@article{MTMT:35478003, title = {Mid- to long-term radiological and respiratory outcomes following surgery for older early-onset scoliosis patients with Marfan syndrome}, url = {https://m2.mtmt.hu/api/publication/35478003}, author = {Taniguchi, Y. and Tauchi, R. and Suzuki, T. and Yanagida, H. and Watanabe, K. and Shimizu, T. and Matsubayashi, Y. and Kawakami, N.}, doi = {10.1038/s41598-024-75413-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {35478003}, abstract = {This study aimed to elucidate mid- to long-term radiological and respiratory outcomes in patients aged 7–11 years at index surgery with Marfan syndrome and early-onset scoliosis (EOS) in a retrospective multicenter study. Primary outcomes were final thoracic height and final percentage of predicted vital capacity (%VC) at or after 16 years of age. We identified 21 (6 male and 15 female) patients with a mean age of 9.9 years and mean follow-up period of 149.3 months. Fifteen patients underwent primary fusion, whereas six underwent growth-friendly surgery (GFS). The mean preoperative and final T1–T12 heights were 204.0 mm and 248.0 mm, respectively. Final pulmonary function tests were available for 16 patients, and the mean final %VC was 54.0% with 10 patients exhibiting a final %VC < 60%. A significant moderate association was observed between the final T1–T12 height and final %VC. The predicted final T1–T12 height required for a final %VC of 60% was approximately 260 mm. Although most older patients with Marfan syndrome and EOS acquired a considerably large final T1–T12 height, a larger thoracic height was required for satisfactory respiratory function in many cases; hence, GFS may be indicated even in this population. © The Author(s) 2024.}, keywords = {Follow-Up Studies; Adolescent; Adolescent; Female; Female; Male; Male; Humans; PATHOPHYSIOLOGY; human; Child; Child; Retrospective Studies; Treatment Outcome; Treatment Outcome; Age of Onset; clinical trial; Diagnostic Imaging; surgery; retrospective study; onset age; multicenter study; lung function test; follow up; Respiratory Function Tests; Complication; Thoracic Vertebrae; Marfan syndrome; Marfan syndrome; Marfan syndrome; vital capacity; vital capacity; Spinal Fusion; respiratory function; spine fusion; scoliosis; scoliosis; procedures; Early-onset scoliosis; adverse event; thoracic vertebra; T1–T12 height; Thoracic height}, year = {2024}, eissn = {2045-2322} }