@article{MTMT:34643757,
	title = {Identification and Functional Analysis of Cynoglossus semilaevis Z-Linked E3 Ubiquitin Ligase rnf34},
	url = {https://m2.mtmt.hu/api/publication/34643757},
	author = {Li, Lu and Li, Xihong and Chen, Yadong and Yang, Yingming and Wang, Na and Xu, Wenteng},
	doi = {10.3390/ani14020311},
	journal-iso = {ANIMALS-BASEL},
	journal = {ANIMALS},
	volume = {14},
	unique-id = {34643757},
	keywords = {Spermatogenesis; UBIQUITIN LIGASE; Cynoglossus semilaevis; RNF34; SIRNA-MEDIATED KNOCKDOWN},
	year = {2024},
	eissn = {2076-2615},
	orcid-numbers = {Xu, Wenteng/0000-0003-3887-9973}
}

@article{MTMT:33451553,
	title = {Ubiquitin-Proteasome System-Regulated Protein Degradation in Spermatogenesis},
	url = {https://m2.mtmt.hu/api/publication/33451553},
	author = {Xiong, Yi and Yu, Chao and Zhang, Qianting},
	doi = {10.3390/cells11061058},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {11},
	unique-id = {33451553},
	abstract = {Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations. The ubiquitin proteasome system (UPS) plays central roles in the precise control of protein homeostasis to ensure the effectiveness of certain protein groups at a given stage and the inactivation of them after this stage. Many UPS components have been demonstrated to regulate the progression of spermatogenesis at different levels. Especially in recent years, novel testis-specific proteasome isoforms have been identified to be essential and unique for spermatogenesis. In this review, we set out to discuss our current knowledge in functions of diverse USP components in mammalian spermatogenesis through: (1) the composition of proteasome isoforms at each stage of spermatogenesis; (2) the specificity of each proteasome isoform and the associated degradation events; (3) the E3 ubiquitin ligases mediating protein ubiquitination in male germ cells; and (4) the deubiquitinases involved in spermatogenesis and male fertility. Exploring the functions of UPS machineries in spermatogenesis provides a global picture of the proteome dynamics during male germ cell production and shed light on the etiology and pathogenesis of human male infertility.},
	keywords = {meiosis; Spermatogenesis; proteasome; Ubiquitination; E3 ubiquitin ligase; deubiquitinating enzyme (DUB)},
	year = {2022},
	eissn = {2073-4409},
	orcid-numbers = {Yu, Chao/0000-0001-9798-2992; Zhang, Qianting/0000-0002-0512-2803}
}

@article{MTMT:32373820,
	title = {Protein expression reveals a molecular sexual identity of avian primordial germ cells at pre-gonadal stages},
	url = {https://m2.mtmt.hu/api/publication/32373820},
	author = {Soler, Laura and Alves, Sabine and Brionne, Aurelien and Jacques, Aurore and Guerin, Vanessa and Cherif-Feildel, Maeva and Combes-Soia, Lucie and Fouchecourt, Sophie and Thelie, Aurore and Blesbois, Elisabeth and McGrew, Michael J. and Labas, Valerie and Govoroun, Marina S.},
	doi = {10.1038/s41598-021-98454-2},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {11},
	unique-id = {32373820},
	issn = {2045-2322},
	abstract = {In poultry, in vitro propagated primordial germ cells (PGCs) represent an important tool for the cryopreservation of avian genetic resources. However, several studies have highlighted sexual differences exhibited by PGCs during in vitro propagation, which may compromise their reproductive capacities. To understand this phenomenon, we compared the proteome of pregonadal migratory male (ZZ) and female (ZW) chicken PGCs propagated in vitro by quantitative proteomic analysis using a GeLC-MS/MS strategy. Many proteins were found to be differentially abundant in chicken male and female PGCs indicating their early sexual identity. Many of the proteins more highly expressed in male PGCs were encoded by genes localised to the Z sex chromosome. This suggests that the known lack of dosage compensation of the transcription of Z-linked genes between sexes persists at the protein level in PGCs, and that this may be a key factor of their autonomous sex differentiation. We also found that globally, protein differences do not closely correlate with transcript differences indicating a selective translational mechanism in PGCs. Male and female PGC expressed protein sets were associated with differential biological processes and contained proteins known to be biologically relevant for male and female germ cell development, respectively. We also discovered that female PGCs have a higher capacity to uptake proteins from the cell culture medium than male PGCs. This study presents the first evidence of an early predetermined sex specific cell fate of chicken PGCs and their sexual molecular specificities which will enable the development of more precise sex-specific in vitro culture conditions for the preservation of avian genetic resources.},
	year = {2021},
	eissn = {2045-2322}
}

@article{MTMT:31232051,
	title = {First person - Levente Kovacs},
	url = {https://m2.mtmt.hu/api/publication/31232051},
	author = {Kovacs, Levente},
	doi = {10.1242/jcs.243055},
	journal-iso = {J CELL SCI},
	journal = {JOURNAL OF CELL SCIENCE},
	volume = {133},
	unique-id = {31232051},
	issn = {0021-9533},
	abstract = {First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Levente Kovacs is first author on 'Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster', published in JCS. Levente conducted the research described in this article while a PhD student in Dr Peter Deak's lab at Department of Genetics, University of Szeged, Hungary. He is now a postdoc in the lab of Prof. David M Glover at the Department of Genetics, University of Cambridge, UK, investigating biochemical and genetical pathways influencing centrosome and cilia biogenesis.},
	year = {2020},
	eissn = {1477-9137}
}