@article{MTMT:33573155,
	title = {Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies},
	url = {https://m2.mtmt.hu/api/publication/33573155},
	author = {Casado, María E. and Collado-Pérez, Roberto and Frago, Laura M. and Barrios, Vicente},
	doi = {10.3390/ijms24021422},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33573155},
	issn = {1661-6596},
	abstract = {Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Casado, María E./0000-0003-3642-0237; Collado-Pérez, Roberto/0000-0003-2831-4530; Frago, Laura M./0000-0002-5927-9240; Barrios, Vicente/0000-0002-5507-7545}
}

@article{MTMT:33728600,
	title = {Effects of High Salt-intake on Renal Injury and Fibrosis in C57BL/6J Mice},
	url = {https://m2.mtmt.hu/api/publication/33728600},
	author = {Cheng, Y. and Tan, S. and Chen, Y. and Huang, D. and Deng, X. and Huang, J. and Huang, H. and Li, P. and Du, B.},
	doi = {10.13386/j.issn1002-0306.2022070254},
	journal-iso = {SCI TECH FOOD IND},
	journal = {SHIPIN GONGYE KEJI / SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY},
	volume = {44},
	unique-id = {33728600},
	issn = {1002-0306},
	year = {2023},
	pages = {397-402}
}

@article{MTMT:34408088,
	title = {Novel Insights into the Important Role of Leptin in Modulating the Pathological Development of Fibrotic-related Diseases},
	url = {https://m2.mtmt.hu/api/publication/34408088},
	author = {Kang, Huiyuan and Lai, Min and Yao, Yan'er and Wang, Bin and Su, Xin and Cheng, Ye},
	doi = {10.2174/1566524023666221121105933},
	journal-iso = {CURR MOL MED},
	journal = {CURRENT MOLECULAR MEDICINE},
	volume = {23},
	unique-id = {34408088},
	issn = {1566-5240},
	abstract = {Leptin, as one of the most important cytokines within the circulation, has been confirmed to play a vital role in the hypothalamus of the central nervous system (CNS), which could modulate energy homeostasis by suppressing food intake. Furthermore, leptin could also influence cell metabolism by acting directly on the leptin receptor, which is a relatively small peptide and is mainly produced and released by fat tissue in mammals. On the other hand, the excessive extracellular matrix (ECM) could induce damage in normal tissues or organ structures, which might further induce fibrotic development in multiple tissues or organs, including the liver, heart, and kidneys. Notably, the sustainable development of fibrosis promotes the structural lesion and functional decline of different organs, which subsequently threatens human health and poses serious risks to human life. Emerging evidence has shown that leptin plays an important role in the fibrotic progression within multiple tissues and organs in mammals and has an alleviating effect on fibrosis. Concerning this notion, it has been proposed that leptin could be identified as a vital therapeutic strategy for fibrotic progression in clinical practice. Consequently, this review summarized the potential mechanisms of leptin in modulating fibrotic development in diverse tissues and organs to provide a theoretical basis for treating fibrotic-related diseases. In addition, the potential mechanisms whereby leptin affects the development of fibrosis were also summarized in the current review.},
	keywords = {Inflammation; EXPRESSION; CELLS; MATRIX; ANGIOGENESIS; HEDGEHOG; Cytokines; INSULIN-RESISTANCE; OBESITY; leptin; Fibrosis; Extracellular; PROMOTION; INDUCED LIVER FIBROSIS},
	year = {2023},
	eissn = {1875-5666},
	pages = {1066-1076},
	orcid-numbers = {Cheng, Ye/0000-0003-2340-7228}
}

@article{MTMT:33842881,
	title = {Mitigation of renal microvascular injury in diabetic kidney disease model mice by electroacupuncture},
	url = {https://m2.mtmt.hu/api/publication/33842881},
	author = {XIANG, Ji-qin and WEI, Wen-jing and LIAO, Mei-hua and ZHANG, Ke-xing and ZHOU, Ying-qi and ZHANG, Wen-jie and TANG, Chun-zhi and XU, Neng-gui and TAO, Rong-rong},
	doi = {10.1016/j.wjam.2023.05.004},
	journal-iso = {WORLD JOURNAL OF ACUPUNCTURE - MOXIBUSTION},
	journal = {WORLD JOURNAL OF ACUPUNCTURE - MOXIBUSTION},
	volume = {33},
	unique-id = {33842881},
	issn = {1003-5257},
	year = {2023},
	pages = {262-272}
}

@article{MTMT:33163142,
	title = {Zingiber officinale ameliorates diabetic nephropathy and hepatotoxicity in rats by preventing tissue injury and controlling liver/kidney function},
	url = {https://m2.mtmt.hu/api/publication/33163142},
	author = {Hamman, Luteino Lorna and Garba, Sani Hyedima and Jacks, Tamunotonye Watson and Zirahei, Joseph Vandi and Dibal, Nathan Isaac and Attah, Martha Orendu Oche},
	doi = {10.3233/MNM-211557},
	journal-iso = {MED J NUTR METABOL},
	journal = {MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM},
	volume = {15},
	unique-id = {33163142},
	issn = {1973-798X},
	abstract = {BACKGROUND: Chronic hyperglycemia results in decrease glucose metabolism leading to nephropathy, hepatotoxicity and neuropathy. Diabetic complications are regarded globally as one of the leading cause of disability and mortality.OBJECTIVE: The study aims to evaluate the role of Zingiber officinale (ZO) on diabetic nephropathy and hepatotoxicity in rats.METHODS: Thirty diabetic rats and six non-diabetic rats were distributed into six groups (n = 6). Group 1 & 2 (nondiabetic and diabetic) received distilled water at 1 ml/kg. Groups 3-5 received (12.5, 25& 50) mg/kg of ZO respectively while group 6 received 100 mg/kg metformin. All treatments lasted for 28 days and rats were euthanized on day 29. Biochemical parameters, kidney and liver histology were evaluated.RESULTS: No significant change (P > 0.05) was noticed in blood glucose and creatinine levels of diabetic rats treated with 25 mg/kg ZO compared to control. The liver of 25 mg/kg ZO treated diabetic rats showed mild distortion of hepatocytes while kidneys of ZO treated diabetic rats showed mild distortion of renal tubules with few collagen deposits and intact Bowman's capsule.CONCLUSIONS: ZO ameliorates diabetic complications by regulating biochemical parameters and preventing renal tubules and hepatocytes damage in rats.},
	keywords = {HEPATOCYTES; NEPHROPATHY; hyperglycemia; Zingiber officinale; distortion.},
	year = {2022},
	eissn = {1973-7998},
	pages = {333-343},
	orcid-numbers = {Dibal, Nathan Isaac/0000-0002-1805-7553}
}

@article{MTMT:32689936,
	title = {Leptin: an entry point for the treatment of peripheral tissue fibrosis and related diseases},
	url = {https://m2.mtmt.hu/api/publication/32689936},
	author = {Liu, Yuexia and Li, Yizhou and Liang, Juntong and Sun, Zhuwen and Wu, Qiong and Liu, Yongnian and Sun, Chao},
	doi = {10.1016/j.intimp.2022.108608},
	journal-iso = {INT IMMUNOPHARMACOL},
	journal = {INTERNATIONAL IMMUNOPHARMACOLOGY},
	volume = {106},
	unique-id = {32689936},
	issn = {1567-5769},
	year = {2022},
	eissn = {1878-1705}
}

@article{MTMT:33034295,
	title = {The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease},
	url = {https://m2.mtmt.hu/api/publication/33034295},
	author = {Li, Yixuan and Gu, Zuhua and Wang, Jun and Wang, Yangang and Chen, Xian and Dong, Bingzi},
	doi = {10.3389/fendo.2022.938830},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {13},
	unique-id = {33034295},
	issn = {1664-2392},
	year = {2022},
	eissn = {1664-2392}
}

@article{MTMT:32785537,
	title = {Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice},
	url = {https://m2.mtmt.hu/api/publication/32785537},
	author = {Zhang, Duoduo and Ji, Pengmin and Sun, Ran and Zhou, Huimin and Huang, Lei and Kong, Liangliang and Li, Weiping and Li, Weizu},
	doi = {10.1016/j.biopha.2022.112936},
	journal-iso = {BIOMED PHARMACOTHER},
	journal = {BIOMEDICINE & PHARMACOTHERAPY},
	volume = {150},
	unique-id = {32785537},
	issn = {0753-3322},
	year = {2022},
	eissn = {1950-6007}
}

@article{MTMT:31895412,
	title = {Curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation},
	url = {https://m2.mtmt.hu/api/publication/31895412},
	author = {Ye, Lin and Hu, Xueting and Hu, Xiang and Yin, Sihui and Chen, Jianqiang and He, Hanghui and Hong, Shanshan and Yang, Bin and Singh, Krishna K. and Feng, Jianpeng and Wang, Yi and Luo, Wu and Liang, Guang},
	doi = {10.1016/j.biopha.2021.111418},
	journal-iso = {BIOMED PHARMACOTHER},
	journal = {BIOMEDICINE & PHARMACOTHERAPY},
	volume = {137},
	unique-id = {31895412},
	issn = {0753-3322},
	year = {2021},
	eissn = {1950-6007}
}

@article{MTMT:31348436,
	title = {Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice},
	url = {https://m2.mtmt.hu/api/publication/31348436},
	author = {Ding, Shixin and Zhang, Han and Sun, Zhenghao and Han, Yuli and Li, Yan and Dong, Xianan and Yin, Yanyan and Li, Weiping and Li, Weizu},
	doi = {10.1016/j.jff.2020.104049},
	journal-iso = {J FUNCT FOODS},
	journal = {JOURNAL OF FUNCTIONAL FOODS},
	volume = {72},
	unique-id = {31348436},
	issn = {1756-4646},
	abstract = {Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury. Ginsenoside Rg1 may have protective effects on kidney aging. In this study, we investigated the tubular interstitial fibrosis and ER stress change in aged mice, and further observed the effects of Rg1 on renal interstitial fibrosis and ER stress in SAMP8 mice. The results demonstrated that the ER stress, apoptosis and interstitial fibrosis were significantly increased in the tubular epithelial cells in 20-month-old (M) and 24M mice. Meanwhile, we found that Rg1 significantly attenuated the tubular epithelial cells ER stress, apoptosis and interstitial fibrosis in SAMP8 mice. This study suggested that ER stress and apoptosis were closely implicated with aging-related renal interstitial fibrosis in aging progression. Rg1 could ameliorate aging-related renal interstitial fibrosis via inhibiting ER stress and apoptosis.},
	keywords = {APOPTOSIS; Endoplasmic reticulum stress; Ginsenoside Rg1; Renal tubular epithelial cells; Renal interstitial fibrosis},
	year = {2020},
	eissn = {2214-9414}
}