TY  - THES
AU  - Felkai, Luca
TI  - Új terápiás lehetőségek vizsgálata gyermekkori lágyrész tumorokban
PY  - 2021
SP  - 90
DO  - 10.14753/SE.2021.2459
UR  - https://m2.mtmt.hu/api/publication/32532419
ID  - 32532419
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kruseova, Jarmila
AU  - Vicha, Ales
AU  - Feriancikova, Barbara
AU  - Eckschlager, Tomas
TI  - Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review
JF  - CANCERS
J2  - CANCERS
VL  - 13
PY  - 2021
IS  - 20
PG  - 17
SN  - 2072-6694
DO  - 10.3390/cancers13205064
UR  - https://m2.mtmt.hu/api/publication/32532410
ID  - 32532410
N1  - Export Date: 7 March 2022            
            Correspondence Address: Eckschlager, T.; Department of Pediatric Hematology and Oncology, V Uvalu 84/1, Czech Republic; email: Tomas.Eckschlager@lfmotol.cuni.cz
AB  - Simple Summary Due to improvements in the treatment of childhood cancer, around 80% of children are cured. However, childhood cancer survivors are at risk of developing late effects, including subsequent malignant neoplasm; these are defined as histologically different cancers, which appear after treatment for primary cancer. The risk of subsequent malignant neoplasm formation is influenced mainly by previous anticancer therapy (chemotherapy, radiotherapy, immunotherapy, and targeted therapy), genetic factors, and the length of survival. For these reasons, at present, for the treatment of tumors with a good prognosis, it is important to consider the possible risk of late side effects e.g. use of radiotherapy in Hodgkin's lymphoma only if chemotherapy does not induce complete remission or in nephroblastoma only in locally advanced stages. Therefore, we study risk factors for the development of subsequent malignant neoplasm. In the review, we present possible risk factors for the development of subsequent neoplasm. Advances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening effects. One of the most serious late effects is a development of subsequent malignant neoplasms (histologically different cancers, which appear after the treatment for primary cancer), which occur in about 3-10% of survivors and are associated with high mortality. In cancers with a very good prognosis, subsequent malignant neoplasms significantly affect long-term survival. Therefore, there is an effort to reduce particularly hazardous treatments. This review discusses the importance of individual factors (gender, genetic factors, cytostatic drugs, radiotherapy) in the development of subsequent malignant neoplasms and the possibilities of their prediction and prevention in the future.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Youlden, D.R.
AU  - Walwyn, T.S.
AU  - Cohn, R.J.
AU  - Harden, H.E.
AU  - Pole, J.D.
AU  - Aitken, J.F.
TI  - Late mortality from other diseases following childhood cancer in Australia and the impact of intensity of treatment
JF  - PEDIATRIC BLOOD & CANCER
J2  - PEDIATR BLOOD CANCER
VL  - 68
PY  - 2021
IS  - 5
PG  - 8
SN  - 1545-5009
DO  - 10.1002/pbc.28835
UR  - https://m2.mtmt.hu/api/publication/31827141
ID  - 31827141
LA  - English
DB  - MTMT
ER  -