TY - JOUR AU - Gharat, Vaibhav AU - Peter, Fabian AU - de Quervain, Dominique J. -F. AU - Papassotiropoulos, Andreas AU - Stetak, Attila TI - Role of GLR-1 in Age-Dependent Short-Term Memory Decline JF - ENEURO J2 - ENEURO VL - 11 PY - 2024 IS - 4 PG - 13 SN - 2373-2822 DO - 10.1523/ENEURO.0420-23.2024 UR - https://m2.mtmt.hu/api/publication/34958491 ID - 34958491 N1 - Funding Agency and Grant Number: NIH Office of Research Infrastructure Programs [P40OD010440]; Swiss National Science Foundation (SNSF) Grant [31003A_178937]; Swiss National Science Foundation (SNF) [31003A_178937] Funding Source: Swiss National Science Foundation (SNF) Funding text: We thank Anne Spang for generously sharing reagents and instruments. We also thank the Caenorhabditis Genetic Centre [supported by NIH Office of Research Infrastructure Programs (P40OD010440) ] for providing nematode strains. We thank Dr. Frederic J. Hoerndli (Colorado State University) for providing akIs201, akIs141, and akEx2681 strains. We finally thank the Imaging Core Facility of the Biozentrum (University of Basel) for the microscopy support. This work was supported by the Swiss National Science Foundation (SNSF) Grant (31003A_178937) to A.S. LA - English DB - MTMT ER - TY - JOUR AU - Hayden, Ashley N. AU - Brandel, Katie L. AU - Pietryk, Edward W. AU - Merlau, Paul R. AU - Vijayakumar, Priyadharshini AU - Leptich, Emily J. AU - Gaytan, Elizabeth S. AU - Williams, Meredith I. AU - Ni, Connie W. AU - Chao, Hsiao-Tuan AU - Rosenfeld, Jill A. AU - Arey, Rachel N. TI - Behavioral screening reveals a conserved residue in Y-Box RNA-binding protein required for associative learning and memory in C. elegans JF - PLOS GENETICS J2 - PLOS GENET VL - 20 PY - 2024 IS - 10 PG - 33 SN - 1553-7390 DO - 10.1371/journal.pgen.1011443 UR - https://m2.mtmt.hu/api/publication/35869886 ID - 35869886 N1 - Funding Agency and Grant Number: National Institute of Neurological Disorders and Stroke; EMBL-EBI Funding text: We thank the Ciosk lab for generously sharing the cey-1 #1087 strain; the CGC for strains; Ben Jussila and In Vivo Biosystems for strains and helpful discussion; Peter Boag for helpful discussion; and members of the Arey lab, particularly Katie L Brandel and Catherine Stuart for their detailed feedback on the manuscript. We thank Drs. Jill Rosenfeld and Hongzheng Dai from Baylor Genetics for confirming the presence and relevance of the YBX3 p.Asn127Tyr variant. We thank Dr. Katka Cermakova from Baylor College of Medicine, and Dr. Amelie Stein from University of Copenhagen for discussion of potential effects of the p.Asn127Tyr variant on protein function. This study makes use of data generated by the DECIPHER community. A full list of centers who contributed to the generation of the data is available from https://deciphergenomics.org/about/stats and via email from contact@deciphergenomics.org. DECIPHER is hosted by EMBL-EBI. LA - English DB - MTMT ER - TY - THES AU - Huy Phu Pham, Thomas TI - Influence of Large Conductance Ca2+- and Voltage- Activated K+ Channels (BK) on Synaptic Plasticity in Young and Aged Mice PY - 2023 UR - https://m2.mtmt.hu/api/publication/35065910 ID - 35065910 LA - English DB - MTMT ER - TY - JOUR AU - Hayden, A.N. AU - Leptich, E.J. AU - Arey, R.N. TI - Invited review: Unearthing the mechanisms of age-related neurodegenerative disease using Caenorhabditis elegans JF - COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY J2 - COMP BIOCHEM PHYS A VL - 267 PY - 2022 SN - 1095-6433 DO - 10.1016/j.cbpa.2022.111166 UR - https://m2.mtmt.hu/api/publication/32757575 ID - 32757575 N1 - Funding Agency and Grant Number: AFAR; Glenn foundation for Medical Research Junior Faculty Research Grant; Bert O Malley, MD Student Scholar in Medical Research Award Funding text: We thank all the members of the Arey lab for their useful discussions, thoughts, and assistance in editing this review article. This work was supported by an AFAR and Glenn foundation for Medical Research Junior Faculty Research Grant to RNA, and by a Bert O Malley, MD Student Scholar in Medical Research Award to ANH. We send our sincerest gratitude to all members of the Center of Precision Environmental Health for their continual support. AB - As human life expectancy increases, neurodegenerative diseases present a growing public health threat, for which there are currently few effective treatments. There is an urgent need to understand the molecular and genetic underpinnings of these disorders so new therapeutic targets can be identified. Here we present the argument that the simple nematode worm Caenorhabditis elegans is a powerful tool to rapidly study neurodegenerative disorders due to their short lifespan and vast array of genetic tools, which can be combined with characterization of conserved neuronal processes and behavior orthologous to those disrupted in human disease. We review how pre-existing C. elegans models provide insight into human neurological disease as well as an overview of current tools available to study neurodegenerative diseases in the worm, with an emphasis on genetics and behavior. We also discuss open questions that C. elegans may be particularly well suited for in future studies and how worms will be a valuable preclinical model to better understand these devastating neurological disorders. © 2022 Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - McCoy, Michael T. AU - Jayanthi, Subramaniam AU - Cadet, Jean Lud TI - Potassium Channels and Their Potential Roles in Substance Use Disorders JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 3 PG - 22 SN - 1661-6596 DO - 10.3390/ijms22031249 UR - https://m2.mtmt.hu/api/publication/31996559 ID - 31996559 N1 - Funding Agency and Grant Number: Intramural Research Program of the National Institute on Drug Abuse (NIDA), NIH; DHHS [DA000552] Funding text: This paper is supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), NIH, and DHHS (Grant number-DA000552 (2021)). AB - Substance use disorders (SUDs) are ubiquitous throughout the world. However, much remains to be done to develop pharmacotherapies that are very efficacious because the focus has been mostly on using dopaminergic agents or opioid agonists. Herein we discuss the potential of using potassium channel activators in SUD treatment because evidence has accumulated to support a role of these channels in the effects of rewarding drugs. Potassium channels regulate neuronal action potential via effects on threshold, burst firing, and firing frequency. They are located in brain regions identified as important for the behavioral responses to rewarding drugs. In addition, their expression profiles are influenced by administration of rewarding substances. Genetic studies have also implicated variants in genes that encode potassium channels. Importantly, administration of potassium agonists have been shown to reduce alcohol intake and to augment the behavioral effects of opioid drugs. Potassium channel expression is also increased in animals with reduced intake of methamphetamine. Together, these results support the idea of further investing in studies that focus on elucidating the role of potassium channels as targets for therapeutic interventions against SUDs. LA - English DB - MTMT ER -