysis was not possible. Our review revealed (a) two studies on endothelial dysfunction, out of which one found an inverse relation between plasma trimethylamine N-oxide levels and FMD and the other did not substantiate a statistically significant correlation with RHI. (b) Twelve studies on atheromatosis, assessed as intimal-medial thickness (IMT), coronary artery calcium (CAC) and arterial plaque, of which, seven studies showed statistically significant associations (negative or positive depending on the microorganism or microbiota metabolite) with IMT, one study revealed significant associations with coronary artery calcium, while one showed absence of correlation and four studies reported statistically significant correlations with arterial plaque. (c) Three studies on arterial stiffness (pulse wave velocity - PWV) with two of them concluding in statistically significant association while the third study did not. Some articles investigated multiple of the correlations described and therefore, belonged to more than one section. Conclusion: Evidence of both positive and inverse associations of gut microbiota composition and their metabolites with different types of SVD has been found. However the small number and heterogeneity of available studies cannot allow to confirm or disprove the hypothesis. © 2022}, keywords = {endothelial dysfunction; arterial stiffness; gut microbiota; Intestinal microbiota; atheromatosis; Gut microbiota metabolite}, year = {2022}, eissn = {2666-6022} } @article{MTMT:33336219, title = {Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors}, url = {https://m2.mtmt.hu/api/publication/33336219}, author = {Hidi, László and Kovács, Gergely Imre and Szabó, Dóra and Makra, Nóra and Pénzes, Kinga and Juhász, János and Sótonyi, Péter and Ostorházi, Eszter}, doi = {10.3389/fcimb.2022.1056319}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {12}, unique-id = {33336219}, issn = {2235-2988}, abstract = {Discovery of human microbiota is fundamentally changing our perceptions of certain diseases and their treatments. However little is known about the human blood vessel microbiota, it may have important effects on vascular pathological lesions and vascular homograft failure. In our prospective survey study fourteen femoral arteries, harvested from donors in multi-organ donations, were examined using the V3-V4 region 16S rRNA sequencing method. The most abundant phyla in the human vascular microbiota were Proteobacteria , Firmicutes and Actinobacteria . At the genus level, the most abundant taxa were Staphylococcus , Corynebacterium , Pseudomonas , Bacillus , Acinetobacter and Propionibacterium . Of the bacterial taxa that have an indirect effect on the development of atherosclerosis, we found Porphyromonas gingivalis , Prevotella nigrescens and Enterobacteriaceae spp. with different abundances in our samples. Of the bacteria that are more common in the intestinal flora of healthy than of atherosclerosis patients, Roseburia and Ruminococcus occurred in the majority of samples. The human arterial wall has a unique microbiota that is significantly different in composition from that of other areas of the body. Our present study provides a basis for ensuing research that investigates the direct role of the microbiota in vascular wall abnormalities and the success of vascular allograft transplantations.}, year = {2022}, eissn = {2235-2988}, orcid-numbers = {Hidi, László/0000-0003-4128-0523; Kovács, Gergely Imre/0000-0002-3172-2626; Szabó, Dóra/0000-0002-8601-3923; Sótonyi, Péter/0000-0002-2216-4298; Ostorházi, Eszter/0000-0002-9459-7316} } @article{MTMT:33961854, title = {Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases}, url = {https://m2.mtmt.hu/api/publication/33961854}, author = {Lu, Jing and Jin, Xiao and Yang, Shengjie and Li, Yujuan and Wang, Xinyue and Wu, Min}, doi = {10.3389/fmicb.2022.1034537}, journal-iso = {FRONT MICROBIOL}, journal = {FRONTIERS IN MICROBIOLOGY}, volume = {13}, unique-id = {33961854}, abstract = {The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.}, keywords = {METABOLITES; cardiovascular diseases; Intestinal microbiota; immune mechanism; gut microbiota regulation}, year = {2022}, eissn = {1664-302X} } @article{MTMT:33505979, title = {Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3}, url = {https://m2.mtmt.hu/api/publication/33505979}, author = {Luo, Tiantian and Guo, Zhigang and Liu, Dan and Guo, Zhongzhou and Wu, Qiao and Li, Qinxian and Lin, Rongzhan and Chen, Peier and Ou, Caiwen and Chen, Minsheng}, doi = {10.1080/19490976.2022.2077602}, journal-iso = {GUT MICROBES}, journal = {GUT MICROBES}, volume = {14}, unique-id = {33505979}, issn = {1949-0976}, abstract = {Maladaptive inflammatory and immune responses are responsible for intestinal barrier integrity and function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) critically contributes to the immune system, but direct data on the gut microbiota and the microbial metabolite trimethylamine N-oxide (TMAO) are lacking. Here, we investigated the impact of PSRC1 deletion on TMAO generation and atherosclerosis. We first found that PSRC1 deletion in apoE(-/-) mice accelerated atherosclerotic plaque formation, and then the gut microbiota and metabolites were detected using metagenomics and untargeted metabolomics. Our results showed that PSRC1 deficiency enriched trimethylamine (TMA)-producing bacteria and functional potential for TMA synthesis and accordingly enhanced plasma betaine and TMAO production. Furthermore, PSRC1 deficiency resulted in a proinflammatory colonic phenotype that was significantly associated with the dysregulated bacteria. Unexpectedly, hepatic RNA-seq indicated upregulated flavin monooxygenase 3 (FMO3) expression following PSRC1 knockout. Mechanistically, PSRC1 overexpression inhibited FMO3 expression in vitro, while an ER alpha inhibitor rescued the downregulation. Consistently, PSRC1-knockout mice exhibited higher plasma TMAO levels with a choline-supplemented diet, which was gut microbiota dependent, as evidenced by antibiotic treatment. To investigate the role of dysbiosis induced by PSRC1 deletion in atherogenesis, apoE(-/-) mice were transplanted with the fecal microbiota from either apoE(-/-) or PSRC1(-/-)apoE(-/-) donor mice. Mice that received PSRC1-knockout mouse feces showed an elevation in TMAO levels, as well as plaque lipid deposition and macrophage accumulation, which were accompanied by increased plasma lipid levels and impaired hepatic cholesterol transport. Overall, we identified PSRC1 as an atherosclerosis-protective factor, at least in part, attributable to its regulation of TMAO generation via a multistep pathway. Thus, PSRC1 holds great potential for manipulating the gut microbiome and alleviating atherosclerosis.}, keywords = {ATHEROSCLEROSIS; PROLINE; gut microbiota; trimethylamine N-Oxide; Flavin monooxygenase 3; serine-rich coiled-coil protein 1}, year = {2022}, eissn = {1949-0984} } @article{MTMT:33961853, title = {Gut dysbiosis and bacterial translocation in the aneurysmal wall and blood in patients with abdominal aortic aneurysm}, url = {https://m2.mtmt.hu/api/publication/33961853}, author = {Nakayama, Ken and Furuyama, Tadashi and Matsubara, Yutaka and Morisaki, Koichi and Onohara, Toshihiro and Ikeda, Tetsuo and Yoshizumi, Tomoharu}, doi = {10.1371/journal.pone.0278995}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {33961853}, issn = {1932-6203}, abstract = {Inflammation plays a part in the development of abdominal aortic aneurysm (AAA), and the gut microbiota affects host inflammation by bacterial translocation. The relationship between abdominal aortic aneurysm and the gut microbiota remains unknown. This study aimed to detect bacterial translocation in the aneurysmal wall and blood of patients with abdominal aortic aneurysm, and to investigate the effect of the gut microbiota on abdominal aortic aneurysm. We investigated 30 patients with abdominal aortic aneurysm from 2017 to 2019. We analysed the aneurysmal wall and blood using highly sensitive reverse transcription-quantitative polymerase chain reaction, and the gut microbiota was investigated using next-generation sequencing. In the 30 patients, bacteria were detected by reverse transcription- quantitative polymerase chain reaction in 19 blood samples (detection rate, 63%) and in 11 aneurysmal wall samples (detection rate, 37%). In the gut microbiota analysis, the Firmicutes/Bacteroidetes ratio was increased. The neutrophil-lymphocyte ratio was higher (2.94 +/- 1.77 vs 1.96 +/- 0.61, P < 0.05) and the lymphocyte-monocyte ratio was lower (4.02 +/- 1.25 vs 5.86 +/- 1.38, P < 0.01) in the bacterial carrier group than in the bacterial non-carrier group in blood samples. The volume of intraluminal thrombus was significantly higher in the bacterial carrier group than in the bacterial non-carrier group in aneurysmal wall samples (64.0% vs 34.7%, P < 0.05). We confirmed gut dysbiosis and bacterial translocation to the blood and aneurysmal wall in patients with abdominal aortic aneurysm. There appears to be a relationship between the gut microbiota and abdominal aortic aneurysm.}, year = {2022}, eissn = {1932-6203} } @article{MTMT:33505978, title = {Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions}, url = {https://m2.mtmt.hu/api/publication/33505978}, author = {Syromyatnikov, Mikhail and Nesterova, Ekaterina and Gladkikh, Maria and Smirnova, Yuliya and Gryaznova, Mariya and Popov, Vasily}, doi = {10.3390/microorganisms10091866}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {10}, unique-id = {33505978}, issn = {2076-2607}, abstract = {High-throughput sequencing has made it possible to extensively study the human gut microbiota. The links between the human gut microbiome and ethnicity, religion, and race remain rather poorly understood. In this review, data on the relationship between gut microbiota composition and the nationality of people and their religion were generalized. The unique gut microbiome of a healthy European (including Slavic nationality) is characterized by the dominance of the phyla Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucomicrobia. Among the African population, the typical members of the microbiota are Bacteroides and Prevotella. The gut microbiome of Asians is very diverse and rich in members of the genera Prevotella, Bacteroides Lactobacillus, Faecalibacterium, Ruminococcus, Subdoligranulum, Coprococcus, Collinsella, Megasphaera, Bifidobacterium, and Phascolarctobacterium. Among Buddhists and Muslims, the Prevotella enterotype is characteristic of the gut microbiome, while other representatives of religions, including Christians, have the Bacteroides enterotype. Most likely, the gut microbiota of people of different nationalities and religions are influenced by food preferences. The review also considers the influences of pathologies such as obesity, Crohn's disease, cancer, diabetes, etc., on the bacterial composition of the guts of people of different nationalities.}, keywords = {GUT; DISEASES; Religion; Microbiota; nationalities}, year = {2022}, eissn = {2076-2607}, orcid-numbers = {Smirnova, Yuliya/0000-0002-5820-1804; Gryaznova, Mariya/0000-0003-2076-3868; Popov, Vasily/0000-0003-1294-8686} } @article{MTMT:33291618, title = {The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea}, url = {https://m2.mtmt.hu/api/publication/33291618}, author = {Szabó, Helga and Piroska, Márton and Hernyes, Anita and Zöldi, Luca and Juhász, János and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Bikov, András and Kunos, Laszlo and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.3390/app122211484}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {12}, unique-id = {33291618}, abstract = {Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample.}, year = {2022}, eissn = {2076-3417}, orcid-numbers = {Piroska, Márton/0000-0002-6000-5044; Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Szabó, Dóra/0000-0002-8601-3923; Bikov, András/0000-0002-8983-740X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:33505977, title = {Differential Response of Ileal and Colonic Microbiota in Rats with High-Fat Diet-Induced Atherosclerosis}, url = {https://m2.mtmt.hu/api/publication/33505977}, author = {Wen, Lingmiao and Xiong, Wei and Wei, Guihua and Zhang, Liudai and Liu, Yanjun and Zhang, Tinglan and Altamirano, Alvin and Yin, Qiaozhi and Zhang, Tiane and Yan, Zhiyong}, doi = {10.3390/ijms231911154}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33505977}, issn = {1661-6596}, abstract = {Growing evidence suggests that gut microbiota are associated with atherosclerosis (AS). However, the functional heterogeneity of each gut segment gives rise to regional differences in gut microbiota. We established a rat model of AS by feeding the rats a high-fat diet for a long period. The pathological and microbiota changes in the ileum and colon of the rats were examined, and correlations between AS and microbiota were analyzed. The aortic mesothelium of the experimental rats was damaged. The intima showed evident calcium salt deposition, indicating that the AS rat model was successfully developed. We noted varying degrees of pathological damage in the ileum and colon of the experimental rats. The 16S rDNA high-throughput sequencing showed significant differences in alpha-diversity, beta-diversity, and microbiota comparisons in the ileum and colon. Furthermore, the ileum and colon of AS rats showed varying degrees of intestinal microbiota disturbance. This article contributes to the study of the relationship between the microbiota in different regions of the gut and AS, and provides new approaches in gut microbiota intervention for the treatment of AS.}, keywords = {ATHEROSCLEROSIS; GUT; HIGH-FAT-DIET; COLONIC MICROBIOTA; ileal microbiota}, year = {2022}, eissn = {1422-0067} } @article{MTMT:32298569, title = {Gut Microbiota and Atherosclerosis-Focusing on the Plaque Stability}, url = {https://m2.mtmt.hu/api/publication/32298569}, author = {Shen, Xinyi and Li, Lihua and Sun, Zhen and Zang, Guangyao and Zhang, Lili and Shao, Chen and Wang, Zhongqun}, doi = {10.3389/fcvm.2021.668532}, journal-iso = {FRONT CARDIOVASC MED}, journal = {FRONTIERS IN CARDIOVASCULAR MEDICINE}, volume = {8}, unique-id = {32298569}, issn = {2297-055X}, abstract = {Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.}, keywords = {METABOLITES; ATHEROSCLEROSIS; THERAPIES; gut microbiota; Plaque stability}, year = {2021}, eissn = {2297-055X} }