@article{MTMT:36166334, title = {Late Mortality Among Survivors of Childhood Cancer in Canada: A Retrospective Cohort Study}, url = {https://m2.mtmt.hu/api/publication/36166334}, author = {McKenzie, K. and Belanger, B. and Parshad, S. and Xie, L. and Grywacheski, V. and Fidler-Benaoudia, M.}, doi = {10.1002/pbc.31700}, journal-iso = {PEDIATR BLOOD CANCER}, journal = {PEDIATRIC BLOOD & CANCER}, unique-id = {36166334}, issn = {1545-5009}, year = {2025}, eissn = {1545-5017} } @article{MTMT:35938104, title = {Second Primary Neoplasms in Pediatric Cancer Survivors With Single Institution Experience From Turkey}, url = {https://m2.mtmt.hu/api/publication/35938104}, author = {Ozdemir, Hamiyet Hekimci and TurkYilmaz, Sena and Ataseven, Eda and Ozek, Gulcihan and Aksoylar, Serap and Kamer, Serra Arun and Kantar, Mehmet}, doi = {10.1097/MPH.0000000000003001}, journal-iso = {J PEDIAT HEMATOL ONC}, journal = {JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY}, volume = {47}, unique-id = {35938104}, issn = {1077-4114}, keywords = {Second primary neoplasm; late side effects; pediatric childhood survivors; radiotherapy induced neoplasm}, year = {2025}, eissn = {1536-3678}, pages = {99-107} } @article{MTMT:35646322, title = {Patterns of Childhood Cancer Mortality in Hungary Since the Turn of the Millennium, Including the Two Years of the COVID-19 Pandemic}, url = {https://m2.mtmt.hu/api/publication/35646322}, author = {Németh, Kristóf and Nyári, Tibor András and Lantos, Tamás}, doi = {10.3390/cancers16233961}, journal-iso = {CANCERS}, journal = {CANCERS}, volume = {16}, unique-id = {35646322}, abstract = {Objectives: We aimed to analyse the pattern of childhood cancer mortality among children under 15 years in Hungary between 2001 and 2021. In addition, annual and cyclical trends were examined. Methods: The number of deaths was obtained from the nationwide population register over the study period by gender, age group, and region for each year. Data were analysed using the Poisson regression method and cyclic trends were investigated using the Walter–Elwood method. Results: Overall, 14,931 childhood deaths (1092 from cancers) were registered between 2001 and 2021. The cancer mortality risk was significantly higher among boys than girls. A significantly decreasing trend was detected for yearly childhood cancer mortality rates, with an annual IRR of 0.976 (95% CI: 0.966–0.986; p < 0.001). This tendency was not influenced by the pandemic. However, different patterns of seasonal variation were revealed in childhood cancer mortality rates during 2020–2021 and 2001–2019. Conclusions: The annual trend in childhood cancer mortality was not affected by the coronavirus pandemic. However, there was a different pattern of childhood cancer mortality during the pandemic and non-pandemic period in Hungary. Considering the seasonal variation in monthly childhood cancer mortality rates, we hypothesized that environmental factors might play an important role in the aetiology of childhood cancer deaths.}, year = {2024}, eissn = {2072-6694}, orcid-numbers = {Nyári, Tibor András/0000-0001-8900-6641; Lantos, Tamás/0000-0002-5081-7313} } @mastersthesis{MTMT:32532419, title = {Új terápiás lehetőségek vizsgálata gyermekkori lágyrész tumorokban}, url = {https://m2.mtmt.hu/api/publication/32532419}, author = {Felkai, Luca}, doi = {10.14753/SE.2021.2459}, unique-id = {32532419}, year = {2021}, orcid-numbers = {Felkai, Luca/0000-0002-8992-4183} } @article{MTMT:32532410, title = {Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review}, url = {https://m2.mtmt.hu/api/publication/32532410}, author = {Kruseova, Jarmila and Vicha, Ales and Feriancikova, Barbara and Eckschlager, Tomas}, doi = {10.3390/cancers13205064}, journal-iso = {CANCERS}, journal = {CANCERS}, volume = {13}, unique-id = {32532410}, abstract = {Simple Summary Due to improvements in the treatment of childhood cancer, around 80% of children are cured. However, childhood cancer survivors are at risk of developing late effects, including subsequent malignant neoplasm; these are defined as histologically different cancers, which appear after treatment for primary cancer. The risk of subsequent malignant neoplasm formation is influenced mainly by previous anticancer therapy (chemotherapy, radiotherapy, immunotherapy, and targeted therapy), genetic factors, and the length of survival. For these reasons, at present, for the treatment of tumors with a good prognosis, it is important to consider the possible risk of late side effects e.g. use of radiotherapy in Hodgkin's lymphoma only if chemotherapy does not induce complete remission or in nephroblastoma only in locally advanced stages. Therefore, we study risk factors for the development of subsequent malignant neoplasm. In the review, we present possible risk factors for the development of subsequent neoplasm. Advances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening effects. One of the most serious late effects is a development of subsequent malignant neoplasms (histologically different cancers, which appear after the treatment for primary cancer), which occur in about 3-10% of survivors and are associated with high mortality. In cancers with a very good prognosis, subsequent malignant neoplasms significantly affect long-term survival. Therefore, there is an effort to reduce particularly hazardous treatments. This review discusses the importance of individual factors (gender, genetic factors, cytostatic drugs, radiotherapy) in the development of subsequent malignant neoplasms and the possibilities of their prediction and prevention in the future.}, year = {2021}, eissn = {2072-6694}, orcid-numbers = {Eckschlager, Tomas/0000-0002-7813-1049} } @article{MTMT:31827141, title = {Late mortality from other diseases following childhood cancer in Australia and the impact of intensity of treatment}, url = {https://m2.mtmt.hu/api/publication/31827141}, author = {Youlden, D.R. and Walwyn, T.S. and Cohn, R.J. and Harden, H.E. and Pole, J.D. and Aitken, J.F.}, doi = {10.1002/pbc.28835}, journal-iso = {PEDIATR BLOOD CANCER}, journal = {PEDIATRIC BLOOD & CANCER}, volume = {68}, unique-id = {31827141}, issn = {1545-5009}, year = {2021}, eissn = {1545-5017} }