TY  - JOUR
AU  - Taniguchi, Y.
AU  - Tauchi, R.
AU  - Suzuki, T.
AU  - Yanagida, H.
AU  - Watanabe, K.
AU  - Shimizu, T.
AU  - Matsubayashi, Y.
AU  - Kawakami, N.
TI  - Mid- to long-term radiological and respiratory outcomes following surgery for older early-onset scoliosis patients with Marfan syndrome
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 14
PY  - 2024
IS  - 1
SN  - 2045-2322
DO  - 10.1038/s41598-024-75413-1
UR  - https://m2.mtmt.hu/api/publication/35478003
ID  - 35478003
N1  - Department of Orthopedic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan            
            Surgical Center, The University of Tokyo Hospital, Tokyo, Japan            
            Department of Orthopedics and Spine Surgery, Meijo Hospital, Nagoya, Japan            
            Department of Orthopedic Surgery, National Hospital Organization, Kobe Medical Center, Kobe, Japan            
            Department of Orthopedic and Spine Surgery, Fukuoka Children’s Hospital, Fukuoka, Japan            
            Department of Orthopedic Surgery, School of Medicine, Niigata University, Niigata, Japan            
            Department of Orthopedic Surgery, Gunma Spine Center, Harunaso Hospital, Takasaki, Japan            
            Division of Spine Surgery, Department of Orthopedic Surgery, Ichinomiya Nishi Hospital, Ichinomiya, Japan            
            Japan Spinal Deformity Institute (JSDI), Iizuka, Japan            
            Export Date: 24 October 2024            
            Correspondence Address: Taniguchi, Y.; Department of Orthopedic Surgery, 7-3-1 Hongo, Bunkyo-Ku, Japan; email: taniguchi-tky@umin.ac.jp
AB  - This study aimed to elucidate mid- to long-term radiological and respiratory outcomes in patients aged 7–11 years at index surgery with Marfan syndrome and early-onset scoliosis (EOS) in a retrospective multicenter study. Primary outcomes were final thoracic height and final percentage of predicted vital capacity (%VC) at or after 16 years of age. We identified 21 (6 male and 15 female) patients with a mean age of 9.9 years and mean follow-up period of 149.3 months. Fifteen patients underwent primary fusion, whereas six underwent growth-friendly surgery (GFS). The mean preoperative and final T1–T12 heights were 204.0 mm and 248.0 mm, respectively. Final pulmonary function tests were available for 16 patients, and the mean final %VC was 54.0% with 10 patients exhibiting a final %VC < 60%. A significant moderate association was observed between the final T1–T12 height and final %VC. The predicted final T1–T12 height required for a final %VC of 60% was approximately 260 mm. Although most older patients with Marfan syndrome and EOS acquired a considerably large final T1–T12 height, a larger thoracic height was required for satisfactory respiratory function in many cases; hence, GFS may be indicated even in this population. © The Author(s) 2024.
LA  - English
DB  - MTMT
ER  -