@article{MTMT:33298784,
	title = {The Role of microRNAs in Inflammation},
	url = {https://m2.mtmt.hu/api/publication/33298784},
	author = {Das, Kaushik and Rao, L. Vijaya Mohan},
	doi = {10.3390/ijms232415479},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33298784},
	issn = {1661-6596},
	abstract = {Inflammation is a biological response of the immune system to various insults, such as pathogens, toxic compounds, damaged cells, and radiation. The complex network of pro- and anti-inflammatory factors and their direction towards inflammation often leads to the development and progression of various inflammation-associated diseases. The role of small non-coding RNAs (small ncRNAs) in inflammation has gained much attention in the past two decades for their regulation of inflammatory gene expression at multiple levels and their potential to serve as biomarkers and therapeutic targets in various diseases. One group of small ncRNAs, microRNAs (miRNAs), has become a key regulator in various inflammatory disease conditions. Their fine-tuning of target gene regulation often turns out to be an important factor in controlling aberrant inflammatory reactions in the system. This review summarizes the biogenesis of miRNA and the mechanisms of miRNA-mediated gene regulation. The review also briefly discusses various pro- and anti-inflammatory miRNAs, their targets and functions, and provides a detailed discussion on the role of miR-10a in inflammation.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Das, Kaushik/0000-0003-0386-0543}
}

@article{MTMT:33623570,
	title = {PREDICTION AND EARLY DIAGNOSIS OF PREECLAMPSIA: SCIENTIFIC PERSPECTIVES AND CLINICAL OPPORTUNITIES},
	url = {https://m2.mtmt.hu/api/publication/33623570},
	author = {Khodzhaeva, Z.S. and Oshkhunova, M.S. and Muminova, K.T. and Gorina, K.A. and Kholin, A.M.},
	doi = {10.18565/aig.2022.218},
	journal-iso = {AKUSERSTVO I GINEKOLOGIA},
	journal = {AKUSERSTVO I GINEKOLOGIA},
	volume = {2022},
	unique-id = {33623570},
	issn = {0300-9092},
	year = {2022},
	eissn = {2412-5679},
	pages = {57-65}
}

@article{MTMT:32949181,
	title = {miR‐24‐3p regulation of retinol binding protein 4 in trophoblast biofunction and preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/32949181},
	author = {Li, Zhan and Ru, Xiaoli and Wang, Shuzhen and Cao, Guangming},
	doi = {10.1002/mrd.23633},
	journal-iso = {MOL REPROD DEV},
	journal = {MOLECULAR REPRODUCTION AND DEVELOPMENT},
	volume = {e},
	unique-id = {32949181},
	issn = {1040-452X},
	year = {2022},
	eissn = {1098-2795},
	pages = {1}
}

@article{MTMT:32517799,
	title = {Upregulation of circRNA hsa_circ_0008726 in Pre-eclampsia Inhibits Trophoblast Migration, Invasion, and EMT by Regulating miR-345-3p/RYBP Axis},
	url = {https://m2.mtmt.hu/api/publication/32517799},
	author = {Shu, Chang and Xu, Peng and Han, Jun and Han, Shumei and He, Jin},
	doi = {10.1007/s43032-021-00804-y},
	journal-iso = {REPROD SCI},
	journal = {REPRODUCTIVE SCIENCES},
	volume = {29},
	unique-id = {32517799},
	issn = {1933-7191},
	year = {2022},
	eissn = {1933-7205},
	pages = {2829-2841},
	orcid-numbers = {He, Jin/0000-0001-8325-9824}
}

@article{MTMT:32888348,
	title = {Mast cell‐derived exosomal miR ‐181a‐5p modulated trophoblast cell viability, migration, and invasion via YY1 / MMP ‐9 axis},
	url = {https://m2.mtmt.hu/api/publication/32888348},
	author = {Wang, Yinfen and Chen, Aner},
	doi = {10.1002/jcla.24549},
	journal-iso = {J CLIN LAB ANAL},
	journal = {JOURNAL OF CLINICAL LABORATORY ANALYSIS},
	volume = {e24549},
	unique-id = {32888348},
	issn = {0887-8013},
	year = {2022},
	eissn = {1098-2825},
	orcid-numbers = {Chen, Aner/0000-0002-7360-6834}
}

@article{MTMT:32480054,
	title = {Epigenetic processes during preeclampsia and effects on fetal development and chronic health},
	url = {https://m2.mtmt.hu/api/publication/32480054},
	author = {Ashraf, Usman M. and Hall, Dalton L. and Rawls, Adam Z. and Alexander, Barbara T.},
	doi = {10.1042/CS20190070},
	journal-iso = {CLIN SCI},
	journal = {CLINICAL SCIENCE},
	volume = {135},
	unique-id = {32480054},
	issn = {0143-5221},
	year = {2021},
	eissn = {1470-8736},
	pages = {2307-2327},
	orcid-numbers = {Alexander, Barbara T./0000-0003-4992-2455}
}

@article{MTMT:31625150,
	title = {miR-483 is downregulated in pre-eclampsia via targeting insulin-like growth factor 1 (IGF1) and regulates the PI3K/Akt/mTOR pathway of endothelial progenitor cells},
	url = {https://m2.mtmt.hu/api/publication/31625150},
	author = {Han, L. and Luo, Q.-Q. and Peng, M.-G. and Zhang, Y. and Zhu, X.-H.},
	doi = {10.1111/jog.14412},
	journal-iso = {J OBSTET GYNAECOL RES},
	journal = {JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH},
	volume = {47},
	unique-id = {31625150},
	issn = {1341-8076},
	year = {2021},
	eissn = {1447-0756},
	pages = {63-72}
}

@article{MTMT:31932623,
	title = {Insight into the key points of preeclampsia pathophysiology: Uterine artery remodeling and the role of micrornas},
	url = {https://m2.mtmt.hu/api/publication/31932623},
	author = {Pankiewicz, K. and Fijałkowska, A. and Issat, T. and Maciejewski, T.M.},
	doi = {10.3390/ijms22063132},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {31932623},
	issn = {1661-6596},
	abstract = {Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregnancy and is thought to be impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries that leads to reduced placental perfusion and release of numerous biological factors causing endothelial damage and development of acute maternal syndrome with systemic multiorgan failure (stage 2—the onset of maternal clinical symptoms, maternal stage). Recently, in the light of the vast body of evidence, two-stage model of preeclampsia has been updated with a few novel pathways leading to clinical manifestation in the second part of pregnancy. This paper reviews current state of knowledge about pathophysiology of preeclampsia and places particular focus on the recent advances in understanding of uterine artery remodeling alterations, as well as the role of microRNAs in preeclampsia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.},
	keywords = {PREECLAMPSIA; microRNA; Two-stage model; Uterine artery remodeling},
	year = {2021},
	eissn = {1422-0067}
}

@{MTMT:32581494,
	title = {The GeneCards Suite},
	url = {https://m2.mtmt.hu/api/publication/32581494},
	author = {Safran, Marilyn and Rosen, Naomi and Twik, Michal and BarShir, Ruth and Stein, Tsippi Iny and Dahary, Dvir and Fishilevich, Simon and Lancet, Doron},
	booktitle = {Practical Guide to Life Science Databases},
	doi = {10.1007/978-981-16-5812-9_2},
	unique-id = {32581494},
	year = {2021},
	pages = {27-56}
}

@article{MTMT:32269801,
	title = {Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia},
	url = {https://m2.mtmt.hu/api/publication/32269801},
	author = {Shan, Li and Hou, Xiaofei},
	doi = {10.3892/mmr.2021.12438},
	journal-iso = {MOL MED REP},
	journal = {MOLECULAR MEDICINE REPORTS},
	volume = {24},
	unique-id = {32269801},
	issn = {1791-2997},
	year = {2021},
	eissn = {1791-3004}
}

@article{MTMT:31188708,
	title = {A review of omics approaches to study preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/31188708},
	author = {Benny, P.A. and Alakwaa, F.M. and Schlueter, R.J. and Lassiter, C.B. and Garmire, L.X.},
	doi = {10.1016/j.placenta.2020.01.008},
	journal-iso = {PLACENTA},
	journal = {PLACENTA},
	volume = {92},
	unique-id = {31188708},
	issn = {0143-4004},
	keywords = {GENETICS; PATHWAY; ARTICLE; INHIBIN; single nucleotide polymorphism; human; NETWORK; priority journal; biological marker; integration; PREECLAMPSIA; PREECLAMPSIA; Molecular Biology; transcriptomics; transcriptomics; proteomics; proteomics; metabolomics; metabolomics; biomarker; DNA methylation; Genome-Wide Association Study; epigenetics; epigenetics; biological functions; Omics; Omics; big data; multi-omics},
	year = {2020},
	eissn = {1532-3102},
	pages = {17-27}
}

@article{MTMT:31625149,
	title = {Values of serum miR-873 and miR-323-3p levels in diagnosis of ectopic pregnancy},
	url = {https://m2.mtmt.hu/api/publication/31625149},
	author = {Liu, L.},
	doi = {10.3760/cma.j.cn431274-20190125-00079},
	journal-iso = {J CHIN PHYS},
	journal = {ZHONGGUO YISHI ZAZHI / JOURNAL OF CHINESE PHYSICIAN},
	volume = {22},
	unique-id = {31625149},
	issn = {1008-1372},
	year = {2020},
	pages = {745-748}
}

@article{MTMT:31344479,
	title = {MiRNA-203a-3p inhibits inflammatory response in preeclampsia through regulating IL24},
	url = {https://m2.mtmt.hu/api/publication/31344479},
	author = {Ma, H. -Y. and Cu, W. and Sun, Y. -H. and Chen, X.},
	journal-iso = {EUR REV MED PHARMACOL SCI},
	journal = {EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES},
	volume = {24},
	unique-id = {31344479},
	issn = {1128-3602},
	year = {2020},
	eissn = {2284-0729},
	pages = {5223-5230}
}

@article{MTMT:31361659,
	title = {Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia},
	url = {https://m2.mtmt.hu/api/publication/31361659},
	author = {Ou, Yuhua and Zhu, Liqiong and Wei, Xiangcai and Bai, Shiyu and Chen, Manqi and Chen, Hui and Zhang, Jianping},
	doi = {10.1038/s41419-020-2679-6},
	journal-iso = {CELL DEATH DIS},
	journal = {CELL DEATH AND DISEASE},
	volume = {11},
	unique-id = {31361659},
	issn = {2041-4889},
	year = {2020},
	eissn = {2041-4889}
}

@article{MTMT:32513978,
	title = {The role of circular Ribonucleic Acid in preeclampsia: a literature review},
	url = {https://m2.mtmt.hu/api/publication/32513978},
	author = {Setiawan, William Alexander and Pranamartha, A.A. Gde Marvy Khrisna},
	doi = {10.51559/inajperinatol.v1i1.4},
	journal-iso = {InaJPerinatol},
	journal = {Indonesian Journal of Perinatology},
	volume = {1},
	unique-id = {32513978},
	issn = {2775-0744},
	year = {2020},
	eissn = {2775-0736},
	pages = {13-17}
}

@article{MTMT:31002880,
	title = {MicroRNA-576-5p enhances the invasion ability of trophoblast cells in preeclampsia by targeting TFAP2A},
	url = {https://m2.mtmt.hu/api/publication/31002880},
	author = {Wang, Xiaoning and Peng, Shiyuan and Cui, Kun and Hou, Fangjuan and Ding, Jie and li, Ali and Wang, Mingxia and Geng, Li},
	doi = {10.1002/mgg3.1025},
	journal-iso = {MOL GENET GENOM MED},
	journal = {MOLECULAR GENETICS AND GENOMIC MEDICINE},
	volume = {8},
	unique-id = {31002880},
	issn = {2324-9269},
	abstract = {Background Preeclampsia (PE) is a common pregnancy-related syndrome characterized by hypertension and proteinuria, and a major cause of maternal mortality. Therefore, there is an urgent need to identify early biomarkers of PE. The aim of the present study was to identify the functions of miR-576-5p in PE. Methods Effects of miR-576-5p and transcription factor AP-2 alpha (TFAP2A) on invasion of human trophoblast HTR8/SVneo cells were investigated. Real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to assess the expression of miR-576-5p, TFAP2A, E-cad, and Vimentin in PE tissues and cells. Additionally, immunofluorescence was used to detect the expression of TFAP2A in PE trophoblastic tissue. Subsequently, constructed miR-576-5p mimics, miR-576-5p inhibitor, and siRNA-TFAP2A plasmids were transfected into HTR8/SVneo cells for further experiments, including a CCK-8 assay for cell proliferation, Transwell assay for cell invasion and the luciferase reporter gene system was employed for target verification. Results A lower expression of miR-576-5p and a higher expression of TFAP2A were identified in PE rats. E-cadherin was highly expressed while Vimentin was downregulated. Further statistical analysis indicated that cell proliferation of HTR8/SVneo cells decreased in the miR-576-5p inhibitor group and increased in the miR-576-5p mimics and siRNA-TFAP2A groups. miR-576-5p inhibitor suppressed cell invasion, and miR-576-5p mimics and siRNA-TFAP2A improved cell invasion. The analysis of luciferase reporter demonstrated a decreased luciferase activity in miR-576-5p mimics group compared with control group, which indicates that TFAP2A may be a target of miR-576-5p. Interference of TFAP2A could downregulate E-cadherin and upregulate Vimentin expression. Conclusion Overexpression of miR-576-5p and knockdown of TFAP2A may elevate cell proliferation and invasion of human trophoblast cells in vitro. Therefore, miR-576-5p may be used as a notable biomarker for the diagnosis, prevention, and treatment of PE. miR-576-5p targeting TFAP2A deserve further investigation in order to explore their potential role in PE.},
	keywords = {INVASION; PREECLAMPSIA; miR-576-5p; TFAP2A},
	year = {2020},
	eissn = {2324-9269}
}

@article{MTMT:31344486,
	title = {Long non-coding RNA HOTAIR modulates the progression of preeclampsia through inhibiting miR-106 in an EZH2-dependent manner},
	url = {https://m2.mtmt.hu/api/publication/31344486},
	author = {Zhao, Yan-Hua and Liu, Yue-Lan and Fei, Kui-Lin and Li, Ping},
	doi = {10.1016/j.lfs.2020.117668},
	journal-iso = {LIFE SCI},
	journal = {LIFE SCIENCES},
	volume = {253},
	unique-id = {31344486},
	issn = {0024-3205},
	year = {2020},
	eissn = {1879-0631}
}

@article{MTMT:31002885,
	title = {HIF-1 alpha Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction},
	url = {https://m2.mtmt.hu/api/publication/31002885},
	author = {Anton, Lauren and DeVine, Ann and Polyak, Erzsebet and Olarerin-George, Anthony and Brown, Amy G. and Falk, Marni J. and Elovitz, Michal A.},
	doi = {10.3389/fphys.2019.00699},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {10},
	unique-id = {31002885},
	abstract = {Preeclampsia is associated with first trimester placental dysfunction. miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. The effects of elevated miR-210 on placental function remain unclear. The objectives of this study were to identify targets of miR-210 in first trimester primary extravillous trophoblasts (EVTs) and to investigate functional pathways altered by elevated placental miR-210 during early pregnancy. EVTs isolated from first trimester placentas were exposed to cobalt chloride (CoCl2), a HIF-1 alpha stabilizer and hypoxia mimetic, and miR-210 expression by qPCR, HIF1 alpha protein levels by western blot and cell invasion were assessed. A custom TruSeq RNA array, including all known/predicted miR-210 targets, was run using miR-210 and miR-negative control transfected EVTs. Mitochondrial function was assessed by high resolution respirometry in transfected EVTs. EVTs exposed to CoCl2 showed a dose and time-dependent increase in miR-210 and HIF1 alpha and reductions in cell invasion. The TruSeq array identified 49 altered genes in miR-210 transfected EVTs with 27 genes repressed and 22 enhanced. Three of the top six significantly repressed genes, NDUFA4, SDHD, and ISCU, are associated with mitochondrial function. miR-210 transfected EVTs had decreased maximal, complex II and complex I+II mitochondrial respiration. This study suggests that miR-210 alters first trimester trophoblast function. miR-210 overexpression alters EVT mitochondrial function in early pregnancy. Mitochondrial dysfunction may lead to increased reactive oxygen species, trophoblast cell damage and likely contributes to the pathogenesis of preeclampsia.},
	keywords = {PREECLAMPSIA; miRNA; MITOCHONDRIAL RESPIRATION; SDHD; extravillous trophoblast; miR-210; ISCU; NDUFA4},
	year = {2019},
	eissn = {1664-042X}
}

@article{MTMT:30714315,
	title = {The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/30714315},
	author = {Apicella, Clara and Ruano, Camino S. M. and Méhats, Céline and Miralles, Francisco and Vaiman, Daniel},
	doi = {10.3390/ijms20112837},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {20},
	unique-id = {30714315},
	issn = {1661-6596},
	year = {2019},
	eissn = {1422-0067}
}

@article{MTMT:30401681,
	title = {Circulating exosomal and Argonaute-bound microRNAs in preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/30401681},
	author = {Biró, Orsolya and Fóthi, Ábel and Alasztics, Bálint and Nagy, Bálint and Orbán, Tamás I. and Rigó, János},
	doi = {10.1016/j.gene.2019.01.012},
	journal-iso = {GENE},
	journal = {GENE},
	volume = {692},
	unique-id = {30401681},
	issn = {0378-1119},
	abstract = {Introduction
		microRNAs (miRNAs) play important role in the regulation of placental development, and abnormal miRNA expression is associated with preeclampsia (PE). miRNAs are released from trophoblast cells to maternal blood flow, where they are highly stable, being encapsulated inside extracellular vesicles, like exosomes or bound to Argonaute proteins. In PE, placental dysfunction leads to aberrant extracellular miRNA secretion. hsa-miR-210 is a hypoxia-sensitive miRNA found to be upregulated in PE; however, it is unknown whether it is the cause or the consequence of the disease.
		
		Objective
		Our aim was to analyze the expression of several miRNAs, including hsa-miR-210 in placenta, exosome and Ago-bound fractions comparing normal (N) and PE pregnancies. We performed in vitro analyses of extracellular hsa-miR-210 secretion of trophoblast cell cultures (of villous and extravillous origin) under hypoxic condition.
		
		Methods
		PE and N placenta samples were collected from C-sections, and blood samples were drawn from each pregnant woman in the third trimester. HTR-8 and JAR cell lines were cultured in exosome-free media and treated with hypoxia-mimetic agents. Exosome and Ago-bound fractions were isolated by membrane affinity spin column method from plasma and cell media. Short RNAs were extracted from exosomes and vesicle-free fractions, and total-RNA was isolated from the placenta samples. The RNA purity and concentration were measured by spectrophotometry. Expression analysis was carried out by qPCR with specific primers to target and reference miRNAs.
		
		Results
		The level of hsa-miR-210 was significantly higher in PE placentas, which could cause a minor increase of exosomal and a high elevation of Ago-bound miR-210 in circulation. Hypoxia lead to intracellular hsa-miR-210 upregulation in trophoblast cell lines. In extravillous cell (HTR-8) media, only the level of exosomal hsa-miR-210 was increased but no change in Ago-bound hsa-miR-210 level was observed. In contrast, in villous cell (JAR) media, the level of exosomal hsa-miR-210 was increased and enhanced release of Ago-bound hsa-miR-210 was also observed.
		
		Conclusion
		Based on our data, we postulate that in PE, exosomal hsa-miR-210 is secreted actively from the trophoblast, and by intercellular communication, it may have a role in disease etiology. In addition, there is a passive release of Ago-bound hsa-miR-210 into the circulation, which may represent by-products of cell-death and is thereby a possible consequence of the disease.},
	year = {2019},
	eissn = {1879-0038},
	pages = {138-144},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Nagy, Bálint/0000-0002-0295-185X; Orbán, Tamás I./0000-0002-3424-3428; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:30662422,
	title = {Role of Circular RNAs in Preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/30662422},
	author = {Jia, Ningyi and Li, Jian},
	doi = {10.1155/2019/7237495},
	journal-iso = {DIS MARKERS},
	journal = {DISEASE MARKERS},
	volume = {2019},
	unique-id = {30662422},
	issn = {0278-0240},
	year = {2019},
	eissn = {1875-8630},
	pages = {1-7}
}

@article{MTMT:30701571,
	title = {Identification of Key circRNAs/lncRNAs/miRNAs/mRNAs and Pathways in Preeclampsia Using Bioinformatics Analysis},
	url = {https://m2.mtmt.hu/api/publication/30701571},
	author = {Liu, Siwei and Xie, Xie and Lei, Huajiang and Zou, Bingyu and Xie, Lan},
	doi = {10.12659/MSM.912801},
	journal-iso = {MED SCI MONIT},
	journal = {MEDICAL SCIENCE MONITOR},
	volume = {25},
	unique-id = {30701571},
	issn = {1234-1010},
	year = {2019},
	eissn = {1643-3750},
	pages = {1679-1693}
}

@article{MTMT:30746878,
	title = {MiR-342-3p suppresses cell migration and invasion in preeclampsia by targeting platelet-derived growth factor receptor a},
	url = {https://m2.mtmt.hu/api/publication/30746878},
	author = {Yang, X. and Guo, F.},
	doi = {10.3892/mmr.2019.10372},
	journal-iso = {MOL MED REP},
	journal = {MOLECULAR MEDICINE REPORTS},
	volume = {20},
	unique-id = {30746878},
	issn = {1791-2997},
	year = {2019},
	eissn = {1791-3004},
	pages = {1772-1780}
}

@article{MTMT:30727239,
	title = {Circular RNAs in hypertension: challenges and clinical promise},
	url = {https://m2.mtmt.hu/api/publication/30727239},
	author = {Zaiou, Mohamed},
	doi = {10.1038/s41440-019-0294-7},
	journal-iso = {HYPERTENS RES},
	journal = {HYPERTENSION RESEARCH},
	volume = {42},
	unique-id = {30727239},
	issn = {0916-9636},
	year = {2019},
	eissn = {1348-4214},
	pages = {1653-1663}
}

@article{MTMT:3357249,
	title = {A mikro-RNS-ek patogenetikai szerepe és expressziós mintázata praeeclampsiában},
	url = {https://m2.mtmt.hu/api/publication/3357249},
	author = {Biró, Orsolya and Rigó, János},
	doi = {10.1556/650.2018.31025},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {159},
	unique-id = {3357249},
	issn = {0030-6002},
	abstract = {Preeclampsia is the leading cause of maternal and fetal morbidity and mortality that affects 3-8% of pregnancies worldwide. Its main symptoms include new onset of high blood pressure and proteinuria after 20 weeks of pregnancy. The cause of the disease is still debated. microRNAs are short, non-coding RNA molecules that play a pivotal part in the posttranscriptional regulation of eukaryotic genes. They are involved in fine-tuning of vital physiological processes such as cell cycle, proliferation, differentiation and cell death. In genomic studies, hundreds of microRNAs were detected in the placenta, which are supposed to regulate placental development and contribute to uncomplicated pregnancy. Several studies have reported changes in the expression of microRNAs in pregnancy. Abnormal microRNA expression may have a role in the development of preeclampsia as it affects the proliferation, migration, and invasion of the trophoblast cells, spiral artery remodeling, and angiogenesis. Some placental microRNAs (e.g., the C19MC microRNA cluster) are able to reach the maternal circulation through their release via exosomes from the trophoblast layer. These 'circulating' microRNA molecules can be applied as biomarkers for the detection of various placental disorders owing to their stability and specificity. Orv Hetil. 2018; 159(14): 547-556.},
	year = {2018},
	eissn = {1788-6120},
	pages = {547-556},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:27371799,
	title = {Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia},
	url = {https://m2.mtmt.hu/api/publication/27371799},
	author = {Hu, Xiaopeng and Ao, Junping and Li, Xinyue and Zhang, Huijuan and Wu, Ji and Cheng, Weiwei},
	doi = {10.1186/s13148-018-0482-3},
	journal-iso = {CLIN EPIGENETICS},
	journal = {CLINICAL EPIGENETICS},
	volume = {10},
	unique-id = {27371799},
	issn = {1868-7075},
	year = {2018},
	eissn = {1868-7083}
}

@article{MTMT:27546979,
	title = {miRNAs in pregnancy-related complications: an update},
	url = {https://m2.mtmt.hu/api/publication/27546979},
	author = {Mavreli, D and Papantoniou, N and Kolialexi, A},
	doi = {10.1080/14737159.2018.1480939},
	journal-iso = {EXPERT REV MOL DIAGN},
	journal = {EXPERT REVIEW OF MOLECULAR DIAGNOSTICS},
	volume = {18},
	unique-id = {27546979},
	issn = {1473-7159},
	year = {2018},
	eissn = {1744-8352},
	pages = {587-589}
}

@article{MTMT:27513917,
	title = {The Drosha rs10719 T > C polymorphism is associated with preeclampsia susceptibility},
	url = {https://m2.mtmt.hu/api/publication/27513917},
	author = {Rezaei, Mahnaz and Eskandari, Fatemeh and Mohammadpour-Gharehbagh, Abbas and Teimoori, Batool and Yaghmaei, Minoo and Mokhtari, Mojgan and Salimi, Saeedeh},
	doi = {10.1080/10641963.2017.1392555},
	journal-iso = {CLIN EXP HYPERTENS},
	journal = {CLINICAL AND EXPERIMENTAL HYPERTENSION},
	volume = {40},
	unique-id = {27513917},
	issn = {1064-1963},
	year = {2018},
	eissn = {1525-6006},
	pages = {440-445},
	orcid-numbers = {Salimi, Saeedeh/0000-0003-3987-0268}
}

@article{MTMT:27231049,
	title = {Development of a miRNA surface-enhanced Raman scattering assay using benchtop and handheld Raman systems},
	url = {https://m2.mtmt.hu/api/publication/27231049},
	author = {Schechinger, M and Marks, H and Locke, A and Choudhury, M and Cote, G},
	doi = {10.1117/1.JBO.23.1.017002},
	journal-iso = {J BIOMED OPT},
	journal = {JOURNAL OF BIOMEDICAL OPTICS},
	volume = {23},
	unique-id = {27231049},
	issn = {1083-3668},
	year = {2018},
	eissn = {1560-2281}
}

@article{MTMT:26853085,
	title = {Relevance of microRNA-122 to pathogenesis of preeclampsia in rats},
	url = {https://m2.mtmt.hu/api/publication/26853085},
	author = {Bai, Y and Zhang, X and Yang, X and Li, F},
	journal-iso = {INT J CLIN EXP MED},
	journal = {INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE},
	volume = {10},
	unique-id = {26853085},
	issn = {1940-5901},
	year = {2017},
	pages = {10103-10112}
}

@article{MTMT:3273020,
	title = {Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension},
	url = {https://m2.mtmt.hu/api/publication/3273020},
	author = {Biró, Orsolya and Alasztics, Bálint and Molvarec, Attila and Joó, József Gábor and Nagy, Bálint and Rigó, János},
	doi = {10.1016/j.preghy.2017.09.002},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {10},
	unique-id = {3273020},
	issn = {2210-7789},
	abstract = {Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy.},
	keywords = {PREECLAMPSIA; microRNA; exosome; Maternal circulation},
	year = {2017},
	eissn = {2210-7797},
	pages = {207-212},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Molvarec, Attila/0000-0002-3229-3034; Joó, József Gábor/0000-0001-9820-6514; Nagy, Bálint/0000-0002-0295-185X; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:31344500,
	title = {Wybrane zagadnienia dotyczące badań nad wolnokrążącym materiałem genetycznym płodu w świetle doniesień prezentowanych na IV Środkowo-Wschodnim Europejskim Sympozjum na temat wolnokrążących kwasów nukleinowych w nieinwazyjnej diagnostyce prenatalnej},
	url = {https://m2.mtmt.hu/api/publication/31344500},
	author = {Orzińska, Agnieszka},
	journal = {Journal of Transfusion Medicine},
	volume = {10},
	unique-id = {31344500},
	year = {2017},
	eissn = {2080-1505},
	pages = {73-75}
}

@article{MTMT:26853043,
	title = {Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2},
	url = {https://m2.mtmt.hu/api/publication/26853043},
	author = {Pan, Q and Niu, H and Cheng, L and Li, X and Zhang, Q and Ning, Y},
	doi = {10.1016/j.placenta.2017.03.008},
	journal-iso = {PLACENTA},
	journal = {PLACENTA},
	volume = {53},
	unique-id = {26853043},
	issn = {0143-4004},
	abstract = {Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits trophoblastic invasion, which is correlated with PE development. In immortalized trophoblast cell lines, transwell assay showed that miR-93 mimics significantly inhibited the migration and invasion of immortalized trophoblast cells, whereas miR-93 inhibitors significantly promoted cell migration and invasion. Moreover, luciferase assays confirmed that miR-93 directly bound to the 3' untranslated region of matrix metalloproteinase-2 (MMP-2), and western blotting showed that miR-93 suppressed the expression of MMP-2 at the protein levels. This study indicated that miR-93 inhibits MMP-2 and reduces migration and invasion of immortalized trophoblast cells. Thus, miR-93 may represent a potential therapeutic target for PE intervention. (C) 2017 Elsevier Ltd. All rights reserved.},
	year = {2017},
	eissn = {1532-3102},
	pages = {48-53}
}

@article{MTMT:26853070,
	title = {New insights into the role of matrix metalloproteinases in preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/26853070},
	author = {Sosa, SEY and Flores-Pliego, A and Espejel-Nuñez, A and Medina-Bastidas, D and Vadillo-Ortega, F and Zaga-Clavellina, V and Estrada-Gutierrez, G},
	doi = {10.3390/ijms18071448},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {18},
	unique-id = {26853070},
	issn = {1661-6596},
	year = {2017},
	eissn = {1422-0067}
}