TY - JOUR AU - Adam, Josephine AU - Rupprecht, Sven AU - Kuenstler, Erika C. S. AU - Hoyer, Dirk TI - Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis - A systematic review JF - AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL J2 - AUTON NEUROSCI-BASIC VL - 249 PY - 2023 PG - 13 SN - 1566-0702 DO - 10.1016/j.autneu.2023.103116 UR - https://m2.mtmt.hu/api/publication/34296481 ID - 34296481 N1 - Export Date: 28 November 2023; CODEN: ANUEB AB - Purpose: The autonomic nervous system interacts with the immune system via the inflammatory response. Heart rate variability (HRV), a marker of autonomic activity, is associated with inflammation, and nosocomial infections/sepsis, and has clinical implications for the monitoring of at-risk patients. Due to the vagal tone's influence on anti-inflammatory immune response, this association may predominately be reflected by vagallymediated HRV indices. However, HRV's predictive significance on inflammation/infection remains unclear.Methods: 843 studies examining the associations/prognostic value of HRV indices on inflammation, and nosocomial infection/sepsis were screened in this systematic review. According to inclusion and exclusion criteria, 68 associative studies and 14 prediction studies were included.Results: HRV and pro-inflammatory state were consistently associated in healthy subjects and patient groups. Pro inflammatory state was related to reduced total power HRV including vagallyand non-vagally-mediated HRV indices. Similar, compared to controls, HRV reductions were observed during nosocomial infections/sepsis. Only limited evidence supports the predictive value of HRV in the development of nosocomial infections/sepsis. Reduced very low frequency power HRV showed the highest predictive value in adults, even with different clinical conditions. In neonates, an increased heart rate characteristic score, combining reduced total power HRV, decreased complexity, and vagally-dominated asymmetry, predicted sepsis.onclusions: Pro-inflammatory state is related to an overall reduction in HRV rather than a singular reduction in vagally-mediated HRV indices, reflecting the complex autonomic-regulatory changes occurring during inflammation. The potential benefit of using continuous HRV monitoring for detecting nosocomial infection-related states, and the implications for clinical outcome, need further clarification. LA - English DB - MTMT ER - TY - JOUR AU - Shah, Meera AU - Shinjo, Samuel Katsuyuki AU - Day, Jessica AU - Gupta, Latika TI - Cardiovascular manifestations in idiopathic inflammatory myopathies JF - CLINICAL RHEUMATOLOGY J2 - CLIN RHEUMATOL VL - 42 PY - 2023 IS - 10 SP - 2557 EP - 2575 PG - 19 SN - 0770-3198 DO - 10.1007/s10067-023-06599-4 UR - https://m2.mtmt.hu/api/publication/34240985 ID - 34240985 N1 - Department of Rheumatology, Indraprastha Apollo Hospital, Delhi, New Delhi, 110076, India Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de São Paulo, SP, São Paulo, Brazil Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, WV10 0QP, United Kingdom Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom Cited By :3 Export Date: 7 February 2024 CODEN: CLRHD Correspondence Address: Gupta, L.; Department of Rheumatology, United Kingdom; email: drlatikagupta@gmail.com AB - Cardiovascular involvement in idiopathic inflammatory myopathies (IIM) is an understudied area which is gaining increasing recognition in recent times. Recent advances in imaging modalities and biomarkers have allowed the detection of subclinical cardiovascular manifestations in IIM. However, despite the availability of these tools, the diagnostic challenges and underestimated prevalence of cardiovascular involvement in these patients remain significant. Notably, cardiovascular involvement remains one of the leading causes of mortality in patients with IIM. In this narrative literature review, we outline the prevalence and characteristics of cardiovascular involvement in IIM. Additionally, we explore investigational modalities for early detection of cardiovascular involvement, as well as newer approaches in screening to facilitate timely management. LA - English DB - MTMT ER - TY - JOUR AU - Fyksen, Tea Saetereng AU - Vanberg, Paul AU - Gjesdal, Knut AU - von Lueder, Thomas G. AU - Bjornerheim, Reidar AU - Steine, Kjetil AU - Atar, Dan AU - Halvorsen, Sigrun TI - Cardiovascular phenotype of long-term anabolic-androgenic steroid abusers compared with strength-trained athletes JF - SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS J2 - SCAND J MED SCI SPOR VL - 32 PY - 2022 IS - 8 SP - 1170 EP - 1181 PG - 12 SN - 0905-7188 DO - 10.1111/sms.14172 UR - https://m2.mtmt.hu/api/publication/33311086 ID - 33311086 N1 - Funding Agency and Grant Number: Anti-Doping Norway; South-Eastern Norway Regional Health Authority; Stein Erik Hagen's foundation for Clinical Heart Research, Norway Funding text: The study was supported by grants from Anti-Doping Norway, the South-Eastern Norway Regional Health Authority, and Stein Erik Hagen's foundation for Clinical Heart Research, Norway AB - Introduction Abuse of anabolic-androgenic steroids (AAS) has been linked to a variety of different cardiovascular (CV) side effects, but still the clinical effects of AAS abuse on CV risk are not clear. The aim of this study was to assess the CV phenotype of a large cohort of men with long-term AAS use compared with strength-trained athletes without AAS use. Methods Fifty one strength-trained men with >= 3 years of AAS use was compared with twenty one strength-trained competing athletes. We verified substance abuse and non-abuse by blood and urine analyses. The participants underwent comprehensive CV evaluation including laboratory analyses, 12-lead ECG with measurement of QT dispersion, exercise ECG, 24 h ECG with analyses of heart rate variability, signal averaged ECG, basic transthoracic echocardiography, and coronary computed tomography angiography (CCTA). Results Hemoglobin levels and hematocrit were higher among the AAS users compared with non-users (16.8 vs. 15.0 g/dl, and 0.50% vs. 0.44%, respectively, both p < 0.01) and HDL cholesterol significantly lower (0.69 vs. 1.25 mmol/L, p < 0.01). Maximal exercise capacity was 270 and 280 W in the AAS and the non-user group, respectively (p = 0.04). Echocardiography showed thicker intraventricular septum and left ventricular (LV) posterior wall among AAS users (p < 0.01 for both), while LV ejection fraction was lower (50 vs. 54%, p = 0.02). Seven AAS users (17%) had evidence of coronary artery disease on CCTA. There were no differences in ECG measures between the groups. Conclusions A divergent CV phenotype dominated by increased CV risk, accelerated coronary artery disease, and concentric myocardial hypertrophy was revealed among the AAS users. LA - English DB - MTMT ER - TY - JOUR AU - Mondal, Sanjib AU - Barman, Prabal AU - Vignesh, Pandiarajan TI - Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping Review for the Clinical Rheumatologists JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 9 PY - 2022 PG - 10 SN - 2296-858X DO - 10.3389/fmed.2022.827539 UR - https://m2.mtmt.hu/api/publication/33311085 ID - 33311085 N1 - Cited By :3 Export Date: 7 February 2024 Correspondence Address: Vignesh, P.; Allergy Immunology Unit, India; email: drvigneshpgi@gmail.com AB - Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM. Cardiac involvement in JDM is often underestimated, and it may be a potential indicator of poor prognosis. Cardiac dysfunction in JDM can occur both in the acute and chronic stages of the disease. Amongst the acute complications, acute congestive heart failure (CHF), myocarditis, arrhythmia, and complete heart block are common. However, these remain unrecognized due to a lack of overt clinical manifestations. Increased rates of cardiovascular abnormalities have been noted with anti-SRP and anti-Jo 1 auto-antibody positivity. Long-term follow-up studies in JDM have shown an increased prevalence of hypertension, atherosclerosis, coronary artery disease, and metabolic syndrome in adolescence and adulthood. Monitoring of body-mass index, blood pressure, and laboratory evaluation of fasting glucose and lipid profile may help in identifying metabolic syndrome in children with JDM. Steroid-sparing agents, daily exercise, and a healthy diet may reduce such long-term cardiac morbidities. Current use of multimodality imaging such as stress-echocardiography, contrast-enhanced echocardiography, cardiac magnetic resonance imaging, and positron emission tomography has increased the diagnostic yield of subclinical heart disease during acute and chronic stages of JDM. This review elaborates on different aspects of cardiac dysfunction in JDM. It also emphasizes the importance of cardiac screening in long-term follow-up of children with JDM. LA - English DB - MTMT ER - TY - JOUR AU - Witczak, B.N. AU - Schwartz, T. AU - Barth, Z. AU - Taraldsrud, E. AU - Lund, M.B. AU - Aaløkken, T.M. AU - Flatø, B. AU - Sjaastad, I. AU - Sanner, H. TI - Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis—a cross-sectional study JF - RHEUMATOLOGY INTERNATIONAL J2 - RHEUMATOL INT VL - 42 PY - 2022 IS - 7 SP - 1213 EP - 1220 PG - 8 SN - 0172-8172 DO - 10.1007/s00296-021-05071-3 UR - https://m2.mtmt.hu/api/publication/34776020 ID - 34776020 N1 - Institute for Experimental Medical Research and KG Jebsen Center for Cardiac Research, Oslo University Hospital and University of Oslo, Oslo, Norway Department of Immunology, Oslo University Hospital, Oslo, Rikshospitalet, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Oslo New University College, Oslo, Norway Department of Respiratory Medicine, Oslo University Hospital, Oslo, Rikshospitalet, Norway Department of Radiology, Oslo University Hospital, Oslo, Rikshospitalet, Norway Department of Rheumatology, Oslo University Hospital, Oslo, Rikshospitalet, Norway Department of Cardiology, Oslo University Hospital, Oslo, Ullevål, Norway Export Date: 08 April 2024; Cited By: 6; Correspondence Address: H. Sanner; Oslo New University College, Oslo, Norway; email: helga.sanner@medisin.uio.no; CODEN: RHIND LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Yiwen AU - Yang, Xiaoqian AU - Qin, Li AU - Luo, Qiang AU - Wang, Han TI - Left ventricle diastolic dysfunction in idiopathic inflammatory myopathies: A meta-analysis and systematic review JF - MODERN RHEUMATOLOGY J2 - MOD RHEUMATOL PY - 2022 SN - 1439-7595 DO - 10.1093/mr/roab041 UR - https://m2.mtmt.hu/api/publication/32602822 ID - 32602822 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [81300243] Funding text: This work was supported by the National Natural Science Foundation of China under Grant 81300243. LA - English DB - MTMT ER - TY - JOUR AU - DeWane, Madeline E. AU - Waldman, Reid AU - Lu, Jun TI - Dermatomyositis: Clinical features and pathogenesis JF - JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY J2 - J AM ACAD DERMATOL VL - 82 PY - 2020 IS - 2 SP - 267 EP - 281 PG - 15 SN - 0190-9622 DO - 10.1016/j.jaad.2019.06.1309 UR - https://m2.mtmt.hu/api/publication/31466847 ID - 31466847 N1 - University of Connecticut School of Medicine, Farmington, CT, United States University of Connecticut Department of Dermatology, Farmington, CT, United States Cited By :58 Export Date: 21 February 2022 CODEN: JAADD Correspondence Address: Lu, J.; Department of Dermatology, 21 South Rd, United States; email: jlu@uchc.edu AB - Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically heterogeneous and that can be difficult to diagnose. Cutaneous manifestations sometimes vary and may or may not parallel myositis and systemic involvement in time course or severity. Recent developments in our understanding of myositis-specific antibodies have the potential to change the diagnostic landscape of DM for dermatologists. Although phenotypic overlap exists, anti-Mi2, -MDA5, -NXP2, -TIF1, and -SAE antibodies may be correlated with distinct DM subtypes in terms of cutaneous manifestations, systemic involvement, and malignancy risk. This review highlights new findings on the DM-specific myositis-specific antibodies and their clinical associations in both adults and children. LA - English DB - MTMT ER - TY - JOUR AU - Ghosh, Ritwik AU - Roy, Devlina AU - Dubey, Souvik AU - Abdelrahman, Khaled AU - Dey, Amit Kumar AU - Chatterjee, Subhankar AU - Lahiri, Durjoy AU - Ray, Biman Kanti TI - Juvenile dermatomyositis presenting as complete heart block in a 10-year-old girl JF - PAEDIATRICS AND INTERNATIONAL CHILD HEALTH J2 - PAEDIATR INT CHILD H VL - 40 PY - 2020 IS - 4 SP - 251 EP - 254 PG - 4 SN - 2046-9047 DO - 10.1080/20469047.2020.1765123 UR - https://m2.mtmt.hu/api/publication/34423441 ID - 34423441 AB - Juvenile dermatomyositis (JDM) is an auto-immune inflammatory condition associated with cardiac disorders including conduction abnormalities and myocardial dysfunction. The time of presentation of cardiac abnormalities can range from disease onset to after long-term follow-up, emphasising the importance of screening for cardiac involvement in JDM. A previously healthy 10-year-old girl presented with syncope, fatigue and weakness associated with a heliotrope rash. JDM was diagnosed based on the clinical, laboratory and imaging findings. An ECG demonstrated complete heart block (CHB). All symptoms resolved following treatment with parenteral corticosteroids. In JDM, it is important to investigate for cardiac manifestations and in CHB to consider administering corticosteroids. LA - English DB - MTMT ER - TY - JOUR AU - Wu, J.-Q. AU - Lu, M.-P. AU - Reed, A.M. TI - Juvenile dermatomyositis: advances in clinical presentation, myositis-specific antibodies and treatment JF - WORLD JOURNAL OF PEDIATRICS J2 - WORLD J PEDIATR VL - 16 PY - 2020 IS - 1 SP - 31 EP - 43 PG - 13 SN - 1708-8569 DO - 10.1007/s12519-019-00313-8 UR - https://m2.mtmt.hu/api/publication/31176683 ID - 31176683 N1 - Department of Rheumatology Immunology and Allergy, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China Department of Pediatrics, Division of Pediatric Rheumatology, Duke University School of Medicine, Durham, 27710, United States Cited By :5 Export Date: 21 February 2022 Correspondence Address: Reed, A.M.; Department of Pediatrics, United States; email: ann.reed@duke.edu LA - English DB - MTMT ER - TY - JOUR AU - Barth, Zoltán AU - Schwartz, T AU - Flato, B AU - Aalokken, TM AU - Koller, Ákos AU - Lund, MB AU - Sjaastad, I AU - Sanner, H TI - The Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium- to Long-standing Juvenile Dermatomyositis JF - ARTHRITIS CARE & RESEARCH J2 - ARTHRIT CARE RES VL - 71 PY - 2019 IS - 4 SP - 492 EP - 497 PG - 6 SN - 2151-464X DO - 10.1002/acr.23687 UR - https://m2.mtmt.hu/api/publication/3392111 ID - 3392111 AB - OBJECTIVE: To explore the associations between microvascular abnormalities assessed by nailfold capillaroscopy (NFC) and pulmonary and cardiac involvement in patients with juvenile dermatomyositis (DM) assessed after medium- to long-term follow-up. METHODS: Fifty-eight juvenile DM patients were examined mean 17.0 (SD 10.6) years after symptom onset. Nailfold capillary density (NCD) and neovascular pattern (defined as scleroderma active or late pattern) were analysed blinded to clinical data. Pulmonary involvement was assessed by pulmonary function tests (PFT) including spirometry, diffusion capacity for carbon monoxide (DLCO) and body plethysmography; also high-resolution computed tomography (HRCT) was performed. Cardiac involvement was assessed by electrocardiography, Holter monitoring (heart rate variability) and echocardiography. RESULTS: Patients with low NCD (<6 capillaries/mm) (n=21), compared to patients with normal NCD (>/= 6 capillaries/mm) (n=37), presented lower forced vital capacity (89.7 vs 98.5% of predicted), total lung capacity (87.8 vs 94.5% of predicted) and more often low DLCO (15/21 (71%) vs 14/37 (38%)); all p's<0.05. HRCT assessed airways disease was more frequent in the low NCD group (6/21 (30%) vs 3/37 (8%); p=0.034). No associations were found between i) NCD and cardiac parameters or ii) neovascular pattern and pulmonary or cardiac parameters. CONCLUSION: In juvenile DM patients, low NCD was associated with lung involvement, which was mostly subclinical. No significant associations with cardiac involvement were found. These results shed light on possible mechanisms underlying organ involvement, but further and preferably larger studies are needed to identify NCD as a potential biomarker for lung and cardiac involvement in juvenile DM. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Liu, Jianyang AU - Zhang, Lijun AU - Liu, Meiyan TI - Mechanisms supporting potential use of bone marrow-derived mesenchymal stem cells in psychocardiology JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 11 PY - 2019 IS - 11 SP - 6717 EP - 6738 PG - 22 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/31088105 ID - 31088105 AB - Despite great efforts made in recent years, globally cardiovascular disease (CVD) remains the most common and devastating disease. Pharmacological, interventional and surgical treatments have proved to be only partly satisfactory for the majority of patients. A major underlying cause of poor prognosis is a high comorbidity rate between CVD and mental illness, which calls for the approaches of psychocardiology. As psychiatric disorders and CVD can influence each other bidirectionally, it is necessary to develop novel therapies targeting both systems simultaneously. Therefore, innovative stem cell (SC) therapy has become the most promising treatment strategy in psychocardiology. Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs), among all different types of SCs, have drawn the most attention due to unique advantages in terms of ethical considerations, low immunogenicity and simplicity of preparation. In this review, we survey recent publications and clinical trials to summarize the knowledge and progress gained so far. Moreover, we discuss the feasibility of the clinical application of BM-MSCs in the area of psychocardiology. LA - English DB - MTMT ER - TY - JOUR AU - Opinc, Aleksandra Halina AU - Makowski, Marcin Adam AU - Lukasik, Zuzanna Malgorzata AU - Makowska, Joanna Samanta TI - Cardiovascular complications in patients with idiopathic inflammatory myopathies: does heart matter in idiopathic inflammatory myopathies? JF - HEART FAILURE REVIEWS J2 - HEART FAIL REV VL - 26 PY - 2019 IS - 1 SP - 111 EP - 125 PG - 15 SN - 1382-4147 DO - 10.1007/s10741-019-09909-8 UR - https://m2.mtmt.hu/api/publication/33616649 ID - 33616649 AB - This review presents a detailed study of original researches and previously published reviews concerning cardiovascular involvement in idiopathic inflammatory myopathies (IIM). We aimed to summarize the current knowledge on the cardiac involvement in IIM, evaluate its impact on mortality and indicate areas still awaiting to be investigated. We searched MEDLINE database (until January 2019) and the reference lists of articles. Selection criteria included only published data, available in English, both original researches and reviews. Articles related to cardiovascular involvement in IIM were selected and analysed. The references were also screened, and relevant articles were included. Cardiovascular involvement is frequent in IIM but typically remains subclinical. Among far less prevalent symptomatic forms, congestive heart failure is the most common. Myocardium and conduction system seems to be predominantly affected. High rate of left ventricular diastolic dysfunction was observed. Non-specific changes of ST-T segment were the most common abnormalities in electrocardiography. Patients with IIM were more frequently affected by atrial fibrillation as compared with other autoimmune diseases. Increased risk of myocardial infarction was observed; furthermore, patients often develop comorbidities that enhance cardiovascular risk. Since cardiovascular disorders remain one of the major causes of death and subclinical involvement is frequent, active screening is justified. Growing availability of the novel imaging techniques may facilitate diagnosis. Correlation between myocardial involvement and the type of autoantibodies and impact of different therapeutic options on the progression of cardiovascular lesions require further studies. LA - English DB - MTMT ER - TY - JOUR AU - Farah, Breno Quintella AU - Andrade-Lima, Aluisio AU - Germano-Soares, Antonio Henrique AU - Destro, Christofaro Diego Giulliano AU - Gomes, de Barros Mauro Virgilio AU - do, Prado Wagner Luiz AU - Ritti-Dias, Raphael M TI - Physical Activity and Heart Rate Variability in Adolescents with Abdominal Obesity JF - PEDIATRIC CARDIOLOGY J2 - PEDIATR CARDIOL VL - 39 PY - 2018 IS - 3 SP - 466 EP - 472 PG - 7 SN - 0172-0643 DO - 10.1007/s00246-017-1775-6 UR - https://m2.mtmt.hu/api/publication/27349880 ID - 27349880 N1 - Cited By :15 Export Date: 19 November 2021 CODEN: PECAD Correspondence Address: Andrade-Lima, A.; Exercise Hemodynamic Laboratory, Av. Professor Melo Moraes, 65, Brazil; email: aluisiolima@live.com LA - English DB - MTMT ER - TY - JOUR AU - Jonathan, I Silverberg AU - Lauren, Kwa AU - Michael, C Kwa AU - Anne, E Laumann AU - Kaveh, Ardalan TI - Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample JF - RHEUMATOLOGY (UNITED KINGDOM) J2 - RHEUMATOLOGY VL - 57 PY - 2018 IS - 4 SP - 694 EP - 702 PG - 9 SN - 1462-0324 DO - 10.1093/rheumatology/kex465 UR - https://m2.mtmt.hu/api/publication/27149824 ID - 27149824 N1 - Funding Agency and Grant Number: Agency for Healthcare Research and Quality (AHRQ)United States Department of Health & Human ServicesAgency for Healthcare Research & Quality [K12 HS023011]; Dermatology Foundation Funding text: This publication was made possible with support from the Agency for Healthcare Research and Quality (AHRQ), grant number K12 HS023011, and the Dermatology Foundation. Export Date: 16 March 2020 CODEN: RUMAF LA - English DB - MTMT ER - TY - JOUR AU - Martins, Edgar William AU - Magalhaes, Roberto AU - Marocolo, Moacir AU - Maior, Alex Souto TI - Cardiac autonomic profile in cervical spinal cord injury subjects practitioners of the physical exercise JF - ACTA SCIENTIARUM HEALTH SCIENCES J2 - ACTA SCI HEALTH SCI VL - 40 PY - 2018 PG - 8 SN - 1679-9291 DO - 10.4025/actascihealthsci.v40i1.33469 UR - https://m2.mtmt.hu/api/publication/27610402 ID - 27610402 LA - English DB - MTMT ER - TY - JOUR AU - Pachman, Lauren M AU - Khojah, Amer M TI - Advances in Juvenile Dermatomyositis: Myositis Specific Antibodies Aid in Understanding Disease Heterogeneity JF - JOURNAL OF PEDIATRICS J2 - J PEDIATR VL - 195 PY - 2018 SP - 16 EP - 27 PG - 12 SN - 0022-3476 DO - 10.1016/j.jpeds.2017.12.053 UR - https://m2.mtmt.hu/api/publication/27354181 ID - 27354181 N1 - Funding Agency and Grant Number: Cure JM Foundation; NIAMS [R21AR066846]; NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R21AR066846, P30AR072579] Funding Source: NIH RePORTER Funding text: Supported by the Cure JM Foundation and NIAMS (R21AR066846). The authors declare no conflicts of interest. LA - English DB - MTMT ER - TY - JOUR AU - Papadopoulou, Charalampia AU - McCann, Liza J. TI - The Vasculopathy of Juvenile Dermatomyositis JF - FRONTIERS IN PEDIATRICS J2 - FRONT PEDIATR VL - 6 PY - 2018 PG - 8 SN - 2296-2360 DO - 10.3389/fped.2018.00284 UR - https://m2.mtmt.hu/api/publication/30585321 ID - 30585321 N1 - Infection, Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom Department of Pediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom Cited By :21 Export Date: 21 February 2022 Correspondence Address: Papadopoulou, C.; Infection, United Kingdom; email: sejjcp6@ucl.ac.uk AB - Juvenile dermatomyositis (JDM) is a rare autoimmune disease mainly characterized by muscle and skin involvement. Vasculopathy is considered central to the pathogenesis of the disease. The exact nature of vasculopathy is not yet understood but it is a complex process with both an inflammatory and a non-inflammatory, occlusive component. Impaired function of JDM vasculature includes immune complex deposition, altered expression of cell adhesion molecules predominantly inducing Th17 cell infiltration, and endothelial cell dysfunction. Development of vasculopathy is associated with the severe extra-muscular manifestations of JDM, such as gastrointestinal and cardiac manifestations, interstitial lung disease, ulcerative skin disease or development of calcinosis, and portends a poor prognosis. Correlation of histopathological findings, autoantibodies, and extensive diagnostic workup represent key elements to the early detection of vasculopathic features and early aggressive treatment. Monitoring of vasculopathy remains challenging due to the lack of non-invasive biomarkers. Current treatment approaches provide variable benefit, but better understanding of the essential pathogenic mechanisms should help lead to improved outcomes. Whilst acknowledging that evidence is limited, this review aims to describe the vasculopathy of JDM in the context of pathophysiology, clinical features, and treatment of disease. LA - English DB - MTMT ER - TY - JOUR AU - Wienke, Judith AU - Deakin, Claire T. AU - Wedderburn, Lucy R. AU - van Wijk, Femke AU - van Royen-Kerkhof, Annet TI - Systemic and Tissue Inflammation in Juvenile Dermatomyositis: From Pathogenesis to the Quest for Monitoring Tools JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 9 PY - 2018 PG - 20 SN - 1664-3224 DO - 10.3389/fimmu.2018.02951 UR - https://m2.mtmt.hu/api/publication/30471113 ID - 30471113 N1 - Export Date: 12 October 2021 AB - Juvenile Dermatomyositis (JDM) is a systemic immune-mediated disease of childhood, characterized by muscle weakness, and a typical skin rash. Other organ systems and tissues such as the lungs, heart, and intestines can be involved, but may be under-evaluated. The inflammatory process in JDM is characterized by an interferon signature and infiltration of immune cells such as T cells and plasmacytoid dendritic cells into the affected tissues. Vasculopathy due to loss and dysfunction of endothelial cells as a result of the inflammation is thought to underlie the symptoms in most organs and tissues. JDM is a heterogeneous disease, and several disease phenotypes, each with a varying combination of affected tissues and organs, are linked to the presence of myositis autoantibodies. These autoantibodies have therefore been extensively studied as biomarkers for the disease phenotype and its associated prognosis. Next to identifying the JDM phenotype, monitoring of disease activity and disease-inflicted damage not only in muscle and skin, but also in other organs and tissues, is an important part of clinical follow-up, as these are key determinants for the long-term outcomes of patients. Various monitoring tools are currently available, among which clinical assessment, histopathological investigation of muscle and skin biopsies, and laboratory testing of blood for specific biomarkers. These investigations also give novel insights into the underlying immunological processes that drive inflammation in JDM and suggest a strong link between the interferon signature and vasculopathy. New tools are being developed in the quest for minimally invasive, but sensitive and specific diagnostic methods that correlate well with clinical symptoms or reflect local, low-grade inflammation. In this review we will discuss the types of (extra)muscular tissue inflammation in JDM and their relation to vasculopathic changes, critically assess the available diagnostic methods including myositis autoantibodies and newly identified biomarkers, and reflect on the immunopathogenic implications of identified markers. LA - English DB - MTMT ER - TY - JOUR AU - Cantez, Serdar AU - Gross, Gil J AU - MacLusky, Ian AU - Feldman, Brian M TI - Cardiac findings in children with juvenile Dermatomyositis at disease presentation JF - PEDIATRIC RHEUMATOLOGY J2 - PEDIATR RHEUMATOL VL - 15 PY - 2017 PG - 4 SN - 1546-0096 DO - 10.1186/s12969-017-0182-0 UR - https://m2.mtmt.hu/api/publication/26771446 ID - 26771446 LA - English DB - MTMT ER - TY - JOUR AU - Diederichsen, Louise P TI - Cardiovascular involvement in myositis JF - CURRENT OPINION IN RHEUMATOLOGY J2 - CURR OPIN RHEUMATOL VL - 29 PY - 2017 IS - 6 SP - 598 EP - 603 PG - 6 SN - 1040-8711 DO - 10.1097/BOR.0000000000000442 UR - https://m2.mtmt.hu/api/publication/27103451 ID - 27103451 LA - English DB - MTMT ER - TY - JOUR AU - Schwartz, T AU - Diederichsen, LP AU - Lundberg, IE AU - Sjaastad, I AU - Sanner, H TI - Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies JF - RMD OPEN J2 - RMD OPEN VL - 2 PY - 2016 IS - 2 SN - 2056-5933 DO - 10.1136/rmdopen-2016-000291 UR - https://m2.mtmt.hu/api/publication/26434397 ID - 26434397 N1 - Funding Agency and Grant Number: KG Jebsen Cardiac Research Center; Center for Heart Failure Research, University of Oslo, Oslo, Norway Funding text: TS and IS are supported by KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway. LA - English DB - MTMT ER -