TY - JOUR AU - Casado, María E. AU - Collado-Pérez, Roberto AU - Frago, Laura M. AU - Barrios, Vicente TI - Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 2 SN - 1661-6596 DO - 10.3390/ijms24021422 UR - https://m2.mtmt.hu/api/publication/33573155 ID - 33573155 AB - Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised. LA - English DB - MTMT ER - TY - JOUR AU - Cheng, Y. AU - Tan, S. AU - Chen, Y. AU - Huang, D. AU - Deng, X. AU - Huang, J. AU - Huang, H. AU - Li, P. AU - Du, B. TI - Effects of High Salt-intake on Renal Injury and Fibrosis in C57BL/6J Mice JF - SHIPIN GONGYE KEJI / SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY J2 - SCI TECH FOOD IND VL - 44 PY - 2023 IS - 5 SP - 397 EP - 402 PG - 6 SN - 1002-0306 DO - 10.13386/j.issn1002-0306.2022070254 UR - https://m2.mtmt.hu/api/publication/33728600 ID - 33728600 N1 - College of Food, South China Agricultural University, Guangzhou, 510642, China Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China Guangdong AIB Polytechnic College, Guangzhou, 510507, China Export Date: 03 April 2023; Cited By: 0; Correspondence Address: B. Du; College of Food, South China Agricultural University, Guangzhou, 510642, China; email: dubing@scau.edu.cn LA - Chinese DB - MTMT ER - TY - JOUR AU - Kang, Huiyuan AU - Lai, Min AU - Yao, Yan'er AU - Wang, Bin AU - Su, Xin AU - Cheng, Ye TI - Novel Insights into the Important Role of Leptin in Modulating the Pathological Development of Fibrotic-related Diseases JF - CURRENT MOLECULAR MEDICINE J2 - CURR MOL MED VL - 23 PY - 2023 IS - 10 SP - 1066 EP - 1076 PG - 11 SN - 1566-5240 DO - 10.2174/1566524023666221121105933 UR - https://m2.mtmt.hu/api/publication/34408088 ID - 34408088 N1 - Funding Agency and Grant Number: Declared none. Funding text: Declared none. AB - Leptin, as one of the most important cytokines within the circulation, has been confirmed to play a vital role in the hypothalamus of the central nervous system (CNS), which could modulate energy homeostasis by suppressing food intake. Furthermore, leptin could also influence cell metabolism by acting directly on the leptin receptor, which is a relatively small peptide and is mainly produced and released by fat tissue in mammals. On the other hand, the excessive extracellular matrix (ECM) could induce damage in normal tissues or organ structures, which might further induce fibrotic development in multiple tissues or organs, including the liver, heart, and kidneys. Notably, the sustainable development of fibrosis promotes the structural lesion and functional decline of different organs, which subsequently threatens human health and poses serious risks to human life. Emerging evidence has shown that leptin plays an important role in the fibrotic progression within multiple tissues and organs in mammals and has an alleviating effect on fibrosis. Concerning this notion, it has been proposed that leptin could be identified as a vital therapeutic strategy for fibrotic progression in clinical practice. Consequently, this review summarized the potential mechanisms of leptin in modulating fibrotic development in diverse tissues and organs to provide a theoretical basis for treating fibrotic-related diseases. In addition, the potential mechanisms whereby leptin affects the development of fibrosis were also summarized in the current review. LA - English DB - MTMT ER - TY - JOUR AU - XIANG, Ji-qin AU - WEI, Wen-jing AU - LIAO, Mei-hua AU - ZHANG, Ke-xing AU - ZHOU, Ying-qi AU - ZHANG, Wen-jie AU - TANG, Chun-zhi AU - XU, Neng-gui AU - TAO, Rong-rong TI - Mitigation of renal microvascular injury in diabetic kidney disease model mice by electroacupuncture JF - WORLD JOURNAL OF ACUPUNCTURE - MOXIBUSTION J2 - WORLD JOURNAL OF ACUPUNCTURE - MOXIBUSTION VL - 33 PY - 2023 IS - 3 SP - 262 EP - 272 PG - 11 SN - 1003-5257 DO - 10.1016/j.wjam.2023.05.004 UR - https://m2.mtmt.hu/api/publication/33842881 ID - 33842881 LA - English DB - MTMT ER - TY - JOUR AU - Hamman, Luteino Lorna AU - Garba, Sani Hyedima AU - Jacks, Tamunotonye Watson AU - Zirahei, Joseph Vandi AU - Dibal, Nathan Isaac AU - Attah, Martha Orendu Oche TI - Zingiber officinale ameliorates diabetic nephropathy and hepatotoxicity in rats by preventing tissue injury and controlling liver/kidney function JF - MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM J2 - MED J NUTR METABOL VL - 15 PY - 2022 IS - 3 SP - 333 EP - 343 PG - 11 SN - 1973-798X DO - 10.3233/MNM-211557 UR - https://m2.mtmt.hu/api/publication/33163142 ID - 33163142 N1 - Department of Human Anatomy, University of Maiduguri, Maiduguri, Nigeria Department of Human Anatomy, Rivers State University, Port Harcourt, Nigeria Cited By :1 Export Date: 25 March 2024 Correspondence Address: Dibal, N.I.; Department of Human Anatomy, PMB1069 Maiduguri, Nigeria; email: nathandibal@unimaid.edu.ng AB - BACKGROUND: Chronic hyperglycemia results in decrease glucose metabolism leading to nephropathy, hepatotoxicity and neuropathy. Diabetic complications are regarded globally as one of the leading cause of disability and mortality.OBJECTIVE: The study aims to evaluate the role of Zingiber officinale (ZO) on diabetic nephropathy and hepatotoxicity in rats.METHODS: Thirty diabetic rats and six non-diabetic rats were distributed into six groups (n = 6). Group 1 & 2 (nondiabetic and diabetic) received distilled water at 1 ml/kg. Groups 3-5 received (12.5, 25& 50) mg/kg of ZO respectively while group 6 received 100 mg/kg metformin. All treatments lasted for 28 days and rats were euthanized on day 29. Biochemical parameters, kidney and liver histology were evaluated.RESULTS: No significant change (P > 0.05) was noticed in blood glucose and creatinine levels of diabetic rats treated with 25 mg/kg ZO compared to control. The liver of 25 mg/kg ZO treated diabetic rats showed mild distortion of hepatocytes while kidneys of ZO treated diabetic rats showed mild distortion of renal tubules with few collagen deposits and intact Bowman's capsule.CONCLUSIONS: ZO ameliorates diabetic complications by regulating biochemical parameters and preventing renal tubules and hepatocytes damage in rats. LA - English DB - MTMT ER - TY - JOUR AU - Liu, Yuexia AU - Li, Yizhou AU - Liang, Juntong AU - Sun, Zhuwen AU - Wu, Qiong AU - Liu, Yongnian AU - Sun, Chao TI - Leptin: an entry point for the treatment of peripheral tissue fibrosis and related diseases JF - INTERNATIONAL IMMUNOPHARMACOLOGY J2 - INT IMMUNOPHARMACOL VL - 106 PY - 2022 PG - 10 SN - 1567-5769 DO - 10.1016/j.intimp.2022.108608 UR - https://m2.mtmt.hu/api/publication/32689936 ID - 32689936 LA - English DB - MTMT ER - TY - JOUR AU - Li, Yixuan AU - Gu, Zuhua AU - Wang, Jun AU - Wang, Yangang AU - Chen, Xian AU - Dong, Bingzi TI - The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 13 PY - 2022 SN - 1664-2392 DO - 10.3389/fendo.2022.938830 UR - https://m2.mtmt.hu/api/publication/33034295 ID - 33034295 LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Duoduo AU - Ji, Pengmin AU - Sun, Ran AU - Zhou, Huimin AU - Huang, Lei AU - Kong, Liangliang AU - Li, Weiping AU - Li, Weizu TI - Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice JF - BIOMEDICINE & PHARMACOTHERAPY J2 - BIOMED PHARMACOTHER VL - 150 PY - 2022 SN - 0753-3322 DO - 10.1016/j.biopha.2022.112936 UR - https://m2.mtmt.hu/api/publication/32785537 ID - 32785537 LA - English DB - MTMT ER - TY - JOUR AU - Ye, Lin AU - Hu, Xueting AU - Hu, Xiang AU - Yin, Sihui AU - Chen, Jianqiang AU - He, Hanghui AU - Hong, Shanshan AU - Yang, Bin AU - Singh, Krishna K. AU - Feng, Jianpeng AU - Wang, Yi AU - Luo, Wu AU - Liang, Guang TI - Curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation JF - BIOMEDICINE & PHARMACOTHERAPY J2 - BIOMED PHARMACOTHER VL - 137 PY - 2021 SN - 0753-3322 DO - 10.1016/j.biopha.2021.111418 UR - https://m2.mtmt.hu/api/publication/31895412 ID - 31895412 LA - English DB - MTMT ER - TY - JOUR AU - Ding, Shixin AU - Zhang, Han AU - Sun, Zhenghao AU - Han, Yuli AU - Li, Yan AU - Dong, Xianan AU - Yin, Yanyan AU - Li, Weiping AU - Li, Weizu TI - Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice JF - JOURNAL OF FUNCTIONAL FOODS J2 - J FUNCT FOODS VL - 72 PY - 2020 PG - 12 SN - 1756-4646 DO - 10.1016/j.jff.2020.104049 UR - https://m2.mtmt.hu/api/publication/31348436 ID - 31348436 AB - Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury. Ginsenoside Rg1 may have protective effects on kidney aging. In this study, we investigated the tubular interstitial fibrosis and ER stress change in aged mice, and further observed the effects of Rg1 on renal interstitial fibrosis and ER stress in SAMP8 mice. The results demonstrated that the ER stress, apoptosis and interstitial fibrosis were significantly increased in the tubular epithelial cells in 20-month-old (M) and 24M mice. Meanwhile, we found that Rg1 significantly attenuated the tubular epithelial cells ER stress, apoptosis and interstitial fibrosis in SAMP8 mice. This study suggested that ER stress and apoptosis were closely implicated with aging-related renal interstitial fibrosis in aging progression. Rg1 could ameliorate aging-related renal interstitial fibrosis via inhibiting ER stress and apoptosis. LA - English DB - MTMT ER -