@article{MTMT:34296481, title = {Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis - A systematic review}, url = {https://m2.mtmt.hu/api/publication/34296481}, author = {Adam, Josephine and Rupprecht, Sven and Kuenstler, Erika C. S. and Hoyer, Dirk}, doi = {10.1016/j.autneu.2023.103116}, journal-iso = {AUTON NEUROSCI-BASIC}, journal = {AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL}, volume = {249}, unique-id = {34296481}, issn = {1566-0702}, abstract = {Purpose: The autonomic nervous system interacts with the immune system via the inflammatory response. Heart rate variability (HRV), a marker of autonomic activity, is associated with inflammation, and nosocomial infections/sepsis, and has clinical implications for the monitoring of at-risk patients. Due to the vagal tone's influence on anti-inflammatory immune response, this association may predominately be reflected by vagallymediated HRV indices. However, HRV's predictive significance on inflammation/infection remains unclear.Methods: 843 studies examining the associations/prognostic value of HRV indices on inflammation, and nosocomial infection/sepsis were screened in this systematic review. According to inclusion and exclusion criteria, 68 associative studies and 14 prediction studies were included.Results: HRV and pro-inflammatory state were consistently associated in healthy subjects and patient groups. Pro inflammatory state was related to reduced total power HRV including vagallyand non-vagally-mediated HRV indices. Similar, compared to controls, HRV reductions were observed during nosocomial infections/sepsis. Only limited evidence supports the predictive value of HRV in the development of nosocomial infections/sepsis. Reduced very low frequency power HRV showed the highest predictive value in adults, even with different clinical conditions. In neonates, an increased heart rate characteristic score, combining reduced total power HRV, decreased complexity, and vagally-dominated asymmetry, predicted sepsis.onclusions: Pro-inflammatory state is related to an overall reduction in HRV rather than a singular reduction in vagally-mediated HRV indices, reflecting the complex autonomic-regulatory changes occurring during inflammation. The potential benefit of using continuous HRV monitoring for detecting nosocomial infection-related states, and the implications for clinical outcome, need further clarification.}, keywords = {PREDICTION; autonomic nervous system; heart rate variability; nosocomial infection}, year = {2023}, eissn = {1872-7484} } @article{MTMT:34240985, title = {Cardiovascular manifestations in idiopathic inflammatory myopathies}, url = {https://m2.mtmt.hu/api/publication/34240985}, author = {Shah, Meera and Shinjo, Samuel Katsuyuki and Day, Jessica and Gupta, Latika}, doi = {10.1007/s10067-023-06599-4}, journal-iso = {CLIN RHEUMATOL}, journal = {CLINICAL RHEUMATOLOGY}, volume = {42}, unique-id = {34240985}, issn = {0770-3198}, abstract = {Cardiovascular involvement in idiopathic inflammatory myopathies (IIM) is an understudied area which is gaining increasing recognition in recent times. Recent advances in imaging modalities and biomarkers have allowed the detection of subclinical cardiovascular manifestations in IIM. However, despite the availability of these tools, the diagnostic challenges and underestimated prevalence of cardiovascular involvement in these patients remain significant. Notably, cardiovascular involvement remains one of the leading causes of mortality in patients with IIM. In this narrative literature review, we outline the prevalence and characteristics of cardiovascular involvement in IIM. Additionally, we explore investigational modalities for early detection of cardiovascular involvement, as well as newer approaches in screening to facilitate timely management.}, keywords = {HEART; MYOSITIS; dermatomyositis; Cardiovascular; Cardiac; Myopathies}, year = {2023}, eissn = {1434-9949}, pages = {2557-2575}, orcid-numbers = {Shah, Meera/0009-0005-3308-7231} } @article{MTMT:33311086, title = {Cardiovascular phenotype of long-term anabolic-androgenic steroid abusers compared with strength-trained athletes}, url = {https://m2.mtmt.hu/api/publication/33311086}, author = {Fyksen, Tea Saetereng and Vanberg, Paul and Gjesdal, Knut and von Lueder, Thomas G. and Bjornerheim, Reidar and Steine, Kjetil and Atar, Dan and Halvorsen, Sigrun}, doi = {10.1111/sms.14172}, journal-iso = {SCAND J MED SCI SPOR}, journal = {SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS}, volume = {32}, unique-id = {33311086}, issn = {0905-7188}, abstract = {Introduction Abuse of anabolic-androgenic steroids (AAS) has been linked to a variety of different cardiovascular (CV) side effects, but still the clinical effects of AAS abuse on CV risk are not clear. The aim of this study was to assess the CV phenotype of a large cohort of men with long-term AAS use compared with strength-trained athletes without AAS use. Methods Fifty one strength-trained men with >= 3 years of AAS use was compared with twenty one strength-trained competing athletes. We verified substance abuse and non-abuse by blood and urine analyses. The participants underwent comprehensive CV evaluation including laboratory analyses, 12-lead ECG with measurement of QT dispersion, exercise ECG, 24 h ECG with analyses of heart rate variability, signal averaged ECG, basic transthoracic echocardiography, and coronary computed tomography angiography (CCTA). Results Hemoglobin levels and hematocrit were higher among the AAS users compared with non-users (16.8 vs. 15.0 g/dl, and 0.50% vs. 0.44%, respectively, both p < 0.01) and HDL cholesterol significantly lower (0.69 vs. 1.25 mmol/L, p < 0.01). Maximal exercise capacity was 270 and 280 W in the AAS and the non-user group, respectively (p = 0.04). Echocardiography showed thicker intraventricular septum and left ventricular (LV) posterior wall among AAS users (p < 0.01 for both), while LV ejection fraction was lower (50 vs. 54%, p = 0.02). Seven AAS users (17%) had evidence of coronary artery disease on CCTA. There were no differences in ECG measures between the groups. Conclusions A divergent CV phenotype dominated by increased CV risk, accelerated coronary artery disease, and concentric myocardial hypertrophy was revealed among the AAS users.}, keywords = {coronary artery disease; Myocardial remodeling; anabolic-androgenic steroids; Cardiovascular phenotype}, year = {2022}, eissn = {1600-0838}, pages = {1170-1181}, orcid-numbers = {Fyksen, Tea Saetereng/0000-0003-0315-4120; Atar, Dan/0000-0003-1513-8793} } @article{MTMT:33311085, title = {Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping Review for the Clinical Rheumatologists}, url = {https://m2.mtmt.hu/api/publication/33311085}, author = {Mondal, Sanjib and Barman, Prabal and Vignesh, Pandiarajan}, doi = {10.3389/fmed.2022.827539}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {9}, unique-id = {33311085}, abstract = {Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM. Cardiac involvement in JDM is often underestimated, and it may be a potential indicator of poor prognosis. Cardiac dysfunction in JDM can occur both in the acute and chronic stages of the disease. Amongst the acute complications, acute congestive heart failure (CHF), myocarditis, arrhythmia, and complete heart block are common. However, these remain unrecognized due to a lack of overt clinical manifestations. Increased rates of cardiovascular abnormalities have been noted with anti-SRP and anti-Jo 1 auto-antibody positivity. Long-term follow-up studies in JDM have shown an increased prevalence of hypertension, atherosclerosis, coronary artery disease, and metabolic syndrome in adolescence and adulthood. Monitoring of body-mass index, blood pressure, and laboratory evaluation of fasting glucose and lipid profile may help in identifying metabolic syndrome in children with JDM. Steroid-sparing agents, daily exercise, and a healthy diet may reduce such long-term cardiac morbidities. Current use of multimodality imaging such as stress-echocardiography, contrast-enhanced echocardiography, cardiac magnetic resonance imaging, and positron emission tomography has increased the diagnostic yield of subclinical heart disease during acute and chronic stages of JDM. This review elaborates on different aspects of cardiac dysfunction in JDM. It also emphasizes the importance of cardiac screening in long-term follow-up of children with JDM.}, keywords = {LONG-TERM; dermatomyositis; Screening; Imaging; CARDIAC DYSFUNCTION; VASCULOPATHY; acute}, year = {2022}, eissn = {2296-858X}, orcid-numbers = {Barman, Prabal/0000-0002-0171-668X} } @article{MTMT:32752598, title = {Associations between cardiac and pulmonary involvement in patients with juvenile dermatomyositis—a cross-sectional study}, url = {https://m2.mtmt.hu/api/publication/32752598}, author = {Witczak, B.N. and Schwartz, T. and Barth, Z. and Taraldsrud, E. and Lund, M.B. and Aaløkken, T.M. and Flatø, B. and Sjaastad, I. and Sanner, H.}, doi = {10.1007/s00296-021-05071-3}, journal-iso = {RHEUMATOL INT}, journal = {RHEUMATOLOGY INTERNATIONAL}, volume = {in press}, unique-id = {32752598}, issn = {0172-8172}, year = {2022}, eissn = {1437-160X}, pages = {in press} } @article{MTMT:32602822, title = {Left ventricle diastolic dysfunction in idiopathic inflammatory myopathies: A meta-analysis and systematic review}, url = {https://m2.mtmt.hu/api/publication/32602822}, author = {Zhang, Yiwen and Yang, Xiaoqian and Qin, Li and Luo, Qiang and Wang, Han}, doi = {10.1093/mr/roab041}, journal-iso = {MOD RHEUMATOL}, journal = {MODERN RHEUMATOLOGY}, unique-id = {32602822}, issn = {1439-7595}, year = {2022}, eissn = {1439-7609} } @article{MTMT:31466847, title = {Dermatomyositis: Clinical features and pathogenesis}, url = {https://m2.mtmt.hu/api/publication/31466847}, author = {DeWane, Madeline E. and Waldman, Reid and Lu, Jun}, doi = {10.1016/j.jaad.2019.06.1309}, journal-iso = {J AM ACAD DERMATOL}, journal = {JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY}, volume = {82}, unique-id = {31466847}, issn = {0190-9622}, abstract = {Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically heterogeneous and that can be difficult to diagnose. Cutaneous manifestations sometimes vary and may or may not parallel myositis and systemic involvement in time course or severity. Recent developments in our understanding of myositis-specific antibodies have the potential to change the diagnostic landscape of DM for dermatologists. Although phenotypic overlap exists, anti-Mi2, -MDA5, -NXP2, -TIF1, and -SAE antibodies may be correlated with distinct DM subtypes in terms of cutaneous manifestations, systemic involvement, and malignancy risk. This review highlights new findings on the DM-specific myositis-specific antibodies and their clinical associations in both adults and children.}, keywords = {dermatomyositis; Interstitial lung disease; Juvenile dermatomyositis; idiopathic inflammatory myopathy; AMYOPATHIC DERMATOMYOSITIS; TIF1; MDA5; myositis-specific antibodies; malignancy-associated dermatomyositis; Mi2; NXP2; SAE}, year = {2020}, eissn = {1097-6787}, pages = {267-281} } @article{MTMT:34423441, title = {Juvenile dermatomyositis presenting as complete heart block in a 10-year-old girl}, url = {https://m2.mtmt.hu/api/publication/34423441}, author = {Ghosh, Ritwik and Roy, Devlina and Dubey, Souvik and Abdelrahman, Khaled and Dey, Amit Kumar and Chatterjee, Subhankar and Lahiri, Durjoy and Ray, Biman Kanti}, doi = {10.1080/20469047.2020.1765123}, journal-iso = {PAEDIATR INT CHILD H}, journal = {PAEDIATRICS AND INTERNATIONAL CHILD HEALTH}, volume = {40}, unique-id = {34423441}, issn = {2046-9047}, abstract = {Juvenile dermatomyositis (JDM) is an auto-immune inflammatory condition associated with cardiac disorders including conduction abnormalities and myocardial dysfunction. The time of presentation of cardiac abnormalities can range from disease onset to after long-term follow-up, emphasising the importance of screening for cardiac involvement in JDM. A previously healthy 10-year-old girl presented with syncope, fatigue and weakness associated with a heliotrope rash. JDM was diagnosed based on the clinical, laboratory and imaging findings. An ECG demonstrated complete heart block (CHB). All symptoms resolved following treatment with parenteral corticosteroids. In JDM, it is important to investigate for cardiac manifestations and in CHB to consider administering corticosteroids.}, keywords = {MYOPATHY; Arrhythmia; childhood; immunosuppression; MRI; CARDIAC DYSFUNCTION; Heart Block; Juvenile dermatomyositis}, year = {2020}, eissn = {2046-9055}, pages = {251-254} } @article{MTMT:31176683, title = {Juvenile dermatomyositis: advances in clinical presentation, myositis-specific antibodies and treatment}, url = {https://m2.mtmt.hu/api/publication/31176683}, author = {Wu, J.-Q. and Lu, M.-P. and Reed, A.M.}, doi = {10.1007/s12519-019-00313-8}, journal-iso = {WORLD J PEDIATR}, journal = {WORLD JOURNAL OF PEDIATRICS}, volume = {16}, unique-id = {31176683}, issn = {1708-8569}, year = {2020}, eissn = {1867-0687}, pages = {31-43} } @article{MTMT:3392111, title = {The Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium- to Long-standing Juvenile Dermatomyositis}, url = {https://m2.mtmt.hu/api/publication/3392111}, author = {Barth, Zoltán and Schwartz, T and Flato, B and Aalokken, TM and Koller, Ákos and Lund, MB and Sjaastad, I and Sanner, H}, doi = {10.1002/acr.23687}, journal-iso = {ARTHRIT CARE RES}, journal = {ARTHRITIS CARE & RESEARCH}, volume = {71}, unique-id = {3392111}, issn = {2151-464X}, abstract = {OBJECTIVE: To explore the associations between microvascular abnormalities assessed by nailfold capillaroscopy (NFC) and pulmonary and cardiac involvement in patients with juvenile dermatomyositis (DM) assessed after medium- to long-term follow-up. METHODS: Fifty-eight juvenile DM patients were examined mean 17.0 (SD 10.6) years after symptom onset. Nailfold capillary density (NCD) and neovascular pattern (defined as scleroderma active or late pattern) were analysed blinded to clinical data. Pulmonary involvement was assessed by pulmonary function tests (PFT) including spirometry, diffusion capacity for carbon monoxide (DLCO) and body plethysmography; also high-resolution computed tomography (HRCT) was performed. Cardiac involvement was assessed by electrocardiography, Holter monitoring (heart rate variability) and echocardiography. RESULTS: Patients with low NCD (<6 capillaries/mm) (n=21), compared to patients with normal NCD (>/= 6 capillaries/mm) (n=37), presented lower forced vital capacity (89.7 vs 98.5% of predicted), total lung capacity (87.8 vs 94.5% of predicted) and more often low DLCO (15/21 (71%) vs 14/37 (38%)); all p's<0.05. HRCT assessed airways disease was more frequent in the low NCD group (6/21 (30%) vs 3/37 (8%); p=0.034). No associations were found between i) NCD and cardiac parameters or ii) neovascular pattern and pulmonary or cardiac parameters. CONCLUSION: In juvenile DM patients, low NCD was associated with lung involvement, which was mostly subclinical. No significant associations with cardiac involvement were found. These results shed light on possible mechanisms underlying organ involvement, but further and preferably larger studies are needed to identify NCD as a potential biomarker for lung and cardiac involvement in juvenile DM. This article is protected by copyright. All rights reserved.}, year = {2019}, eissn = {2151-4658}, pages = {492-497}, orcid-numbers = {Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:31088105, title = {Mechanisms supporting potential use of bone marrow-derived mesenchymal stem cells in psychocardiology}, url = {https://m2.mtmt.hu/api/publication/31088105}, author = {Liu, Jianyang and Zhang, Lijun and Liu, Meiyan}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {11}, unique-id = {31088105}, issn = {1943-8141}, abstract = {Despite great efforts made in recent years, globally cardiovascular disease (CVD) remains the most common and devastating disease. Pharmacological, interventional and surgical treatments have proved to be only partly satisfactory for the majority of patients. A major underlying cause of poor prognosis is a high comorbidity rate between CVD and mental illness, which calls for the approaches of psychocardiology. As psychiatric disorders and CVD can influence each other bidirectionally, it is necessary to develop novel therapies targeting both systems simultaneously. Therefore, innovative stem cell (SC) therapy has become the most promising treatment strategy in psychocardiology. Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs), among all different types of SCs, have drawn the most attention due to unique advantages in terms of ethical considerations, low immunogenicity and simplicity of preparation. In this review, we survey recent publications and clinical trials to summarize the knowledge and progress gained so far. Moreover, we discuss the feasibility of the clinical application of BM-MSCs in the area of psychocardiology.}, keywords = {Inflammation; autonomic nervous system; platelet activation; Psychocardiology; bone marrow-derived mesenchymal stem/stromal cells}, year = {2019}, eissn = {1943-8141}, pages = {6717-6738} } @article{MTMT:33616649, title = {Cardiovascular complications in patients with idiopathic inflammatory myopathies: does heart matter in idiopathic inflammatory myopathies?}, url = {https://m2.mtmt.hu/api/publication/33616649}, author = {Opinc, Aleksandra Halina and Makowski, Marcin Adam and Lukasik, Zuzanna Malgorzata and Makowska, Joanna Samanta}, doi = {10.1007/s10741-019-09909-8}, journal-iso = {HEART FAIL REV}, journal = {HEART FAILURE REVIEWS}, volume = {26}, unique-id = {33616649}, issn = {1382-4147}, abstract = {This review presents a detailed study of original researches and previously published reviews concerning cardiovascular involvement in idiopathic inflammatory myopathies (IIM). We aimed to summarize the current knowledge on the cardiac involvement in IIM, evaluate its impact on mortality and indicate areas still awaiting to be investigated. We searched MEDLINE database (until January 2019) and the reference lists of articles. Selection criteria included only published data, available in English, both original researches and reviews. Articles related to cardiovascular involvement in IIM were selected and analysed. The references were also screened, and relevant articles were included. Cardiovascular involvement is frequent in IIM but typically remains subclinical. Among far less prevalent symptomatic forms, congestive heart failure is the most common. Myocardium and conduction system seems to be predominantly affected. High rate of left ventricular diastolic dysfunction was observed. Non-specific changes of ST-T segment were the most common abnormalities in electrocardiography. Patients with IIM were more frequently affected by atrial fibrillation as compared with other autoimmune diseases. Increased risk of myocardial infarction was observed; furthermore, patients often develop comorbidities that enhance cardiovascular risk. Since cardiovascular disorders remain one of the major causes of death and subclinical involvement is frequent, active screening is justified. Growing availability of the novel imaging techniques may facilitate diagnosis. Correlation between myocardial involvement and the type of autoantibodies and impact of different therapeutic options on the progression of cardiovascular lesions require further studies.}, keywords = {RISK; MAGNETIC-RESONANCE; heart failure; POLYMYOSITIS; dermatomyositis; ISCHEMIC-STROKE; PULMONARY-HYPERTENSION; idiopathic inflammatory myopathy; ADULT POLYMYOSITIS; CARDIAC INVOLVEMENT; pericardial tamponade; Conduction system; Inclusion body myositis; POLYMYOSITIS-DERMATOMYOSITIS}, year = {2019}, eissn = {1573-7322}, pages = {111-125}, orcid-numbers = {Opinc, Aleksandra Halina/0000-0002-7881-5731; Lukasik, Zuzanna Malgorzata/0000-0001-9551-3578; Makowska, Joanna Samanta/0000-0003-2036-375X} } @article{MTMT:27349880, title = {Physical Activity and Heart Rate Variability in Adolescents with Abdominal Obesity}, url = {https://m2.mtmt.hu/api/publication/27349880}, author = {Farah, Breno Quintella and Andrade-Lima, Aluisio and Germano-Soares, Antonio Henrique and Destro, Christofaro Diego Giulliano and Gomes, de Barros Mauro Virgilio and do, Prado Wagner Luiz and Ritti-Dias, Raphael M}, doi = {10.1007/s00246-017-1775-6}, journal-iso = {PEDIATR CARDIOL}, journal = {PEDIATRIC CARDIOLOGY}, volume = {39}, unique-id = {27349880}, issn = {0172-0643}, year = {2018}, eissn = {1432-1971}, pages = {466-472} } @article{MTMT:27149824, title = {Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample}, url = {https://m2.mtmt.hu/api/publication/27149824}, author = {Jonathan, I Silverberg and Lauren, Kwa and Michael, C Kwa and Anne, E Laumann and Kaveh, Ardalan}, doi = {10.1093/rheumatology/kex465}, journal-iso = {RHEUMATOLOGY}, journal = {RHEUMATOLOGY (UNITED KINGDOM)}, volume = {57}, unique-id = {27149824}, issn = {1462-0324}, year = {2018}, eissn = {1462-0332}, pages = {694-702} } @article{MTMT:27610402, title = {Cardiac autonomic profile in cervical spinal cord injury subjects practitioners of the physical exercise}, url = {https://m2.mtmt.hu/api/publication/27610402}, author = {Martins, Edgar William and Magalhaes, Roberto and Marocolo, Moacir and Maior, Alex Souto}, doi = {10.4025/actascihealthsci.v40i1.33469}, journal-iso = {ACTA SCI HEALTH SCI}, journal = {ACTA SCIENTIARUM HEALTH SCIENCES}, volume = {40}, unique-id = {27610402}, issn = {1679-9291}, year = {2018}, eissn = {1807-8648} } @article{MTMT:27354181, title = {Advances in Juvenile Dermatomyositis: Myositis Specific Antibodies Aid in Understanding Disease Heterogeneity}, url = {https://m2.mtmt.hu/api/publication/27354181}, author = {Pachman, Lauren M and Khojah, Amer M}, doi = {10.1016/j.jpeds.2017.12.053}, journal-iso = {J PEDIATR}, journal = {JOURNAL OF PEDIATRICS}, volume = {195}, unique-id = {27354181}, issn = {0022-3476}, year = {2018}, eissn = {1097-6833}, pages = {16-27} } @article{MTMT:30585321, title = {The Vasculopathy of Juvenile Dermatomyositis}, url = {https://m2.mtmt.hu/api/publication/30585321}, author = {Papadopoulou, Charalampia and McCann, Liza J.}, doi = {10.3389/fped.2018.00284}, journal-iso = {FRONT PEDIATR}, journal = {FRONTIERS IN PEDIATRICS}, volume = {6}, unique-id = {30585321}, issn = {2296-2360}, abstract = {Juvenile dermatomyositis (JDM) is a rare autoimmune disease mainly characterized by muscle and skin involvement. Vasculopathy is considered central to the pathogenesis of the disease. The exact nature of vasculopathy is not yet understood but it is a complex process with both an inflammatory and a non-inflammatory, occlusive component. Impaired function of JDM vasculature includes immune complex deposition, altered expression of cell adhesion molecules predominantly inducing Th17 cell infiltration, and endothelial cell dysfunction. Development of vasculopathy is associated with the severe extra-muscular manifestations of JDM, such as gastrointestinal and cardiac manifestations, interstitial lung disease, ulcerative skin disease or development of calcinosis, and portends a poor prognosis. Correlation of histopathological findings, autoantibodies, and extensive diagnostic workup represent key elements to the early detection of vasculopathic features and early aggressive treatment. Monitoring of vasculopathy remains challenging due to the lack of non-invasive biomarkers. Current treatment approaches provide variable benefit, but better understanding of the essential pathogenic mechanisms should help lead to improved outcomes. Whilst acknowledging that evidence is limited, this review aims to describe the vasculopathy of JDM in the context of pathophysiology, clinical features, and treatment of disease.}, keywords = {PATHOPHYSIOLOGY; ANTIBODIES; dermatomyositis; juvenile; VASCULOPATHY}, year = {2018}, eissn = {2296-2360} } @article{MTMT:30471113, title = {Systemic and Tissue Inflammation in Juvenile Dermatomyositis: From Pathogenesis to the Quest for Monitoring Tools}, url = {https://m2.mtmt.hu/api/publication/30471113}, author = {Wienke, Judith and Deakin, Claire T. and Wedderburn, Lucy R. and van Wijk, Femke and van Royen-Kerkhof, Annet}, doi = {10.3389/fimmu.2018.02951}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {9}, unique-id = {30471113}, issn = {1664-3224}, abstract = {Juvenile Dermatomyositis (JDM) is a systemic immune-mediated disease of childhood, characterized by muscle weakness, and a typical skin rash. Other organ systems and tissues such as the lungs, heart, and intestines can be involved, but may be under-evaluated. The inflammatory process in JDM is characterized by an interferon signature and infiltration of immune cells such as T cells and plasmacytoid dendritic cells into the affected tissues. Vasculopathy due to loss and dysfunction of endothelial cells as a result of the inflammation is thought to underlie the symptoms in most organs and tissues. JDM is a heterogeneous disease, and several disease phenotypes, each with a varying combination of affected tissues and organs, are linked to the presence of myositis autoantibodies. These autoantibodies have therefore been extensively studied as biomarkers for the disease phenotype and its associated prognosis. Next to identifying the JDM phenotype, monitoring of disease activity and disease-inflicted damage not only in muscle and skin, but also in other organs and tissues, is an important part of clinical follow-up, as these are key determinants for the long-term outcomes of patients. Various monitoring tools are currently available, among which clinical assessment, histopathological investigation of muscle and skin biopsies, and laboratory testing of blood for specific biomarkers. These investigations also give novel insights into the underlying immunological processes that drive inflammation in JDM and suggest a strong link between the interferon signature and vasculopathy. New tools are being developed in the quest for minimally invasive, but sensitive and specific diagnostic methods that correlate well with clinical symptoms or reflect local, low-grade inflammation. In this review we will discuss the types of (extra)muscular tissue inflammation in JDM and their relation to vasculopathic changes, critically assess the available diagnostic methods including myositis autoantibodies and newly identified biomarkers, and reflect on the immunopathogenic implications of identified markers.}, keywords = {AUTOANTIBODIES; Biomarkers; personalized medicine; VASCULOPATHY; Juvenile dermatomyositis; Disease monitoring; tissue inflammation; interferon signature}, year = {2018}, eissn = {1664-3224} } @article{MTMT:26771446, title = {Cardiac findings in children with juvenile Dermatomyositis at disease presentation}, url = {https://m2.mtmt.hu/api/publication/26771446}, author = {Cantez, Serdar and Gross, Gil J and MacLusky, Ian and Feldman, Brian M}, doi = {10.1186/s12969-017-0182-0}, journal-iso = {PEDIATR RHEUMATOL}, journal = {PEDIATRIC RHEUMATOLOGY}, volume = {15}, unique-id = {26771446}, issn = {1546-0096}, year = {2017}, eissn = {1546-0096} } @article{MTMT:27103451, title = {Cardiovascular involvement in myositis}, url = {https://m2.mtmt.hu/api/publication/27103451}, author = {Diederichsen, Louise P}, doi = {10.1097/BOR.0000000000000442}, journal-iso = {CURR OPIN RHEUMATOL}, journal = {CURRENT OPINION IN RHEUMATOLOGY}, volume = {29}, unique-id = {27103451}, issn = {1040-8711}, year = {2017}, eissn = {1531-6963}, pages = {598-603} } @article{MTMT:26434397, title = {Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies}, url = {https://m2.mtmt.hu/api/publication/26434397}, author = {Schwartz, T and Diederichsen, LP and Lundberg, IE and Sjaastad, I and Sanner, H}, doi = {10.1136/rmdopen-2016-000291}, journal-iso = {RMD OPEN}, journal = {RMD OPEN}, volume = {2}, unique-id = {26434397}, issn = {2056-5933}, year = {2016}, eissn = {2056-5933} }