@article{MTMT:34237369,
	title = {Steroid-triazole conjugates: A brief overview of synthesis and their application as anticancer agents},
	url = {https://m2.mtmt.hu/api/publication/34237369},
	author = {Agarwal, Devesh S. and Sakhuja, Rajeev and Beteck, Richard M. and Legoabe, Lesetja J.},
	doi = {10.1016/j.steroids.2023.109258},
	journal-iso = {STEROIDS},
	journal = {STEROIDS},
	volume = {197},
	unique-id = {34237369},
	issn = {0039-128X},
	abstract = {Steroids are biomolecules that play pivotal roles in various physiological and drug discovery processes. Abundant research has been fuelled towards steroid-heterocycles conjugates over the last few decades as potential thera-peutic agents against various diseases especially as anticancer agents. In this context various steroid-triazole conjugates have been synthesized and studied for their anticancer potential against various cancer cell lines. A thorough search of the literatures revealed that a concise review pertaining the present topic is not compiled. Therefore, in thus review we summarize the synthesis, anticancer activity against various cancer cell lines and structure activity relationship (SAR) of various steroid-triazole conjugates. This review can lay down the path towards the development of various steroid-heterocycles conjugates with lesser side effects and profound efficacy.},
	keywords = {synthesis; STEROIDS; Anticancer agents; Triazoles; Steroid-triazole conjugates},
	year = {2023},
	eissn = {1878-5867}
}

@mastersthesis{MTMT:34142651,
	title = {Evaluation of the oncopharmacological potentials of the novel A-ring modified 13α-estrone derivatives},
	url = {https://m2.mtmt.hu/api/publication/34142651},
	author = {Hazhmat, Ali},
	unique-id = {34142651},
	year = {2023}
}

@article{MTMT:32764802,
	title = {A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery},
	url = {https://m2.mtmt.hu/api/publication/32764802},
	author = {Bansal, Ranju and Suryan, Amruta},
	doi = {10.1021/acsbiomedchemau.1c00071},
	journal-iso = {ACS BIO & MED CHEM AU},
	journal = {ACS BIO & MED CHEM AU},
	volume = {2},
	unique-id = {32764802},
	year = {2022},
	eissn = {2694-2437},
	pages = {340-369},
	orcid-numbers = {Bansal, Ranju/0000-0002-8448-4887}
}

@{MTMT:33852679,
	title = {Green synthesis of triazolo-nucleoside conjugates via azide-alkyne C-N bond formation},
	url = {https://m2.mtmt.hu/api/publication/33852679},
	author = {Kumar, R. and Maity, J. and Mathur, D. and Verma, A. and Rana, N. and Kumar, M. and Kumar, S. and Prasad, A.K.},
	booktitle = {Green-Bond Forming Reactions Volume 1 Carbon–Carbon and Carbon-Heteroatom Bond forming},
	doi = {10.1515/9783110759549-004},
	unique-id = {33852679},
	abstract = {Modified nucleosides are the core precursors for the synthesis of artificial nucleic acids, and are important in the field of synthetic and medicinal chemistry. In order to synthesize various triazolo-compounds, copper and ruthenium catalysed azide-alkyne 1,3-dipolar cycloaddition reactions also known as click reaction have emerged as a facile and efficient tool due to its simplicity and convenient conditions. Introduction of a triazole ring in nucleosides enhances their therapeutic value and various photophysical properties. This review primarily focuses on the plethora of synthetic methodologies being employed to synthesize sugar modified triazolyl nucleosides, their therapeutic importance and various other applications. © 2022 Walter de Gruyter GmbH, Berlin/Boston. All rights reserved.},
	keywords = {Click chemistry; Antiviral; Anticancer activity; Azide-alkyne; Triazolo-nucleoside},
	year = {2022},
	pages = {61-104}
}

@article{MTMT:33319630,
	title = {Green synthesis of triazolo-nucleoside conjugates via azide-alkyne C-N bond formation},
	url = {https://m2.mtmt.hu/api/publication/33319630},
	author = {Kumar, Rajesh and Maity, Jyotirmoy and Mathur, Divya and Verma, Abhishek and Rana, Neha and Kumar, Manish and Kumar, Sandeep and Prasad, Ashok K.},
	doi = {10.1515/psr-2021-0090},
	journal-iso = {PHYS SCI REV},
	journal = {PHYSICAL SCIENCES REVIEWS},
	unique-id = {33319630},
	issn = {2365-6581},
	abstract = {Modified nucleosides are the core precursors for the synthesis of artificial nucleic acids, and are important in the field of synthetic and medicinal chemistry. In order to synthesize various triazolo-compounds, copper and ruthenium catalysed azide-alkyne 1,3-dipolar cycloaddition reactions also known as click reaction have emerged as a facile and efficient tool due to its simplicity and convenient conditions. Introduction of a triazole ring in nucleosides enhances their therapeutic value and various photophysical properties. This review primarily focuses on the plethora of synthetic methodologies being employed to synthesize sugar modified triazolyl nucleosides, their therapeutic importance and various other applications.},
	keywords = {Click chemistry; Antiviral; Anticancer activity; Azide-alkyne; Triazolo-nucleoside},
	year = {2022},
	eissn = {2365-659X},
	orcid-numbers = {Mathur, Divya/0000-0002-0277-1509}
}

@article{MTMT:33015365,
	title = {HFIP in Organic Synthesis},
	url = {https://m2.mtmt.hu/api/publication/33015365},
	author = {Motiwala, Hashim F. and Armaly, Ahlam M. and Cacioppo, Jackson G. and Coombs, Thomas C. and Koehn, Kimberly R. K. and Norwood, Verrill M. and Aubé, Jeffrey},
	doi = {10.1021/acs.chemrev.1c00749},
	journal-iso = {CHEM REV},
	journal = {CHEMICAL REVIEWS},
	volume = {122},
	unique-id = {33015365},
	issn = {0009-2665},
	year = {2022},
	eissn = {1520-6890},
	pages = {12544-12747},
	orcid-numbers = {Motiwala, Hashim F./0000-0001-5926-3743; Cacioppo, Jackson G./0000-0002-6514-0739; Coombs, Thomas C./0000-0002-3742-5147; Norwood, Verrill M./0000-0001-5493-3787; Aubé, Jeffrey/0000-0003-1049-5767}
}

@book{MTMT:32879080,
	title = {ESSENTIALS OF ORGANIC CHEMISTRY [AMINO ACIDS, PEPTIDES, AND PROTEINS]},
	url = {https://m2.mtmt.hu/api/publication/32879080},
	isbn = {9789391150730},
	author = {Atul, Kumar Srivastava and Rohit, Srivastava},
	publisher = {Ignited Minds Edutech Pvt. Ltd.},
	unique-id = {32879080},
	year = {2021}
}

@article{MTMT:32150746,
	title = {Recent syntheses of steroid derivatives using the CuAAC “click” reaction},
	url = {https://m2.mtmt.hu/api/publication/32150746},
	author = {Ibrahim-Ouali, Malika and Dumur, Frédéric},
	doi = {10.24820/ark.5550190.p011.543},
	journal-iso = {ARKIVOC},
	journal = {ARKIVOC},
	volume = {2021},
	unique-id = {32150746},
	issn = {1551-7012},
	year = {2021},
	eissn = {1551-7004},
	pages = {130-149}
}

@article{MTMT:32034033,
	title = {Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications},
	url = {https://m2.mtmt.hu/api/publication/32034033},
	author = {Perrone, Daniela and Marchesi, Elena and Preti, Lorenzo and Navacchia, Maria Luisa},
	doi = {10.3390/molecules26113100},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {26},
	unique-id = {32034033},
	issn = {1420-3049},
	year = {2021},
	eissn = {1420-3049},
	orcid-numbers = {Perrone, Daniela/0000-0001-5189-011X; Navacchia, Maria Luisa/0000-0001-7175-1504}
}

@article{MTMT:32372365,
	title = {Efficient copper-catalyzed tandem oxidative iodination and alkyne-azide cycloaddition in the presence of glycine-type ligands},
	url = {https://m2.mtmt.hu/api/publication/32372365},
	author = {Yuan, Donghe and Wang, Shilei and Zhu, Gongming and Zhu, Anlian and Li, Lingjun},
	doi = {10.1016/j.tet.2020.131911},
	journal-iso = {TETRAHEDRON},
	journal = {TETRAHEDRON},
	volume = {81},
	unique-id = {32372365},
	issn = {0040-4020},
	abstract = {Tandem oxidative iodination and alkyne-azide cycloaddition reaction has provided one of the most widely used methods for preparation of 5-iodo-1,2,3-triazoles. However, stoichiometric copper salts are involved in this type of reaction in order to enhance the reaction effectiveness, which caused some problems related to toxic metal contaminations and less sustainability. In this paper, we described that a copper-catalyzed (10 mol%) tandem oxidative iodination and alkyne-azide cycloaddition could be completed in the presence of the newly-found glycine-type ligands with low-cost Nal as the iodine resource. In the novel reaction system, a wide range of terminal alkyne, organic azide and inexpensive iodide could react effectively in one pot to give structurally diverse 5-iodo-1,4-subsitutied 1,2,3-triazoles. Natural product derivatives and alkynyl pyridines that hardly react under traditional conditions could also be transferred smoothly to the target products for the first time. (C) 2020 Elsevier Ltd. All rights reserved.},
	keywords = {CuAAC reaction; 5-iodo-1,2,3-triazole; Oxidation iodination; Glycine-type ligands},
	year = {2021},
	eissn = {1464-5416}
}

@article{MTMT:31854725,
	title = {Promising applications of steroid conjugates for cancer research and treatment},
	url = {https://m2.mtmt.hu/api/publication/31854725},
	author = {Zolottsev, Vladimir A. and Latysheva, Alexandra S. and Pokrovsky, Vadim S. and Khan, Irina I. and Misharin, Alexander Y.},
	doi = {10.1016/j.ejmech.2020.113089},
	journal-iso = {EUR J MED CHEM},
	journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},
	volume = {210},
	unique-id = {31854725},
	issn = {0223-5234},
	abstract = {The conjugation of biologically active molecules is a powerful tool for drug discovery used to target a variety of multifunctional diseases including cancer. Conjugated drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. Steroids are widely used for conjugation with other biological active molecules. This review refers to investigations of steroid conjugates as potential anticancer agents carried out mostly over the past decade. It consists of five parts in which the data concerning structure and anticancer activity of steroid conjugates with DNA alkylating agents, metallocomplexes, approved drugs, some biological active molecules, some natural compounds and related synthetic analogs are described. (C) 2020 Elsevier Masson SAS. All rights reserved.},
	keywords = {BREAST-CANCER; BIOLOGICAL EVALUATION; PLATINUM(II) COMPLEXES; ANTIPROLIFERATIVE ACTIVITY; androgen receptor; Lymphoproliferative Disorders; ESTROGEN-RECEPTOR-ALPHA; Steroid conjugates; ALKYLATING CORTICOSTEROID ESTER; NITROGEN-MUSTARD; LEO 1031},
	year = {2021},
	eissn = {1768-3254}
}

@mastersthesis{MTMT:31318244,
	title = {Antiproliferative and antimetastatic properties of modified estradiol analogs against gynecological cancer cell lines [Módosított ösztradiol analógok antiproliferatív és antimetasztatikus hatása nőgyógyászati tumoros sejtvonalakon]},
	url = {https://m2.mtmt.hu/api/publication/31318244},
	author = {Sinka, Izabella},
	doi = {10.14232/phd.10502},
	publisher = {SZTE},
	unique-id = {31318244},
	year = {2020}
}

@article{MTMT:31262741,
	title = {STEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTS},
	url = {https://m2.mtmt.hu/api/publication/31262741},
	author = {Zolottsev, V. A. and Latysheva, A. S. and Pokrovsky, V. S. and Khan, I. I. and Almanza, R. L. M. and Misharin, A. Y.},
	doi = {10.17650/1726-9784-2019-19-1-22-52},
	journal-iso = {RUSS J BIOTHERAP},
	journal = {RUSSIAN JOURNAL OF BIOTHERAPEUTICS},
	volume = {19},
	unique-id = {31262741},
	issn = {1726-9784},
	year = {2020},
	eissn = {1726-9792},
	pages = {22-52}
}

@article{MTMT:3360324,
	title = {Synthesis of Novel C-2-or C-15-Labeled BODIPY-Estrone Conjugates},
	url = {https://m2.mtmt.hu/api/publication/3360324},
	author = {Bacsa, Ildikó and Konc, C and Orosz, AB and Kecskeméti, Gábor and Laczkó-Rigó, Réka and Laczka, Csilla and Mernyák, Erzsébet},
	doi = {10.3390/molecules23040821},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {23},
	unique-id = {3360324},
	issn = {1420-3049},
	abstract = {Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps. Fluorescent dyes based on BODIPY-core were provided by azide or alkyne functional groups. Fluorescent labeling of estrone was efficiently achieved at the C-2 or C-15 position. The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays. © 2018 by the authors.},
	keywords = {ESTRONE; Fluorescent labeling; CuAAC; BODIPY; Estrone conjugates},
	year = {2018},
	eissn = {1420-3049},
	orcid-numbers = {Bacsa, Ildikó/0000-0001-8277-631X; Kecskeméti, Gábor/0000-0002-5584-6869; Mernyák, Erzsébet/0000-0003-4494-1817}
}

@article{MTMT:30391897,
	title = {Homogeneous Catalysis: A Powerful Technology for the Modification of Important Biomolecules},
	url = {https://m2.mtmt.hu/api/publication/30391897},
	author = {Shelke, Yogesh G. and Yashmeen, Afsana and Gholap, Aniket V. A. and Gharpure, Santosh J. and Kapdi, Anant R.},
	doi = {10.1002/asia.201801020},
	journal-iso = {CHEM-ASIAN J},
	journal = {CHEMISTRY-AN ASIAN JOURNAL},
	volume = {13},
	unique-id = {30391897},
	issn = {1861-4728},
	abstract = {Homogeneous catalysis plays an important and ubiquitous role in the synthesis of simple and complex molecules, including drug compounds, natural products, and agrochemicals. In recent years, the wide-reaching importance of homogeneous catalysis has made it an indispensable tool for the modification of biomolecules, such as carbohydrates (sugars), amino acids, peptides, nucleosides, nucleotides, and steroids. Such a synthetic strategy offers several advantages, which have led to the development of new molecules of biological relevance at a rapid rate relative to the number of available synthetic methods. Given the powerful nature of homogeneous catalysis in effecting these synthetic transformations, this Focus Review has been compiled to highlight these important developments.},
	keywords = {PEPTIDES; carbohydrates; amino acids; synthetic methods; homogeneous catalysis},
	year = {2018},
	eissn = {1861-471X},
	pages = {2991-3013}
}

@article{MTMT:3406423,
	title = {Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines},
	url = {https://m2.mtmt.hu/api/publication/3406423},
	author = {Sinka, Izabella and Kiss, Anita and Mernyák, Erzsébet and Wölfling, János and Schneider, Gyula and Ocsovszki, Imre and Kuo, C-Y and Wang, H-C and Zupkó, István},
	doi = {10.1016/j.ejps.2018.07.029},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {123},
	unique-id = {3406423},
	issn = {0928-0987},
	year = {2018},
	eissn = {1879-0720},
	pages = {362-370},
	orcid-numbers = {Kiss, Anita/0000-0003-3352-0996; Mernyák, Erzsébet/0000-0003-4494-1817; Wölfling, János/0000-0002-3037-309X; Ocsovszki, Imre/0000-0003-1290-996X; Zupkó, István/0000-0003-3243-5300}
}

@inproceedings{MTMT:27624695,
	title = {Recent Advances in Triazolyl Nucleosides},
	url = {https://m2.mtmt.hu/api/publication/27624695},
	author = {Smriti, Srivastava and Vipin, K Maikhuri and Divya, Mathur and Ashok, K Prasad},
	booktitle = {Green Chemistry in Environmental Sustainability and Chemical Education},
	doi = {10.1007/978-981-10-8390-7_16},
	publisher = {Springer Nature Ltd},
	unique-id = {27624695},
	year = {2018},
	pages = {153-173}
}

@article{MTMT:3201077,
	title = {Synthesis and in vitro investigation of potential antiproliferative monosaccharide-D-secoestrone bioconjugates},
	url = {https://m2.mtmt.hu/api/publication/3201077},
	author = {Bodnár, Brigitta and Mernyák, Erzsébet and Szabó, Johanna and Wölfling, János and Schneider, Gyula and Zupkó, István and Kupihár, Zoltán and Kovács, Lajos},
	doi = {10.1016/j.bmcl.2017.03.029},
	journal-iso = {BIOORG MED CHEM LETT},
	journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
	volume = {27},
	unique-id = {3201077},
	issn = {0960-894X},
	abstract = {The syntheses of monosaccharide–D-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-D-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC). The antiproliferative activities of the conjugates were investigated in vitro against a panel of human adherent cancer cell lines (HeLa, A2780 and MCF-7) by means of MTT assays. The protected D-glucose-containing D-secoestrone oxime bioconjugate (24b) proved to be the most effective with an IC50 value in the low micromolar range against A2780 cell line. © 2017 Elsevier Ltd},
	year = {2017},
	eissn = {1464-3405},
	pages = {1938-1942},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817; Wölfling, János/0000-0002-3037-309X; Zupkó, István/0000-0003-3243-5300; Kupihár, Zoltán/0000-0001-5499-7617; Kovács, Lajos/0000-0002-0331-3980}
}

@article{MTMT:3255572,
	title = {Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone},
	url = {https://m2.mtmt.hu/api/publication/3255572},
	author = {Jopp, S and Liesegang, M and Ehlers, P and Nagyné Frank, Éva and Schneider, Gyula and Wölfling, János and Villinger, A and Langer, P},
	doi = {10.1055/s-0036-1588537},
	journal-iso = {SYNLETT},
	journal = {SYNLETT},
	volume = {28},
	unique-id = {3255572},
	issn = {0936-5214},
	year = {2017},
	eissn = {1437-2096},
	pages = {2647-2649},
	orcid-numbers = {Nagyné Frank, Éva/0000-0002-1332-0551; Wölfling, János/0000-0002-3037-309X}
}

@article{MTMT:27239467,
	title = {Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents},
	url = {https://m2.mtmt.hu/api/publication/27239467},
	author = {Malkowski, Sarah N and Dishuck, Carolyn F and Lamanilao, Gene G and Embry, Carter P and Grubb, Christopher S and Cafiero, Mauricio and Peterson, Larryn W},
	doi = {10.3390/molecules22101682},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {22},
	unique-id = {27239467},
	issn = {1420-3049},
	year = {2017},
	eissn = {1420-3049}
}