@article{MTMT:33323970,
	title = {Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups},
	url = {https://m2.mtmt.hu/api/publication/33323970},
	author = {Lapp, H. E. and Margolis, A. E. and Champagne, F. A.},
	journal-iso = {NEUROTOXICOLOGY},
	journal = {NEUROTOXICOLOGY},
	volume = {93},
	unique-id = {33323970},
	issn = {0161-813X},
	abstract = {Products containing BPA structural analog replacements have increased in response to growing public concern over adverse effects of BPA. Although humans are regularly exposed to a mixture of bisphenols, few studies have examined effects of prenatal exposure to BPA alternatives or bisphenol mixtures. In the present study, we investigate the effect of exposure to an environmentally-relevant, low-dose (150 ug/kg body weight per day) mixture of BPA, BPS, and BPF during gestation on the brain transcriptome in Long-Evans pups and dams using Tag RNA-sequencing. We also examined the association between dam licking and grooming, which also has enduring effects on pup neural development, and the transcriptomes. Associations between licking and grooming and the transcriptome were region-specific, with the hypothalamus having the greatest number of differentially expressed genes associated with licking and grooming in both dams and pups. Prenatal bisphenol exposure also had region-specific effects on gene expression and pup gene expression was affected more robustly than dam gene expression. In dams, the prelimbic cortex had the greatest number of differentially expressed genes asso-ciated with prenatal bisphenol exposure. Prenatal bisphenol exposure changed the expression of over 2000 genes in pups, with the majority being from the pup amygdala. We used Gene Set Enrichment Analysis (GSEA) to asses enrichment of gene ontology biological processes for each region. Top GSEA terms were diverse and varied by brain region and included processes known to have strong associations with steroid hormone regulation, cilium -related terms, metabolic/biosynthetic process terms, and immune terms. Finally, hypothesis-driven analysis of genes related to estrogen response, parental behavior, and epigenetic regulation of gene expression revealed region-specific expression associated with licking and grooming and bisphenol exposure that were distinct in dams and pups. These data highlight the effects of bisphenols on multiple physiological process that are highly dependent on timing of exposure (prenatal vs. adulthood) and brain region, and reiterate the contributions of multiple environmental and experiential factors in shaping the brain.},
	keywords = {Brain; Gene Expression; Prenatal; Maternal Behavior; Bisphenol; amygdala},
	year = {2022},
	eissn = {1872-9711},
	pages = {22-36}
}

@article{MTMT:32350275,
	title = {Impact of BPA on behavior, neurodevelopment and neurodegeneration},
	url = {https://m2.mtmt.hu/api/publication/32350275},
	author = {Rebolledo-Solleiro, Daniela and Castillo Flores, Laura Y. and Solleiro-Villavicencio, Helena},
	doi = {10.2741/4898},
	journal-iso = {FRONT BIOSCI-LANDMARK},
	journal = {FRONTIERS IN BIOSCIENCE-LANDMARK},
	volume = {26},
	unique-id = {32350275},
	issn = {2768-6701},
	abstract = {Bisphenol A (BPA), a compound used in the manufacturing of plastics and epoxy resins, is an endocrine disruptor with significant adverse impact on the human's health. Here, we review the animal models and clinical studies as well as the molecular and cellular mechanisms that show that BPA alters the normal function of the reproductive system, metabolism, brain function and behavior and contributes to the development of certain neurodevelopmental disorders including autism spectrum and attention-deficit and hyperactivity disorders. BPA also causes aberrant cognitive function, behavioral disturbances, and neurodegenerative diseases, including Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. It has recently been proposed that exposure to BPA may be associated with the development of certain neurodegenerative diseases and neurodevelopmental disorders; however, it is a line of research that is just emerging. This work aims to review the available information about the association between exposure to BPA and cognitive function, behavioral disturbances, neurodegenerative diseases (Parkinson ' s Disease, Amyotrophic lateral sclerosis, Multiple Sclerosis), and neurodevelopmental disorders (Autism Spectrum and Attention-Deficit/Hyperactivity Disorders). Likewise, the molecular and cellular mechanisms that may be involved with these pathological conditions will be analyzed.},
	keywords = {BEHAVIOR; MECHANISMS; review; cognition; Neurodevelopment disorders; Bisphenol A; NEUROLOGICAL DISEASES; BPA-A},
	year = {2021},
	eissn = {2768-6698},
	pages = {363-400}
}

@article{MTMT:31103136,
	title = {Impact of perinatal bisphenol A and 17 beta estradiol exposure: Comparing hormone receptor response},
	url = {https://m2.mtmt.hu/api/publication/31103136},
	author = {Rivas Leonel, Ellen Cristina and Pegorin Campos, Silvana Gisele and Alves Guerra, Luiz Henrique and Bedolo, Carolina Marques and Leite Vilamaior, Patricia Simone and Calmon, Marilia Freitas and Rahal, Paula and Amorim, Christiani Andrade and Taboga, Sebastido Roberto},
	doi = {10.1016/j.ecoenv.2019.109918},
	journal-iso = {ECOTOX ENVIRON SAFE},
	journal = {ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY},
	volume = {188},
	unique-id = {31103136},
	issn = {0147-6513},
	abstract = {Hormonal regulation controls mammary gland (MG) development. Therefore some hormone-related factors can disrupt the early phases of MGs development, making the gland more susceptible to long term modifications in its response to circulating hormones. Endocrine disruptors, such as bisphenol A (BPA), are able to cause alterations in hormone receptor expression, leading to changes in the cell proliferation index, which may expose the tissue to neoplastic alterations. Thus, we evaluated the variations in hormone receptor expression in the MG of 6-month old Mongolian gerbils exposed to BPA and 17 beta estradiol during the perinatal period. Receptors for estrogen alpha (ER alpha), beta (ER beta), progesterone (PGR), prolactin (PRL-R), and co-localization of connexin 43 (Cx43) and ER alpha in gerbils were analyzed, and serum concentrations of estradiol and progesterone were assessed. No alterations in body, liver, and ovary-uterus complex weights were observed. However, there was an increase in epithelial ER alpha expression in the 17 beta estradiol (E2) group and in PGR in the BPA group. Although immunohistochemistry did not show alterations in ER beta expression, western blotting revealed a decrease in this protein in the BPA group. PRL-R was more present in epithelial cells in the vehicle control (VC), E2, and BPA groups in comparison to the intact control group. Cx43 was more frequent in E2 and BPA groups, suggesting a protective response from the gland against possible malignancy. Serum concentration of estradiol reduced in VC, E2, and BPA groups, confirming that alterations also impacts steroid levels. Consequently, perinatal exposure to BPA and the reference endogenous estrogen, 17 beta estradiol, are able to increase the tendency of endocrine disruption in MG in a long term manner, since repercussions are observed even 6 months after exposure.},
	keywords = {ESTROGEN; Estrogen receptor; progesterone receptor; mammary gland; Xenoestrogen; Mongolian gerbil},
	year = {2020},
	eissn = {1090-2414}
}

@article{MTMT:31518810,
	title = {Molecular interactions of thyroxine binding globulin and thyroid hormone receptor with estrogenic compounds 4-nonylphenol, 4-tert-octylphenol and bisphenol A metabolite (MBP)},
	url = {https://m2.mtmt.hu/api/publication/31518810},
	author = {Sheikh, Ishfaq A.},
	doi = {10.1016/j.lfs.2020.117738},
	journal-iso = {LIFE SCI},
	journal = {LIFE SCIENCES},
	volume = {253},
	unique-id = {31518810},
	issn = {0024-3205},
	abstract = {Aim: Endocrine disruption due to environmental chemical contaminants is a global human health issue. The aim of present study was to investigate the structural binding aspects of possible interference of commonly detected environmental contaminants on thyroid function.Material and methods: Three compounds, 4-tert-octylphenol (4-tert-OP), 4-nonylphenol (4-NP), and 4-methyl-2,4-bis(4-hydroxypentyl)pent-1-ene (MBP) were subjected to induced fit docking (IFD) against thyroxine binding globulin (TBG) and thyroid hormone receptor (THR). Structural analysis included molecular interactions of the amino acid residues and binding energy estimation between the ligands and the target proteins.Key results: All the ligands were successfully placed in the ligand binding pocket of TBG and THR using induced fit docking (IFD). The IFD results revealed high percentage of commonality in interacting amino acid residues between the aforementioned compounds and the native ligand for both TBG and THR. The results of our study further revealed that all the compounds have the potential to interfere with thyroid transport and signaling. However, MBP showed higher binding affinity for both TBG and THR, suggesting higher thyroid disruptive potential as compared to 4-t-OP and 4-NP. Furthermore, our results also suggest that the reported disruptive effects of BPA could actually be exerted through its metabolite; MBP.Significance: This work implies that all the three compounds 4-NP, 4-t-OP and especially MBP have the potential to interfere with thyroid hormone transport and signaling. This potentially leads to disruption of thyroid hormone function.},
	keywords = {STRUCTURAL CHARACTERIZATION; Endocrine disruption; 4-Tert-octylphenol; 4-NONYLPHENOL; BPA metabolite},
	year = {2020},
	eissn = {1879-0631}
}

@article{MTMT:31194217,
	title = {Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures},
	url = {https://m2.mtmt.hu/api/publication/31194217},
	author = {Jócsák, Gergely and Ioja, Enikő and Kiss, Dávid Sándor and Tóth, István and Bárány, Zoltán Balázs and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila},
	doi = {10.3390/brainsci9120359},
	journal-iso = {BRAIN SCI},
	journal = {BRAIN SCIENCES},
	volume = {9},
	unique-id = {31194217},
	year = {2019},
	eissn = {2076-3425},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:30591984,
	title = {Thyroid function disruptors: from nature to chemicals},
	url = {https://m2.mtmt.hu/api/publication/30591984},
	author = {Oliveira, Karen Jesus and Chiamolera, Maria Isabel and Giannocco, Gisele and Pazos-Moura, Carmen Cabanelas and Ortiga-Carvalho, Tania Maria},
	doi = {10.1530/JME-18-0081},
	journal-iso = {J MOL ENDOCRINOL},
	journal = {JOURNAL OF MOLECULAR ENDOCRINOLOGY},
	volume = {62},
	unique-id = {30591984},
	issn = {0952-5041},
	abstract = {The modern concept of thyroid disruptors includes synthetic chemicals and bioactive compounds from food that interfere with any aspect of the hypot halamus-pituitarythyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local actions of thyroid hormones. This review highlights relevant disruptors that affect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we r eview effects from the gestational period to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies.},
	keywords = {thyroid hormones; TSH; bioactive food compounds; chemical disruptors},
	year = {2019},
	eissn = {1479-6813},
	pages = {R1-R19}
}

@article{MTMT:30912525,
	title = {Prenatal Bisphenol A exposure and early childhood neurodevelopment in Shandong, China},
	url = {https://m2.mtmt.hu/api/publication/30912525},
	author = {Pan, Rui and Wang, Caifeng and Shi, Rong and Zhang, Yan and Wang, Yiwen and Cai, Chen and Ding, Guodong and Yuan, Tao and Tian, Ying and Gao, Yu},
	doi = {10.1016/j.ijheh.2019.03.002},
	journal-iso = {INT J HYG ENVIR HEAL},
	journal = {INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH},
	volume = {222},
	unique-id = {30912525},
	issn = {1438-4639},
	abstract = {Background: Several epidemiological studies suggest that prenatal exposure to BPA may interfere with the neurodevelopment of pre-school and school-age children. However, a limited number of studies are available for effects during children at a younger age, especially in China.Methods: Based on Laizhou Wan Birth Cohort (LWBC), BPA concentrations were measured in urine among 506 pregnant women during their hospital admission for delivery and neurodevelopment of their children was assessed using the Gesell Development Schedules at 12 months (n = 368) and 24 months (n = 296). Linear regression and generalized linear models were used to analyze the association between prenatal BPA exposure and the children's developmental quotient scores (DQs).Results: The median of maternal BPA concentration was 0.48 mu g/L or 1.05 mu g/g creatinine. Maternal BPA concentrations were adversely associated with children DQs at 12 months of age, with a 10-fold increase in prenatal BPA concentrations correlated to 1.43-point decrease in DQs in the adaptive domain (beta = -1.43; 95% CI: -2.30 to -0.56, p = 0.001). When stratified by gender, prenatal BPA concentrations were adversely associated with the adaptive domain DQs among boys (p-trend = 0.012) and girls (p-trend = 0.028) and the social domain DQs (p-trend = 0.019) only among girls. At 24 months of age, the significant adverse association was only found in the language domain among girls (beta = -1.69; 95% CI: -3.23 to -0.15, p = 0.032).Conclusion: Based on a Chinese population, we found potential impacts of prenatal BPA exposure on childhood neurodevelopment at 12 and 24 months of age, especially among girls.},
	keywords = {CHILDREN; CHINA; Prenatal; neurodevelopment; Bisphenol A},
	year = {2019},
	eissn = {1618-131X},
	pages = {896-902}
}

@article{MTMT:31103138,
	title = {Bisphenol a and human diseases. Mechanisms of action},
	url = {https://m2.mtmt.hu/api/publication/31103138},
	author = {Дергачева, Наталья Игоревна and Паткин, Евгений Львович and Сучкова, Ирина Олеговна and Софронов, Генрих Александрович and Dergacheva, Natalia I. and Patkin, Eugene L. and Suchkova, Irina O. and Sofronov, Henrikh A.},
	doi = {10.17816/ecogen17387-98},
	journal-iso = {EKOL GENET},
	journal = {EKOLOGICHESKAYA GENETIKA / ECOLOGICAL GENETICS},
	volume = {17},
	unique-id = {31103138},
	issn = {1811-0932},
	abstract = {В обзоре рассматриваются молекулярные механизмы и биологические эффекты воздействия экотоксиканта бисфенола А, который относится к химическим веществам, разрушающим эндокринную систему, и обладает эпигенетической токсичностью.The review describes the molecular mechanisms and biological effects of bisphenol A exposure, which is a chemical (ecotoxicant) that destroys the endocrine system and has epigenetic toxicity.},
	keywords = {CANCER; Gene Expression; congenital abnormalities; chronic diseases; Epimutation; xenoestrogens; Epigenetic modifications; ontogenesis; рак; онтогенез; экспрессия генов; ксеноэстрогены; эпигенетические модификации; эпимутации; врожденные патологии; хронические болезни},
	year = {2019},
	eissn = {2411-9202},
	pages = {87-98}
}

@article{MTMT:27603498,
	title = {Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment},
	url = {https://m2.mtmt.hu/api/publication/27603498},
	author = {Ghassabian, Akhgar and Trasande, Leonardo},
	doi = {10.3389/fendo.2018.00204},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {9},
	unique-id = {27603498},
	issn = {1664-2392},
	year = {2018},
	eissn = {1664-2392},
	orcid-numbers = {Ghassabian, Akhgar/0000-0001-9551-4706}
}

@article{MTMT:27603497,
	title = {The state of bisphenol research in the lesser developed countries of the EU: a mini-review},
	url = {https://m2.mtmt.hu/api/publication/27603497},
	author = {Thoene, Michael and Rytel, Liliana and Nowicka, Natalia and Wojtkiewicz, Joanna},
	doi = {10.1039/c8tx00064f},
	journal-iso = {TOXICOL RES-UK},
	journal = {TOXICOLOGY RESEARCH},
	volume = {7},
	unique-id = {27603497},
	issn = {2045-452X},
	year = {2018},
	eissn = {2045-4538},
	pages = {371-380},
	orcid-numbers = {Thoene, Michael/0000-0002-5881-175X}
}

@article{MTMT:27348520,
	title = {Comparative approaches to understanding thyroid hormone regulation of neurogenesis},
	url = {https://m2.mtmt.hu/api/publication/27348520},
	author = {Gothie, Jean-David and Demeneix, Barbara and Remaud, Sylvie},
	doi = {10.1016/j.mce.2017.05.020},
	journal-iso = {MOL CELL ENDOCRINOL},
	journal = {MOLECULAR AND CELLULAR ENDOCRINOLOGY},
	volume = {459},
	unique-id = {27348520},
	issn = {0303-7207},
	year = {2017},
	eissn = {1872-8057},
	pages = {104-115}
}