@article{MTMT:31338073,
	title = {An Unusual Combination of Acute Pancreatitis Etiologies: Hypertriglyceridemia and Carbamazepine Use},
	url = {https://m2.mtmt.hu/api/publication/31338073},
	author = {Herek, Sevgi and Herek, Celalettin and Onar, Mediha İrem and Gümülcineli, Pervin and Saçlı, Ömer and Atay, Ahmet Engin},
	journal-iso = {Bagcilar Medical Bulletin},
	journal = {Bagcilar Medical Bulletin},
	unique-id = {31338073},
	eissn = {2547-9431}
}

@article{MTMT:34530314,
	title = {Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/34530314},
	author = {Tarján, Dorottya and Szalai, Eszter and Lipp, Mónika Bernadett and Verbói, Máté and Kói, Tamás and Erőss, Bálint Mihály and Teutsch, Brigitta and Faluhelyi, Nándor and Hegyi, Péter and Mikó, Alexandra},
	doi = {10.3390/ijms25021273},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34530314},
	issn = {1661-6596},
	abstract = {Infected necrotizing pancreatitis (INP) is associated with an increased risk of organ failure and mortality. Its early recognition and timely initiation of antibiotic therapy can save patients’ lives. We systematically searched three databases on 27 October 2022. In the eligible studies, the presence of infection in necrotizing pancreatitis was confirmed via a reference test, which involved either the identification of gas within the necrotic collection through computed tomography imaging or the examination of collected samples, which yielded positive results in Gram staining or culture. Laboratory biomarkers compared between sterile necrotizing pancreatitis and INP were used as the index test, and our outcome measures included sensitivity, specificity, the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC). Within the first 72 hours (h) after admission, the AUC of C-reactive protein (CRP) was 0.69 (confidence interval (CI): 0.62–0.76), for procalcitonin (PCT), it was 0.69 (CI: 0.60–0.78), and for white blood cell count, it was 0.61 (CI: 0.47–0.75). After the first 72 h, the pooled AUC of CRP showed an elevated level of 0.88 (CI: 0.75–1.00), and for PCT, it was 0.86 (CI: 0.60–1.11). The predictive value of CRP and PCT for infection is poor within 72 h after hospital admission but seems good after the first 72 h. Based on these results, infection is likely in case of persistently high CRP and PCT, and antibiotic initiation may be recommended.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Erőss, Bálint Mihály/0000-0003-3658-8427; Teutsch, Brigitta/0000-0002-9530-7886; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:33581972,
	title = {Early prediction of the severe course, survival, and ICU requirements in acute pancreatitis by artificial intelligence},
	url = {https://m2.mtmt.hu/api/publication/33581972},
	author = {İnce, A.T. and Silahtaroğlu, G. and Seven, G. and Koçhan, K. and Yıldız, K. and Şentürk, H.},
	doi = {10.1016/j.pan.2022.12.005},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {23},
	unique-id = {33581972},
	issn = {1424-3903},
	year = {2023},
	eissn = {1424-3911},
	pages = {176-186}
}

@article{MTMT:33560475,
	title = {Acute Pancreatitis Severity Prediction: It Is Time to Use Artificial Intelligence},
	url = {https://m2.mtmt.hu/api/publication/33560475},
	author = {Tarján, Dorottya and Hegyi, Péter},
	doi = {10.3390/jcm12010290},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {12},
	unique-id = {33560475},
	abstract = {The clinical course of acute pancreatitis (AP) can be variable depending on the severity of the disease, and it is crucial to predict the probability of organ failure to initiate early adequate treatment and management. Therefore, possible high-risk patients should be admitted to a high-dependence unit. For risk assessment, we have three options: (1) There are univariate biochemical markers for predicting severe AP. One of their main characteristics is that the absence or excess of these factors affects the outcome of AP in a dose-dependent manner. Unfortunately, all of these parameters have low accuracy; therefore, they cannot be used in clinical settings. (2) Score systems have been developed to prognosticate severity by using 4–25 factors. They usually require multiple parameters that are not measured on a daily basis, and they often require more than 24 h for completion, resulting in the loss of valuable time. However, these scores can foresee specific organ failure or severity, but they only use dichotomous parameters, resulting in information loss. Therefore, their use in clinical settings is limited. (3) Artificial intelligence can detect the complex nonlinear relationships between multiple biochemical parameters and disease outcomes. We have recently developed the very first easy-to-use tool, EASY-APP, which uses multiple continuous variables that are available at the time of admission. The web-based application does not require all of the parameters for prediction, allowing early and easy use on admission. In the future, prognostic scores should be developed with the help of artificial intelligence to avoid information loss and to provide a more individualized risk assessment.},
	keywords = {MORTALITY; machine learning; albumin; SEVERITY; CRP; WBC; BISAP},
	year = {2023},
	eissn = {2077-0383},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:33761635,
	title = {Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry},
	url = {https://m2.mtmt.hu/api/publication/33761635},
	author = {Váncsa, Szilárd and Sipos, Zoltán and Váradi, Alex and Nagy, Rita and Ocskay, Klementina and Juhász, Márk Félix and Márta, Katalin and Teutsch, Brigitta and Mikó, Alexandra and Hegyi, Péter Jenő and Vincze, Áron and Izbéki, Ferenc and Czakó, László and Papp, Mária and Hamvas, József and Varga, Márta and Török, Imola and Mickevicius, Artautas and Erőss, Bálint Mihály and Párniczky, Andrea and Szentesi, Andrea Ildikó and Pár, Gabriella and Hegyi, Péter},
	doi = {10.1002/ueg2.12389},
	journal-iso = {UEG JOURNAL},
	journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL},
	volume = {11},
	unique-id = {33761635},
	issn = {2050-6406},
	abstract = {Non-alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic-associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP.We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in-hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis.MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate-to-severe AP (OR = 1.43, CI: 1.09-1.89). However, the odds of in-hospital mortality (OR = 0.89, CI: 0.42-1.89) and severe AP (OR = 1.70, CI: 0.97-3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39-5.09). In addition, the presence of one, two, and three diagnostic criteria dose-dependently increased the odds of moderate-to-severe AP (OR = 1.23, CI: 0.88-1.70, OR = 1.38, CI: 0.93-2.04, and OR = 3.04, CI: 1.63-5.70, respectively) and severe AP (OR = 1.13, CI: 0.54-2.27, OR = 2.08, CI: 0.97-4.35, and OR = 4.76, CI: 1.50-15.4, respectively). Furthermore, in patients with alcohol abuse and aged ≥60 years, the effect of MAFLD became insignificant.MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose-dependent effect on the outcomes of AP.},
	keywords = {MORTALITY; Prognosis; metabolic syndrome; SEVERITY; Acute pancreatitis; STEATOSIS; Non-Alcoholic Fatty Liver Disease; NAFLD; MAFLD; Metabolic-associated fatty liver disease},
	year = {2023},
	eissn = {2050-6414},
	pages = {371-382},
	orcid-numbers = {Váncsa, Szilárd/0000-0002-9347-8163; Sipos, Zoltán/0000-0001-7845-8116; Váradi, Alex/0000-0001-8229-6340; Nagy, Rita/0000-0002-2663-4912; Ocskay, Klementina/0000-0001-5848-2506; Márta, Katalin/0000-0002-2213-4865; Teutsch, Brigitta/0000-0002-9530-7886; Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Czakó, László/0000-0002-6331-0802; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Imrei, Marcell/0000-0003-0175-7462; Németh, Balázs/0000-0001-5338-7577; Maurovich-Horvat, Pál/0000-0003-0885-736X; Doros, Attila/0000-0002-6496-9895; Zubek, László/0000-0003-0583-3290; Gál, János/0000-0001-9160-6478; Tari, Edina/0000-0002-8540-0614}
}

@article{MTMT:34185521,
	title = {Serum C-reactive protein on the seventh day after pancreatitis could add value in predicting the course of disease progression},
	url = {https://m2.mtmt.hu/api/publication/34185521},
	author = {Elshal, Mohamed and Auf, Ahmed and El, Fady George A. and Raslan, Mohamed M.},
	doi = {10.4103/ejs.ejs_202_22},
	journal-iso = {EGYPTIAN JOURNAL OF SURGERY},
	journal = {EGYPTIAN JOURNAL OF SURGERY},
	volume = {41},
	unique-id = {34185521},
	issn = {1110-1121},
	abstract = {Background The incidence of acute pancreatitis (AP) has increased recently. Although most cases follow a mild course, some cases follow a severe course that may lead to death. Different scoring systems are used for the assessment of the severity of the attack such as Acute Physiology and Chronic Health Examination, Ranson, and modified computed tomography severity index.The most popular method of grading is based on contrast-enhanced computed tomography imaging. The computed tomography severity index (CTSI), developed by Balthazar and Ranson, clarifies the degree of pancreatic and peripancreatic inflammation, extent of parenchyma necrosis, and fluid collection measured by the computed tomography. C-reactive protein (CRP) is an acute-phase reactant that is synthesized by hepatocytes. This synthesis is induced by the release of IL-1and IL-6. CRP is one of the most sensitive markers for inflammation used today. Patients and methods A prospective observational comparative study was done on 70 patients with AP; they were followed up by a correlation between CTSI and CRP levels on day 2 and day 7 after presentation. Results It was found that there is a statistically significant increase in CRP levels in correlation with CTSI. Results showed that CRP levels rise significantly in severe and in necrotizing pancreatitis. Conclusion CRP is a straightforward way to predict severity for patients with AP. Based on this study, CRP levels are useful in patients who have contraindications for computed tomography with intravenous contrast such as patients with renal failure and pregnant women.},
	keywords = {C-REACTIVE PROTEIN; computed tomography severity index},
	year = {2022},
	pages = {1140-1147}
}

@article{MTMT:32865751,
	title = {EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32865751},
	author = {Kui, Balázs and Pintér, József and Molontay, Roland and Nagy, Marcell and Borbásné Farkas, Kornélia and Gede, Noémi and Vincze, Áron and Bajor, Judit and Gódi, Szilárd and Czimmer, József and Szabó, Imre and Illés, Anita and Sarlós, Patrícia and Hágendorn, Roland and Pár, Gabriella and Papp, Mária and Vitális, Zsuzsanna and Kovács, György and Fehér, Eszter and Földi, Ildikó and Izbéki, Ferenc and Gajdán, László and Fejes, Roland and Németh, Balázs and Török, Imola and Farkas, Hunor and Mickevicius, Artautas and Sallinen, Ville and Galeev, Shamil and Ramírez-Maldonado, Elena and Párniczky, Andrea and Erőss, Bálint Mihály and Hegyi, Péter Jenő and Márta, Katalin and Váncsa, Szilárd and Sutton, Robert and Szatmary, Peter and Latawiec, Diane and Halloran, Chris and de-Madaria, Enrique and Pando, Elizabeth and Alberti, Piero and Gómez-Jurado, Maria José and Tantau, Alina and Szentesi, Andrea Ildikó and Hegyi, Péter},
	doi = {10.1002/ctm2.842},
	journal-iso = {CLIN TRANSL MED},
	journal = {CLINICAL AND TRANSLATIONAL MEDICINE},
	volume = {12},
	unique-id = {32865751},
	issn = {2001-1326},
	abstract = {Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed.The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit-learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross-validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross-validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP).The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy-to-use web application in the Streamlit Python-based framework (http://easy-app.org/).The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model.},
	keywords = {Artificial intelligence; Acute pancreatitis; severity prediction},
	year = {2022},
	eissn = {2001-1326},
	orcid-numbers = {Molontay, Roland/0000-0002-0666-5279; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Vincze, Áron/0000-0003-2217-7686; Czimmer, József/0000-0001-7831-3523; Sarlós, Patrícia/0000-0002-5086-9455; Papp, Mária/0000-0003-3662-4010; Vitális, Zsuzsanna/0000-0001-8198-5312; Izbéki, Ferenc/0000-0001-7767-4319; Németh, Balázs/0000-0001-5338-7577; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Váncsa, Szilárd/0000-0002-9347-8163; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34783215,
	title = {Develop a Novel Nomogram to Predict Respiratory Failure in Acute Pancreatitis at Early Stage},
	url = {https://m2.mtmt.hu/api/publication/34783215},
	author = {Qiu, X. and Huang, F. and Li, Z. and Wei, X. and Wu, J. and Huang, J. and Liu, S.},
	doi = {10.7754/Clin.Lab.2021.210826},
	journal-iso = {CLIN LAB},
	journal = {CLINICAL LABORATORY},
	volume = {68},
	unique-id = {34783215},
	issn = {1433-6510},
	year = {2022},
	eissn = {1433-6510},
	pages = {810-816}
}

@article{MTMT:33100315,
	title = {Diagnosis and Treatment of Acute Pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/33100315},
	author = {Walkowska, J. and Zielinska, N. and Tubbs, R.S. and Podgórski, M. and Dłubek-Ruxer, J. and Olewnik, Ł.},
	doi = {10.3390/diagnostics12081974},
	journal-iso = {DIAGNOSTICS},
	journal = {DIAGNOSTICS},
	volume = {12},
	unique-id = {33100315},
	issn = {2075-4418},
	abstract = {The pancreas is a glandular organ that is responsible for the proper functioning of the digestive and endocrine systems, and therefore, it affects the condition of the entire body. Consequently, it is important to effectively diagnose and treat diseases of this organ. According to clinicians, pancreatitis-a common disease affecting the pancreas-is one of the most complicated and demanding diseases of the abdomen. The classification of pancreatitis is based on clinical, morphologic, and histologic criteria. Medical doctors distinguish, inter alia, acute pancreatitis (AP), the most common causes of which are gallstone migration and alcohol abuse. Effective diagnostic methods and the correct assessment of the severity of acute pancreatitis determine the selection of an appropriate treatment strategy and the prediction of the clinical course of the disease, thus preventing life-threatening complications and organ dysfunction or failure. This review collects and organizes recommendations and guidelines for the management of patients suffering from acute pancreatitis.},
	year = {2022},
	eissn = {2075-4418}
}

@article{MTMT:33574754,
	title = {The clinical significance of body mass index in the early evaluation of acute biliary pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/33574754},
	author = {Zheng, Z.X. and Bi, J.T. and Cai, X. and Liu, Y.Q.},
	doi = {10.1016/j.heliyon.2022.e12003},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {8},
	unique-id = {33574754},
	year = {2022},
	eissn = {2405-8440}
}

@article{MTMT:32313144,
	title = {Effectiveness and safety of Liuhedan for treating acute pancreatitis A protocol for systematic review and meta analysis},
	url = {https://m2.mtmt.hu/api/publication/32313144},
	author = {Cheng, Tao and Liu, Bo-Fu and Han, Tian-Yong and Gu, Zhi-Han and Pan, Pan and Yu Haifang},
	doi = {10.1097/MD.0000000000024863},
	journal-iso = {MEDICINE},
	journal = {MEDICINE},
	volume = {100},
	unique-id = {32313144},
	issn = {0025-7974},
	abstract = {Background: Liuhedan is a famous traditional Chinese medicine (TCM) formula used to treat acute pancreatitis (AP) in China. However, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of Liuhedan for treating AP. The aim of this study is to summarize previous evidence, assessing the efficacy and safety of Liuhedan in the treatment of AP. Methods: We will search the EMBASE, WANFANG DATA, Web of Knowledge, CNKI, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30, 2021 to retrieve relevant studies using the search strategy: ("Liuhedan" OR "Liuhe Pill" OR "Liu-He-Dan") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I-2 statistic. Results: This study assessed the efficiency and safety of Liuhedan for treating acute pancreatitis. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of Liuhedan for treating AP. Ethics and dissemination: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.},
	keywords = {MORTALITY; Prognosis; Meta-analysis; systematic review; Acute pancreatitis; Traditional Chinese medicine; duration of hospital stays; liuhedan},
	year = {2021},
	eissn = {1536-5964},
	orcid-numbers = {Cheng, Tao/0000-0001-7861-7922}
}

@article{MTMT:32313145,
	title = {Effectiveness and safety of proton pump inhibitors for treating acute pancreatitis A protocol for systematic review and meta analysis},
	url = {https://m2.mtmt.hu/api/publication/32313145},
	author = {Cheng, Tao and Liu, Bo-Fu and Han, Tian-Yong and Gu, Zhi-Han and Pan, Pan and Yu, Haifang},
	doi = {10.1097/MD.0000000000024808},
	journal-iso = {MEDICINE},
	journal = {MEDICINE},
	volume = {100},
	unique-id = {32313145},
	issn = {0025-7974},
	abstract = {Background: Previous studies have showed that anti-acid therapy with proton pump inhibitors (PPIs) can inhibit pancreatic secretion and it may be used in treating acute pancreatitis (AP). But at present, there is no systematic reviews for the evidence and the therapeutic effectiveness and safety of anti-acid therapy with PPIs in AP were not unclear. Therefore, we will undertake a systematic review of the literature to summarize previous evidence regarding this topic, in order to clarify the effectiveness and safety of anti-acid therapy with PPIs in AP. Methods: We will search the EMBASE, WANFANG DATA, Web of Knowledge, China National Knowledge Infrastructure, PubMed, ClinicalTrials.gov and Cochrane Library from inception to June 30,2021 to retrieve relevant studies using the search strategy: ("Proton pump inhibitors" OR "PPI" OR "PPIs" OR "Omeprazole" OR "Tenatoprazole" OR "Pantoprazole" OR "acid suppression therapy" OR "acid suppression drugs") AND ("pancreatitis" OR "pancreatitides"). Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I-2 statistic. Results: This study assessed the efficiency and safety of proton pump inhibitors for treating acute pancreatitis. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of PPIs for treating AP. Ethics and dissemination: Ethical approval is unnecessary as this protocol is only for systematic review and does not involve privacy data. The findings of this study will be disseminated electronically through a peer-review publication or presented at a relevant conference.},
	keywords = {MORTALITY; Prognosis; Meta-analysis; systematic review; Proton pump inhibitors; Acute pancreatitis; duration of hospital stays},
	year = {2021},
	eissn = {1536-5964},
	orcid-numbers = {Cheng, Tao/0000-0001-7861-7922}
}

@article{MTMT:32546426,
	title = {Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality},
	url = {https://m2.mtmt.hu/api/publication/32546426},
	author = {Ocskay, Klementina and Vinkó, Zsófia and Németh, Dávid and Szabó, László and Bajor, Judit and Gódi, Szilárd and Sarlós, Patrícia and Czakó, László and Izbéki, Ferenc and Hamvas, József and Papp, Mária and Varga, Márta and Török, Imola and Mickevicius, Artautas and Sallinen, Ville and Maldonado, Elena Ramirez and Galeev, Shamil and Mikó, Alexandra and Erőss, Bálint Mihály and Imrei, Marcell and Hegyi, Péter Jenő and Faluhelyi, Nándor and Farkas, Orsolya and Kanizsai, Péter László and Miseta, Attila János and Nagy, Tamás and Hágendorn, Roland and Márton, Zsolt and Szakács, Zsolt and Szentesi, Andrea Ildikó and Hegyi, Péter and Párniczky, Andrea},
	doi = {10.1038/s41598-021-03449-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {11},
	unique-id = {32546426},
	issn = {2045-2322},
	abstract = {The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.},
	year = {2021},
	eissn = {2045-2322},
	orcid-numbers = {Ocskay, Klementina/0000-0001-5848-2506; Sarlós, Patrícia/0000-0002-5086-9455; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Imrei, Marcell/0000-0003-0175-7462; Kanizsai, Péter László/0000-0001-7896-2857; Miseta, Attila János/0000-0002-7984-3347; Nagy, Tamás/0000-0001-5437-1411; Szakács, Zsolt/0000-0002-7035-941X; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:32053186,
	title = {Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases},
	url = {https://m2.mtmt.hu/api/publication/32053186},
	author = {Szakó, Lajos and Gede, Noémi and Váradi, Alex and Tinusz, Benedek and Vörhendi, Nóra and Mosztbacher, Dóra and Vincze, Áron and Takács, Tamás and Czakó, László and Izbéki, Ferenc and Gajdán, László and Dunás-Varga, Veronika and Hamvas, József and Papp, Mária and Fehér, Krisztina Eszter and Varga, Márta and Mickevicius, Artautas and Török, Imola and Ocskay, Klementina and Juhász, Márk Félix and Váncsa, Szilárd and Faluhelyi, Nándor and Farkas, Orsolya and Miseta, Attila János and Vereczkei, András and Mikó, Alexandra and Hegyi, Péter Jenő and Szentesi, Andrea Ildikó and Párniczky, Andrea and Erőss, Bálint Mihály and Hegyi, Péter},
	doi = {10.1016/j.pan.2021.05.007},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {21},
	unique-id = {32053186},
	issn = {1424-3903},
	abstract = {Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre-existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP.Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups.The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p < 0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p < 0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p = 0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p < 0.001), a previous episode of AP (p < 0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p < 0.001), current smoking (p < 0.001), and increased alcohol consumption (unit/week) (p = 0.014).Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP.},
	keywords = {PANCREAS; Pancreatic Pseudocyst; Acute pancreatitis; Pancreatic Fluid Collection; Pancreatic local complication},
	year = {2021},
	eissn = {1424-3911},
	pages = {1161-1172},
	orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Mosztbacher, Dóra/0000-0002-2446-9247; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Ocskay, Klementina/0000-0001-5848-2506; Váncsa, Szilárd/0000-0002-9347-8163; Miseta, Attila János/0000-0002-7984-3347; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:32115157,
	title = {Leukocyte cell population data from the blood cell analyzer as a predictive marker for severity of acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32115157},
	author = {Wang, Y. and Xu, Z. and Zhou, Y. and Xie, M. and Qi, X. and Xu, Z. and Cai, Q. and Sheng, H. and Chen, E. and Zhao, B. and Mao, E.},
	doi = {10.1002/jcla.23863},
	journal-iso = {J CLIN LAB ANAL},
	journal = {JOURNAL OF CLINICAL LABORATORY ANALYSIS},
	volume = {35},
	unique-id = {32115157},
	issn = {0887-8013},
	year = {2021},
	eissn = {1098-2825}
}

@article{MTMT:32615946,
	title = {Comparability of size measurements of the pancreas in magnetic resonance imaging and transabdominal ultrasound},
	url = {https://m2.mtmt.hu/api/publication/32615946},
	author = {Aghdassi, Ali A. and Schauer, Birgit and Duscha, David and Ittermann, Till and Pickartz, Tilman and Budde, Christoph and Simon, Peter and Moskwa, Patryk and Kromrey, Marie L. and Buelow, Robin and Voelzke, Henry and Kuehn, Jens and Lerch, Markus M.},
	doi = {10.1002/ca.23551},
	journal-iso = {CLIN ANAT},
	journal = {CLINICAL ANATOMY},
	volume = {33},
	unique-id = {32615946},
	issn = {0897-3806},
	abstract = {Introduction Transabdominal ultrasound (US) and magnetic resonance imaging (MRI) are commonly used for the examination of the pancreas in clinical routine. We therefore were interested in the concordance of these two imaging methods for the size measurement of the pancreas and how age, gender, and body mass index (BMI) affect the organ size. Methods A total of 342 participants from the Study of Health in Pomerania underwent whole-body MRI and transabdominal US on the same day, and the diameter of the pancreatic head, body, and tail were measured. The agreement between US and MRI measurements was assessed by Bland and Altman plots. Intraclass correlation coefficients were used to compare observers. A multivariable regression model was applied using the independent variables age, gender, and body mass index. Results Compared to MRI, abdominal US returned smaller values for each segment of the pancreas, with a high level of inconsistency between these two methods. The mean difference was 0.39, 0.18, and 0.54 cm for the head, body, and tail, respectively. A high interobserver variability was detected for US. Multivariable analysis showed that pancreatic size in all three segments increased with BMI in both genders whereas pancreatic head and tail size decreased with age, an effect more marked in women. Conclusions Agreement of pancreatic size measurements is poor between US and MRI. These limitations should be considered when evaluating morphologic features for pathologic conditions or setting limits of normal size. Adjustments for BMI, gender, and age may also be warranted.},
	keywords = {BODY; PERFORMANCE; QUALITY; WEIGHT; Health; COMPUTED-TOMOGRAPHY; Ultrasonography; duct},
	year = {2020},
	eissn = {1098-2353},
	pages = {431-439},
	orcid-numbers = {Aghdassi, Ali A./0000-0002-0569-7316; Schauer, Birgit/0000-0001-9847-130X; Lerch, Markus M./0000-0002-9643-8263}
}

@article{MTMT:31471171,
	title = {Renal doppler changes in patients with acute pancreatitis: A prospective study},
	url = {https://m2.mtmt.hu/api/publication/31471171},
	author = {Bush, Nikhil and Rana, Surinder S and Gupta, Pankaj and Kang, Mandeep and Gupta, Rajesh and Suri, Vikas and Ramachandran, Raja and Kumar, Susheel and Dhibar, Deba Prasad},
	doi = {10.1016/j.pan.2020.08.007},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {20},
	unique-id = {31471171},
	issn = {1424-3903},
	year = {2020},
	eissn = {1424-3911},
	pages = {1275-1280}
}

@article{MTMT:31690633,
	title = {Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes},
	url = {https://m2.mtmt.hu/api/publication/31690633},
	author = {Chadalavada, Pravallika and Simons-Linares, C. Roberto and Chahal, Prabhleen},
	doi = {10.1016/j.pan.2020.07.401},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {20},
	unique-id = {31690633},
	issn = {1424-3903},
	abstract = {Background: We sought to study the causative drugs, prevalence and outcomes of drug-induced acute pancreatitis (DIAP).Methods: Retrospective study of DIAP patients at a tertiary teaching hospital. The diagnosis and severity of pancreatitis were determined based on the Revised Atlanta Classification. The cases were further subclassified using the Badalov et al., 2008 classification, and Naranjo score to evaluate and determine the odds of drug-related adverse reaction as a causative factor for AP.Results: Out of 841 AP patients, a total of 31 patients (3.6%) with DIAP were included. The mean age was 52.9 years, 51.6% were male. The most common causative drugs are listed in Table 3. Most cases were mild in severity (87%), moderate AP occurred in 2 patients (6.5%) and severe AP in 2 patients (6.5%). 19.3% had systemic inflammatory response syndrome at presentation, but it persisted beyond 48 h in only 9.6%. 9.6% developed acute kidney injury. One patient with valproate induced DIAP had pancreatic necrosis, splenic vein thrombus, and sub occlusive superior mesenteric vein thrombus on abdominal imaging. Three patients had recurrent AP, and two (6.5%) of them eventually developed chronic pancreatitis. Notably, none of our patients developed complications such as shock, acute respiratory distress syndrome, bacteremia, or death. 1 patient had an acute peripancreatic fluid collection on initial imaging and another patient developed a pseudocyst on follow up imaging. None of them required drainage.Conclusion: Our study showed a prevalence of DIAP of (3.6%) and hydrochlorothiazide, azathioprine, and doxycycline were the most common culprit drugs. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.},
	keywords = {Acute pancreatitis; cannabis; Drug induced pancreatitis; Medication pancreatitis; Arnica},
	year = {2020},
	eissn = {1424-3911},
	pages = {1281-1286}
}

@article{MTMT:31487014,
	title = {Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis – An international cohort study},
	url = {https://m2.mtmt.hu/api/publication/31487014},
	author = {Demcsák, Alexandra and Soós, Alexandra and Kincses, Lilla and Capunge, Ines and Minkov, Georgi and Kovacheva-Slavova, Mila and Nakov, Radislav and Wu, Dong and Huang, Wei and Xia, Qing and Deng, Lihui and Hollenbach, Marcus and Schneider, Alexander and Hirth, Michael and Ioannidis, Orestis and Vincze, Áron and Bajor, Judit and Sarlós, Patrícia and Czakó, László and Illés, Dóra and Izbéki, Ferenc and Gajdán, László and Papp, Mária and Hamvas, József and Varga, Márta and Kanizsai, Péter László and Bóna, Ernő and Mikó, Alexandra and Váncsa, Szilárd and Juhász, Márk Félix and Ocskay, Klementina and Darvasi, Erika and Miklós, Emőke and Erőss, Bálint Mihály and Szentesi, Andrea Ildikó and Párniczky, Andrea and Casadei, Riccardo and Ricci, Claudio and Ingaldi, Carlo and Mastrangelo, Laura and Jovine, Elio and Cennamo, Vincenzo and Marino, Marco V. and Barauskas, Giedrius and Ignatavicius, Povilas and Pelaez-Luna, Mario and Rios, Andrea Soriano and Turcan, Svetlana and Tcaciuc, Eugen and Małecka-Panas, Ewa and Zatorski, Hubert and Nunes, Vitor and Gomes, Antonio and Gonçalves, Tiago Cúrdia and Freitas, Marta and Constantino, Júlio and Ramos Moreira e Sá, Milene Raquel and Pereira, Jorge and Mateescu, Bogdan and Constantinescu, Gabriel and Sandru, Vasile and Negoi, Ionut and Ciubotaru, Cezar and Negoita, Valentina and Bunduc, Stefania and Gheorghe, Cristian and Barbu, Sorin and Tantau, Alina and Tantau, Marcel and Dumitru, Eugen and Suceveanu, Andra Iulia and Tocia, Cristina and Gherbon, Adriana and Litvin, Andrey and Shirinskaya, Natalia and Rabotyagova, Yliya and Bezmarevic, Mihailo and Hegyi, Péter Jenő and Han, Jimin and Rodriguez-Oballe, Juan Armando and Salas, Isabel Miguel and Comas, Eva Pijoan and Garcia, Daniel de la Iglesia and Cuadrado, Andrea Jardi and Castiñeira, Adriano Quiroga and Chang, Yu-Ting and Chang, Ming-Chu and Kchaou, Ali and Tlili, Ahmed and Kacar, Sabite and Gökbulut, Volkan and Duman, Deniz and Kani, Haluk Tarik and Altintas, Engin and Chooklin, Serge and Chuklin, Serhii and Gougol, Amir and Papachristou, George and Hegyi, Péter},
	doi = {10.1016/j.pan.2020.08.009},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {20},
	unique-id = {31487014},
	issn = {1424-3903},
	year = {2020},
	eissn = {1424-3911},
	pages = {1323-1331},
	orcid-numbers = {Nakov, Radislav/0000-0002-5056-8417; Ioannidis, Orestis/0000-0002-0861-8783; Vincze, Áron/0000-0003-2217-7686; Bajor, Judit/0000-0002-3941-4871; Sarlós, Patrícia/0000-0002-5086-9455; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Kanizsai, Péter László/0000-0001-7896-2857; Váncsa, Szilárd/0000-0002-9347-8163; Ocskay, Klementina/0000-0001-5848-2506; Erőss, Bálint Mihály/0000-0003-3658-8427; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Ignatavicius, Povilas/0000-0002-6112-6235; Pelaez-Luna, Mario/0000-0002-9100-9304; Mateescu, Bogdan/0000-0002-2607-8653; Barbu, Sorin/0000-0001-8058-2554; Dumitru, Eugen/0000-0002-7268-3723; Shirinskaya, Natalia/0000-0001-8295-5203; Cuadrado, Andrea Jardi/0000-0002-1671-0408; Kchaou, Ali/0000-0001-8305-1679; Chuklin, Serhii/0000-0001-8979-721X; Hegyi, Péter/0000-0003-0399-7259}
}

@mastersthesis{MTMT:31041306,
	title = {Important therapeutic targets in acute pancreatitis [Fontos terápiás célpontok az akut pankreátitiszben]},
	url = {https://m2.mtmt.hu/api/publication/31041306},
	author = {Tóth, Emese},
	doi = {10.14232/phd.10329},
	publisher = {SZTE},
	unique-id = {31041306},
	year = {2020}
}

@article{MTMT:31356472,
	title = {The prognostic value of immature granulocyte in patients with acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31356472},
	author = {Karakulak, S. and Narcı, H. and Ayrık, C. and Erdoğan, S. and Üçbilek, E.},
	doi = {10.1016/j.ajem.2020.03.028},
	journal-iso = {AM J EMERG MED},
	journal = {AMERICAN JOURNAL OF EMERGENCY MEDICINE},
	unique-id = {31356472},
	issn = {0735-6757},
	year = {2020},
	eissn = {1532-8171}
}

@article{MTMT:31384691,
	title = {Analysis of 1060 Cases of Drug-Induced Acute Pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31384691},
	author = {Meczker, Ágnes and Hanák, Lilla and Párniczky, Andrea and Szentesi, Andrea Ildikó and Erőss, Bálint Mihály and Hegyi, Péter},
	doi = {10.1053/j.gastro.2020.07.016},
	journal-iso = {GASTROENTEROLOGY},
	journal = {GASTROENTEROLOGY},
	volume = {159},
	unique-id = {31384691},
	issn = {0016-5085},
	keywords = {MORTALITY; SEVERITY; Acute pancreatitis; drug-induced pancreatitis},
	year = {2020},
	eissn = {1528-0012},
	pages = {1958-1961.e8},
	orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259; Szakács, Zsolt/0000-0002-7035-941X; Vincze, Áron/0000-0003-2217-7686; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:31367499,
	title = {Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31367499},
	author = {Silva-Vaz, Pedro and Abrantes, Ana Margarida and Morgado-Nunes, Sara and Castelo-Branco, Miguel and Gouveia, António and Botelho, Maria Filomena and Tralhão, José Guilherme},
	doi = {10.3390/ijms21124300},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31367499},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067}
}

@article{MTMT:31123094,
	title = {Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice},
	url = {https://m2.mtmt.hu/api/publication/31123094},
	author = {Silva-Vaz, Pedro and Abrantes, Ana Margarida and Castelo-Branco, Miguel and Gouveia, António and Botelho, Maria Filomena and Tralhão, José Guilherme},
	doi = {10.3390/ijms21010338},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31123094},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067}
}

@article{MTMT:31471182,
	title = {Diagnosis and management of acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31471182},
	author = {Urbina, Valeria Garro and Gutiérrez, Mónica Thuel},
	journal-iso = {Revista Medica Sinergia},
	journal = {Revista Medica Sinergia},
	volume = {5},
	unique-id = {31471182},
	year = {2020}
}

@article{MTMT:31611551,
	title = {Progression to recurrent acute pancreatitis after a first attack of acute pancreatitis in adults},
	url = {https://m2.mtmt.hu/api/publication/31611551},
	author = {Yu, Bingjun and Li, Jiarong and Li, Nianshuang and Zhu, Yin and Chen, Youxiang and He, Wenhua and Lu, Nonghua},
	doi = {10.1016/j.pan.2020.09.006},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {20},
	unique-id = {31611551},
	issn = {1424-3903},
	year = {2020},
	eissn = {1424-3911},
	pages = {1340-1346}
}