TY - JOUR AU - Agarwal, Devesh S. AU - Sakhuja, Rajeev AU - Beteck, Richard M. AU - Legoabe, Lesetja J. TI - Steroid-triazole conjugates: A brief overview of synthesis and their application as anticancer agents JF - STEROIDS J2 - STEROIDS VL - 197 PY - 2023 PG - 34 SN - 0039-128X DO - 10.1016/j.steroids.2023.109258 UR - https://m2.mtmt.hu/api/publication/34237369 ID - 34237369 N1 - Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333 031, India Cited By :2 Export Date: 13 March 2024 CODEN: STEDA Correspondence Address: Legoabe, L.J.; Centre of Excellence for Pharmaceutical Sciences, Private Bag X6001, South Africa; email: lesetja.legoabe@nwu.ac.za AB - Steroids are biomolecules that play pivotal roles in various physiological and drug discovery processes. Abundant research has been fuelled towards steroid-heterocycles conjugates over the last few decades as potential thera-peutic agents against various diseases especially as anticancer agents. In this context various steroid-triazole conjugates have been synthesized and studied for their anticancer potential against various cancer cell lines. A thorough search of the literatures revealed that a concise review pertaining the present topic is not compiled. Therefore, in thus review we summarize the synthesis, anticancer activity against various cancer cell lines and structure activity relationship (SAR) of various steroid-triazole conjugates. This review can lay down the path towards the development of various steroid-heterocycles conjugates with lesser side effects and profound efficacy. LA - English DB - MTMT ER - TY - THES AU - Hazhmat, Ali TI - Evaluation of the oncopharmacological potentials of the novel A-ring modified 13α-estrone derivatives PY - 2023 UR - https://m2.mtmt.hu/api/publication/34142651 ID - 34142651 LA - English DB - MTMT ER - TY - JOUR AU - Bansal, Ranju AU - Suryan, Amruta TI - A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery JF - ACS BIO & MED CHEM AU J2 - ACS BIO & MED CHEM AU VL - 2 PY - 2022 IS - 4 SP - 340 EP - 369 PG - 30 SN - 2694-2437 DO - 10.1021/acsbiomedchemau.1c00071 UR - https://m2.mtmt.hu/api/publication/32764802 ID - 32764802 N1 - Cited By :4 Export Date: 23 May 2023 Correspondence Address: Bansal, R.; University Institute of Pharmaceutical Sciences, India; email: ranju29in@yahoo.co.in LA - English DB - MTMT ER - TY - CHAP AU - Kumar, R. AU - Maity, J. AU - Mathur, D. AU - Verma, A. AU - Rana, N. AU - Kumar, M. AU - Kumar, S. AU - Prasad, A.K. TI - Green synthesis of triazolo-nucleoside conjugates via azide-alkyne C-N bond formation T2 - Green-Bond Forming Reactions Volume 1 Carbon–Carbon and Carbon-Heteroatom Bond forming PB - De Gruyter CY - Berlin SN - 9783110759495 PY - 2022 SP - 61 EP - 104 PG - 44 DO - 10.1515/9783110759549-004 UR - https://m2.mtmt.hu/api/publication/33852679 ID - 33852679 N1 - Department of Chemistry, R.D.S. College, B.R.A. Bihar University, Muzaffarpur, India Department of Chemistry, St. Stephen's College, University of Delhi, Delhi, India Department of Chemistry, Daulat Ram College, University of Delhi, Delhi, India Department of Chemistry, Bioorganic Laboratory, University of Delhi, Delhi, India Export Date: 23 May 2023 Correspondence Address: Prasad, A.K.; Department of Chemistry, India; email: ashokenzyme@gmail.com AB - Modified nucleosides are the core precursors for the synthesis of artificial nucleic acids, and are important in the field of synthetic and medicinal chemistry. In order to synthesize various triazolo-compounds, copper and ruthenium catalysed azide-alkyne 1,3-dipolar cycloaddition reactions also known as click reaction have emerged as a facile and efficient tool due to its simplicity and convenient conditions. Introduction of a triazole ring in nucleosides enhances their therapeutic value and various photophysical properties. This review primarily focuses on the plethora of synthetic methodologies being employed to synthesize sugar modified triazolyl nucleosides, their therapeutic importance and various other applications. © 2022 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Kumar, Rajesh AU - Maity, Jyotirmoy AU - Mathur, Divya AU - Verma, Abhishek AU - Rana, Neha AU - Kumar, Manish AU - Kumar, Sandeep AU - Prasad, Ashok K. TI - Green synthesis of triazolo-nucleoside conjugates via azide-alkyne C-N bond formation JF - PHYSICAL SCIENCES REVIEWS J2 - PHYS SCI REV PY - 2022 PG - 44 SN - 2365-6581 DO - 10.1515/psr-2021-0090 UR - https://m2.mtmt.hu/api/publication/33319630 ID - 33319630 AB - Modified nucleosides are the core precursors for the synthesis of artificial nucleic acids, and are important in the field of synthetic and medicinal chemistry. In order to synthesize various triazolo-compounds, copper and ruthenium catalysed azide-alkyne 1,3-dipolar cycloaddition reactions also known as click reaction have emerged as a facile and efficient tool due to its simplicity and convenient conditions. Introduction of a triazole ring in nucleosides enhances their therapeutic value and various photophysical properties. This review primarily focuses on the plethora of synthetic methodologies being employed to synthesize sugar modified triazolyl nucleosides, their therapeutic importance and various other applications. LA - English DB - MTMT ER - TY - JOUR AU - Motiwala, Hashim F. AU - Armaly, Ahlam M. AU - Cacioppo, Jackson G. AU - Coombs, Thomas C. AU - Koehn, Kimberly R. K. AU - Norwood, Verrill M. AU - Aubé, Jeffrey TI - HFIP in Organic Synthesis JF - CHEMICAL REVIEWS J2 - CHEM REV VL - 122 PY - 2022 IS - 15 SP - 12544 EP - 12747 PG - 204 SN - 0009-2665 DO - 10.1021/acs.chemrev.1c00749 UR - https://m2.mtmt.hu/api/publication/33015365 ID - 33015365 N1 - Divison of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Department of Chemistry, University of North Carolina Wilmington, Wilmington, NC 28403, United States Cited By :43 Export Date: 23 May 2023 CODEN: CHREA Correspondence Address: Motiwala, H.F.; Divison of Chemical Biology and Medicinal Chemistry, United States; email: hashimmotiwala@gmail.com Correspondence Address: Aubé, J.; Divison of Chemical Biology and Medicinal Chemistry, United States; email: jaube@unc.edu Chemicals/CAS: hexafluoro 2 propanol, 920-66-1; propanol, 62309-51-7, 71-23-8; proton, 12408-02-5, 12586-59-3; hexafluoroisopropanol; Hydrocarbons, Fluorinated; Propanols; Protons; Solvents LA - English DB - MTMT ER - TY - BOOK AU - Atul, Kumar Srivastava AU - Rohit, Srivastava TI - ESSENTIALS OF ORGANIC CHEMISTRY [AMINO ACIDS, PEPTIDES, AND PROTEINS] PB - Ignited Minds Edutech Pvt. Ltd. CY - New Delhi PY - 2021 SN - 9789391150730 UR - https://m2.mtmt.hu/api/publication/32879080 ID - 32879080 LA - English DB - MTMT ER - TY - JOUR AU - Ibrahim-Ouali, Malika AU - Dumur, Frédéric TI - Recent syntheses of steroid derivatives using the CuAAC “click” reaction JF - ARKIVOC J2 - ARKIVOC VL - 2021 PY - 2021 IS - 9 SP - 130 EP - 149 PG - 20 SN - 1551-7012 DO - 10.24820/ark.5550190.p011.543 UR - https://m2.mtmt.hu/api/publication/32150746 ID - 32150746 N1 - Export Date: 2 May 2022 CODEN: AGFUA Correspondence Address: Ibrahim-Ouali, M.; Aix Marseille Univ, iSm2, France; email: malika.ibrahim@univ-amu.fr LA - English DB - MTMT ER - TY - JOUR AU - Perrone, Daniela AU - Marchesi, Elena AU - Preti, Lorenzo AU - Navacchia, Maria Luisa TI - Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 11 SN - 1420-3049 DO - 10.3390/molecules26113100 UR - https://m2.mtmt.hu/api/publication/32034033 ID - 32034033 N1 - Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, 44121, Italy Institute of Organic Synthesis and Photoreactivity National Research Council, Bologna, 40129, Italy Cited By :1 Export Date: 2 May 2022 CODEN: MOLEF Correspondence Address: Perrone, D.; Department of Chemical, Italy; email: prd@unife.it Correspondence Address: Navacchia, M.L.; Institute of Organic Synthesis and Photoreactivity National Research CouncilItaly; email: marialuisa.navacchia@isof.cnr.it Chemicals/CAS: adenosine, 58-61-7; azide, 12596-60-0, 14343-69-2; DNA, 9007-49-2; epidermal growth factor receptor, 79079-06-4; Adenosine; Alkynes; Azides; DNA; EGFR protein, human; ErbB Receptors; Nucleic Acids; Nucleosides; Nucleotides; Oligonucleotides, Antisense; RNA, Guide; Triazoles LA - English DB - MTMT ER - TY - JOUR AU - Yuan, Donghe AU - Wang, Shilei AU - Zhu, Gongming AU - Zhu, Anlian AU - Li, Lingjun TI - Efficient copper-catalyzed tandem oxidative iodination and alkyne-azide cycloaddition in the presence of glycine-type ligands JF - TETRAHEDRON J2 - TETRAHEDRON VL - 81 PY - 2021 PG - 5 SN - 0040-4020 DO - 10.1016/j.tet.2020.131911 UR - https://m2.mtmt.hu/api/publication/32372365 ID - 32372365 N1 - Cited By :2 Export Date: 23 May 2023 CODEN: TETRA Correspondence Address: Li, L.; Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, China; email: lingjunlee@htu.cn Correspondence Address: Zhu, G.; Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, China; email: zhugm1201@163.com Chemicals/CAS: azide, 12596-60-0, 14343-69-2; copper, 15158-11-9, 7440-50-8; glycine, 56-40-6, 6000-43-7, 6000-44-8 AB - Tandem oxidative iodination and alkyne-azide cycloaddition reaction has provided one of the most widely used methods for preparation of 5-iodo-1,2,3-triazoles. However, stoichiometric copper salts are involved in this type of reaction in order to enhance the reaction effectiveness, which caused some problems related to toxic metal contaminations and less sustainability. In this paper, we described that a copper-catalyzed (10 mol%) tandem oxidative iodination and alkyne-azide cycloaddition could be completed in the presence of the newly-found glycine-type ligands with low-cost Nal as the iodine resource. In the novel reaction system, a wide range of terminal alkyne, organic azide and inexpensive iodide could react effectively in one pot to give structurally diverse 5-iodo-1,4-subsitutied 1,2,3-triazoles. Natural product derivatives and alkynyl pyridines that hardly react under traditional conditions could also be transferred smoothly to the target products for the first time. (C) 2020 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Zolottsev, Vladimir A. AU - Latysheva, Alexandra S. AU - Pokrovsky, Vadim S. AU - Khan, Irina I. AU - Misharin, Alexander Y. TI - Promising applications of steroid conjugates for cancer research and treatment JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 210 PY - 2021 PG - 22 SN - 0223-5234 DO - 10.1016/j.ejmech.2020.113089 UR - https://m2.mtmt.hu/api/publication/31854725 ID - 31854725 N1 - Funding Agency and Grant Number: Program of State Academies of Sciences Fundamental Research for 2013e2020; Russian Science FoundationRussian Science Foundation (RSF) [18-75-10008] Funding text: Authors thank the Program of State Academies of Sciences Fundamental Research for 2013e2020 (V A.Z., A.S.L., A.Y.M.) and Russian Science Foundation #18-75-10008 (V A.Z., A.S.L., I.I.K., V.S.P.) for financial support. AB - The conjugation of biologically active molecules is a powerful tool for drug discovery used to target a variety of multifunctional diseases including cancer. Conjugated drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. Steroids are widely used for conjugation with other biological active molecules. This review refers to investigations of steroid conjugates as potential anticancer agents carried out mostly over the past decade. It consists of five parts in which the data concerning structure and anticancer activity of steroid conjugates with DNA alkylating agents, metallocomplexes, approved drugs, some biological active molecules, some natural compounds and related synthetic analogs are described. (C) 2020 Elsevier Masson SAS. All rights reserved. LA - English DB - MTMT ER - TY - THES AU - Sinka, Izabella TI - Antiproliferative and antimetastatic properties of modified estradiol analogs against gynecological cancer cell lines [Módosított ösztradiol analógok antiproliferatív és antimetasztatikus hatása nőgyógyászati tumoros sejtvonalakon] PB - Szegedi Tudományegyetem (SZTE) PY - 2020 SP - 49 DO - 10.14232/phd.10502 UR - https://m2.mtmt.hu/api/publication/31318244 ID - 31318244 N1 - Kaohsiung Medical University College of Pharmacy Graduate Institute of Natural Products LA - English DB - MTMT ER - TY - JOUR AU - Zolottsev, V. A. AU - Latysheva, A. S. AU - Pokrovsky, V. S. AU - Khan, I. I. AU - Almanza, R. L. M. AU - Misharin, A. Y. TI - STEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTS JF - RUSSIAN JOURNAL OF BIOTHERAPEUTICS J2 - RUSS J BIOTHERAP VL - 19 PY - 2020 IS - 1 SP - 22 EP - 52 PG - 31 SN - 1726-9784 DO - 10.17650/1726-9784-2019-19-1-22-52 UR - https://m2.mtmt.hu/api/publication/31262741 ID - 31262741 N1 - Institute of Biomedical Chemistry, 10 Pogodinskaya St, Moscow, 119121, Russian Federation N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 24 Kashirskoe Shosse, Moscow, 115478, Russian Federation Peoples’ Friendship, University of Russia, (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation Cited By :1 Export Date: 21 March 2024 Correspondence Address: Pokrovsky, V.S.; Institute of Biomedical Chemistry, 10 Pogodinskaya St, Russian Federation; email: vadimpokrovsky@yandex.ru LA - English DB - MTMT ER - TY - JOUR AU - Bacsa, Ildikó AU - Konc, C AU - Orosz, AB AU - Kecskeméti, Gábor AU - Laczkó-Rigó, Réka AU - Laczka, Csilla AU - Mernyák, Erzsébet TI - Synthesis of Novel C-2-or C-15-Labeled BODIPY-Estrone Conjugates JF - MOLECULES J2 - MOLECULES VL - 23 PY - 2018 IS - 4 PG - 13 SN - 1420-3049 DO - 10.3390/molecules23040821 UR - https://m2.mtmt.hu/api/publication/3360324 ID - 3360324 N1 - Department of Organic Chemistry, University of Szeged, Szeged, H-6720, Hungary Department of Medicinal Chemistry, University of Szeged, Dómtér 8, Szeged, H-6720, Hungary Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Export Date: 30 August 2019 CODEN: MOLEF Correspondence Address: Mernyák, E.; Department of Organic Chemistry, University of SzegedHungary; email: bobe@chem.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; Alkynes; Azides; Boron Compounds; Estrone Funding details: SNN 124329 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Acknowledgments: The work of Erzsébet Mernyák and Csilla Özvegy-Laczka in this project was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by National Research, Development, and Innovation Office-NKFIH through project OTKA SNN 124329. Department of Organic Chemistry, University of Szeged, Szeged, H-6720, Hungary Department of Medicinal Chemistry, University of Szeged, Dómtér 8, Szeged, H-6720, Hungary Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Cited By :1 Export Date: 11 February 2020 CODEN: MOLEF Correspondence Address: Mernyák, E.; Department of Organic Chemistry, University of SzegedHungary; email: bobe@chem.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; Alkynes; Azides; Boron Compounds; Estrone Funding details: SNN 124329 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Acknowledgments: The work of Erzsébet Mernyák and Csilla Özvegy-Laczka in this project was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by National Research, Development, and Innovation Office-NKFIH through project OTKA SNN 124329. Funding Agency and Grant Number: Hungarian Academy of SciencesHungarian Academy of Sciences; National Research, Development, and Innovation Office-NKFIH [OTKA SNN 124329] Funding text: The work of Erzsebet Mernyak and Csilla Ozvegy-Laczka in this project was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by National Research, Development, and Innovation Office-NKFIH through project OTKA SNN 124329. Department of Organic Chemistry, University of Szeged, Szeged, H-6720, Hungary Department of Medicinal Chemistry, University of Szeged, Dómtér 8, Szeged, H-6720, Hungary Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Cited By :1 Export Date: 29 August 2020 CODEN: MOLEF Correspondence Address: Mernyák, E.; Department of Organic Chemistry, University of SzegedHungary; email: bobe@chem.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; Alkynes; Azides; Boron Compounds; Estrone Funding details: SNN 124329 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Acknowledgments: The work of Erzsébet Mernyák and Csilla Özvegy-Laczka in this project was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by National Research, Development, and Innovation Office-NKFIH through project OTKA SNN 124329. Department of Organic Chemistry, University of Szeged, Szeged, H-6720, Hungary Department of Medicinal Chemistry, University of Szeged, Dómtér 8, Szeged, H-6720, Hungary Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Cited By :1 Export Date: 10 January 2021 CODEN: MOLEF Correspondence Address: Mernyák, E.; Department of Organic Chemistry, University of SzegedHungary; email: bobe@chem.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; Alkynes; Azides; Boron Compounds; Estrone Funding details: OTKA SNN 124329 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Acknowledgments: The work of Erzsébet Mernyák and Csilla Özvegy-Laczka in this project was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by National Research, Development, and Innovation Office-NKFIH through project OTKA SNN 124329. CAplus AN 2018:1757861; MEDLINE PMID: 29614041 (Journal; Article); AB - Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps. Fluorescent dyes based on BODIPY-core were provided by azide or alkyne functional groups. Fluorescent labeling of estrone was efficiently achieved at the C-2 or C-15 position. The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays. © 2018 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Shelke, Yogesh G. AU - Yashmeen, Afsana AU - Gholap, Aniket V. A. AU - Gharpure, Santosh J. AU - Kapdi, Anant R. TI - Homogeneous Catalysis: A Powerful Technology for the Modification of Important Biomolecules JF - CHEMISTRY-AN ASIAN JOURNAL J2 - CHEM-ASIAN J VL - 13 PY - 2018 IS - 20 SP - 2991 EP - 3013 PG - 23 SN - 1861-4728 DO - 10.1002/asia.201801020 UR - https://m2.mtmt.hu/api/publication/30391897 ID - 30391897 N1 - Funding Agency and Grant Number: Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Science and Educational Research Board (SERB) [EMR/2016/005439]; Council for Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) - India [02(0298)/17/EMR-II] Funding text: A.R.K. acknowledges the Alexander von Humboldt Foundation for an equipment grant. A.R.K. also thanks the Science and Educational Research Board (SERB) for a research grant (EMR/2016/005439) and the Council for Scientific and Industrial Research (CSIR) through the EMR scheme (02(0298)/17/EMR-II), as well as research fellowships for Y.G.S. and A.V.A.G. Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Mumbai, Matunga 400019, India Department of Chemistry, Indian Institute of Technology, Bombay, Main Gate Road, Mumbai, Powai 400076, India Cited By :3 Export Date: 24 May 2021 CODEN: CAAJB Correspondence Address: Gharpure, S.J.; Department of Chemistry, Main Gate Road, India; email: sjgharpure@chem.iitb.ac.in Funding details: EMR/ 2016/005439 Funding details: Alexander von Humboldt-Stiftung Funding details: Department of Science and Technology, Ministry of Science and Technology, India, DST Funding details: Bangladesh Council of Scientific and Industrial Research, BCSIR, 02(0298)/17/EMR-II Funding text 1: A.R.K. acknowledges the Alexander von Humboldt Foundation for an equipment grant. A.R.K. also thanks the Science and Educational Research Board (SERB) for a research grant (EMR/ 2016/005439) and the Council for Scientific and Industrial Research (CSIR) through the EMR scheme (02(0298)/17/EMR-II), as well as research fellowships for Y.G.S. and A.V.A.G. Funding text 2: versity of Mumbai (M.Sc. 2002) and the Uni- versity of York (M.Sc. 2005; Prof. Ian J. S. Fair- lamb). He completed his Ph.D. in 2008 under the supervision of Prof. Fairlamb at the Uni- versity of York, U.K., before undertaking post- doctoral work in the research group of Prof. Lutz Ackermann at the Georg-August Univer- sität Gçttingen as an Alexander von Hum- boldt Fellow. After returning to India in 2010, he was successful in securing the prestigious DST Fast Track fellowship and the DST Inspire faculty award. He is currently an UGC-FRP As- sistant Professor at the Institute of Chemical Technology, Mumbai. The central theme of his research is the application of palladium catalysis for the sustainable synthesis of important heterocyclic molecules, including pharmaceutical drugs, as well as the modification of several bioactive molecules. AB - Homogeneous catalysis plays an important and ubiquitous role in the synthesis of simple and complex molecules, including drug compounds, natural products, and agrochemicals. In recent years, the wide-reaching importance of homogeneous catalysis has made it an indispensable tool for the modification of biomolecules, such as carbohydrates (sugars), amino acids, peptides, nucleosides, nucleotides, and steroids. Such a synthetic strategy offers several advantages, which have led to the development of new molecules of biological relevance at a rapid rate relative to the number of available synthetic methods. Given the powerful nature of homogeneous catalysis in effecting these synthetic transformations, this Focus Review has been compiled to highlight these important developments. LA - English DB - MTMT ER - TY - JOUR AU - Sinka, Izabella AU - Kiss, Anita AU - Mernyák, Erzsébet AU - Wölfling, János AU - Schneider, Gyula AU - Ocsovszki, Imre AU - Kuo, C-Y AU - Wang, H-C AU - Zupkó, István TI - Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 123 PY - 2018 SP - 362 EP - 370 PG - 9 SN - 0928-0987 DO - 10.1016/j.ejps.2018.07.029 UR - https://m2.mtmt.hu/api/publication/3406423 ID - 3406423 N1 - Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary Department of Organic Chemistry, University of Szeged, Szeged, Hungary Department of Biochemistry, University of Szeged, Szeged, Hungary Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 11 February 2020 CODEN: EPSCE Correspondence Address: Zupkó, I.; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Eövtös u. 6, Hungary; email: zupko@pharm.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; estradiol, 50-28-2; Antineoplastic Agents; Estradiol; Focal Adhesion Kinase 1; Protein Kinase Inhibitors; PTK2 protein, human Funding details: GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00038 Funding details: K109293, K113150 Funding details: Ministry of Science and Technology, Taiwan, MOST106-2911-I-037-504 Funding details: Hungarian Scientific Research Fund Funding text 1: The authors are grateful for financial support from the Hungarian Scientific Research Fund (OTKA K109293 and K113150 ). Financial support from the Economic Development and Innovation Operative Programs ( GINOP-2.3.2-15-2016-00012 and GINOP-2.3.2-15-2016-00038 ) and Taiwan Ministry of Science and Technology Grant ( MOST106-2911-I-037-504 ) is gratefully acknowledged. Appendix A Funding Agency and Grant Number: Hungarian Scientific Research FundOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [OTKA K109293, K113150]; Economic Development and Innovation Operative Programs [GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00038]; Taiwan Ministry of Science and Technology Grant [MOST106-2911-I-037-504] Funding text: The authors are grateful for financial support from the Hungarian Scientific Research Fund (OTKA K109293 and K113150). Financial support from the Economic Development and Innovation Operative Programs (GINOP-2.3.2-15-2016-00012 and GINOP-2.3.2-15-2016-00038) and Taiwan Ministry of Science and Technology Grant (MOST106-2911-I-037-504) is gratefully acknowledged. Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary Department of Organic Chemistry, University of Szeged, Szeged, Hungary Department of Biochemistry, University of Szeged, Szeged, Hungary Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 29 August 2020 CODEN: EPSCE Correspondence Address: Zupkó, I.; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Eövtös u. 6, Hungary; email: zupko@pharm.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; estradiol, 50-28-2; Antineoplastic Agents; Estradiol; Focal Adhesion Kinase 1; Protein Kinase Inhibitors; PTK2 protein, human Funding details: GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00038 Funding details: MOST106-2911-I-037-504 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Hungarian Scientific Research Fund, OTKA, K109293, K113150 Funding text 1: The authors are grateful for financial support from the Hungarian Scientific Research Fund (OTKA K109293 and K113150 ). Financial support from the Economic Development and Innovation Operative Programs ( GINOP-2.3.2-15-2016-00012 and GINOP-2.3.2-15-2016-00038 ) and Taiwan Ministry of Science and Technology Grant ( MOST106-2911-I-037-504 ) is gratefully acknowledged. Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary Department of Organic Chemistry, University of Szeged, Szeged, Hungary Department of Biochemistry, University of Szeged, Szeged, Hungary Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 10 January 2021 CODEN: EPSCE Correspondence Address: Zupkó, I.; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Eövtös u. 6, Hungary; email: zupko@pharm.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; estradiol, 50-28-2; Antineoplastic Agents; Estradiol; Focal Adhesion Kinase 1; Protein Kinase Inhibitors; PTK2 protein, human Funding details: GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00038 Funding details: MOST106-2911-I-037-504 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Hungarian Scientific Research Fund, OTKA, K109293, K113150 Funding text 1: The authors are grateful for financial support from the Hungarian Scientific Research Fund (OTKA K109293 and K113150 ). Financial support from the Economic Development and Innovation Operative Programs ( GINOP-2.3.2-15-2016-00012 and GINOP-2.3.2-15-2016-00038 ) and Taiwan Ministry of Science and Technology Grant ( MOST106-2911-I-037-504 ) is gratefully acknowledged. Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary Department of Organic Chemistry, University of Szeged, Szeged, Hungary Department of Biochemistry, University of Szeged, Szeged, Hungary Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 31 May 2021 CODEN: EPSCE Correspondence Address: Zupkó, I.; Department of Pharmacodynamics and Biopharmacy, Szeged, Eövtös u. 6, Hungary; email: zupko@pharm.u-szeged.hu LA - English DB - MTMT ER - TY - CHAP AU - Smriti, Srivastava AU - Vipin, K Maikhuri AU - Divya, Mathur AU - Ashok, K Prasad ED - Parmar, Virinder S Malhotra Priti ED - Mathur, Divya TI - Recent Advances in Triazolyl Nucleosides T2 - Green Chemistry in Environmental Sustainability and Chemical Education PB - Springer Nature CY - Singapore SN - 9789811083891 PB - Springer Nature PY - 2018 SP - 153 EP - 173 PG - 21 DO - 10.1007/978-981-10-8390-7_16 UR - https://m2.mtmt.hu/api/publication/27624695 ID - 27624695 LA - English DB - MTMT ER - TY - JOUR AU - Bodnár, Brigitta AU - Mernyák, Erzsébet AU - Szabó, Johanna AU - Wölfling, János AU - Schneider, Gyula AU - Zupkó, István AU - Kupihár, Zoltán AU - Kovács, Lajos TI - Synthesis and in vitro investigation of potential antiproliferative monosaccharide-D-secoestrone bioconjugates JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 27 PY - 2017 IS - 9 SP - 1938 EP - 1942 PG - 5 SN - 0960-894X DO - 10.1016/j.bmcl.2017.03.029 UR - https://m2.mtmt.hu/api/publication/3201077 ID - 3201077 N1 - Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :3 Export Date: 11 February 2020 CODEN: BMCLE Correspondence Address: Kupihár, Z.; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Hungary; email: kupihar.zoltan@med.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; glucose, 50-99-7, 84778-64-3; Alkynes; Antineoplastic Agents; Azides; D-secoestrone; Estrone; Glucose; Glycoconjugates; Monosaccharides; Oximes Funding details: Hungarian Scientific Research Fund Funding details: K109293, K113150 Funding details: European Social Fund, ESF, A/2-11/1-2012-0001 Funding details: A-11/1/KONV-2012-0047, T?MOP-4.2.2 Funding text 1: The authors thank the Hungarian Scientific Research Fund ? Hungary (OTKA K113150 and K109293), the New Hungary Development Plan (T?MOP-4.2.2.A-11/1/KONV-2012-0047) for financial support. This research was also supported by the European Union and the State of Hungary, co-financed by the European Social Fund ? Belgium and Hungary (T?MOP-4.2.4.A/2-11/1-2012-0001 ?National Excellence Program?). Funding Agency and Grant Number: Hungarian Scientific Research Fund HungaryOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [OTKA K113150, K109293]; New Hungary Development Plan [TAMOP-4.2.2.A-11/1/KONV-2012-0047]; European UnionEuropean Union (EU); State of Hungary; European Social Fund - Belgium and Hungary [TAMOP-4.2.4.A/2-11/1-2012-0001] Funding text: The authors thank the Hungarian Scientific Research Fund Hungary (OTKA K113150 and K109293), the New Hungary Development Plan (TAMOP-4.2.2.A-11/1/KONV-2012-0047) for financial support. This research was also supported by the European Union and the State of Hungary, co-financed by the European Social Fund - Belgium and Hungary (TAMOP-4.2.4.A/2-11/1-2012-0001 'National Excellence Program'). Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :3 Export Date: 29 August 2020 CODEN: BMCLE Correspondence Address: Kupihár, Z.; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Hungary; email: kupihar.zoltan@med.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; glucose, 50-99-7, 84778-64-3; Alkynes; Antineoplastic Agents; Azides; D-secoestrone; Estrone; Glucose; Glycoconjugates; Monosaccharides; Oximes Funding details: European Social Fund, ESF, T?MOP-4.2.4, A/2-11/1-2012-0001 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: European Commission, EC Funding details: Hungarian Scientific Research Fund, OTKA, K109293, K113150 Funding details: -2012-0047 Funding text 1: The authors thank the Hungarian Scientific Research Fund ? Hungary (OTKA K113150 and K109293), the New Hungary Development Plan (T?MOP-4.2.2.A-11/1/KONV-2012-0047) for financial support. This research was also supported by the European Union and the State of Hungary, co-financed by the European Social Fund ? Belgium and Hungary (T?MOP-4.2.4.A/2-11/1-2012-0001 ?National Excellence Program?). Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :4 Export Date: 10 January 2021 CODEN: BMCLE Correspondence Address: Kupihár, Z.; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Hungary; email: kupihar.zoltan@med.u-szeged.hu Chemicals/CAS: azide, 12596-60-0, 14343-69-2; estrone, 53-16-7; glucose, 50-99-7, 84778-64-3; Alkynes; Antineoplastic Agents; Azides; D-secoestrone; Estrone; Glucose; Glycoconjugates; Monosaccharides; Oximes Funding details: European Social Fund, ESF, T?MOP-4.2.4, A/2-11/1-2012-0001 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: European Commission, EC Funding details: Hungarian Scientific Research Fund, OTKA, K109293, K113150 Funding details: -2012-0047 Funding text 1: The authors thank the Hungarian Scientific Research Fund ? Hungary (OTKA K113150 and K109293), the New Hungary Development Plan (T?MOP-4.2.2.A-11/1/KONV-2012-0047) for financial support. This research was also supported by the European Union and the State of Hungary, co-financed by the European Social Fund ? Belgium and Hungary (T?MOP-4.2.4.A/2-11/1-2012-0001 ?National Excellence Program?). AB - The syntheses of monosaccharide–D-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-D-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC). The antiproliferative activities of the conjugates were investigated in vitro against a panel of human adherent cancer cell lines (HeLa, A2780 and MCF-7) by means of MTT assays. The protected D-glucose-containing D-secoestrone oxime bioconjugate (24b) proved to be the most effective with an IC50 value in the low micromolar range against A2780 cell line. © 2017 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Jopp, S AU - Liesegang, M AU - Ehlers, P AU - Nagyné Frank, Éva AU - Schneider, Gyula AU - Wölfling, János AU - Villinger, A AU - Langer, P TI - Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone JF - SYNLETT J2 - SYNLETT VL - 28 PY - 2017 IS - 19 SP - 2647 EP - 2649 PG - 3 SN - 0936-5214 DO - 10.1055/s-0036-1588537 UR - https://m2.mtmt.hu/api/publication/3255572 ID - 3255572 LA - English DB - MTMT ER - TY - JOUR AU - Malkowski, Sarah N AU - Dishuck, Carolyn F AU - Lamanilao, Gene G AU - Embry, Carter P AU - Grubb, Christopher S AU - Cafiero, Mauricio AU - Peterson, Larryn W TI - Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents JF - MOLECULES J2 - MOLECULES VL - 22 PY - 2017 IS - 10 PG - 14 SN - 1420-3049 DO - 10.3390/molecules22101682 UR - https://m2.mtmt.hu/api/publication/27239467 ID - 27239467 N1 - Cited By :11 Export Date: 2 May 2022 CODEN: MOLEF Correspondence Address: Peterson, L.W.; Department of Chemistry, 2000 North Parkway, United States; email: petersonl@rhodes.edu Chemicals/CAS: amino acid, 65072-01-7; azide, 12596-60-0, 14343-69-2; copper, 15158-11-9, 7440-50-8; Alkynes; Amino Acids; Anti-Bacterial Agents; Azides; Copper; Nucleosides; Triazoles LA - English DB - MTMT ER -