@article{MTMT:33041863,
	title = {Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues},
	url = {https://m2.mtmt.hu/api/publication/33041863},
	author = {Yu, S. and Luo, F. and Xu, Y. and Zhang, Y. and Jin, L.H.},
	doi = {10.3389/fimmu.2022.905370},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {13},
	unique-id = {33041863},
	issn = {1664-3224},
	abstract = {The innate immune response provides the first line of defense against invading pathogens, and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster employs multiple innate immune reactions to resist infection. First, epithelial tissues function as physical barriers to prevent pathogen invasion. In addition, macrophage-like plasmatocytes eliminate intruders through phagocytosis, and lamellocytes encapsulate large particles, such as wasp eggs, that cannot be phagocytosed. Regarding humoral immune responses, the fat body, equivalent to the mammalian liver, secretes antimicrobial peptides into hemolymph, killing bacteria and fungi. Drosophila has been shown to be a powerful in vivo model for studying the mechanism of innate immunity and host-pathogen interactions because Drosophila and higher organisms share conserved signaling pathways and factors. Moreover, the ease with which Drosophila genetic and physiological characteristics can be manipulated prevents interference by adaptive immunity. In this review, we discuss the signaling pathways activated in Drosophila innate immunity, namely, the Toll, Imd, JNK, JAK/STAT pathways, and other factors, as well as relevant regulatory networks. We also review the mechanisms by which different tissues, including hemocytes, the fat body, the lymph gland, muscles, the gut and the brain coordinate innate immune responses. Furthermore, the latest studies in this field are outlined in this review. In summary, understanding the mechanism underlying innate immunity orchestration in Drosophila will help us better study human innate immunity-related diseases. Copyright © 2022 Yu, Luo, Xu, Zhang and Jin.},
	keywords = {DROSOPHILA; innate immunity; immune response; SIGNALING PATHWAY; Tissue communication},
	year = {2022},
	eissn = {1664-3224}
}

@article{MTMT:31940120,
	title = {Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry},
	url = {https://m2.mtmt.hu/api/publication/31940120},
	author = {Balog, József Ágoston and Honti, Viktor and Kurucz, Judit Éva and Kari, Beáta and Puskás, László and Andó, István and Szebeni, Gábor},
	doi = {10.1016/j.gpb.2020.06.022},
	journal-iso = {GENOM PROTEOM BIOINF},
	journal = {GENOMICS PROTEOMICS & BIOINFORMATICS},
	volume = {19},
	unique-id = {31940120},
	issn = {1672-0229},
	year = {2021},
	eissn = {2210-3244},
	pages = {243-252},
	orcid-numbers = {Andó, István/0000-0002-4648-9396; Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:31469409,
	title = {The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Drosophila Lymph Gland},
	url = {https://m2.mtmt.hu/api/publication/31469409},
	author = {Luo, Fangzhou and Yu, Shichao and Jin, Li Hua},
	doi = {10.3389/fcell.2020.00382},
	journal-iso = {FRONT CELL DEV BIOL},
	journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
	volume = {8},
	unique-id = {31469409},
	issn = {2296-634X},
	abstract = {Hematopoiesis is a necessary process for development and immune defense in Drosophila from the embryonic period to adulthood. There are two main stages in this process: the first stage occurs in the head mesoderm during the embryonic stage, and the second occurs in a specialized hematopoietic organ along the dorsal vessel, the lymph gland, during the larval stage. The lymph gland consists of paired lobes, each of which has distinct regions: the cortical zone (CZ), which contains mature hemocytes; the medullary zone (MZ), which contains hematopoietic progenitors; and the posterior signaling center (PSC), which specifically expresses the early B-cell factor (EBF) transcription factor Collier (Col) and the HOX factor Antennapedia (Antp) to form a microenvironment similar to that of the mammalian bone marrow hematopoietic stem cell niche. The PSC plays a key role in regulating hematopoietic progenitor differentiation. Moreover, the PSC contributes to the cellular immune response to wasp parasitism triggered by elevated ROS levels. Two recent studies have revealed that hematopoietic progenitor maintenance is directly regulated by Col expressed in the MZ and is independent of the PSC, challenging the traditional model. In this review, we summarize the regulatory networks of PSC cell proliferation, the controversy regarding PSC-mediated regulation of hematopoietic progenitor differentiation, and the wasp egg infection response. In addition, we discuss why the PSC is an ideal model for investigating mammalian hematopoietic stem cell niches and leukemia.},
	keywords = {DIFFERENTIATION; LEUKEMIA; DROSOPHILA; immune response; Signaling network; lymph gland; posterior signaling center; hematopoietic stem cells niche},
	year = {2020},
	eissn = {2296-634X}
}

@article{MTMT:31692738,
	title = {Candidate genetic determinants of intraspecific variation in pea aphid susceptibility to RNA interference},
	url = {https://m2.mtmt.hu/api/publication/31692738},
	author = {Yoon, June-Sun and Tian, Hong-gang and McMullen, John G. II and Chung, Seung Ho and Douglas, Angela E.},
	doi = {10.1016/j.ibmb.2020.103408},
	journal-iso = {INSECT BIOCHEM MOLEC},
	journal = {INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY},
	volume = {123},
	unique-id = {31692738},
	issn = {0965-1748},
	abstract = {RNA interference (RNAi) plays a key role in insect defense against viruses and transposable elements, and it is being applied as an experimental tool and for insect pest control. However, RNAi efficiency is highly variable for some insects, notably the pea aphid Acyrthosiphon pisum. In this study, we used natural variation in RNAi susceptibility of pea aphids to identify genes that influence RNAi efficiency. Susceptibility to orally-delivered dsRNA against the gut aquaporin gene AQP1 (ds-AQP1) varied widely across a panel of 83 pea aphid genotypes, from zero to total mortality. Genome-wide association between aphid performance on ds-AQP1 supplemented diet and aphid genetic variants yielded 103 significantly associated single nucleotide polymorphisms (SNPs), including variants in 55 genes, at the 10-4 probability cut-off. When ds-AQP1 was co-administered with dsRNA against six candidate genes, aphid mortality was reduced for three (50%) genes: the orthologs of the Drosophila genes trachealess (CG42865), headcase (CG15532) and a gene coding a peritrophin-A domain (CG8192), indicating that these genes function to promote RNAi efficiency against AQP1 in the pea aphid. Aphid susceptibility (quantified as mortality) to ds-AQP1 was correlated with RNAi against a further gene, snakeskin with essential gut function unrelated to AQP1, for some but not all aphid genotypes tested, suggesting that the determinants of RNAi efficiency may be partly gene-specific. This study demonstrates high levels of natural variation in susceptibility to RNAi and demonstrates the value of harnessing this variation to identify genes influencing RNAi efficiency.},
	keywords = {RNA Interference; GENOME-WIDE ASSOCIATION; Aquaporin; Acyrthosiphon pisum; RNAi efficiency},
	year = {2020},
	eissn = {1879-0240},
	orcid-numbers = {Chung, Seung Ho/0000-0003-4108-8320}
}