TY - JOUR AU - Alperth, Fabian AU - Feistritzer, Theresa AU - Huber, Melanie AU - Kunert, Olaf AU - Bucar, Franz TI - Natural Deep Eutectic Solvents for the Extraction of Spilanthol from Acmella oleracea (L.) R.K.Jansen JF - MOLECULES J2 - MOLECULES VL - 29 PY - 2024 IS - 3 PG - 15 SN - 1420-3049 DO - 10.3390/molecules29030612 UR - https://m2.mtmt.hu/api/publication/34562583 ID - 34562583 N1 - Export Date: 28 February 2024; CODEN: MOLEF AB - With a growing focus on green chemistry, the extraction of natural products with natural deep eutectic solvents (NADES), which are eutectic mixtures of hydrogen bond donors and acceptors, has become an ever-expanding field of research. However, the use of NADES for the extraction of spilanthol from Acmella oleracea (L.) R.K.Jansen has not yet been investigated. Therefore, in this study, 20 choline chloride-based NADES, and for comparison, ethanol, were used as green extraction agents for spilanthol from Acmella oleracea flower heads. The effects of time, water addition, and temperature on NADES extractions were investigated and analysed by HPLC-DAD quantification. Additionally, UHPLC-DAD-ESI-MSn results for dichloromethane extracts, as well as the isolation of spilanthol and other main constituents as reference compounds, are reported. The best green extraction results were achieved by choline chloride (ChCl) with 1,2-propanediol (P, 1:2 molar ratio, +20% water) at 244.58 µg/mL, comparable to yields with ethanol (245.93 µg/mL). Methylurea (MeU, 1:2, +20% water) also showed promising results as a hydrogen bond donor in combination with choline chloride (208.12 µg/mL). In further experiments with NADES ChCl/P (1:2) and ChCl/MeU (1:2), extraction time had the least effect on spilanthol extraction with NADES, while yield decreased with water addition over 20% and increased with extraction temperature up to 80 °C. NADES are promising extraction agents for the extraction of spilanthol, and these findings could lead to applicable extracts for medicinal purposes, due to their non-toxic constituents. LA - English DB - MTMT ER - TY - JOUR AU - Cai, F. AU - Wang, C. TI - Comprehensive review of the phytochemistry, pharmacology, pharmacokinetics, and toxicology of alkamides (2016–2022) JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY VL - 220 PY - 2024 SN - 0031-9422 DO - 10.1016/j.phytochem.2024.114006 UR - https://m2.mtmt.hu/api/publication/34747043 ID - 34747043 N1 - Export Date: 20 March 2024 CODEN: PYTCA Correspondence Address: Wang, C.; The Institute of Chinese Materia Medica, China; email: wchcxm@hotmail.com AB - Alkamides refer to a class of natural active small-molecule products composed of fatty acids and amine groups. These compounds are widely distributed in plants, and their unique structures and various pharmacological activities have caught the attention of scholars. This review provides a collection of literatures related to the phytochemistry, pharmacological effects, pharmacokinetics, and toxicity of alkamides published in 2016–2022 and their summary to provide references for further development of this class of ingredients. A total of 234 components (including chiral isomers) were summarized, pharmacological activities, such as anti-inflammatory, antitumor, antidiabetic, analgesic, neuroprotective, insecticidal, antioxidant, and antibacterial, and miscellaneous properties of alkamides were discussed. In addition, the pharmacokinetic characteristics and toxicity of alkamides were reviewed. However, information on the pharmacological mechanisms of the action, drug safety, and pharmacokinetics of alkamides is limited and thus requires further investigation and evaluation. © 2024 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Cai, Fujie AU - Wang, Changhong TI - Comprehensive review of the phytochemistry, pharmacology, pharmacokinetics, and toxicology of alkamides (2016–2022) JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY PY - 2024 SN - 0031-9422 DO - 10.1016/j.phytochem.2024.114006 UR - https://m2.mtmt.hu/api/publication/34562592 ID - 34562592 LA - English DB - MTMT ER - TY - JOUR AU - Chen, J. AU - Mei, Q. AU - Wang, L. AU - Wei, Y. TI - DEFB114 protein enhances host resistance to fungal infection through the NOD1/2-ATG16L1-NF-κB signaling pathway JF - BIOORGANIC CHEMISTRY J2 - BIOORG CHEM VL - 146 PY - 2024 SN - 0045-2068 DO - 10.1016/j.bioorg.2024.107245 UR - https://m2.mtmt.hu/api/publication/34747041 ID - 34747041 N1 - Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Southwest Minzu University, Chengdu, 610041, China Key Laboratory of Animal Science of State Ethnic Affairs Commission, Southwest Minzu University, Chengdu, 610041, China Animal Genetics and Breeding Key Laboratory of Sichuan Province, Sichuan Animal Sciences Academy, Chengdu, 610066, China Export Date: 20 March 2024 CODEN: BOCMB Correspondence Address: Wang, L.; Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, China; email: qinxin916@aliyun.com AB - The overuse of antibiotics has led to the enhanced resistance of many pathogenic bacteria, posing a threat to human health. Therefore, there is a need to develop green and safe alternatives to antibiotics. Beta-defensins play a crucial role in host defense against pathogens and have multifunctional properties, exerting key roles in innate and adaptive immunity, as well as non-immune processes. In this study, a 210 bp long cDNA sequence of yak DEFB114 gene was amplified and successfully expressed in a prokaryotic system. The DEFB114 protein exhibited significant inhibitory effects on the growth of Aspergillus fumigatus in vitro. When co-cultured with yak macrophages, DEFB114 protein enhanced macrophage phagocytic activity and increased nucleic acid fluorescence intensity (P < 0.05). DEFB114 protein also enhanced the activity of yak macrophages stimulated by inactivated Aspergillus fumigatus spores, increased the release of nitric oxide (NO), and promoted the expression of genes such as γ-actin, Lgals, Man2b, and Capg (P < 0.05). In mice experiments, DEFB114 protein promoted resistance against Aspergillus fumigatus infection, by regulating the NOD1/2-ATG16L1-NF-κB pathway to modulate the host immune response and exert its anti-infective effects. In summary, the yak DEFB114 protein could inhibit the growth of Aspergillus fumigatus and enhance the animal's resistance to pathogenic microorganisms, thereby having significant implications in the treatment and prevention of fungal infections. © 2024 Elsevier Inc. LA - English DB - MTMT ER - TY - JOUR AU - Batista, Lecildo Lira AU - Koga, Rosemary de Carvalho Rocha AU - Teixeira, Abrahao Victor Tavares de Lima AU - Teixeira, Thiago Afonso AU - de Melo, Ester Lopes AU - Carvalho, Jose Carlos Tavares TI - Clinical Safety of a Pharmaceutical Formulation Containing an Extract of Acmella oleracea (L.) in Patients With Premature Ejaculation: A Pilot Study JF - AMERICAN JOURNAL OF MENS HEALTH J2 - AM J MENS HEALTH VL - 17 PY - 2023 IS - 2 PG - 11 SN - 1557-9883 DO - 10.1177/15579883231167819 UR - https://m2.mtmt.hu/api/publication/33858076 ID - 33858076 AB - Acmella oleracea (L.) R. K. Jansen (Asteraceae) is a plant species widely used in traditional Amazonian medicine to treat sexual dysfunction. The use of this plant has gained popularity because of its sensory properties, such as a tingling sensation. In this study on patients with premature ejaculation, we evaluated the clinical action of a nano-formulation containing an ethanolic extract of A. oleracea inflorescences. Major constituents in the extracts were identified based on gas chromatographic analysis. Participants used a spray preparation based on the A. oleracea extract for 12 weeks, during which they were instructed to apply the product 5 min prior to sexual intercourse. To assess therapeutic efficacy, participants were required to record the mean intravaginal latency time for ejaculation (IELT). During the period of spray treatment, the nano-formulation of A. oleracea increased participant IELT values (M = 293 s) compared with the baseline values (193 s). This nano-formulation reported clinical action in patients with premature ejaculation. It is accordingly considered to have potential application as a therapeutic alternative with benefits for both patients and their partners. Given the small number of participants in this study, further multicenter studies involving a larger number of participants are needed to confirm these observations. LA - English DB - MTMT ER - TY - JOUR AU - Chu, Wei AU - Li, Ya-ling AU - Li, Jun-jie AU - Lin, Jia AU - Li, Mi AU - Wang, Jiao AU - He, Jian-zheng AU - Zhang, Yue-mei AU - Yao, Juan AU - Jin, Xiao-jie AU - Cai, Hui AU - Liu, Yong-qi TI - Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization JF - BIOMEDICINE & PHARMACOTHERAPY J2 - BIOMED PHARMACOTHER VL - 164 PY - 2023 PG - 15 SN - 0753-3322 DO - 10.1016/j.biopha.2023.114902 UR - https://m2.mtmt.hu/api/publication/34088591 ID - 34088591 AB - Background: Intestinal mucositis (IM) is characterized by damage to the intestinal mucosa resulting from inhi-bition of epithelial cell division and loss of renewal capacity following anticancer chemotherapy and radio-therapy. Cytarabine (Ara-C), the main chemotherapy drug for the treatment of leukemia and lymphoma, is a frequent cause of IM. Guiqi Baizhu prescription (GQBZP) is a traditional Chinese medicine with anti-cancer and anti-inflammatory effects.Purpose: To determine if GQBZP can ameliorate Ara-C induced IM and identify and characterize the pharma-cologic and pharmacodynamic mechanisms.Study design and methods: IM was induced in mice with Ara-C and concurrently treated with orally administered GQBZP. Body weight and food intake was monitored, with HE staining to calculate ileal histomorphometric scoring and villus length/crypt depth. Immunoblotting was used to detect intestinal tissue inflammatory factors. M1 macrophages (M1) were labeled with CD86 by flow cytometry and iNOS + F4/80 by immunofluorescence. Virtual screening was used to find potentially active compounds in GQBZP that targeted JAK2. In vitro, RAW264.7 cells were skewed to M1 macrophage polarization by lipopolysaccharide (LPS) and interferon-gamma (INF-gamma) and treated orally with GQBZP or potential active compounds. M1 was labeled with CD86 by flow cytometry and iNOS by immunofluorescence. ELISA was used to detect inflammatory factor expression. Active compounds against JAK2, p-JAK2, STAT1 and p-STAT1 were identified by western blotting and HCS fluorescence. Molecular dynamics simulations and pharmacokinetic predictions were carried out on representative active compounds.Results: Experimental results with mice in vivo suggest that GQBZP significantly attenuated Ara-C-induced ileal damage and release of pro-inflammatory factors by inhibiting macrophage polarization to M1. Molecular docking was used to identify potentially active compounds in GQBZP that targeted JAK2, a key factor in macrophage polarization to M1. By examining the main components of each herb and applying Lipinski's rules, ten poten-tially active compounds were identified. In vitro experimental results suggested that all 10 compounds of GQBZP targeted JAK2 and could inhibit M1 polarization in RAW264.7 cells treated with LPS and INF-gamma. Among them, acridine and senkyunolide A down-regulated the expression of JAK2 and STAT1. MD simulations revealed that acridine and senkyunolide A were stable in the active site of JAK2 and exhibited good interactions with the surrounding amino acids.Conclusions: GQBZP can ameliorate Ara-C-induced IM by reducing macrophage polarization to M1, and acridine and senkyunolide A are representative active compounds in GQBZP that target JAK2 to inhibit M1 polarization. Targeting JAK2 to regulate M1 polarization may be a valuable therapeutic strategy for IM. LA - English DB - MTMT ER - TY - JOUR AU - Kavallieratos, Nickolas G. AU - Spinozzi, Eleonora AU - Filintas, Constantin S. AU - Nika, Erifili P. AU - Skourti, Anna AU - Panariti, Anna Maria E. AU - Ferrati, Marta AU - Petrelli, Riccardo AU - Ricciutelli, Massimo AU - Angeloni, Simone AU - Drenaggi, Ettore AU - Sensini, Alessia AU - Maggi, Filippo AU - Canale, Angelo AU - Benelli, Giovanni TI - Acmella oleracea extracts as green pesticides against eight arthropods attacking stored products JF - ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH J2 - ENVIRON SCI POLLUT R VL - 30 PY - 2023 IS - 41 SP - 94904 EP - 94927 PG - 24 SN - 0944-1344 DO - 10.1007/s11356-023-28577-8 UR - https://m2.mtmt.hu/api/publication/34329631 ID - 34329631 N1 - Export Date: 28 November 2023; CODEN: ESPLE AB - Developing sustainable control tools for managing noxious pests attacking stored foodstuffs is a timely research challenge. Acmella oleracea (L.) R. K. Jansen is a crop widely cultivated for its multiple usages on an industrial level. In this study, the extracts prepared with A. oleracea aerial parts were applied on wheat kernels for the management of eight important arthropod pests attacking stored products, i.e., Cryptolestes ferrugineus, Tenebrio molitor, Oryzaephilus surinamensis, Trogoderma granarium, Tribolium castaneum, Tribolium confusum, Alphitobius diaperinus (adults/larvae), and Acarus siro (adults/nymphs). Extraction of A. oleracea was optimized on the base of the yield and content of spilanthol and other N-alkylamides which were analysed by HPLC-DAD-MS. Two concentrations of n-hexane or methanol extracts (500 ppm and 1000 ppm), obtained through Soxhlet extraction, were tested to acquire mortality data on the above-mentioned pests after 4, 8, and 16 h and 1 to 7 days of exposure. Both extracts achieved complete mortality (100.0%) of C. ferrugineus adults. In the case of A. diaperinus adults, mortalities were very low at any concentrations of both extracts. In general, the n-hexane extract was more efficient than methanol extract against almost all species and stages. Considering both extracts, the susceptibility order, from most to least susceptible species/stage, was C. ferrugineus adults > A. diaperinus larvae > C. ferrugineus larvae > T. granarium adults > T. molitor larvae > O. surinamensis adults > O. surinamensis larvae > T. confusum larvae > T. castaneum larvae > A. siro adults > T. molitor adults > A. siro nymphs > T. granarium larvae > T. castaneum adults > T. confusum adults > A. diaperinus adults. Our research provides useful knowledge on the efficacy of N-alkylamides-rich A. oleracea extracts as grain protectants, pointing out the importance of targeting the most susceptible species/ developmental stages. LA - English DB - MTMT ER - TY - JOUR AU - Abdul, Rahim R. AU - Jayusman, P.A. AU - Lim, V. AU - Ahmad, N.H. AU - Abdul, Hamid Z.A. AU - Mohamed, S. AU - Muhammad, N. AU - Ahmad, F. AU - Mokhtar, N. AU - Mohamed, N. AU - Shuid, A.N. AU - Naina, Mohamed I. TI - Phytochemical Analysis, Antioxidant and Bone Anabolic Effects of Blainvillea acmella (L.) Philipson JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 12 PY - 2022 SN - 1663-9812 DO - 10.3389/fphar.2021.796509 UR - https://m2.mtmt.hu/api/publication/32690427 ID - 32690427 N1 - Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang, Malaysia Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Pulau Pinang, Malaysia Anatomy Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Physiology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Faculty of Medicine UiTM, Sg Buloh, Malaysia Export Date: 20 February 2022 Correspondence Address: Naina Mohamed, I.; Pharmacology Department, Malaysia; email: isanaina@ppukm.ukm.edu.my Correspondence Address: Shuid, A.N.; Faculty of Medicine UiTMMalaysia; email: anazrun@uitm.edu.my LA - English DB - MTMT ER - TY - JOUR AU - Hajnády, Zoltán AU - Nagy-Pénzes, Máté AU - Demény, Máté Ágoston AU - Kovács, Katalin AU - El-Hamoly, Tarek AU - Maléth, József AU - Hegyi, Péter AU - Polgár, Zsuzsanna AU - Hegedűs, Csaba AU - Virág, László TI - OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis JF - BIOMEDICINES J2 - BIOMEDICINES VL - 10 PY - 2022 IS - 10 PG - 17 SN - 2227-9059 DO - 10.3390/biomedicines10102543 UR - https://m2.mtmt.hu/api/publication/33153168 ID - 33153168 N1 - * Megosztott szerzőség AB - Acute pancreatitis (AP) is a potentially life-threatening gastrointestinal disease with a complex pathology including oxidative stress. Oxidative stress triggers oxidative DNA lesions such as formation of 7,8-dihydro-8-oxo-2′-oxoguanine (8-oxoG) and also causes DNA strand breaks. DNA breaks can activate the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP1) which contributes to AP pathology. 8-oxoG is recognized by 8-oxoG glycosylase 1 (OGG1) resulting in the removal of 8-oxoG from DNA as an initial step of base excision repair. Since OGG1 also possesses a DNA nicking activity, OGG1 activation may also trigger PARP1 activation. In the present study we investigated the role played by OGG1 in AP. We found that the OGG1 inhibitor compound TH5487 reduced edema formation, inflammatory cell migration and necrosis in a cerulein-induced AP model in mice. Moreover, TH5487 caused 8-oxoG accumulation and reduced tissue poly(ADP-ribose) levels. Consistent with the indirect PARP inhibitory effect, TH5487 shifted necrotic cell death (LDH release and Sytox green uptake) towards apoptosis (caspase activity) in isolated pancreatic acinar cells. In the in vivo AP model, TH5487 treatment suppressed the expression of various cytokine and chemokine mRNAs such as those of TNF, IL-1β, IL1ra, IL6, IL16, IL23, CSF, CCL2, CCL4, CCL12, IL10 and TREM as measured with a cytokine array and verified by RT-qPCR. As a potential mechanism underlying the transcriptional inhibitory effect of the OGG1 inhibitor we showed that while 8-oxoG accumulation in the DNA facilitates NF-κB binding to its consensus sequence, when OGG1 is inhibited, target site occupancy of NF-κB is impaired. In summary, OGG1 inhibition provides protection from tissue injury in AP and these effects are likely due to interference with the PARP1 and NF-κB activation pathways. LA - English DB - MTMT ER - TY - JOUR AU - Jeong, Won Ahn AU - Su, Kil Jang AU - Bo, Ram Jo AU - Hyun, Soo Kim AU - Eui, Young Jeoung AU - Kithenya, Hillary AU - Yeong, Min Yoo AU - Seong, Soo Joo TI - Promotion effects of steam-dried Betula platyphylla extract on hair regrowth JF - KOREAN JOURNAL OF FOOD SCIENCE AND TECHNOLOGY J2 - KOREAN J FOOD SCI TECHNOL VL - 54 PY - 2022 IS - 1 SP - 43 EP - 51 PG - 9 SN - 0367-6293 DO - 10.9721/KJFST.2022.54.1.43 UR - https://m2.mtmt.hu/api/publication/32785087 ID - 32785087 N1 - Export Date: 3 August 2022 LA - Korean DB - MTMT ER - TY - JOUR AU - Nagy-Pénzes, Máté AU - Hajnády, Zoltán AU - Regdon, Zsolt AU - Demény, Máté Ágoston AU - Kovács, Katalin AU - El-Hamoly, Tarek AU - Maléth, József AU - Hegyi, Péter AU - Hegedűs, Csaba AU - Virág, László TI - Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling JF - BIOMEDICINES J2 - BIOMEDICINES VL - 10 PY - 2022 IS - 6 PG - 20 SN - 2227-9059 DO - 10.3390/biomedicines10061371 UR - https://m2.mtmt.hu/api/publication/32886684 ID - 32886684 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Spinozzi, Eleonora AU - Ferrati, Marta AU - Baldassarri, Cecilia AU - Cappellacci, Loredana AU - Marmugi, Margherita AU - Caselli, Alice AU - Benelli, Giovanni AU - Maggi, Filippo AU - Petrelli, Riccardo TI - A Review of the Chemistry and Biological Activities of Acmella oleracea ("jambu", Asteraceae), with a View to the Development of Bioinsecticides and Acaricides JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 20 PG - 22 SN - 2223-7747 DO - 10.3390/plants11202721 UR - https://m2.mtmt.hu/api/publication/33344133 ID - 33344133 N1 - Funding Agency and Grant Number: Italian Ministry of Health [PRIN 2017CBNCYT_005] Funding text: Riccardo Petrelli would like to thank the Italian Ministry of Health for financial support (PRIN 2017CBNCYT_005). AB - Human pathologies, environmental pollution, and resistance phenomena caused by the intensive use of chemical pesticides have shifted the attention of the agrochemical industries towards eco-friendly insecticides and acaricides. Acmella oleracea (L.) R. K. Jansen (jambu) is a plant native to South America, widely distributed and cultivated in many countries due to its numerous pharmacological properties. This review analyzes literature about the plant, its uses, and current knowledge regarding insecticidal and acaricidal activity. Acmella oleracea has proven to be a potential pesticide candidate against several key arthropod pest and vector species. This property is inherent to its essential oil and plant extract, which contain spilanthol, the main representative of N-alkylamides. As a result, there is a scientific basis for the industrial exploitation of jambu in the preparation of green insecticides. However, studies related to its toxicity towards non-target species and those aimed at formulating and developing marketable products are lacking. LA - English DB - MTMT ER - TY - JOUR AU - Abdul, Rahim Rohanizah AU - Jayusman, Putri Ayu AU - Muhammad, Norliza AU - Mohamed, Norazlina AU - Lim, Vuanghao AU - Ahmad, Nor Hazwani AU - Mohamad, Sharlina AU - Abdul, Hamid Zuratul Ain AU - Ahmad, Fairus AU - Mokhtar, Norfilza AU - Shuid, Ahmad Nazrun AU - Mohamed, Isa Naina TI - Potential Antioxidant and Anti-Inflammatory Effects of Spilanthes acmella and Its Health Beneficial Effects: A Review JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 18 PY - 2021 IS - 7 PG - 15 SN - 1661-7827 DO - 10.3390/ijerph18073532 UR - https://m2.mtmt.hu/api/publication/32014709 ID - 32014709 N1 - Funding Agency and Grant Number: Universiti Kebangsaan Malaysia (UKM) [DIP-2018-015, FF-2019-236] Funding text: This research was funded by Dana Impak Perdana UKM (DIP-2018-015) and Dana Fundamental PPUKM (FF-2019-236) from Universiti Kebangsaan Malaysia (UKM). Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, Malaysia Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, 13200, Malaysia School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, NibongTebal, 14300, Malaysia Anatomy Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, Malaysia Physiology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, Malaysia Faculty of Medicine UiTM, Sg Buloh, 47000, Malaysia Export Date: 14 May 2021 Correspondence Address: Mohamed, I.N.; Pharmacology Department, Malaysia; email: isanaina@ppukm.ukm.edu.my AB - Oxidative stress and inflammation are two common risk factors of various life-threatening disease pathogenesis. In recent years, medicinal plants that possess antioxidant and anti-inflammatory activities were extensively studied for their potential role in treating and preventing diseases. Spilanthes acmella (S. acmella), which has been traditionally used to treat toothache in Malaysia, contains various active metabolites responsible for its anti-inflammatory, antiseptic, and anesthetic bioactivities. These bioactivities were attributed to bioactive compounds, such as phenolic, flavonoids, and alkamides. The review focused on the summarization of in vitro and in vivo experimental reports on the antioxidant and anti-inflammatory actions of S. acmella, as well as how they contributed to potential health benefits in lowering the risk of diseases that were related to oxidative stress. The molecular mechanism of S. acmella in reducing oxidative stress and inflammatory targets, such as inducible nitric oxide synthase (iNOS), transcription factors of the nuclear factor-kappa B family (NF-kappa B), cyclooxygenase-2 (COX-2), and mitogen-activated protein kinase (MAPK) signaling pathways were discussed. Besides, the antioxidant potential of S. acmella was measured by total phenolic content (TPC), total flavonid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and superoxide anion radical scavenging (SOD) and thiobarbituric acid reactive substance (TBARS) assays. This review revealed that S. acmella might have a potential role as a reservoir of bioactive agents contributing to the observed antioxidant, anti-inflammatory, and health beneficial effects. LA - English DB - MTMT ER - TY - JOUR AU - Anamika, Sinha AU - Ashish, Jain AU - Sheetal, Mali AU - Amit, Patil AU - Himmat, Jaiswal AU - Hrishikesh, Saoji TI - Comparative Evaluation of Efficacy of Spilanthes Acmella Flower Extract as an Intracanal Medicament with Calcium hydroxide and 2%Chlorhexidine gel –An in Vitro Study JF - ANNALS OF THE ROMANIAN SOCIETY FOR CELL BIOLOGY J2 - ANNALS ROMANIAN SOC CELL BIOL VL - 25 PY - 2021 IS - 6 SP - 6773 EP - 6782 PG - 10 SN - 1583-6258 UR - https://m2.mtmt.hu/api/publication/32778812 ID - 32778812 LA - English DB - MTMT ER - TY - JOUR AU - El-Hamoly, T AU - Hajnády, Zoltán AU - Nagy-Pénzes, Máté AU - Bakondi, Edina AU - Regdon, Zsolt AU - Demény, Máté Ágoston AU - Kovács, Katalin AU - Hegedűs, Csaba AU - Abd, El-Rahman SS AU - Szabó, Éva AU - Maléth, József AU - Hegyi, Péter AU - Virág, László TI - Poly(ADP-ribose) polymerase 1 promotes inflammation and fibrosis in a mouse model of chronic pancreatitis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 7 PG - 15 SN - 1661-6596 DO - 10.3390/ijms22073593 UR - https://m2.mtmt.hu/api/publication/31938546 ID - 31938546 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Lira Batista, Lecildo AU - Corrêa do Nascimento, Lucas AU - Guimarães, Gabriel Francisconi AU - Matias Pereira, Arlindo César AU - Rocha Koga, Rosemary de Carvalho AU - Teixeira dos Santos, Abrahão Victor Tavares de Lima AU - Fernandes, Caio Pinho AU - Teixeira, Thiago Afonso AU - Hu, Yutao AU - Hu, Xuebo AU - Carvalho, José Carlos Tavares TI - A Review of Medicinal Plants Traditionally used to Treat Male Sexual Dysfunctions – the Overlooked Potential of Acmella oleracea (L.) R.K. Jansen JF - PHARMACOGNOSY REVIEWS J2 - PHARMACOGN REV VL - 15 PY - 2021 IS - 29 SP - 01 EP - 11 PG - 11 SN - 0973-7847 DO - 10.5530/phrev.2021.15.1 UR - https://m2.mtmt.hu/api/publication/32778813 ID - 32778813 LA - English DB - MTMT ER - TY - JOUR AU - Li, Yuqiang AU - Li, Bingfeng AU - Chen, Tianyi AU - Wu, Bin AU - Chu, Jianlin AU - He, Bingfang TI - Exploiting the Reversibility of GT(BP1) Catalyzed One-pot Reactions for the Synergistical Synthesis of Ponasterone A and Phenolic Glycosides JF - BIOTECHNOLOGY AND BIOPROCESS ENGINEERING J2 - BIOTECHNOL BIOPROC E VL - 26 PY - 2021 IS - 3 SP - 408 EP - 418 PG - 11 SN - 1226-8372 DO - 10.1007/s12257-020-0135-1 UR - https://m2.mtmt.hu/api/publication/32160359 ID - 32160359 N1 - College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211800, China School of Biology and Environment, Nanjing Polytechnic Institute, Nanjing, 210048, China School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211800, China Export Date: 20 August 2022 Correspondence Address: Chu, J.; School of Pharmaceutical Sciences, China; email: 564297686@qq.com Correspondence Address: He, B.; School of Pharmaceutical Sciences, China; email: bingfanghe@njtech.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Park, I. AU - Byun, H.S. AU - Hur, G.M. AU - Na, M. TI - Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 84 PY - 2021 IS - 5 SP - 1598 EP - 1606 PG - 9 SN - 0163-3864 DO - 10.1021/acs.jnatprod.1c00146 UR - https://m2.mtmt.hu/api/publication/32116836 ID - 32116836 N1 - College of Pharmacy, Chungnam National University, Daejeon, 34134, South Korea Department of Pharmacology, Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea Export Date: 29 July 2021 CODEN: JNPRD Correspondence Address: Na, M.; College of Pharmacy, South Korea; email: mkna@cnu.ac.kr Correspondence Address: Hur, G.M.; Department of Pharmacology, South Korea; email: gmhur@cnu.ac.kr AB - Three new alkamides, tulipiferamides A-C (1-3, respectively), and 30 known compounds (4-33) were obtained from the roots of Liriodendron tulipifera (Magnoliaceae). Dehydrotemisin (4), an elemane sesquiterpene lactone, was isolated for the first time from nature. The structures were deduced by the interpretation of NMR spectroscopic and MS spectral data. The geometries of the double bonds in tulipiferamides A-C (1-3, respectively) were determined on the basis of 1H-1H coupling constants and 13C chemical shifts. The presence of the alkamide type in this plant is reported for the first time. An analysis of the inflammatory response revealed that seven compounds (1, 4, 7, 9, 14, 23, and 27) suppressed the nitric oxide production induced by LPS in RAW264.7 macrophages. Furthermore, tulipiferamide A (1) inhibits NF-κB activation by selectively targeting IKKβ, an upstream kinase of NF-κB, resulting in the suppression of inflammatory mediators, including iNOS, COX-2, IL-1β, TNFα, and IL-6. Our results provide a rationale for the further development of tulipiferamide A as a selective IKKβ inhibitor to modulate inflammatory diseases. © 2021 American Chemical Society and American Society of Pharmacognosy. LA - English DB - MTMT ER - TY - JOUR AU - Regdon, Zsolt AU - Demény, Máté Ágoston AU - Kovács, Katalin AU - Hajnády, Zoltán AU - Nagy-Pénzes, Máté AU - Bakondi, Edina AU - Kiss, Alexandra AU - Hegedűs, Csaba AU - Virág, László TI - High‐content screening identifies inhibitors of oxidative stress‐induced parthanatos: cytoprotective and anti‐inflammatory effects of ciclopirox JF - BRITISH JOURNAL OF PHARMACOLOGY J2 - BR J PHARMACOL VL - 178 PY - 2021 IS - 5 SP - 1095 EP - 1113 PG - 19 SN - 0007-1188 DO - 10.1111/bph.15344 UR - https://m2.mtmt.hu/api/publication/31831963 ID - 31831963 N1 - Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary MTA-DE Cell Biology and Signaling Research Group, Debrecen, Hungary Cited By :7 Export Date: 4 October 2023 CODEN: BJPCB Correspondence Address: Hegedűs, C.; Department of Medical Chemistry, Hungary; email: hcsaba@med.unideb.hu Correspondence Address: Virág, L.; Department of Medical Chemistry, Hungary; email: lvirag@med.unideb.hu Correspondence Address: Virág, L.; MTA-DE Cell Biology and Signaling Research GroupHungary; email: lvirag@med.unideb.hu AB - Background and Purpose Excessive oxidative stress can induce PARP1‐mediated programmed necrotic cell death, termed parthanatos. Inhibition of parthanatos may be therapeutically beneficial in a wide array of diseases associated with tissue injury and inflammation. Our goal was to identify novel molecules inhibiting parthanatos. Experimental Approach A small library of 774 pharmacologically active compounds was screened in a Sytox Green uptake assay, which identified 20 hits that reduced hydrogen‐peroxide‐induced parthanatos with an efficiency comparable to the benchmark PARP inhibitor, PJ34. Key Results Of these hits, two compounds, antifungal ciclopirox and dopamine receptor agonist apomorphine, inhibited PAR polymer synthesis. These two compounds prevented the binding of PARP1 to oxidatively damaged DNA but did not directly interfere with the interaction between DNA and PARP1. Both compounds inhibited mitochondrial superoxide and H2O2 production and suppressed DNA breakage. Since H2O2‐induced damage is dependent on Fe2+‐catalysed hydroxyl radical production (Fenton chemistry), we determined the iron chelation activity of the two test compounds and found that ciclopirox and, to a lesser extent, apomorphine act as iron chelators. We also show that the Fe2+ chelation and indirect PARP inhibitory effects of ciclopirox translate to anti‐inflammatory actions as demonstrated in a mouse dermatitis model, where ciclopirox reduced ear swelling, inflammatory cell recruitment and poly(ADP‐ribosyl)ation. Conclusion and Implications Our findings indicate that the antimycotic drug, ciclopirox, acts as an iron chelator and thus targets an early event in hydrogen‐peroxide‐induced parthanatos. Ciclopirox has the potential to be repurposed as a cytoprotective and anti‐inflammatory agent. LA - English DB - MTMT ER - TY - JOUR AU - Spinozzi, E. AU - Pavela, R. AU - Bonacucina, G. AU - Perinelli, D.R. AU - Cespi, M. AU - Petrelli, R. AU - Cappellacci, L. AU - Fiorini, D. AU - Scortichini, S. AU - Garzoli, S. AU - Angeloni, C. AU - Freschi, M. AU - Hrelia, S. AU - Quassinti, L. AU - Bramucci, M. AU - Lupidi, G. AU - Sut, S. AU - Dall'Acqua, S. AU - Benelli, G. AU - Canale, A. AU - Drenaggi, E. AU - Maggi, F. TI - Spilanthol-rich essential oil obtained by microwave-assisted extraction from Acmella oleracea (L.) R.K. Jansen and its nanoemulsion: Insecticidal, cytotoxic and anti-inflammatory activities JF - INDUSTRIAL CROPS AND PRODUCTS J2 - IND CROP PROD VL - 172 PY - 2021 SN - 0926-6690 DO - 10.1016/j.indcrop.2021.114027 UR - https://m2.mtmt.hu/api/publication/32498022 ID - 32498022 N1 - School of Pharmacy, University of Camerino, Camerino, 62032, Italy Crop Research Institute, Drnovska 507, 161 06, Prague 6, Ruzyne, Czech Republic Department of Plant Protection, Czech University of Life Sciences Prague, Kamycka 129, Praha 6, Suchdol, 165 00, Czech Republic School of Science and Technology, University of Camerino, Camerino, 62032, Italy Department of Drug Chemistry and Technology, Sapienza University, P.le Aldo Moro 5, Rome, 00185, Italy Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, Rimini, 47921, Italy Department of Pharmaceutical and Pharmacological Sciences, Natural Product Laboratory, University of Padova, Padova, Italy Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, Pisa, 56124, Italy Export Date: 17 November 2021 CODEN: ICRDE Correspondence Address: Maggi, F.; School of Pharmacy, via S. Agostino 1, Italy; email: filippo.maggi@unicam.it AB - Acmella oleracea (L.) R.K. Jansen, also named jambù, is an edible and medicinal plant native to Brazil but extensively cultivated all over the world due to its diverse utilizations in food, cosmetics, pharmaceutics, and pest management science. Most of applications are related to the presence of active ingredients, namely alkylamides, among which spilanthol is the most important one. On the other hand, the plant biomass resulting from the large-scale cultivation of A. oleracea may yield an essential oil (EO), which can be used for some industrial purposes, for instance as larvicide against vector mosquitoes. This EO is mainly characterized by mono- and sesquiterpenes, however also spilanthol can be detected in the mixture. To maximize the content of spilanthol in the A. oleracea EO, A. oleracea aerial parts obtained from a cultivation in central Italy were subjected to microwave-assisted extraction (MAE). This procedure allowed to obtain a higher yield and spilanthol content when compared with traditional hydrodistillation (0.47 v 0.22 %, and 13.31 vs 2.24 %, respectively). The EO terpene fraction was mainly represented by β-pinene (10.8 %), myrcene (12.3 %), (E)-caryophyllene (19.4 %) and α-humulene (1.1 %). The A. oleracea EO was encapsulated into a nanoemulsion (NE) containing 6 % EO using a high-energy method. The formulation physical stability was assessed by optical microscope and DLS analyses at different timepoints showing stability up to one year of storage. The A. oleracea EO and its NE, along with the isolated spilanthol, were evaluated for acute toxicity against the 3rd instar larvae of Culex quinquefasciatus, a filariasis and arbovirus vector of public health importance, achieving LC50 values of 16.1, 407.5, and 3.1 μL/L, respectively. The larvicidal activity seemed to be not dependent on the interaction with the cholinergic system, as shown by the high IC50 values of A. oleracea EO and spilanthol exhibited in the anti-acetylcholinesterase (AChE) assay. Testing LC30 values, the A. oleracea-borne products showed a significant impact on larval development, fecundity, fertility and natality of C. quinquefasciatus. Testing LC30 values, the A. oleracea EO-NE provided a higher efficacy than spilanthol, reducing the adult fertility, in terms of egg hatchability (%) and the overall abundance of F1 larvae. These results can be considered as promising for the development of new mosquito larvicides. The safety use of A. oleracea EO, NE and spilanthol was demonstrated in assays on mammalian fibroblasts and microglia cells, showing low level of cytotoxicity coupled with protective effects against inflammation. © 2021 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - Stein, Renan AU - Berger, Markus AU - de, Cecco Bianca Santana AU - Mallmann, Luana Peixoto AU - Terraciano, Paula Barros AU - Driemeier, David AU - Rodrigues, Eliseu AU - Beys-da-Silva, Walter Orlando AU - Konrath, Eduardo Luis TI - Chymase inhibition: A key factor in the anti-inflammatory activity of ethanolic extracts and spilanthol isolated from Acmella oleracea JF - JOURNAL OF ETHNOPHARMACOLOGY J2 - J ETHNOPHARMACOL VL - 270 PY - 2021 PG - 11 SN - 0378-8741 DO - 10.1016/j.jep.2020.113610 UR - https://m2.mtmt.hu/api/publication/32014708 ID - 32014708 N1 - Funding Agency and Grant Number: CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ); FAPERGS (Brazil)Fundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001] Funding text: This work was supported by CNPq and FAPERGS (Brazil). This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) - Finance Code 001. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), CEP, Porto Alegre, RS 90610-000, Brazil Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), CEP, Porto Alegre, RS 90035-007, Brazil Departamento de Patologia Clínica Veterinária, Faculdade de Medicina Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), CEP, Porto Alegre, RS 91540-000, Brazil Instituto de Ciência e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul (UFRGS), CEP, Porto Alegre, RS 91501-970, Brazil Laboratório de Embriologia e Diferenciação Celular, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), CEP, Porto Alegre, RS 90035-007, Brazil Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul- UFRGS, CEP, Porto Alegre, RS 90610-000, Brazil Export Date: 14 May 2021 CODEN: JOETD Correspondence Address: Konrath, E.L.; Programa de Pós-Graduação em Ciências Farmacêuticas, CEP, Brazil; email: eduardo.konrath@ufrgs.br AB - Ethnopharmacological relevance: Acmella oleracea (L.) R. K. Jansen (Asteraceae), known as jambii in Brazil, is used in traditional medicine as analgesic and for inflammatory conditions, characterized by the presence of N-alkylamides, mainly spilanthol. This bioactive compound is responsible for the above-described pharmacological properties, including sialagogue and anesthetic. Aim of the study: This study aimed to characterize the anti-inflammatory effects of A. oleracea leaves (AOEE-L) and flowers (AOEE-F) extracts, including an isolated alkylamide (spilanthol), using in vitro and in vivo models. The mechanism underlying this effect was also investigated. Materials and methods: Extracts were analyzed by HPLC-ESI-MS/MS in order to characterize the N-alkylamides content. AOEE-L, AOEE-F (25-100 mu g/mL) and spilanthol (50-200 mu M) were tested in vitro on VSMC after stimulation with hyperglycemic medium (25 mM glucose). Their effects over nitric oxide (NO) generation, chymase inhibition and expression, catalase (CAT), superoxide anion (SOD) radical activity were evaluated. After an acute administration of extracts (10-100 mg/mL) and spilanthol (6.2 mg/mL), the anti-inflammatory effects were evaluated by applying the formalin test in rats. Blood was collected to measure serum aminotransferases activities, NO activity, creatinine and urea. Results: A number of distinct N-alkylamides were detected and quantified in AOEE-L and AOEE-F. Spilanthol was identified in both extracts and selected for experimental tests. Hyperglycemic stimulation in VSMC promoted the expression of inflammatory parameters, including chymase, NO, CAT and SOD activity and chymase expression, all of them attenuated by the presence of the extracts and spilanthol. The administration of extracts or spilanthol significantly inhibited edema formation, NO production and cell tissue infiltration in the formalin test, without causing kidney and liver toxicity. Conclusion: Taken together, these results provide evidence for the anti-inflammatory activity of leaves and flowers extracts of jambii associated distinctly with their chemical profile. The effects appear to be associated with the inhibition of chymase activity, suppression of the proinflammatory cytokine NO and antioxidant activities. LA - English DB - MTMT ER - TY - JOUR AU - An, Lijun AU - Ma, Jun AU - Yang, Xueyuan AU - Liang, Yue AU - Wang, Huimei AU - Tuerhong, Muhetaer AU - Lall, Namrita AU - Abudukeremu, Munira AU - Zhang, Yi AU - Lee, Dongho AU - Xu, Jing AU - Wu, Xiaohui AU - Guo, Yuanqiang TI - Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo JF - BIOORGANIC CHEMISTRY J2 - BIOORG CHEM VL - 98 PY - 2020 PG - 7 SN - 0045-2068 DO - 10.1016/j.bioorg.2020.103758 UR - https://m2.mtmt.hu/api/publication/31492246 ID - 31492246 N1 - Funding Agency and Grant Number: National Key Research and Development Program of China [2018YFA0507204]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1703107, U1801288, 21665013]; Natural Science Foundation of Tianjin, ChinaNatural Science Foundation of Tianjin [19JCYBJC28100]; Hundred Young Academic Leaders Program of Nankai University; State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences) [GTZK201902]; State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Peking Union Medical College) [GTZK201902] Funding text: This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107, U1801288, and 21665013), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902). State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China College of Chemistry and Environmental Sciences, Kashgar University, Kashgar, 844000, China Department of Plant and Soil Sciences, University of Pretoria, Pretoria, 0002, South Africa Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, and Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China College of Pharmacy, Tianjin Medical University, Tianjin, 300070, China Cited By :1 Export Date: 14 May 2021 CODEN: BOCMB Correspondence Address: Xu, J.; State Key Laboratory of Medicinal Chemical Biology, China; email: xujing611@nankai.edu.cn AB - Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated. LA - English DB - MTMT ER - TY - JOUR AU - Balieiro, Odiane C. AU - Pinheiro, Mayra Suelen da Silva AU - Silva, Simone Y. S. AU - Oliveira, Marilene Nunes AU - Silva, Sebastiao C. AU - Gomes, Adriano A. AU - Pinto, Licarion TI - Analytical and preparative chromatographic approaches for extraction of spilanthol from Acmella oleracea flowers JF - MICROCHEMICAL JOURNAL J2 - MICROCHEM J VL - 157 PY - 2020 PG - 8 SN - 0026-265X DO - 10.1016/j.microc.2020.105035 UR - https://m2.mtmt.hu/api/publication/31726917 ID - 31726917 N1 - Funding Agency and Grant Number: CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [28/2018 - 438734/2018-1]; FAPESPA/Vale [ICAAF 037/2011]; CAPESCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001] Funding text: The authors acknowledge the financial support of CAPES Finacial code 001, CNPq (CALL MCTIC/CNPQ No 28/2018 - 438734/2018-1) and FAPESPA/Vale ICAAF 037/2011. The authors also acknowledge the LabCrom and Labfarqui of UNICAMP for the mass spectroscopy analysis. Faculdade de Química, Instituto de Ciências Exatas da Universidade Federal do Sul e Sudeste do Pará, Folha 17, Quadra 04, Lote Especial, Nova Marabá, Marabá, Pará CEP: 68.505.080, Brazil Laboratório de Quimiometria e Instrumentação Analítica-LQIA, Instituto de Química da Universidade Federal do Rio Grande do Sul, Agronomia 9500, Porto Alegre, RS, Brazil Universidade Federal de Pernambuco, Departamento de química fundamental, Recife, PE CEP 50740-540, Brazil Cited By :2 Export Date: 14 May 2021 CODEN: MICJA Correspondence Address: Silva, S.Y.S.; Faculdade de Química, Folha 17, Quadra 04, Lote Especial, Nova Marabá, Brazil; email: simote@unifesspa.edu.br AB - Acmella oleracea, a plant with high spilanthol content, can be found in Brazilian north region. Despite the commercial interest of spilanthol for local communities and industries, due to its anesthetic properties, there are few works that have made a chemical study of it and almost none with analytical strategies. In this work, the influence of 4 solvents, namely acetonitrile, methanol, dichloromethane and ethanol, chosen from those mainly reported in published papers and their interaction in the extraction of spilanthol from Acmella oleracea flowers has been studied. The influence of each solvent proportions was discussed, and pure ethanol was selected as the one with better extraction efficiency. A model was built using the spilanthol peak area obtained by a HPLC-DAD system. Using the optimized solvent, it was possible to extract spilanthol from up to 10 g of grounded flowers using 25 mL of the solvent, producing an extract highly concentrated. The spilanthol content in this extract was isolated and characterized by liquid chromatography coupled to a triple quadrupole mass spectrometer. Therefore, this work presents an extensive analytical study of the spilanthol optimum extraction procedure, purification of the standard, validation of the analytical line and evaluation of the extraction efficiency with a recovery test. LA - English DB - MTMT ER - TY - JOUR AU - Bhopen, Singh S. AU - Singh, K. AU - Singh, Butola S. AU - Rawat, S. AU - Arunachalam, K. TI - Determination of macronutrients, micronutrients and heavy metals present in spilanthes acmella hutch and dalz: Possible health effects JF - NATURAL PRODUCT SCIENCES J2 - NAT PROD SCI VL - 26 PY - 2020 IS - 1 SP - 50 EP - 58 PG - 9 SN - 1226-3907 DO - 10.20307/nps.2020.26.1.50 UR - https://m2.mtmt.hu/api/publication/32014711 ID - 32014711 N1 - School of Environment and Natural Resources, Doon University, Dehradun, Uttarakhand, India Composite Lab, Doon University, Dehradun, India Export Date: 14 May 2021 CODEN: NPSCF Correspondence Address: Arunachalam, K.; School of Environment and Natural Resources, India; email: akusum44@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Rondanelli, M. AU - Fossari, F. AU - Vecchio, V. AU - Braschi, V. AU - Riva, A. AU - Allegrini, P. AU - Petrangolini, G. AU - Iannello, G. AU - Faliva, M.A. AU - Peroni, G. AU - Nichetti, M. AU - Gasparri, C. AU - Spadaccini, D. AU - Infantino, V. AU - Mustafa, S. AU - Alalwan, T. AU - Perna, S. TI - Acmella oleracea for pain management JF - FITOTERAPIA J2 - FITOTERAPIA VL - 140 PY - 2020 SN - 0367-326X DO - 10.1016/j.fitote.2019.104419 UR - https://m2.mtmt.hu/api/publication/31035042 ID - 31035042 N1 - IRCCS Mondino Foundation, Pavia, 27100, Italy Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia, 27100, Italy Research and Development Unit, Milan, Indena 20139, Italy General Management, Azienda di Servizi alla Persona “Istituto Santa Margherita”, Pavia, 27100, Italy University of Bari, Department of Biomedical Science and Human Oncology, Bari, 70121, Italy Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O., Box 32038, Bahrain Export Date: 3 January 2020 CODEN: FTRPA Correspondence Address: Gasparri, C.; Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of PaviaItaly; email: clara.gasparri01@universitadipavia.it Chemicals/CAS: amide, 17655-31-1; inducible nitric oxide synthase, 501433-35-8 IRCCS Mondino Foundation, Pavia, 27100, Italy Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia, 27100, Italy Research and Development Unit, Milan, Indena 20139, Italy General Management, Azienda di Servizi alla Persona “Istituto Santa Margherita”, Pavia, 27100, Italy University of Bari, Department of Biomedical Science and Human Oncology, Bari, 70121, Italy Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O., Box 32038, Bahrain Cited By :4 Export Date: 31 March 2021 CODEN: FTRPA Correspondence Address: Gasparri, C.; Endocrinology and Nutrition Unit, Italy; email: clara.gasparri01@universitadipavia.it Chemicals/CAS: amide, 17655-31-1; inducible nitric oxide synthase, 501433-35-8; Analgesics; Anti-Inflammatory Agents; Antioxidants; Phytochemicals IRCCS Mondino Foundation, Pavia, 27100, Italy Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia, 27100, Italy Research and Development Unit, Milan, Indena 20139, Italy General Management, Azienda di Servizi alla Persona “Istituto Santa Margherita”, Pavia, 27100, Italy University of Bari, Department of Biomedical Science and Human Oncology, Bari, 70121, Italy Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O., Box 32038, Bahrain Cited By :5 Export Date: 14 May 2021 CODEN: FTRPA Correspondence Address: Gasparri, C.; Endocrinology and Nutrition Unit, Italy; email: clara.gasparri01@universitadipavia.it AB - Despite advances in medicine and numerous agents that counteract pain, millions of patients continue to suffer. Attention has been given to identify novel botanical interventions that produce analgesia by interacting with nociceptive-transducing channels. The aim of this review is to provide an overview of the actual knowledge of Acmella oleracea (L.) and its activities, particularly those that are anti-inflammatory, anti-oxidant, and painkiller. These activities are attributed to numerous bioactive compounds, such as phytosterols, phenolic compounds and N-alkylamides (spilanthol, responsible for many activities, primarily anesthetic). This review includes 99 eligible studies to consider the anti-inflammatory, anti-oxidant, and painkiller of Acmella. Studies reported in this review confirmed anti-inflammatory and anti-oxidant activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. The antinociceptive effects has been demonstrated and have been related to different processes, including inhibition of prostaglandin synthesis, activation of opioidergic, serotoninergic and GABAergic systems, and anesthetic activity through blockage of voltage-gated Na Channels. acmella oleracea represents a promise for pain management, particularly in chronic degenerative diseases, where pain is a significant critical issue. © 2019 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - TGG, Uthpala AU - HN, Fernando AU - Amila, Thibbotuwawa AU - M, Jayasinghe TI - Importance of nutrigenomics and nutrigenetics in food Science JF - MOJ FOOD PROCESSING AND TECHNOLOGY J2 - MOJ FOOD PROC TECH VL - 8 PY - 2020 IS - 3 SP - 114 EP - 119 PG - 6 SN - 2381-182X UR - https://m2.mtmt.hu/api/publication/32778811 ID - 32778811 LA - English DB - MTMT ER - TY - JOUR AU - Singh, S.B. AU - Singh, K. AU - Butola, S.S. AU - Rawat, S. AU - Arunachalam, K. TI - Effects of seasonal variation on antioxidant potential and metabolite contents of Spilanthes acmella hutch and dalz JF - MEDICINAL PLANTS J2 - MED PLANTS VL - 11 PY - 2019 IS - 4 SP - 380 EP - 386 PG - 7 SN - 0975-4261 DO - 10.5958/0975-6892.2019.00049.2 UR - https://m2.mtmt.hu/api/publication/32014712 ID - 32014712 N1 - School of Environment and Natural Resources, Doon University, Dehradun, 248012, India Composite-Lab, Doon University, Dehradun, 248012, India Export Date: 14 May 2021 Correspondence Address: Arunachalam, K.; School of Environment and Natural Resources, India; email: akusum44@gmail.com LA - English DB - MTMT ER -