TY - JOUR AU - Herek, Sevgi AU - Herek, Celalettin AU - Onar, Mediha İrem AU - Gümülcineli, Pervin AU - Saçlı, Ömer AU - Atay, Ahmet Engin TI - An Unusual Combination of Acute Pancreatitis Etiologies: Hypertriglyceridemia and Carbamazepine Use JF - Bagcilar Medical Bulletin J2 - Bagcilar Medical Bulletin SN - 2547-9431 UR - https://m2.mtmt.hu/api/publication/31338073 ID - 31338073 LA - English DB - MTMT ER - TY - JOUR AU - Tarján, Dorottya AU - Szalai, Eszter AU - Lipp, Mónika Bernadett AU - Verbói, Máté AU - Kói, Tamás AU - Erőss, Bálint Mihály AU - Teutsch, Brigitta AU - Faluhelyi, Nándor AU - Hegyi, Péter AU - Mikó, Alexandra TI - Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 2 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25021273 UR - https://m2.mtmt.hu/api/publication/34530314 ID - 34530314 N1 - * Megosztott szerzőség AB - Infected necrotizing pancreatitis (INP) is associated with an increased risk of organ failure and mortality. Its early recognition and timely initiation of antibiotic therapy can save patients’ lives. We systematically searched three databases on 27 October 2022. In the eligible studies, the presence of infection in necrotizing pancreatitis was confirmed via a reference test, which involved either the identification of gas within the necrotic collection through computed tomography imaging or the examination of collected samples, which yielded positive results in Gram staining or culture. Laboratory biomarkers compared between sterile necrotizing pancreatitis and INP were used as the index test, and our outcome measures included sensitivity, specificity, the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC). Within the first 72 hours (h) after admission, the AUC of C-reactive protein (CRP) was 0.69 (confidence interval (CI): 0.62–0.76), for procalcitonin (PCT), it was 0.69 (CI: 0.60–0.78), and for white blood cell count, it was 0.61 (CI: 0.47–0.75). After the first 72 h, the pooled AUC of CRP showed an elevated level of 0.88 (CI: 0.75–1.00), and for PCT, it was 0.86 (CI: 0.60–1.11). The predictive value of CRP and PCT for infection is poor within 72 h after hospital admission but seems good after the first 72 h. Based on these results, infection is likely in case of persistently high CRP and PCT, and antibiotic initiation may be recommended. LA - English DB - MTMT ER - TY - JOUR AU - İnce, A.T. AU - Silahtaroğlu, G. AU - Seven, G. AU - Koçhan, K. AU - Yıldız, K. AU - Şentürk, H. TI - Early prediction of the severe course, survival, and ICU requirements in acute pancreatitis by artificial intelligence JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 23 PY - 2023 IS - 2 SP - 176 EP - 186 PG - 11 SN - 1424-3903 DO - 10.1016/j.pan.2022.12.005 UR - https://m2.mtmt.hu/api/publication/33581972 ID - 33581972 N1 - Export Date: 21 January 2023 LA - English DB - MTMT ER - TY - JOUR AU - Tarján, Dorottya AU - Hegyi, Péter TI - Acute Pancreatitis Severity Prediction: It Is Time to Use Artificial Intelligence JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 1 PG - 7 SN - 2077-0383 DO - 10.3390/jcm12010290 UR - https://m2.mtmt.hu/api/publication/33560475 ID - 33560475 N1 - Heart and Vascular Center, Division of Pancreatic Diseases, Semmelweis University, Budapest, 1083, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7623, Hungary Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, 6725, Hungary Cited By :1 Export Date: 1 October 2023 Correspondence Address: Hegyi, P.; Heart and Vascular Center, Hungary; email: hegyi2009@gmail.com AB - The clinical course of acute pancreatitis (AP) can be variable depending on the severity of the disease, and it is crucial to predict the probability of organ failure to initiate early adequate treatment and management. Therefore, possible high-risk patients should be admitted to a high-dependence unit. For risk assessment, we have three options: (1) There are univariate biochemical markers for predicting severe AP. One of their main characteristics is that the absence or excess of these factors affects the outcome of AP in a dose-dependent manner. Unfortunately, all of these parameters have low accuracy; therefore, they cannot be used in clinical settings. (2) Score systems have been developed to prognosticate severity by using 4–25 factors. They usually require multiple parameters that are not measured on a daily basis, and they often require more than 24 h for completion, resulting in the loss of valuable time. However, these scores can foresee specific organ failure or severity, but they only use dichotomous parameters, resulting in information loss. Therefore, their use in clinical settings is limited. (3) Artificial intelligence can detect the complex nonlinear relationships between multiple biochemical parameters and disease outcomes. We have recently developed the very first easy-to-use tool, EASY-APP, which uses multiple continuous variables that are available at the time of admission. The web-based application does not require all of the parameters for prediction, allowing early and easy use on admission. In the future, prognostic scores should be developed with the help of artificial intelligence to avoid information loss and to provide a more individualized risk assessment. LA - English DB - MTMT ER - TY - JOUR AU - Váncsa, Szilárd AU - Sipos, Zoltán AU - Váradi, Alex AU - Nagy, Rita AU - Ocskay, Klementina AU - Juhász, Márk Félix AU - Márta, Katalin AU - Teutsch, Brigitta AU - Mikó, Alexandra AU - Hegyi, Péter Jenő AU - Vincze, Áron AU - Izbéki, Ferenc AU - Czakó, László AU - Papp, Mária AU - Hamvas, József AU - Varga, Márta AU - Török, Imola AU - Mickevicius, Artautas AU - Erőss, Bálint Mihály AU - Párniczky, Andrea AU - Szentesi, Andrea Ildikó AU - Pár, Gabriella AU - Hegyi, Péter ED - Imrei, Marcell / Collaborator ED - Földi, Mária / Collaborator ED - Miklós, Emőke / Collaborator ED - Gódi, Szilárd / Collaborator ED - Hágendorn, Roland / Collaborator ED - Sarlós, Patricia / Collaborator ED - Bajor, Judit / Collaborator ED - Szabó, Imre / Collaborator ED - Czimmer, József / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Farkas, Orsolya / Collaborator ED - Kanizsai, Péter / Collaborator ED - Nagy, Tamás / Collaborator ED - Németh, Balázs / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Takács, Tamás / Collaborator ED - Gajdán, László / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - Bod, Barnabás / Collaborator ED - Novák, János / Collaborator ED - Macarie, Melania / Collaborator ED - Maurovich-Horvat, Pál / Collaborator ED - Doros, Attila / Collaborator ED - Deák, Pál Ákos / Collaborator ED - Varga, Csaba / Collaborator ED - Gaál, Szabolcs / Collaborator ED - Zubek, László / Collaborator ED - Gál, János / Collaborator ED - Patai, Árpád / Collaborator ED - Tornai, Tamás / Collaborator ED - Lázár, Balázs / Collaborator ED - Hussein, Tamás / Collaborator ED - Kovács, Beáta / Collaborator ED - Tarján, Dorottya / Collaborator ED - Lipp, Mónika Bernadett / Collaborator ED - Urbán, Orsolya / Collaborator ED - Emese, Fürst / Collaborator ED - Tari, Edina / Collaborator TI - Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 11 PY - 2023 IS - 4 SP - 371 EP - 382 PG - 12 SN - 2050-6406 DO - 10.1002/ueg2.12389 UR - https://m2.mtmt.hu/api/publication/33761635 ID - 33761635 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary Department of Metagenomics, University of Debrecen, Debrecen, Hungary Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary Heim Pál National Pediatric Institute, Budapest, Hungary Department of Medical Genetics, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Gastroenterology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Peterfy Hospital, Budapest, Hungary Department of Gastroenterology, BMKK Dr. Réthy Pál Hospital, Békéscsaba, Hungary County Emergency Clinical Hospital of Targu Mures - Gastroenterology and George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania Clinics of Abdominal Surgery, Nephrology and Gastroenterology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary Cited By :1 Export Date: 1 October 2023 Correspondence Address: Hegyi, P.Szigeti Street 12, Hungary; email: hegyi2009@gmail.com AB - Non-alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic-associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP.We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in-hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis.MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate-to-severe AP (OR = 1.43, CI: 1.09-1.89). However, the odds of in-hospital mortality (OR = 0.89, CI: 0.42-1.89) and severe AP (OR = 1.70, CI: 0.97-3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39-5.09). In addition, the presence of one, two, and three diagnostic criteria dose-dependently increased the odds of moderate-to-severe AP (OR = 1.23, CI: 0.88-1.70, OR = 1.38, CI: 0.93-2.04, and OR = 3.04, CI: 1.63-5.70, respectively) and severe AP (OR = 1.13, CI: 0.54-2.27, OR = 2.08, CI: 0.97-4.35, and OR = 4.76, CI: 1.50-15.4, respectively). Furthermore, in patients with alcohol abuse and aged ≥60 years, the effect of MAFLD became insignificant.MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose-dependent effect on the outcomes of AP. LA - English DB - MTMT ER - TY - JOUR AU - Elshal, Mohamed AU - Auf, Ahmed AU - El, Fady George A. AU - Raslan, Mohamed M. TI - Serum C-reactive protein on the seventh day after pancreatitis could add value in predicting the course of disease progression JF - EGYPTIAN JOURNAL OF SURGERY J2 - EGYPTIAN JOURNAL OF SURGERY VL - 41 PY - 2022 IS - 3 SP - 1140 EP - 1147 PG - 8 SN - 1110-1121 DO - 10.4103/ejs.ejs_202_22 UR - https://m2.mtmt.hu/api/publication/34185521 ID - 34185521 AB - Background The incidence of acute pancreatitis (AP) has increased recently. Although most cases follow a mild course, some cases follow a severe course that may lead to death. Different scoring systems are used for the assessment of the severity of the attack such as Acute Physiology and Chronic Health Examination, Ranson, and modified computed tomography severity index.The most popular method of grading is based on contrast-enhanced computed tomography imaging. The computed tomography severity index (CTSI), developed by Balthazar and Ranson, clarifies the degree of pancreatic and peripancreatic inflammation, extent of parenchyma necrosis, and fluid collection measured by the computed tomography. C-reactive protein (CRP) is an acute-phase reactant that is synthesized by hepatocytes. This synthesis is induced by the release of IL-1and IL-6. CRP is one of the most sensitive markers for inflammation used today. Patients and methods A prospective observational comparative study was done on 70 patients with AP; they were followed up by a correlation between CTSI and CRP levels on day 2 and day 7 after presentation. Results It was found that there is a statistically significant increase in CRP levels in correlation with CTSI. Results showed that CRP levels rise significantly in severe and in necrotizing pancreatitis. Conclusion CRP is a straightforward way to predict severity for patients with AP. Based on this study, CRP levels are useful in patients who have contraindications for computed tomography with intravenous contrast such as patients with renal failure and pregnant women. LA - English DB - MTMT ER - TY - JOUR AU - Kui, Balázs AU - Pintér, József AU - Molontay, Roland AU - Nagy, Marcell AU - Borbásné Farkas, Kornélia AU - Gede, Noémi AU - Vincze, Áron AU - Bajor, Judit AU - Gódi, Szilárd AU - Czimmer, József AU - Szabó, Imre AU - Illés, Anita AU - Sarlós, Patrícia AU - Hágendorn, Roland AU - Pár, Gabriella AU - Papp, Mária AU - Vitális, Zsuzsanna AU - Kovács, György AU - Fehér, Eszter AU - Földi, Ildikó AU - Izbéki, Ferenc AU - Gajdán, László AU - Fejes, Roland AU - Németh, Balázs AU - Török, Imola AU - Farkas, Hunor AU - Mickevicius, Artautas AU - Sallinen, Ville AU - Galeev, Shamil AU - Ramírez-Maldonado, Elena AU - Párniczky, Andrea AU - Erőss, Bálint Mihály AU - Hegyi, Péter Jenő AU - Márta, Katalin AU - Váncsa, Szilárd AU - Sutton, Robert AU - Szatmary, Peter AU - Latawiec, Diane AU - Halloran, Chris AU - de-Madaria, Enrique AU - Pando, Elizabeth AU - Alberti, Piero AU - Gómez-Jurado, Maria José AU - Tantau, Alina AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter TI - EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis JF - CLINICAL AND TRANSLATIONAL MEDICINE J2 - CLIN TRANSL MED VL - 12 PY - 2022 IS - 6 PG - 13 SN - 2001-1326 DO - 10.1002/ctm2.842 UR - https://m2.mtmt.hu/api/publication/32865751 ID - 32865751 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office Research Fund [K131996, FK131864, K128222, FK124632]; University of Pecs Medical School Research Fund [300909] Funding text: The research was supported by National Research, Development and Innovation Office Research Fund (project grants K131996 to Peter Hegyi, FK131864 to Artautas Mickevicius, K128222 to Laszlo Gajdan, FK124632 to Balazs Csaba Nemeth), and by funding from the University of Pecs Medical School Research Fund (300909) to Andrea Szentesi. The funders had no effect on the concept, data collection, analysis and writing of the manuscript. We wish to thank all further contributing members of the Hungarian Pancreatic Study Group, full names together with affiliations are listed in the Supplementary material. AB - Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed.The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit-learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross-validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross-validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP).The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy-to-use web application in the Streamlit Python-based framework (http://easy-app.org/).The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model. LA - English DB - MTMT ER - TY - JOUR AU - Qiu, X. AU - Huang, F. AU - Li, Z. AU - Wei, X. AU - Wu, J. AU - Huang, J. AU - Liu, S. TI - Develop a Novel Nomogram to Predict Respiratory Failure in Acute Pancreatitis at Early Stage JF - CLINICAL LABORATORY J2 - CLIN LAB VL - 68 PY - 2022 IS - 4 SP - 810 EP - 816 PG - 7 SN - 1433-6510 DO - 10.7754/Clin.Lab.2021.210826 UR - https://m2.mtmt.hu/api/publication/34783215 ID - 34783215 N1 - Export Date: 11 April 2024; Cited By: 3; Correspondence Address: S. Liu; Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China; email: poempower@163.com; CODEN: CLLAF LA - English DB - MTMT ER - TY - JOUR AU - Walkowska, J. AU - Zielinska, N. AU - Tubbs, R.S. AU - Podgórski, M. AU - Dłubek-Ruxer, J. AU - Olewnik, Ł. TI - Diagnosis and Treatment of Acute Pancreatitis JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 12 PY - 2022 IS - 8 PG - 35 SN - 2075-4418 DO - 10.3390/diagnostics12081974 UR - https://m2.mtmt.hu/api/publication/33100315 ID - 33100315 N1 - Department of Anatomical Dissection and Donation, Medical University of Lodz, Lodz, 90-752, Poland Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, United States Department of Neurosurgery and Ochsner Neuroscience Institute, Ochsner Health System, New Orleans, LA 70112, United States Department of Anatomical Sciences, St. George’s University, P.O. Box 7, St. George’s, Grenada Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, United States Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, United States Department of Diagnostic Imaging and Interventional Radiology, Lodz, 90-549, Poland Export Date: 19 September 2022 Correspondence Address: Olewnik, Ł.; Department of Anatomical Dissection and Donation, Poland; email: lukasz.olewnik@umed.lodz.pl AB - The pancreas is a glandular organ that is responsible for the proper functioning of the digestive and endocrine systems, and therefore, it affects the condition of the entire body. Consequently, it is important to effectively diagnose and treat diseases of this organ. According to clinicians, pancreatitis-a common disease affecting the pancreas-is one of the most complicated and demanding diseases of the abdomen. The classification of pancreatitis is based on clinical, morphologic, and histologic criteria. Medical doctors distinguish, inter alia, acute pancreatitis (AP), the most common causes of which are gallstone migration and alcohol abuse. Effective diagnostic methods and the correct assessment of the severity of acute pancreatitis determine the selection of an appropriate treatment strategy and the prediction of the clinical course of the disease, thus preventing life-threatening complications and organ dysfunction or failure. This review collects and organizes recommendations and guidelines for the management of patients suffering from acute pancreatitis. LA - English DB - MTMT ER - TY - JOUR AU - Zheng, Z.X. AU - Bi, J.T. AU - Cai, X. AU - Liu, Y.Q. TI - The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis JF - HELIYON J2 - HELIYON VL - 8 PY - 2022 IS - 12 SN - 2405-8440 DO - 10.1016/j.heliyon.2022.e12003 UR - https://m2.mtmt.hu/api/publication/33574754 ID - 33574754 N1 - Export Date: 19 January 2023 Correspondence Address: Zheng, Z.X.; Department of General Surgery, China; email: pollitzheng@sina.com.cn LA - English DB - MTMT ER - TY - JOUR AU - Cheng, Tao AU - Liu, Bo-Fu AU - Han, Tian-Yong AU - Gu, Zhi-Han AU - Pan, Pan AU - Yu Haifang, null TI - Effectiveness and safety of Liuhedan for treating acute pancreatitis A protocol for systematic review and meta analysis JF - MEDICINE J2 - MEDICINE VL - 100 PY - 2021 IS - 8 PG - 3 SN - 0025-7974 DO - 10.1097/MD.0000000000024863 UR - https://m2.mtmt.hu/api/publication/32313144 ID - 32313144 N1 - Funding Agency and Grant Number: Science Foundation of Science and Technology Department of Sichuan [2018SZ0390] Funding text: This work was supported financially by grants from the Science Foundation of Science and Technology Department of Sichuan (No. 2018SZ0390). AB - Background: Liuhedan is a famous traditional Chinese medicine (TCM) formula used to treat acute pancreatitis (AP) in China. However, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of Liuhedan for treating AP. The aim of this study is to summarize previous evidence, assessing the efficacy and safety of Liuhedan in the treatment of AP. Methods: We will search the EMBASE, WANFANG DATA, Web of Knowledge, CNKI, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30, 2021 to retrieve relevant studies using the search strategy: ("Liuhedan" OR "Liuhe Pill" OR "Liu-He-Dan") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I-2 statistic. Results: This study assessed the efficiency and safety of Liuhedan for treating acute pancreatitis. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of Liuhedan for treating AP. Ethics and dissemination: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference. LA - English DB - MTMT ER - TY - JOUR AU - Cheng, Tao AU - Liu, Bo-Fu AU - Han, Tian-Yong AU - Gu, Zhi-Han AU - Pan, Pan AU - Yu, Haifang TI - Effectiveness and safety of proton pump inhibitors for treating acute pancreatitis A protocol for systematic review and meta analysis JF - MEDICINE J2 - MEDICINE VL - 100 PY - 2021 IS - 8 PG - 3 SN - 0025-7974 DO - 10.1097/MD.0000000000024808 UR - https://m2.mtmt.hu/api/publication/32313145 ID - 32313145 N1 - Funding Agency and Grant Number: Science Foundation of Science and Technology Department of Sichuan [2018SZ0390] Funding text: This work was supported financially by grants from the Science Foundation of Science and Technology Department of Sichuan (No. 2018SZ0390). AB - Background: Previous studies have showed that anti-acid therapy with proton pump inhibitors (PPIs) can inhibit pancreatic secretion and it may be used in treating acute pancreatitis (AP). But at present, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of anti-acid therapy with PPIs in AP were not unclear. Therefore, we will undertake a systematic review of the literature to summarize previous evidence regarding this topic, in order to clarify the effectiveness and safety of anti-acid therapy with PPIs in AP. Methods: We will search the EMBASE, WANFANG DATA, Web of Knowledge, China National Knowledge Infrastructure, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30,2021 to retrieve relevant studies using the search strategy: ("Proton pump inhibitors" OR "PPI" OR "PPIs" OR "Omeprazole" OR "Tenatoprazole" OR "Pantoprazole" OR "acid suppression therapy" OR "acid suppression drugs") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I-2 statistic. Results: This study assessed the efficiency and safety of proton pump inhibitors for treating acute pancreatitis. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of PPIs for treating AP. Ethics and dissemination: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference. LA - English DB - MTMT ER - TY - JOUR AU - Ocskay, Klementina AU - Vinkó, Zsófia AU - Németh, Dávid AU - Szabó, László AU - Bajor, Judit AU - Gódi, Szilárd AU - Sarlós, Patrícia AU - Czakó, László AU - Izbéki, Ferenc AU - Hamvas, József AU - Papp, Mária AU - Varga, Márta AU - Török, Imola AU - Mickevicius, Artautas AU - Sallinen, Ville AU - Maldonado, Elena Ramirez AU - Galeev, Shamil AU - Mikó, Alexandra AU - Erőss, Bálint Mihály AU - Imrei, Marcell AU - Hegyi, Péter Jenő AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Kanizsai, Péter László AU - Miseta, Attila János AU - Nagy, Tamás AU - Hágendorn, Roland AU - Márton, Zsolt AU - Szakács, Zsolt AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter AU - Párniczky, Andrea TI - Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-021-03449-8 UR - https://m2.mtmt.hu/api/publication/32546426 ID - 32546426 N1 - * Megosztott szerzőség AB - The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay. LA - English DB - MTMT ER - TY - JOUR AU - Szakó, Lajos AU - Gede, Noémi AU - Váradi, Alex AU - Tinusz, Benedek AU - Vörhendi, Nóra AU - Mosztbacher, Dóra AU - Vincze, Áron AU - Takács, Tamás AU - Czakó, László AU - Izbéki, Ferenc AU - Gajdán, László AU - Dunás-Varga, Veronika AU - Hamvas, József AU - Papp, Mária AU - Fehér, Krisztina Eszter AU - Varga, Márta AU - Mickevicius, Artautas AU - Török, Imola AU - Ocskay, Klementina AU - Juhász, Márk Félix AU - Váncsa, Szilárd AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Miseta, Attila János AU - Vereczkei, András AU - Mikó, Alexandra AU - Hegyi, Péter Jenő AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Erőss, Bálint Mihály AU - Hegyi, Péter TI - Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 21 PY - 2021 IS - 6 SP - 1161 EP - 1172 PG - 12 SN - 1424-3903 DO - 10.1016/j.pan.2021.05.007 UR - https://m2.mtmt.hu/api/publication/32053186 ID - 32053186 N1 - Megosztott utolsó szerzőség AB - Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre-existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP.Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups.The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p < 0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p < 0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p = 0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p < 0.001), a previous episode of AP (p < 0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p < 0.001), current smoking (p < 0.001), and increased alcohol consumption (unit/week) (p = 0.014).Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP. LA - English DB - MTMT ER - TY - JOUR AU - Wang, Y. AU - Xu, Z. AU - Zhou, Y. AU - Xie, M. AU - Qi, X. AU - Xu, Z. AU - Cai, Q. AU - Sheng, H. AU - Chen, E. AU - Zhao, B. AU - Mao, E. TI - Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis JF - JOURNAL OF CLINICAL LABORATORY ANALYSIS J2 - J CLIN LAB ANAL VL - 35 PY - 2021 IS - 7 PG - 15 SN - 0887-8013 DO - 10.1002/jcla.23863 UR - https://m2.mtmt.hu/api/publication/32115157 ID - 32115157 N1 - Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Export Date: 28 July 2021 CODEN: JCANE Correspondence Address: Zhao, B.; Department of Emergency, China; email: zhaobing124@163.com Correspondence Address: Mao, E.; Department of Emergency, China; email: maoeq@yeah.net Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Export Date: 29 July 2021 CODEN: JCANE Correspondence Address: Zhao, B.; Department of Emergency, China; email: zhaobing124@163.com Correspondence Address: Mao, E.; Department of Emergency, China; email: maoeq@yeah.net Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Export Date: 30 July 2021 CODEN: JCANE Correspondence Address: Zhao, B.; Department of Emergency, China; email: zhaobing124@163.com Correspondence Address: Mao, E.; Department of Emergency, China; email: maoeq@yeah.net Funding Agency and Grant Number: National Natural Science Foundation Youth Project of China [81601665]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600501] Funding text: National Natural Science Foundation Youth Project of China, Grant/Award Number: 81601665; National Natural Science Foundation of China, Grant/Award Number: 81600501 Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Export Date: 7 September 2021 CODEN: JCANE Correspondence Address: Zhao, B.; Department of Emergency, China; email: zhaobing124@163.com Correspondence Address: Mao, E.; Department of Emergency, China; email: maoeq@yeah.net Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Export Date: 23 September 2021 CODEN: JCANE Correspondence Address: Zhao, B.; Department of Emergency, China; email: zhaobing124@163.com Correspondence Address: Mao, E.; Department of Emergency, China; email: maoeq@yeah.net LA - English DB - MTMT ER - TY - JOUR AU - Aghdassi, Ali A. AU - Schauer, Birgit AU - Duscha, David AU - Ittermann, Till AU - Pickartz, Tilman AU - Budde, Christoph AU - Simon, Peter AU - Moskwa, Patryk AU - Kromrey, Marie L. AU - Buelow, Robin AU - Voelzke, Henry AU - Kuehn, Jens AU - Lerch, Markus M. TI - Comparability of size measurements of the pancreas in magnetic resonance imaging and transabdominal ultrasound JF - CLINICAL ANATOMY J2 - CLIN ANAT VL - 33 PY - 2020 IS - 3 SP - 431 EP - 439 PG - 9 SN - 0897-3806 DO - 10.1002/ca.23551 UR - https://m2.mtmt.hu/api/publication/32615946 ID - 32615946 N1 - Funding Agency and Grant Number: Bundesministerium fur Bildung und ForschungFederal Ministry of Education & Research (BMBF) [BMBF 0314107, 01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK0, BMBF GANI-MED 03IS2061A]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [AG 203/2-1, DFG GRK1947]; Dr. Mildred Scheel Stiftung fur KrebsforschungDeutsche Krebshilfe [109102]; European Social FundEuropean Social Fund (ESF) [ESF/14-BM-A55-0008/18, ESF/14-BMA55-0045/16]; FP7 Health [EU-FP-7: EPC-TM]; Seventh Framework ProgrammeEuropean Commission [EU-FP7-REGPOT-2010-1] Funding text: Bundesministerium fur Bildung und Forschung, Grant/Award Numbers: BMBF 0314107, 01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK0, BMBF GANI-MED 03IS2061A; Deutsche Forschungsgemeinschaft, Grant/Award Numbers: AG 203/2-1, DFG GRK1947, A3; Dr. Mildred Scheel Stiftung fur Krebsforschung, Grant/Award Number: 109102; European Social Fund, Grant/Award Numbers: ESF/14-BM-A55-0008/18, ESF/14-BMA55-0045/16; FP7 Health, Grant/Award Number: EU-FP-7: EPC-TM; Seventh Framework Programme, Grant/Award Number: EU-FP7-REGPOT-2010-1 AB - Introduction Transabdominal ultrasound (US) and magnetic resonance imaging (MRI) are commonly used for the examination of the pancreas in clinical routine. We therefore were interested in the concordance of these two imaging methods for the size measurement of the pancreas and how age, gender, and body mass index (BMI) affect the organ size. Methods A total of 342 participants from the Study of Health in Pomerania underwent whole-body MRI and transabdominal US on the same day, and the diameter of the pancreatic head, body, and tail were measured. The agreement between US and MRI measurements was assessed by Bland and Altman plots. Intraclass correlation coefficients were used to compare observers. A multivariable regression model was applied using the independent variables age, gender, and body mass index. Results Compared to MRI, abdominal US returned smaller values for each segment of the pancreas, with a high level of inconsistency between these two methods. The mean difference was 0.39, 0.18, and 0.54 cm for the head, body, and tail, respectively. A high interobserver variability was detected for US. Multivariable analysis showed that pancreatic size in all three segments increased with BMI in both genders whereas pancreatic head and tail size decreased with age, an effect more marked in women. Conclusions Agreement of pancreatic size measurements is poor between US and MRI. These limitations should be considered when evaluating morphologic features for pathologic conditions or setting limits of normal size. Adjustments for BMI, gender, and age may also be warranted. LA - English DB - MTMT ER - TY - JOUR AU - Bush, Nikhil AU - Rana, Surinder S AU - Gupta, Pankaj AU - Kang, Mandeep AU - Gupta, Rajesh AU - Suri, Vikas AU - Ramachandran, Raja AU - Kumar, Susheel AU - Dhibar, Deba Prasad TI - Renal doppler changes in patients with acute pancreatitis: A prospective study JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 7 SP - 1275 EP - 1280 PG - 6 SN - 1424-3903 DO - 10.1016/j.pan.2020.08.007 UR - https://m2.mtmt.hu/api/publication/31471171 ID - 31471171 N1 - Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Nephrology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Export Date: 4 January 2021 CODEN: PANCC Correspondence Address: Rana, S.S.; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER)India; email: drsurinderrana@gmail.com Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Nephrology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Export Date: 22 January 2021 CODEN: PANCC Correspondence Address: Rana, S.S.; Department of Gastroenterology, India; email: drsurinderrana@gmail.com Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Department of Nephrology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India Export Date: 29 July 2021 CODEN: PANCC Correspondence Address: Rana, S.S.; Department of Gastroenterology, India; email: drsurinderrana@gmail.com Chemicals/CAS: C reactive protein, 9007-41-4; creatinine, 19230-81-0, 60-27-5; hemoglobin, 9008-02-0; procalcitonin, 56645-65-9 LA - English DB - MTMT ER - TY - JOUR AU - Chadalavada, Pravallika AU - Simons-Linares, C. Roberto AU - Chahal, Prabhleen TI - Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 7 SP - 1281 EP - 1286 PG - 6 SN - 1424-3903 DO - 10.1016/j.pan.2020.07.401 UR - https://m2.mtmt.hu/api/publication/31690633 ID - 31690633 N1 - Export Date: 4 January 2021 CODEN: PANCC Correspondence Address: Simons-Linares, C.R.; Digestive Disease Institute, Gastroenterology and Hepatology department, Cleveland Clinic, 9500 Euclid avenue, United States; email: robertosimons@outlook.com Cited By :1 Export Date: 13 May 2021 CODEN: PANCC Correspondence Address: Simons-Linares, C.R.; Digestive Disease Institute, 9500 Euclid avenue, United States; email: robertosimons@outlook.com Cited By :1 Export Date: 29 July 2021 CODEN: PANCC Correspondence Address: Simons-Linares, C.R.; Digestive Disease Institute, 9500 Euclid avenue, United States; email: robertosimons@outlook.com Chemicals/CAS: atazanavir, 198904-31-3; azathioprine, 446-86-6; cetuximab, 205923-56-4; colchicine, 64-86-8; cotrimoxazole, 8064-90-2; darunavir, 206361-99-1, 635728-49-3; doxycycline, 10592-13-9, 17086-28-1, 564-25-0, 94088-85-4; esomeprazole, 119141-88-7, 202742-32-3, 217087-09-7, 217087-10-0, 161796-84-5; ethinylestradiol, 57-63-6; floxuridine, 50-91-9; gemfibrozil, 25812-30-0; hydrochlorothiazide, 58-93-5; ipilimumab, 477202-00-9; irinotecan, 100286-90-6, 97682-44-5; lamivudine, 134678-17-4, 134680-32-3; liraglutide, 204656-20-2; lisinopril, 76547-98-3, 83915-83-7; mercaptopurine, 31441-78-8, 50-44-2, 6112-76-1; metronidazole, 39322-38-8, 443-48-1; nivolumab, 946414-94-4; paracetamol, 103-90-2; sitagliptin, 486460-32-6, 654671-78-0, 654671-77-9; tigecycline, 220620-09-7; valproic acid, 1069-66-5, 99-66-1 Tradenames: bactrim AB - Background: We sought to study the causative drugs, prevalence and outcomes of drug-induced acute pancreatitis (DIAP).Methods: Retrospective study of DIAP patients at a tertiary teaching hospital. The diagnosis and severity of pancreatitis were determined based on the Revised Atlanta Classification. The cases were further subclassified using the Badalov et al., 2008 classification, and Naranjo score to evaluate and determine the odds of drug-related adverse reaction as a causative factor for AP.Results: Out of 841 AP patients, a total of 31 patients (3.6%) with DIAP were included. The mean age was 52.9 years, 51.6% were male. The most common causative drugs are listed in Table 3. Most cases were mild in severity (87%), moderate AP occurred in 2 patients (6.5%) and severe AP in 2 patients (6.5%). 19.3% had systemic inflammatory response syndrome at presentation, but it persisted beyond 48 h in only 9.6%. 9.6% developed acute kidney injury. One patient with valproate induced DIAP had pancreatic necrosis, splenic vein thrombus, and sub occlusive superior mesenteric vein thrombus on abdominal imaging. Three patients had recurrent AP, and two (6.5%) of them eventually developed chronic pancreatitis. Notably, none of our patients developed complications such as shock, acute respiratory distress syndrome, bacteremia, or death. 1 patient had an acute peripancreatic fluid collection on initial imaging and another patient developed a pseudocyst on follow up imaging. None of them required drainage.Conclusion: Our study showed a prevalence of DIAP of (3.6%) and hydrochlorothiazide, azathioprine, and doxycycline were the most common culprit drugs. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Demcsák, Alexandra AU - Soós, Alexandra AU - Kincses, Lilla AU - Capunge, Ines AU - Minkov, Georgi AU - Kovacheva-Slavova, Mila AU - Nakov, Radislav AU - Wu, Dong AU - Huang, Wei AU - Xia, Qing AU - Deng, Lihui AU - Hollenbach, Marcus AU - Schneider, Alexander AU - Hirth, Michael AU - Ioannidis, Orestis AU - Vincze, Áron AU - Bajor, Judit AU - Sarlós, Patrícia AU - Czakó, László AU - Illés, Dóra AU - Izbéki, Ferenc AU - Gajdán, László AU - Papp, Mária AU - Hamvas, József AU - Varga, Márta AU - Kanizsai, Péter László AU - Bóna, Ernő AU - Mikó, Alexandra AU - Váncsa, Szilárd AU - Juhász, Márk Félix AU - Ocskay, Klementina AU - Darvasi, Erika AU - Miklós, Emőke AU - Erőss, Bálint Mihály AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Casadei, Riccardo AU - Ricci, Claudio AU - Ingaldi, Carlo AU - Mastrangelo, Laura AU - Jovine, Elio AU - Cennamo, Vincenzo AU - Marino, Marco V. AU - Barauskas, Giedrius AU - Ignatavicius, Povilas AU - Pelaez-Luna, Mario AU - Rios, Andrea Soriano AU - Turcan, Svetlana AU - Tcaciuc, Eugen AU - Małecka-Panas, Ewa AU - Zatorski, Hubert AU - Nunes, Vitor AU - Gomes, Antonio AU - Gonçalves, Tiago Cúrdia AU - Freitas, Marta AU - Constantino, Júlio AU - Ramos Moreira e Sá, Milene Raquel AU - Pereira, Jorge AU - Mateescu, Bogdan AU - Constantinescu, Gabriel AU - Sandru, Vasile AU - Negoi, Ionut AU - Ciubotaru, Cezar AU - Negoita, Valentina AU - Bunduc, Stefania AU - Gheorghe, Cristian AU - Barbu, Sorin AU - Tantau, Alina AU - Tantau, Marcel AU - Dumitru, Eugen AU - Suceveanu, Andra Iulia AU - Tocia, Cristina AU - Gherbon, Adriana AU - Litvin, Andrey AU - Shirinskaya, Natalia AU - Rabotyagova, Yliya AU - Bezmarevic, Mihailo AU - Hegyi, Péter Jenő AU - Han, Jimin AU - Rodriguez-Oballe, Juan Armando AU - Salas, Isabel Miguel AU - Comas, Eva Pijoan AU - Garcia, Daniel de la Iglesia AU - Cuadrado, Andrea Jardi AU - Castiñeira, Adriano Quiroga AU - Chang, Yu-Ting AU - Chang, Ming-Chu AU - Kchaou, Ali AU - Tlili, Ahmed AU - Kacar, Sabite AU - Gökbulut, Volkan AU - Duman, Deniz AU - Kani, Haluk Tarik AU - Altintas, Engin AU - Chooklin, Serge AU - Chuklin, Serhii AU - Gougol, Amir AU - Papachristou, George AU - Hegyi, Péter TI - Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis – An international cohort study JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 7 SP - 1323 EP - 1331 PG - 9 SN - 1424-3903 DO - 10.1016/j.pan.2020.08.009 UR - https://m2.mtmt.hu/api/publication/31487014 ID - 31487014 N1 - Department of Pediatrics and Pediatric Health Centre, University of Szeged, Szeged, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Clínica Sagrada Esperança, Luanda, Angola Department of Surgery, University Hospital, Stara Zagora, Bulgaria Department of Gastroenterology, Queen Yoanna University Hospital, Medical University of Sofia, Sofia, Bulgaria Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, China Division of Gastroenterology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany Department of Gastroenterology and Hepatology, Klinikum Bad Hersfeld, Bad Hersfeld, Germany Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Fourth Surgical Department, Medical School, Aristotle, University of Thessaloniki, Thessaloniki, Greece Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Medicine, University of Szeged, Szeged, Hungary Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary Division of Gastroenterology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary Péterfy Hospital, Budapest, Hungary Department of Gastroenterology, BMKK Dr. Réthy Pál Hospital, Békéscsaba, Hungary Department of Emergency Medicine, Medical School, University of Pécs, Pécs, Hungary Heim Pál National Pediatric Institute, Budapest, Hungary Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy Unit of General Surgery, Ausl Bologna Bellaria, Maggiore Hospital, Bologna, Italy Department of Surgery, Ausl Bologna Bellaria, Maggiore Hospital, Bologna, Italy Unit of Gastroenterology and Digestive Endoscopy, Ausl Bologna Bellaria, Maggiore Hospital, Bologna, Italy Emergency and General Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy General Surgery Department, Hospital Universitario Marques de Valdecilla, Santander, Spain Division of HPB Surgery, Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Pancreatic Disorders Unit, National Institute of Medical Sciences and Nutrition Salvador Zubiran, UNAM., Mexico City, Mexico Department of Gastroenterology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland HPB Surgery, Department of Surgery, Hospital Prof. Dr. Fernando Fonseca, Amadora, Portugal Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal School of Medicine, University of Minho, Braga/Guimarães, Portugal ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal Unidade HBP, Serviço de Cirurgia Geral, Centro Hospitalar Tondela-Viseu, Viseu, Portugal Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Gastroenterology Department, Bucharest Emergency Hospital, Bucharest, Romania Surgery Department, Emergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Fundeni Clinical Institute, Gastroenterology, Hepatology and Liver Transplant Department, Bucharest, Romania Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 4th Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania The 4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Department of Gastroenterology, Iuliu Hatieganu University of Medicine and Pharmacy, Prof. Octavian Fodor Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania Faculty of Medicine, Ovidius University of Constanta, County, Emergency, and Clinical Hospital of Constanta, Constanta, Romania Diabetes, Nutrition, Metabolic Diseases and Internal Medicine Clinic, University of Medicine and Pharmacy V. Babes Timisoara, County Hospital Pius Branzeu, Timisoara, Romania Department of Surgical Disciplines, Immanuel Kant Baltic Federal University, Regional Clinical Hospital, Kaliningrad, Russian Federation Omsk State Medical Information-Analytical Centre, Omsk State Medical University, Omsk State Clinical Emergency Hospital #2, Omsk, Russian Federation Medical Academy Named after S.I. Georgievsky, Crimean Federal University Named after V.I. Vernadsky, Simferopol, Russian Federation Department of Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military Medical Academy, University of Defense, Belgrade, Serbia Department of Gastroenterology, Slovak Medical University in Bratislava, Bratislava, Slovakia Division of Gastroenterology, Department of Internal Medicine, Daegu Catholic University Medical Center and School of Medicine, Daegu, South Korea Department of Gastroenterology, University Hospital Santa María - University Hospital Arnau de Vilanova, Lerida, Spain Department of Gastroenterology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Digestive Surgery, Habib Bourguiba Teaching Hospital, Sfax, Tunisia Department of Gastroenterology, Yüksek Ihtisas Hastanesi, Ankara, Turkey Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey Gastroenterology Department, Faculty of Medicine, Ovidius University, Constanta, Romania Department of Surgery, Regional Clinical Hospital, Lviv, Ukraine Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary Cited By :12 Export Date: 16 October 2023 CODEN: PANCC Correspondence Address: Hegyi, P.12 Szigeti ut, Hungary; email: p.hegyi@tm-pte.org Chemicals/CAS: Proton Pump Inhibitors Funding text 1: This study was supported by Project Grants of the National Research Development and Innovation Office ( K131996 to PH and FK131864 to AM), by the János Bolyai Research Scholarship granted by the Hungarian Academy of Sciences (to AP), by ‘GINOP-2.3.2-15-2016-00048–STAY ALIVE’ co-financed by the European Union (European Regional Development Fund) within the framework of the Széchenyi 2020 Programme, and by a Human Resources Development Operational Programme Grant , Grant Number: EFOP 3.6.2-16-2017-00006–LIVE LONGER , co-financed by the European Union (European Regional Development Fund) within the framework of the Széchenyi 2020 Programme. LA - English DB - MTMT ER - TY - THES AU - Tóth, Emese TI - Important therapeutic targets in acute pancreatitis [Fontos terápiás célpontok az akut pankreátitiszben] PB - Szegedi Tudományegyetem (SZTE) PY - 2020 SP - 116 DO - 10.14232/phd.10329 UR - https://m2.mtmt.hu/api/publication/31041306 ID - 31041306 LA - English DB - MTMT ER - TY - JOUR AU - Karakulak, S. AU - Narcı, H. AU - Ayrık, C. AU - Erdoğan, S. AU - Üçbilek, E. TI - The prognostic value of immature granulocyte in patients with acute pancreatitis JF - AMERICAN JOURNAL OF EMERGENCY MEDICINE J2 - AM J EMERG MED PY - 2020 SN - 0735-6757 DO - 10.1016/j.ajem.2020.03.028 UR - https://m2.mtmt.hu/api/publication/31356472 ID - 31356472 N1 - Export Date: 22 June 2020 CODEN: AJEME Mersin University, Faculty of Medicine, Department of Emergency Medicine, Mersin, Turkey Mersin University, Faculty of Medicine, Department of Biostatistics, Mersin, Turkey Mersin University, Faculty of Medicine, Department of Gastroenterology, Mersin, Turkey Export Date: 29 July 2021 CODEN: AJEME Correspondence Address: Narcı, H.; Department of Emergency Medicine, Turkey; email: hsnnarci@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Meczker, Ágnes AU - Hanák, Lilla AU - Párniczky, Andrea AU - Szentesi, Andrea Ildikó AU - Erőss, Bálint Mihály AU - Hegyi, Péter ED - Erdősi, Dalma / Collaborator ED - Mikó, Alexandra / Collaborator ED - Szakács, Zsolt / Collaborator ED - Dobszai, Dalma / Collaborator ED - Szapáry, László Botond / Collaborator ED - Bajor, Judit / Collaborator ED - Mikó, A. / Collaborator ED - Vincze, Áron / Collaborator ED - Matuz, Mária / Collaborator ED - Csupor, Dezső / Collaborator ED - Pethő, Gábor / Collaborator TI - Analysis of 1060 Cases of Drug-Induced Acute Pancreatitis JF - GASTROENTEROLOGY J2 - GASTROENTEROLOGY VL - 159 PY - 2020 IS - 5 SP - 1958 EP - 1961.e8 PG - 12 SN - 0016-5085 DO - 10.1053/j.gastro.2020.07.016 UR - https://m2.mtmt.hu/api/publication/31384691 ID - 31384691 N1 - * Megosztott szerzőség Brief Communication LA - English DB - MTMT ER - TY - JOUR AU - Silva-Vaz, Pedro AU - Abrantes, Ana Margarida AU - Morgado-Nunes, Sara AU - Castelo-Branco, Miguel AU - Gouveia, António AU - Botelho, Maria Filomena AU - Tralhão, José Guilherme TI - Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 12 PG - 18 SN - 1661-6596 DO - 10.3390/ijms21124300 UR - https://m2.mtmt.hu/api/publication/31367499 ID - 31367499 N1 - Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 4 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI), General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Faculty of Health Sciences, University of Beira Interior, Clinical Academic Centre of Beiras, CACBPortugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 15 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI), General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Faculty of Health Sciences, University of Beira Interior, Clinical Academic Centre of Beiras, CACBPortugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 22 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; General Surgery Department, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Faculty of Health Sciences, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Clinical Academic Centre of Beiras, Portugal; email: pedro.silvavaz@gmail.com Export Date: 3 February 2021 Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 8 March 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; General Surgery Department, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Faculty of Health Sciences, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Clinical Academic Centre of Beiras, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :3 Export Date: 28 July 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; General Surgery Department, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Faculty of Health Sciences, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Clinical Academic Centre of Beiras, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Amato Lusitano, Unidade Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Clinical Academic Centre of Beiras, CACB, Covilhã, 6200-506, Portugal Biophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal CNC.IBILI Consortium, Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, 3000-548, Portugal Clinical Academic Center of Coimbra, CACC, Coimbra, 3004-561, Portugal Polytechnic Institute of Castelo Branco, Escola Superior de Gestão, Castelo Branco, 6000-084, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :3 Export Date: 29 July 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; General Surgery Department, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Faculty of Health Sciences, Portugal; email: pedro.silvavaz@gmail.com Correspondence Address: Silva-Vaz, P.; Clinical Academic Centre of Beiras, Portugal; email: pedro.silvavaz@gmail.com Chemicals/CAS: amylase, 9000-90-2, 9000-92-4, 9001-19-8; C reactive protein, 9007-41-4; creatinine, 19230-81-0, 60-27-5; hepcidin, 342809-17-0; procalcitonin, 56645-65-9; triacylglycerol lipase, 9001-62-1; hepcidin, 342809-17-0, 1356390-47-0, 2222618-29-1; Biomarkers; Hepcidins Manufacturers: DRG, Germany LA - English DB - MTMT ER - TY - JOUR AU - Silva-Vaz, Pedro AU - Abrantes, Ana Margarida AU - Castelo-Branco, Miguel AU - Gouveia, António AU - Botelho, Maria Filomena AU - Tralhão, José Guilherme TI - Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 1 PG - 26 SN - 1661-6596 DO - 10.3390/ijms21010338 UR - https://m2.mtmt.hu/api/publication/31123094 ID - 31123094 N1 - Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 19 February 2020 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Export Date: 22 February 2020 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Funding Agency and Grant Number: FCT, PortugalPortuguese Foundation for Science and Technology [PEst-C/SAU/UI3282/2013, UID/NEU/04539/2013]; COMPETE-FEDEREuropean Union (EU) Funding text: This research was funded by FCT, Portugal (Strategic Project PEst-C/SAU/UI3282/2013 e UID/NEU/04539/2013), COMPETE-FEDER. Export Date: 19 June 2020 Export Date: 22 June 2020 Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :3 Export Date: 17 September 2020 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :3 Export Date: 18 September 2020 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Export Date: 22 December 2020 Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :5 Export Date: 29 December 2020 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :5 Export Date: 4 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :5 Export Date: 14 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :5 Export Date: 15 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, University of Beira Interior (CICS-UBI)Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :6 Export Date: 22 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :6 Export Date: 25 January 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :6 Export Date: 10 March 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :8 Export Date: 30 April 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Funding Agency and Grant Number: FCT, PortugalPortuguese Foundation for Science and Technology [PEst-C/SAU/UI3282/2013, UID/NEU/04539/2013]; COMPETE-FEDER Funding text: This research was funded by FCT, Portugal (Strategic Project PEst-C/SAU/UI3282/2013 e UID/NEU/04539/2013), COMPETE-FEDER. Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :8 Export Date: 13 May 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :12 Export Date: 28 July 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :12 Export Date: 29 July 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :12 Export Date: 29 July 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com Chemicals/CAS: angiopoietin 2, 194368-66-6; C reactive protein, 9007-41-4; calcium, 7440-70-2, 14092-94-5; creatinine, 19230-81-0, 60-27-5; elastase, 9004-06-2; endothelial leukocyte adhesion molecule 1, 128875-25-2; gelatinase B, 146480-36-6; hepcidin, 342809-17-0; histone, 9062-68-4; intercellular adhesion molecule 1, 126547-89-5; interleukin 8, 114308-91-7; procalcitonin, 56645-65-9; thrombomodulin, 112049-68-0; thromboplastin, 9035-58-9; Biomarkers; Interleukins; Tumor Necrosis Factor-alpha Health Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, 6200-506, Portugal General Surgery Department, Hospital Local de Saúde de Castelo Branco, Castelo Branco, 6000-085, Portugal Faculty of Health Sciences, University of Beira Interior, Covilhã, 6200-506, Portugal Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Faculty of Medicine, University of Coimbra, Coimbra, 3000-548, Portugal Biophysics and Biomathematics Institute, IBILI-Faculty of Medicine of University of Coimbra, Coimbra, 3000-348, Portugal Surgery Department, Centro Hospitalar e Universitário de Coimbra (CHUC), University Hospital, Faculty of Medicine, Coimbra, 3000-075, Portugal Cited By :18 Export Date: 22 September 2021 Correspondence Address: Silva-Vaz, P.; Health Sciences Research Centre, Portugal; email: pedro.silvavaz@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Urbina, Valeria Garro AU - Gutiérrez, Mónica Thuel TI - Diagnosis and management of acute pancreatitis JF - Revista Medica Sinergia J2 - Revista Medica Sinergia VL - 5 PY - 2020 IS - 7 UR - https://m2.mtmt.hu/api/publication/31471182 ID - 31471182 LA - English DB - MTMT ER - TY - JOUR AU - Yu, Bingjun AU - Li, Jiarong AU - Li, Nianshuang AU - Zhu, Yin AU - Chen, Youxiang AU - He, Wenhua AU - Lu, Nonghua TI - Progression to recurrent acute pancreatitis after a first attack of acute pancreatitis in adults JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 7 SP - 1340 EP - 1346 PG - 7 SN - 1424-3903 DO - 10.1016/j.pan.2020.09.006 UR - https://m2.mtmt.hu/api/publication/31611551 ID - 31611551 N1 - Funding Agency and Grant Number: national natural science foundation of ChinaNational Natural Science Foundation of China (NSFC) [:81,660,114, 81,860,122] Funding text: The study design and data collection were funded by the national natural science foundation of China: (No:81,660,114 and 81,860,122). LA - English DB - MTMT ER -